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Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II
Open accessAbstract
Defining Defensins' Mode of Action: Defensins are antimicrobial host defense peptides that play a role in innate immunity. Many such peptides act by disrupting the bacterial membrane; however, Schneider et al. (p. 1168 ) now show that the fungal defensin, plecstasin, targets cell wall biosynthesis. Biochemical studies identified Lipid II as the cellular target of plecstasin and the residues involved in complex formation were identified using NMR spectroscopy and computational modeling. Initial studies identified two defensins from invertebrates that also target Lipid II. Plecstasin is active against some drug-resistant Gram-positive bacteria, and its action against a validated target makes it a promising lead for further drug development.
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Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Development and validation of a genetic algorithm for flexible docking 1 1Edited by F. E. Cohen
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HADDOCK: A Protein−Protein Docking Approach Based on Biochemical or Biophysical Information
Dominguez, C., Boelens, R., & Bonvin, A. M. J. J. (2003) · Journal of the American Chemical Society · doi:10.1021/ja026939x · Cited by 3,187
Self-citationStructure, biochemistry and mechanism of action of glycopeptide antibiotics
Reynolds, P. E. (1989) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01967563 · Cited by 699
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Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities
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Metadata
- Authors
- Schneider, T., Kruse, T., Wimmer, R., Wiedemann, I., Sass, V., Pag, U., Jansen, A., Nielsen, A. K., Mygind, P. H., Raventós, D. S., Neve, S., Ravn, B., Bonvin, A. M. J. J., De Maria, L., Andersen, A. S., Gammelgaard, L. K., Sahl, H.-G., & Kristensen, H.-H.
- Venue
- Science
- Published
- 2010-05-28
- Volume
- 328
- Issue
- 5982
- Pages
- 1168-1172
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979404035
- Cited by
- 550
- References
- 4
- FWCI
- 35.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Schneider, T., Kruse, T., Wimmer, R., Wiedemann, I., Sass, V., Pag, U., Jansen, A., Nielsen, A. K., Mygind, P. H., Raventós, D. S., Neve, S., Ravn, B., Bonvin, A. M. J. J., De Maria, L., Andersen, A. S., Gammelgaard, L. K., Sahl, H.-G., & Kristensen, H.-H. (2010). Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II. Science. https://doi.org/10.1126/science.1185723
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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