The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice
Abstract
As the human life span increases, the number of people suffering from cognitive decline is rising dramatically. The mechanisms underlying age-associated memory impairment are, however, not understood. Here we show that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity. During learning, aged mice display a specific deregulation of histone H4 lysine 12 (H4K12) acetylation and fail to initiate a hippocampal gene expression program associated with memory consolidation. Restoration of physiological H4K12 acetylation reinstates the expression of learning-induced genes and leads to the recovery of cognitive abilities. Our data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the aging mouse brain.
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In the citing paper
“Restoration of physiological H4 acetylation through administration of histone deacetylase inhibitors, avoids the manifestation of age-associated memory impairment in mice (Peleg et al., 2010), indicating that reversion of epigenetic changes may have neuroprotective effects.”
From The Hallmarks of Aging (2013) · cites this paper as Peleg et al., 2010
In the citing paper
“CHIP can interact with heat shock protein 70 (Hsp70) and induces ubiquitination of tau [170].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [170]
In the citing paper
“For example, H4K12 histone acetylation is decreased in aged mice, leading to deficits in the expression of genes associated with learning and memory [170].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [170]
In the citing paper
“Pharmacologic treatment that alters histone modification such as acetylation status also shows an effect on longevity in aging and progeroid mouse models, suggesting that potential future therapeutic interventions targeting epigenetic regulators may be feasible175,176.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [175]
Citations
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ATP-citrate lyase links cellular metabolism to histone acetylation
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ChIP-seq accurately predicts tissue-specific activity of enhancers
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Self-citationRegulation of histone acetylation during memory formation in the hippocampus
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Chromatin Acetylation, Memory, and LTP Are Impaired in CBP+/− Mice
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Ketone bodies as signaling metabolites
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Metadata
- Authors
- Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari-Javan, S., Agis-Balboa, R. C., Cota, P., Wittnam, J. L., Gogol-Doering, A., Opitz, L., Salinas-Riester, G., Dettenhofer, M., Kang, H., Farinelli, L., Chen, W., & Fischer, A.
- Affiliations
- European Neuroscience Institute Göttingen (DE)
- Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Grisebach Str. 5, D-37077 Goettingen, Germany.
- Max Delbrueck Center for Molecular Medicine, Institute for Medical Systems Biology, Robert-Rössle-Strasse 10, D-13125 Berlin-Buch, Germany.
- University of Göttingen (DE)
- Harvard University (US)
- Max Delbrück Center (DE)
- Fasteris SA, CH-1228 Plan-les-Ouates, Switzerland.
- Corresponding author
- Peleg, Shahaf
- Sananbenesi, Farahnaz
- Zovoilis, Athanasios
- Fischer, André
- ORCID
- Venue
- Science
- Published
- 2010-05-07
- Volume
- 328
- Issue
- 5979
- Pages
- 753-756
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2149591661
- Cited by
- 951
- References
- 24
- Citations by year
- 2026: 16 · 2025: 30 · 2024: 51 · 2023: 38 · 2022: 42 · 2021: 50 · 2020: 52 · 2019: 50 · 2018: 60 · 2017: 60 · 2016: 81 · 2015: 77 · 2014: 76 · 2013: 94 · 2012: 73
- FWCI
- 51.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- GRO (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- histone acetylation, H4K12 acetylation, hippocampus, chromatin plasticity, memory consolidation, cognitive decline, brain aging, biomarkers, gene-environment interaction
- MeSH terms
- Formins, Acetylation, Aging, Animals, Chromatin, Conditioning, Psychological, Fear, Gene Expression Regulation, Hippocampus, Histones, Hydroxamic Acids, Learning, Lysine, Memory, Memory Disorders, Mice, Inbred C57BL, Microfilament Proteins, Nerve Tissue Proteins, Nuclear Proteins, Transcription, Genetic, Signal Transduction, Up-Regulation, Gene Expression Profiling, Transcription Initiation Site, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Mice, Histone Deacetylase Inhibitors
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