Cited by 488Neural and Behavioral Psychology StudiesObsessive-Compulsive Spectrum DisordersGambling Behavior and Treatments

New developments in human neurocognition: clinical, genetic and brain imaging correlates of impulsivity and compulsivity

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Fineberg, Naomi A, Chamberlain, Samuel R., Goudriaan, Anna E., Stein, Dan J., Vanderschuren, Louk J. M. J., Gillan, Claire M., Shekar, Sameer, Gorwood, Philip A. P. M. +7 more·2014·CNS Spectrums

Abstract

Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically and neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated with risk-seeking and compulsivity with harm-avoidance. However, they are increasingly recognized to be linked by shared neuropsychological mechanisms involving dysfunctional inhibition of thoughts and behaviors. In this article, we selectively review new developments in the investigation of the neurocognition of impulsivity and compulsivity in humans, in order to advance our understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research.

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Authors
Fineberg, N. A., Chamberlain, S. R., Goudriaan, A. E., Stein, D. J., Vanderschuren, L. J. M. J., Gillan, C. M., Shekar, S., Gorwood, P. A. P. M., Voon, V., Morein-Zamir, S., Denys, D., Sahakian, B. J., Moeller, F. G., Robbins, T. W., & Potenza, M. N.
Affiliations
  • University of Hertfordshire (GB)
  • University of Cambridge (GB)
  • Amsterdam UMC Location University of Amsterdam (NL)
  • University of Cape Town (ZA)
  • Utrecht University (NL)
  • Queen Elizabeth II Hospital (GB)
  • Inserm (FR)
  • Netherlands Institute for Neuroscience (NL)
  • Virginia Commonwealth University (US)
  • Yale University (US)
Corresponding author
Fineberg, Naomi A
Venue
CNS Spectrums
Published
2014-02
Volume
19
Issue
1
Pages
69-89
ISSN
  • 1092-8529 (ISSN-L)
  • 2165-6509
OpenAlex
W2087042918
Cited by
488
References
258
Citations by year
2026: 19 · 2025: 29 · 2024: 31 · 2023: 31 · 2022: 45 · 2021: 47 · 2020: 84 · 2019: 54 · 2018: 41 · 2017: 32 · 2016: 27 · 2015: 27 · 2014: 19 · 2013: 1 · 2012: 1
FWCI
3.38
Type
journal article
Language
en
Open access
Locations
  • CNS Spectrums (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion, other-oa)
  • PubMed Central (acceptedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Anglia Ruskin Research Online (Anglia Ruskin University) (submittedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
  • ePrints Soton (University of Southampton) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion, other-oa)
Funders
  • National Center for Responsible Gaming
  • Yale University
  • Wellcome Trust (089589/Z/09/Z, 093875/Z/10/Z, 89589/Z/09/Z)
  • Academy of Medical Sciences (AMS-SGCL10-Chamberlain)
  • ZonMw (91207006, 31160003)
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (31160003)
  • National Institutes of Health (UL1TR000058, 5p50da009262-20, DA027844)
  • National Institute on Alcohol Abuse and Alcoholism (AA017539, RL1AA017539)
  • National Institute on Drug Abuse (#P50 DA009262, R01DA022628, P20DA024157, P50DA033935, R01DA018647, R01DA035058, R01DA019039, P20DA027844, DA027844, DA022628)
  • National Center for Advancing Translational Sciences
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Keywords
impulsivity, compulsivity, neurocognitive function, inhibitory control, risk seeking, harm avoidance, addiction, genetic correlates, neuroimaging, neuropsychology
MeSH terms
Animals, Compulsive Behavior, Humans, Impulsive Behavior, Prognosis, Behavior, Addictive, Cognitive Science, Substance-Related Disorders

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