Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill
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The learning of new skills is characterized by an initial phase of rapid improvement in performance and a phase of more gradual improvements as skills are automatized and performance asymptotes. Using in vivo striatal recordings, we observed region-specific changes in neural activity during the different phases of skill learning, with the associative or dorsomedial striatum being preferentially engaged early in training and the sensorimotor or dorsolateral striatum being engaged later in training. Ex vivo recordings from medium spiny striatal neurons in brain slices of trained mice revealed that the changes observed in vivo corresponded to regional- and training-specific changes in excitatory synaptic transmission in the striatum. Furthermore, the potentiation of glutamatergic transmission observed in dorsolateral striatum after extensive training was preferentially expressed in striatopallidal neurons, rather than striatonigral neurons. These findings demonstrate that region- and pathway-specific plasticity sculpts the circuits involved in the performance of the skill as it becomes automatized.
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There is explicit evidence for transfer from dorsomedial to dorsolateral striatum over the course of training.
“There is also explicit evidence for the transfer from dorsomedial to dorsolateral over the course of training (Belin et al., 2009; Graybiel, 2008; Yin et al., 2009; Thorn et al., 2010).”
From Goals and Habits in the Brain (2013) · cites this paper as Yin et al., 2009
Neurophysiological studies in non-human primates and rodents have found dissociable contributions of the DMS and DLS to early versus late stages of training.
“neuro-physiological studies in non-human primates [9], as well as in rodents [10], have also found dissociable contributions of the DMS and DLS to early versus late stages of training.”
From Contributions of the striatum to learning, motivation, and performance: an associative account (2012) · cites this paper as [10]
A large body of research implicates the dorsal striatum in the implementation of already learned instrumental motor behaviors, with dissociations between the DLS and DMS.
“A large body of research has also implicated the dorsal striatum in the implementation of already learned instrumental motor behaviors, often with dissociations emerging between the DLS and DMS [7–10].”
From Contributions of the striatum to learning, motivation, and performance: an associative account (2012) · cites this paper as [10]
It is unlikely that striatal regions differ functionally in terms of their respective contributions to learning versus performance.
“It is unlikely therefore, that these regions differ functionally in terms of their respective contributions to learning vs performance [10,11].”
From Contributions of the striatum to learning, motivation, and performance: an associative account (2012) · cites this paper as [10]
There is overwhelming evidence for a role of the dorsolateral striatum in performance of well-learned motor programs.
“there is overwhelming evidence for a role of the DLS in performance of well-learned motor programs [5,7–10,18]”
From Contributions of the striatum to learning, motivation, and performance: an associative account (2012) · cites this paper as [10]
Dopamine depletion in the striatum leads to loss of dendritic spines on striatal medium spiny neurons in animal models and in Parkinson's disease.
“DA-depletion in the striatum leads to the loss of dendritic spines on striatal medium spiny neurons (MSNs) in both animal models87–89 and in PD90.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [87]
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Motor skill learning depends on protein synthesis in the dorsal striatum after training
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- Authors
- Yin, H. H., Mulcare, S. P., Hilário, M. R. F., Clouse, E., Holloway, T., Davis, M. I., Hansson, A. C., Lovinger, D. M., & Costa, R. M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Costa, Rui M
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2009-02-08
- Volume
- 12
- Issue
- 3
- Pages
- 333-341
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC2774785
- OpenAlex
- W2061863046
- Cited by
- 818
- References
- 51
- Citations by year
- 2026: 32 · 2025: 44 · 2024: 67 · 2023: 57 · 2022: 48 · 2021: 56 · 2020: 50 · 2019: 52 · 2018: 41 · 2017: 44 · 2016: 51 · 2015: 45 · 2014: 49 · 2013: 46 · 2012: 37
- FWCI
- 21.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (Z01AA000407)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- striatum, skill acquisition, skill consolidation, dorsomedial striatum, dorsolateral striatum, striatopallidal neurons, striatonigral neurons, medium spiny neurons, glutamatergic neurotransmission, synaptic potentiation, neuroplasticity
- MeSH terms
- Animals, Corpus Striatum, Learning, Male, Mice, Inbred C57BL, Motor Skills, Nerve Net, Neuronal Plasticity, Psychomotor Performance, Mice
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