Reprogramming of T Cells to Natural Killer–Like Cells upon Bcl11b Deletion

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

Kärre, K., Ljunggren, H., Piontek, G., & Kiessling, R. (1986) · Nature · doi:10.1038/319675a0 · Cited by 2,333

Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro

Schmitt, T. M., & Zúñiga-Pflücker, J. C. (2002) · Immunity · doi:10.1016/s1074-7613(02)00474-0 · Cited by 1,120

Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism.

Ljunggren, H., & Kärre, K. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.162.6.1745 · Cited by 741

Launching the T-cell-lineage developmental programme

Rothenberg, E. V., Moore, J. E., & Yui, M. A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2232 · Cited by 514

Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46

Walzer, T., Bléry, M., Chaix, J., Fuséri, N., Chasson, L., Robbins, S. H., Jaeger, S., André, P., Gauthier, L., Daniel, L., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609692104 · Cited by 496

A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127

Vosshenrich, C. A. J., García‐Ojeda, M. E., Samson, S., Pasqualetto, V., Enault, L., Goff, O. R.-L., Corcuff, E., Guy‐Grand, D., Rocha, B., Cumano, A., et al. (2006) · Nature Immunology · doi:10.1038/ni1395 · Cited by 475

The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development

Gascoyne, D. M., Long, E., Veiga‐Fernandes, H., de Boer, J., Williams, O., Seddon, B. P., Coles, M. C., Kioussis, D., & Brady, H. J. M. (2009) · Nature Immunology · doi:10.1038/ni.1787 · Cited by 446

Naive T cell homeostasis: from awareness of space to a sense of place

Takada, K., & Jameson, S. C. (2009) · Nature reviews. Immunology · doi:10.1038/nri2657 · Cited by 393

Bcl11b is required for differentiation and survival of αβ T lymphocytes

Wakabayashi, Y., Watanabe, H., Inoue, J., Takeda, N., Sakata, J., Mishima, Y., Hitomi, J., Yamamoto, T., Utsuyama, M., Niwa, O., et al. (2003) · Nature Immunology · doi:10.1038/ni927 · Cited by 372

Role of NK cells in the control of metastatic spread and growth of tumor cells in mice

Gorelik, E., Wiltrout, R. H., Okumura, K., Habu, S., & Herberman, R. B. (1982) · International Journal of Cancer · doi:10.1002/ijc.2910300118 · Cited by 366

Genetic and Epigenetic Control of Early Lymphocyte Development

Ikawa, T. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_370 · Cited by 15

The effect of ethephon on immune system in male offspring of mice

Wang, S., Jin, H., Tang, Q., Fu, J., Ren, Z., Peng, C., Shang, L., Hao, W., & Wei, X. (2016) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2016.12.007 · Cited by 15

CD5−NK1.1+ γδ T Cells that Develop in a Bcl11b-Independent Manner Participate in Early Protection against Infection

Hatano, S., Murakami, T., Noguchi, N., Yamada, H., & Yoshikai, Y. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.007 · Cited by 15

Transcriptional Regulation of Mouse Tissue-Resident Natural Killer Cell Development

Valero-Pacheco, N., & Beaulieu, A. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00309 · Cited by 16

Identification of two novel variants of the BCL11B gene in two Chinese pedigrees associated with neurodevelopmental disorders

Che, F., Tie, X., Hong, L., Zhang, X., Duan, M., Zhang, L., & Yang, Y. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.927357 · Cited by 15

Transcription factor-induced enhancer modulations during cell fate conversions

van Oevelen, C. J. C., Kallin, E. M., & Graf, T. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.07.003 · Cited by 15

The Transcriptional Landscape

Nielsen, H. (2010) · Methods in molecular biology · doi:10.1007/978-1-59745-248-9_1 · Cited by 17

Transcriptional Establishment of Cell-Type Identity: Dynamics and Causal Mechanisms of T-Cell Lineage CommitmentPreprint

Rothenberg, E. V., Champhekar, A. S., Damle, S. S., Real, M. M. D., Kueh, H. Y., Li, L., & Yui, M. A. (2013) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2013.78.020271 · Cited by 13

