Spatially Ordered Dynamics of the Bacterial Carbon Fixation Machinery
Abstract
Carboxysomes in a Row: The carboxysome is an organelle-like proteinaceous microcompartment that sequesters the enzymes of carbon fixation from the rest of the cytoplasm in cyanobacteria. Cyanobacterial carbon fixation is a major component of the global carbon cycle. Savage et al. (p. 1258 ) now show that carboxysomes are linearly arranged within the cytoplasm in a process that involves the bacterial cytoskeleton. This arrangement is important in carboxysome partitioning during cell division. When carboxysome partitioning is disrupted by interfering with the bacterial cytoskeleton, carbon fixation is impaired.
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Two cytoskeletal proteins, par A and merB, are involved in the organization of the specific carboxysomal pattern.
“It seems that two cytoskeletal proteins, par A (involved in chromosome and plasmid segregation) and merB (involved in cell morphology), are involved in the organization of this specific carboxysomal pattern (Savage et al. 2010).”
From Renewable energy from Cyanobacteria: energy production optimization by metabolic pathway engineering (2011) · cites this paper as Savage et al. 2010
In cyanobacteria, carboxysomes possess a specific organization through the cell, not found in other prokaryotes, and this distribution is closely linked to CO2 fixation efficiency.
“A recent study has shown that in cyanobacteria, carboxysomes possess a specific organization through the cell, not found in other prokaryotes, and this distribution is closely linked to the CO2 fixation efficiency.”
From Renewable energy from Cyanobacteria: energy production optimization by metabolic pathway engineering (2011) · cites this paper as Savage et al. 2010
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- Authors
- Savage, D. F., Afonso, B., Chen, A. H., & Silver, P. A.
- Affiliations
- Harvard University (US)
- Corresponding author
- Savage, David F.
- Afonso, Bruno
- Silver, Pamela A.
- Venue
- Science
- Published
- 2010-03-05
- Volume
- 327
- Issue
- 5970
- Pages
- 1258-1261
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2007325299
- Cited by
- 308
- References
- 20
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 17 · 2023: 13 · 2022: 15 · 2021: 24 · 2020: 18 · 2019: 15 · 2018: 19 · 2017: 22 · 2016: 21 · 2015: 16 · 2014: 20 · 2013: 22 · 2012: 33
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Metalloenzymes and iron-sulfur proteins
- Keywords
- carboxysomes, cyanobacteria, CO2 fixation, Pará, cytoskeleton, cell division, spatial organization, fluorescent labeling, metabolic compartmentation
- MeSH terms
- Bacterial Proteins, Carbon Dioxide, Cell Division, Cytoskeleton, Diffusion, Genes, Bacterial, Recombinant Fusion Proteins, Ribulose-Bisphosphate Carboxylase, Gene Deletion, Cytoplasmic Structures, Synechococcus
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