The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Transition to Addiction Is Associated with a Persistent Impairment in Synaptic Plasticity
Abstract
Addicts Lose Plasticity: What are the biological mechanisms associated with the transition from occasional drug use to addiction? In rats, like in humans, even after a prolonged period of drug intake, only a limited number of animals develop addiction-like behavior despite the amount of drug taken by all subjects being the same. Kasanetz et al. (p. 1709 ) compared the expression of N -methyl- d -aspartate (NMDA)–dependent long-term depression (NMDA-LTD) in the nucleus accumbens of addicted and nonaddicted rats. Initially, once drug self-administration had been learned and consolidated, but before the appearance of addiction-like behavior, LTD was suppressed in all animals independently of their vulnerability to addiction at a later stage. However, after 2 months, when addiction-like behavior appears, LTD was persistently lost in the addicted animals. In contrast, normal NMDA-LTD reappeared in animals that maintained a controlled drug intake without becoming addicted.
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Cites
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Drug addiction: updating actions to habits to compulsions ten years on
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Metadata
- Authors
- Kasanetz, F., Deroche-Gamonet, V., Berson, N., Balado, E., Lafourcade, M., Manzoni, O., & Piazza, P. V.
- Venue
- Science
- Published
- 2010-06-25
- Volume
- 328
- Issue
- 5986
- Pages
- 1709-1712
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982298072
- Cited by
- 364
- References
- 30
- FWCI
- 12.18
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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