Network-based analysis of heterogeneous patient-matched brain and extracranial melanoma metastasis pairs reveals three homogeneous subgroups

Grützmann, K., Kraft, T. A., Meinhardt, M., Meier, F. E., Westphal, D., & Seifert, M. (2024) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2024.02.013 · Cited by 13

Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b

Shibata, K., Motozono, C., Nagae, M., Shimizu, T., Ishikawa, E., Motooka, D., Okuzaki, D., Izumi, Y., Takahashi, M., Fujimori, N., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34802-8 · Cited by 13

Natural Killer Cells and Their Role in Immunity

Sharrock, J. (2019) · EMJ Allergy & Immunology · doi:10.33590/emjallergyimmunol/10311326 · Cited by 13

Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells

Zhong, C., & Zhu, J. (2015) · Mediators of Inflammation · doi:10.1155/2015/264502 · Cited by 13

BCL11B depletion induces the development of highly cytotoxic innate T cells out of IL-15 stimulated peripheral blood αβ CD8+ T cells

Forkel, H., Grabarczyk, P., Depke, M., Troschke‐Meurer, S., Simm, S., Hammer, E., Michalik, S., Hentschker, C., Corleis, B., Loyal, L., et al. (2022) · OncoImmunology · doi:10.1080/2162402x.2022.2148850 · Cited by 12

Dynamical Analysis of the Regulatory Network Controlling Natural Killer Cells Differentiation

Liquitaya-Montiel, A. J., & Mendoza, L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01029 · Cited by 12

Hematopoietic lineage-converted T cells carrying tumor-associated antigen-recognizing TCRs effectively kill tumor cells

Hu, F., Huang, D., Luo, Y., Zhou, P., Lv, C., Wang, K., Weng, Q., Liu, X., Guan, Y., Geng, Y., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000498 · Cited by 12

The perception and response of T cells to a changing environment are based on the law of initial value

Huseby, E. S., & Teixeiro, E. (2022) · Science Signaling · doi:10.1126/scisignal.abj9842 · Cited by 13

BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells

Li, Y., Wang, X., Huang, M., Wang, X., Li, C., Li, S., Tang, Y., Yu, S., Wang, Y., Song, W., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00276-1 · Cited by 14

A mutant BCL11B-N440K protein interferes with BCL11A function during T lymphocyte and neuronal development

Okuyama, K., Yamashita, M., Koumoundourou, A., Wiegreffe, C., Ohno‐Oishi, M., Murphy, S. J. H., Zhao, X., Yoshida, H., Ebihara, T., Satoh‐Takayama, N., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01997-5 · Cited by 11

Transcriptional Control of NK Cell Differentiation and Function

Male, V. H., & Brady, H. J. M. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_376 · Cited by 11

A dynamical model of the regulatory network controlling lymphopoiesis

Mendoza, L., & Méndez, A. (2015) · Biosystems · doi:10.1016/j.biosystems.2015.09.004 · Cited by 11

Recipient tissue microenvironment determines developmental path of intestinal innate lymphoid progenitors

Clark, P. A., Gogoi, M., Rodríguez‐Rodríguez, N., Ferreira, A. C. F., Murphy, J. E., Walker, J. A., Crisp, A., Jolin, H. E., Shields, J. D., & McKenzie, A. N. J. (2024) · Nature Communications · doi:10.1038/s41467-024-52155-2 · Cited by 10

In utero human cytomegalovirus infection expands NK-like FcγRIII+CD8+ T cells that mediate Fc antibody functions

Semmes, E. C., Nettere, D., Nelson, A. N., Hurst, J. H., Cain, D. W., Burt, T. D., Kurtzberg, J., Reeves, R. K., Coyne, C. B., Fouda, G. G., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci181342 · Cited by 13

The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors

Chiara, V. D., Daxinger, L., & Staal, F. J. T. (2021) · Cells · doi:10.3390/cells10051074 · Cited by 11

Deconstructing deployment of the innate immune lymphocyte army for barrier homeostasis and protection

Almeida, F. F., Jacquelot, N., & Belz, G. T. (2018) · Immunological Reviews · doi:10.1111/imr.12709 · Cited by 10

