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Challenges of Antibacterial Discovery

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Silver, Lynn L.·2011·Clinical Microbiology Reviews
DOI 10.1128/cmr.00030-10
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Abstract

SUMMARY: The discovery of novel small-molecule antibacterial drugs has been stalled for many years. The purpose of this review is to underscore and illustrate those scientific problems unique to the discovery and optimization of novel antibacterial agents that have adversely affected the output of the effort. The major challenges fall into two areas: (i) proper target selection, particularly the necessity of pursuing molecular targets that are not prone to rapid resistance development, and (ii) improvement of chemical libraries to overcome limitations of diversity, especially that which is necessary to overcome barriers to bacterial entry and proclivity to be effluxed, especially in Gram-negative organisms. Failure to address these problems has led to a great deal of misdirected effort.

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Metadata

Authors
Silver, L. L.
Venue
Clinical Microbiology Reviews
Publisher
American Society for Microbiology
Published
2011-01
Volume
24
Issue
1
Pages
71-109
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
DOI
10.1128/cmr.00030-10
OpenAlex
W2139516496
Cited by
1,376
References
9
FWCI
27.74
Type
journal article
Language
en
Open access
green
Licence
journals.asm.org/non-commercial-tdm-license (tdm)

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Silver, L. L. (2011). Challenges of Antibacterial Discovery. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.00030-10

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