Generation of dual-attribute iTNK cells from hPSCs for cancer immunotherapy

Zhang, Y., He, Y., Dai, C., Zhou, Z., Miao, Y., Zhao, Z., Lei, Q., Li, C., Wang, C., & Deng, H. (2024) · Cell Reports Methods · doi:10.1016/j.crmeth.2024.100843 · Cited by 9

The development of innate lymphoid cells

Das, A., Ding, Y., Harly, C., & Bhandoola, A. (2026) · Nature Immunology · doi:10.1038/s41590-025-02414-1 · Cited by 9

Chronic T cell receptor stimulation unmasks NK receptor signaling in peripheral T cell lymphomas via epigenetic reprogramming

Carras, S., Chartoire, D., Mareschal, S., Heiblig, M., Marçais, A., Robinot, R., Urb, M., Pommier, R. M., Julia, E., Chebel, A., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci139675 · Cited by 9

A novel SATB1 protein isoform with different biophysical properties

Ζελένκα, Τ., Papamatheakis, D.-A., Tzerpos, P., Panagopoulos, G., Tsolis, K. C., Papadakis, V. M., Metaxas, D. M., Papadogkonas, G., Mores, E., Kapsetaki, M., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1242481 · Cited by 10

Lineage determination in the immune system

Rothenberg, E. V. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00965.x · Cited by 9

Maintaining CD4–CD8 lineage integrity in T cells: Where plasticity serves versatility

Wang, L., Xiong, Y., & Bosselut, R. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.08.008 · Cited by 9

The Role of TOX in the Development of Innate Lymphoid Cells

Seehus, C. R., & Kaye, J. G. (2015) · Mediators of Inflammation · doi:10.1155/2015/243868 · Cited by 9

Tcf1 at the crossroads of CD4+ and CD8+ T cell identity

Gullicksrud, J. A., Shan, Q., & Xue, H. (2017) · Frontiers in Biology · doi:10.1007/s11515-017-1445-3 · Cited by 9

Dual role of BCL11B in T-cell malignancies

Przybylski, G. K., Przybylska, J., & Li, Y. (2024) · Blood Science · doi:10.1097/bs9.0000000000000204 · Cited by 8

DNA-binding affinity and specificity determine the phenotypic diversity in BCL11B-related disorders

Lessel, I., Barešić, A., Chinn, I. K., May, J., Goenka, A., Chandler, K., Posey, J. E., Afenjar, A., Averdunk, L., Bedeschi, M. F., et al. (2025) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.12.012 · Cited by 8

CellNavi predicts genes directing cellular transitions by learning a gene graph-enhanced cell state manifold

Wang, T., Pan, Y., Ju, F., Zheng, S., Liu, C., Min, Y., Jiang, Q., Liu, X., Xia, H., Liu, G., et al. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01755-1 · Cited by 9

Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor suppressor allele that contributes to leukemogenesis

Go, R., Takizawa, K., Hirose, S., Katsuragi, Y., Aoyagi, Y., Mishima, Y., & Kominami, R. (2012) · Leukemia Research · doi:10.1016/j.leukres.2012.04.028 · Cited by 8

Genetic regulation onex vivodifferentiated natural killer cells from human umbilical cord blood CD34+cells

Pinho, M. J., Marques, C. J., Carvalho, F., Punzel, M., Sousa, M., & Barros, A. (2012) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2012.700716 · Cited by 8

A New Avenue to Cure Cancer by Turning Adaptive Immune T Cells to Innate Immune NK Cells via Reprogramming

Su, D., & Vankayalapati, R. (2010) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjq016 · Cited by 8

The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes

Tanaka, H., & Taniuchi, I. (2013) · Current topics in microbiology and immunology · doi:10.1007/82_2013_323 · Cited by 8

Irreversibility of T-Cell Specification: Insights from Computational Modelling of a Minimal Network Architecture

Manesso, E., Kueh, H. Y., Freedman, G., Rothenberg, E. V., & Peterson, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161260 · Cited by 8

A human NK cell progenitor that originates in the thymus and generates KIR + NKG2A − NK cells

Reiß, J., Ghosh, S., Scheid, M., Graafen, L., Scherenschlich, N., Weinhold, S., Raba, K., Paulusch, S., Domenico, E. D., Pham, T. X. U., et al. (2025) · Science Advances · doi:10.1126/sciadv.adv9650 · Cited by 7

Single-Cell Analysis of Thymocyte Differentiation: Identification of Transcription Factor Interactions and a Major Stochastic Component in αβ-Lineage Commitment

Boudil, A., Skhiri, L., Candéias, S. M., Pasqualetto, V., Legrand, A., Bedora-Faure, M., Gautreau‐Rolland, L., Rocha, B., & Ezine, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073098 · Cited by 7

Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas

Pinkney, K. A., Jiang, W., Lee, B. J., Loredan, D. G., Li, C., Bhagat, G., & Zha, S. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0191-8 · Cited by 7

Alteration of Bcl11b upon stimulation of both the MAP kinase- and Gsk3-dependent signaling pathways in double-negative thymocytes

Selman, W. H., Esfandiari, E., & Filtz, T. M. (2018) · Biochemistry and Cell Biology · doi:10.1139/bcb-2018-0132 · Cited by 7

Transcriptional repressors, corepressors and chromatin modifying enzymes in T cell development

Shapiro, M. J., & Shapiro, V. S. (2010) · Cytokine · doi:10.1016/j.cyto.2010.11.013 · Cited by 7

Regulation of blood cell transdifferentiation by oxygen sensing neuronsPreprint

Corcoran, S., Mase, A., Hashmi, Y., Ouyang, D., Augsburger, J., Jacobs, T., Kukar, K., & Brückner, K. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.22.056622 · Cited by 7

Mutations at BCL11B Exon 4 Associated with T Cell Acute Lymphoblastic Leukemia Are Facilitated by AID and Formation of Non-B DNA Conformations

Roy, U., Sharma, A., Sharma, S., Dahal, S., Kumari, N., Desai, S. S., Kumari, S., Dixit, J., Arun Sharma, M., Nujoom, N., et al. (2024) · Molecular and Cellular Biology · doi:10.1080/10985549.2024.2419661 · Cited by 6

T Cell Development: From T-Lineage Specification to Intrathymic Maturation

Golzari-Sorkheh, M., Yoganathan, K., Chen, E. L. Y., Singh, J., & Zúñiga‐Pflücker, J. C. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-77921-3_4 · Cited by 6

Transcriptional priming and chromatin regulation during stochastic cell fate specification

Ordway, A. J., Helt, R. N., & Johnston, R. J. (2024) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2023.0046 · Cited by 7

T-Cell Development: From T-Lineage Specification to Intrathymic Maturation

Yoganathan, K., Chen, E. L. Y., Singh, J., & Zúñiga‐Pflücker, J. C. (2019) · Springer eBooks · doi:10.1007/978-3-030-12040-5_4 · Cited by 6

Transcription factors regulate early T cell development via redeployment of other factors

Hosokawa, H., Masuhara, K., & Koizumi, M. (2021) · BioEssays · doi:10.1002/bies.202000345 · Cited by 7

CTIP2, une protéine multifonctionnelle

Douce, V. L., Cherrier, T., Riclet, R., Rohr, O., & Schwartz, C. (2014) · médecine/sciences · doi:10.1051/medsci/20143008019 · Cited by 6

Histone methyltransferase DOT1L maintains cell state and restricts cytotoxic potential of CD8 T cells

Malik, M., de Leeuw, W.-J., Aslam, M. A., Kwesi‐Maliepaard, E. M., van den Brand, T., van den Broek, B., Kempers, M., Hoekman, L., Proost, N., van Welsem, T., et al. (2025) · Science Advances · doi:10.1126/sciadv.adw1289 · Cited by 5

Transcriptional rewiring in CD8+ T cells: implications for CAR-T cell therapy against solid tumours

Srinivasan, S., Armitage, J. D., Nilsson, J. A., & Waithman, J. C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1412731 · Cited by 5

Nuclear location and the control of developmental progression

Lin, Y. C., & Murre, C. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.11.010 · Cited by 5

Genes regulated by BCL11B during T‐cell development are enriched for de novo mutations found in schizophrenia patients

Fahey, L., Donohoe, G. J., Broin, P. Ó., & Morris, D. W. (2020) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32811 · Cited by 5

In vivo blockade of T cell development reveals alternative pathways for generation of intraepithelial lymphocytes in mice

Mondoon, S., Shibata, K., & Yoshikai, Y. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.09.008 · Cited by 5

The Toolbox for Untangling Chromosome Architecture in Immune Cells

Liu, S., & Zhao, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.670884 · Cited by 6

Realization of the T Lineage Program Involves GATA-3 Induction of Bcl11b and Repression of Cdkn2b Expression

Thompson, P. K., Chen, E. L. Y., de Pooter, R. F., Frelin, C., Vogel, W., Lee, C. R., Venables, T., Shah, D., Iscove, N. N., Leid, M. E., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100366 · Cited by 5

In search of lost time: Enhancers as modulators of timing in lymphocyte development and differentiation

Chu, J., Pease, N. A., & Kueh, H. Y. (2021) · Immunological Reviews · doi:10.1111/imr.12946 · Cited by 5

Directly reprogrammed NK cells driven by BCL11B depletion enhance targeted immunotherapy against pancreatic ductal adenocarcinoma

Kim, H., Kim, J. Y., Lee, J. Y., Seol, B., Choi, J. E., & Cho, Y. S. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01730-1 · Cited by 4

Single-cell CRISPR screening characterizes transcriptional deregulation in T-cell acute lymphoblastic leukemia

Meyers, S., Gielen, O., Cools, J., & Demeyer, S. (2024) · Haematologica · doi:10.3324/haematol.2023.284901 · Cited by 4

ILC Lineage Specification: To Be or Not 11b, That Is the Question

Kostrzewski, T. M., & Brady, H. J. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.08.005 · Cited by 4

Illegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing

Champagne, D., & Shockett, P. E. (2014) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2014.01.007 · Cited by 4

Fitting structure to function in gene regulatory networks

Rothenberg, E. V. (2017) · History & Philosophy of the Life Sciences · doi:10.1007/s40656-017-0164-z · Cited by 5

Immune Cell Development and Epigenetics

Sekiya, T. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809912-4.00002-7 · Cited by 4

Pathobiology of Acute Lymphoblastic Leukemia

Burns, M., Armstrong, S. A., & Gutiérrez, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35762-3.00064-0 · Cited by 4

Unveiling the N-Terminal Homodimerization of BCL11B by Hybrid Solvent Replica-Exchange Simulations

Schulig, L., Grabarczyk, P., Geist, N., Delin, M., Forkel, H., Kulke, M., Delcea, M., Schmidt, C. A., & Link, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073650 · Cited by 4

Oncogenic isoform switch of tumor suppressor BCL11B in adult T-cell leukemia/lymphoma

Permatasari, H. K., Nakahata, S., Ichikawa, T., Fauzi, Y. R., Kiyonari, H., Shide, K., Kameda, T., Shimoda, K., Ono, M., Taki, T., et al. (2022) · Experimental Hematology · doi:10.1016/j.exphem.2022.04.004 · Cited by 4

Cell identity and plasticity uncoupled

Stefano, B. D. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00943-7 · Cited by 4

Maintenance of Lineage Identity: Lessons from a B Cell

Belcheva, K. T., & Chaudhuri, J. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200497 · Cited by 4

A Bcl11bN797K variant isolated from an immunodeficient patient inhibits early thymocyte development in mice

Matsumoto, K., Okuyama, K., Sidwell, T., Yamashita, M., Endo, T. A., Satoh‐Takayama, N., Ohno, H., Morio, T., Rothenberg, E. V., & Taniuchi, I. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1363704 · Cited by 4

NOTCH assembles a transcriptional repressive complex containing NuRD and PRC1 to repress genes involved in cell proliferation and differentiationPreprint

Doyen, C. M., Depierre, D., Yatim, A., Heurteau, A., Lelièvre, J., Lévy, Y., Cuvier, O., & Benkirane, M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/513549 · Cited by 5

Targeting BCL11B in CAR-engineered lymphoid progenitors drives NK-like cell development with prolonged anti-leukemic activity

Baatz, F., Ghosh, A., Herbst, J., Polten, S., Meyer, J., Rhiel, M., Maetzig, T., Geffers, R., Rothe, M., Bastone, A. L., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.02.024 · Cited by 3

BCL11B helps to define T-lineage in lymphomas/leukaemias with a mixed/ambiguous immunophenotype

Shuyu, E., Vega, F., Khanlari, M., Fang, H., Xu, J., Li, S., Hu, S., Wang, S. A., Wei, Q., Wang, W. J., et al. (2025) · Pathology · doi:10.1016/j.pathol.2025.01.010 · Cited by 3

Animals have expanded the evolutionary legacy of unicellular ancestors in blood cells

Nagahata, Y., Nishimura, Y., Kaitani, R., Leong, J. C. K., Oda‐Ishii, I., Kohtsuka, H., Abe, S., Ishida, T., Carmona-Rivas, M., Najle, S. R., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2528110123 · Cited by 3

BCL11B promotes T‐cell acute lymphoblastic leukaemia cell survival via the XRCC5/C11ORF21 axis

Yu, X., Li, Y., Yang, P., Wang, Y., Liu, X., Cai, L., Lai, J., Zhang, Y., Zha, X., Przybylski, G. K., et al. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1580 · Cited by 3

T-cell immunobiology and cytokine storm of COVID-19

Eltayeb, A., & Redwan, E. M. M. M. (2025) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2024.10.003 · Cited by 4

Phantom of the immunologic opera: Unmasking the role of innate lymphoid cells (ILC) in inborn errors of immunity (IEI)

Eken, A., Johnson, S. A., Erdem, Ş., & Hsieh, E. W. Y. (2025) · Journal of human immunity · doi:10.70962/jhi.20250045 · Cited by 2

T-Cell Development

Harrington, L. E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-7020-6896-6.00008-9 · Cited by 4

Using mouse models to study function of transcriptional factors in T cell development

Li, P., Xiao, Y., Liu, Z., & Liu, P. (2012) · Cell Regeneration · doi:10.1186/2045-9769-1-8 · Cited by 4

Insight into cellular dedifferentiation in regenerative medicine

Hu, T. H., Yao, B., Huang, S., & Fu, X. (2019) · Science China Life Sciences · doi:10.1007/s11427-019-9571-y · Cited by 3

Netrin G1 Ligand is a new stromal immunomodulator that promotes pancreatic cancerPreprint

Costa, D. B. V., Francescone, R., Franco‐Barraza, J., Luong, T., Graves, M., de Aquino, A. M., Steele, N. G., Gardiner, J. C., dos Santos, S. A. A., Ogier, C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.15.594354 · Cited by 3

A stem cell knockout village reveals lineage rewiring and a non-canonical islet cell fate in monogenic diabetesPreprint

Liu, D., Song, B., Li, Z., Zhang, S., Fabiha, T., Zhao, J., Inoki, A., Piccand, J., Soh, C.-L., Dixon, G., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.23.696311 · Cited by 4

The transcription factor BCL11B drives NK cell cytotoxicity and antitumor activity

Kumar, A., Zhang, B., Baldys, A. M., Fischer, C., Lenvik, A. J., Felices, M., Davis, Z., Bendzick, L. E., Weis, A., Bryceson, Y. T., et al. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf179 · Cited by 2

Practical approaches to the diagnosis and differential diagnosis of T-lymphoblastic leukemia/lymphoma

(17594), W. W., Khoury, J. D., Fang, H., Medeiros, L. J., & (17594), W. W. (2026) · Human Pathology · doi:10.1016/j.humpath.2026.106198 · Cited by 2

Generation of Inducible BCL11B Knockout in TAL1/LMO1 Transgenic Mouse T Cell Leukemia/Lymphoma Model

Przybylski, G. K., Korsak, D., Iżykowska, K., Nowicka, K., Zalewski, T., Tubacka, M., Mosor, M., Januszkiewicz‐Lewandowska, D., Frydrychowicz, M., Boruczkowski, M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094932 · Cited by 2

High-resolution mapping of cell cycle dynamics during steady-state T cell development and regeneration in vivo

Kunze‐Schumacher, H., Verheyden, N. A., Grewers, Z., Meyer‐Hermann, M., Greiff, V., Robert, P. A., & Krueger, A. (2025) · Cell Reports · doi:10.1016/j.celrep.2024.115132 · Cited by 2

Double the Double: Revisiting BCL11B 's Multimerization

Susemihl, A., Geist, N., Grabarczyk, P., Schmidt, C. A., Delcea, M., & Schulig, L. (2025) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.26811 · Cited by 2

Complex Interplays in Immune T-Cell Differentiation and Developmental Fate Determination

Duc, H. T. (2011) · Immunotherapy · doi:10.2217/imt.11.95 · Cited by 2

The DN2 Myeloid-T (DN2mt) Progenitor is a Target Cell for Leukemic Transformation by the TLX1 Oncogene

Riz, I. (2013) · Journal of Bone Marrow Research · doi:10.4172/2329-8820.1000105 · Cited by 2

Induction of Bcl11b during T cell commitment through a tripartite mechanism

Georgopoulos, K. (2016) · Nature Immunology · doi:10.1038/ni.3520 · Cited by 2

Logical modeling of thymus and natural killer lymphocyte differentiation

Ye, J., Chen, Q., & Wang, R. (2021) · Journal of Biological Physics · doi:10.1007/s10867-021-09563-y · Cited by 2

Switch hitter: Bcl11b in T cells and ILC2s

Harly, C., & Bhandoola, A. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20191739 · Cited by 2

The Epigenetics of Early Lymphocyte DevelopmentPreprint

Murre, C. (2013) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2013.78.020149 · Cited by 2

Bcl11b and Atoh8 Coordinate Cellular Plasticity for Reprogramming and Transformation

Huang, M.-F., Shoemaker, R., & Lee, D. (2022) · Cellular Reprogramming · doi:10.1089/cell.2022.0128 · Cited by 2

Engineered NKG2C + NK-like T cells exhibit superior antitumor efficacy while mitigating cytokine release syndromePreprint

Lupo, K. B., Panjwani, M. K., Shahid, S., Sottile, R., Lawry, C., Kolk, G., Kontopolous, T., Daniyan, A. F., Chandran, S. S., Klebanoff, C. A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.16.603785 · Cited by 2

The Majority of the Serine/Threonine Phosphorylation Sites in Bcl11b Protein Are Dispensable for the Differentiation of T Cells

Okuyama, K., Nomura, A., Nishino, K., Tanaka, H., Harly, C., Chihara, R., Harada, Y., Muroi, S., Kubo, M., Kosako, H., et al. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200101 · Cited by 1

The double-positive cells in the tumor microenvironment

Long, X., Du, Y., Li, Y., Guan, F., Wang, S., Huang, M., & Wu, M. (2026) · Journal of Translational Internal Medicine · doi:10.1515/jtim-2026-0002 · Cited by 1

Mature T‐cell leukemia/lymphoma with an NK ‐like immunophenotype: A report of 7 cases

Wang, W. J., Wang, S. A., Fang, H., Jorgensen, J. L., Hu, S., Qiu, L., Xu, J., Medeiros, L. J., & Wang, W. (2026) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.70020 · Cited by 1

An Essential Developmental Checkpoint for Production of the T Cell Lineage

Ikawa, T., Hirose, S., Masuda, K., Kakugawa, K., Satoh, R., Shibano-Satoh, A., Kominami, R., Katsura, Y., & Kawamoto, H. (2010) · Science · doi:10.1126/science.1188995 · Cited by 327

An Early T Cell Lineage Commitment Checkpoint Dependent on the Transcription Factor Bcl11b

Li, L., Leid, M. E., & Rothenberg, E. V. (2010) · Science · doi:10.1126/science.1188989 · Cited by 396

Critical roles of Bcl11b in T‐cell development and maintenance of T‐cell identity

Liu, P., Li, P., & Burke, S. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00953.x · Cited by 125

Bcl11b: a novel regulator of T-lineage commitment (36.50)

Li, L., & Rothenberg, E. V. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.184.supp.36.50

Reprogramming T cells into NK-like cells for use in cancer immunotherapy via B-cell CLL/lymphoma 11B (BCL11B) deletion

(2010) · Science-Business eXchange · doi:10.1038/scibx.2010.749