Reprogramming of T Cells to Natural Killer–Like Cells upon Bcl11b Deletion

Li, Peng, Burke, Shannon, Wang, Juexuan, Chen, Xiongfeng, Ortiz, Mariaestela, Lee, Song-Choon, Lu, Dong, Campos, Lia, Goulding, David, Ng, Bee Ling, Dougan, Gordon, Huntly, Brian, Gottgens, Bertie, Jenkins, Nancy A., Copeland, Neal G., Colucci, Francesco, Liu, Pentao·2010·Science
DOI 10.1126/science.1188063

Cited by (374)

Items 301–374 of 374

  1. T cells as trained killers
    Rebecca Kirk · 2010 · Nature Reviews Clinical Oncology
  2. The Current Status of Directed Differentiation Technology
    Seung Eun Lee, Dongho Choi · 2015 · Hanyang Medical Reviews
  3. Long-range control of T-cell development
    Dominic van Essen · 2013 · Blood
  4. A natural killer’s hike through epigenetic landscapes
    Timo Rückert, Chiara Romagnani · 2021 · Science Immunology
  5. T-cell commitment inheritance—an agent-based multi-scale model
    Emil Andersson, Ellen V. Rothenberg, Carsten Peterson, Victor Olariu · 2024 · npj Systems Biology and Applications
  6. The Molecular Basis of T Cell Development and How Epigenetic/Transcriptional Deregulation Leads to T-ALL
    Will Bailis, Warren S. Pear · 2014 · Epigenetics and human health
  7. Comprehensive transcriptome mining of the direct conversion of mesodermal cells
    Bijan Akbari, Ping Wee, Moein Yaqubi, Abdulshakour Mohammadnia · 2017 · Scientific Reports
  8. Understanding immune system development: An epigenetic perspective
    Ayush Madhok, Anjali deSouza, Sanjeev Galande · 2020 · Elsevier eBooks
  9. Temporal scaling in developmental gene networks by epigenetic timing control
    Phuc Hong Nguyen, Nicholas A. Pease, Kenneth K.H. Ng, Blythe Irwin, Hao Yuan Kueh · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  10. Single-cell analyses identify tobacco smoke exposure-associated, dysfunctional CD16 + CD8 T cells with high cytolytic potential in peripheral blood
    Suzanne N. Martos, Michelle R. Campbell, Oswaldo A. Lozoya, Brian D. Bennett, Isabel J. B. Thompson, Ma Wan, Gary S. Pittman, Douglas A. Bell · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  11. The role of LMO4 in T cell acute lymphoblastic leukaemia
    Eleni Georgiades · 2014 · University of Birmingham Institutional Research Archive (University of Birmingham)
  12. Mechanisms of Notch signaling specificity in lymphocytes and their leukemic counterparts
    Rebecca Gentek · 2013 · UvA-DARE (University of Amsterdam)
  13. Involvement of PP6 in Dephosphorylation of Bcl11b, a Tumor Suppressor Transcription Factor
    Chelsea R. Parker Harp · 2012
  14. Analysis of a Transcriptional Network Involving PU.1, Notch, and Gata3 in the Lymphomyeloid Lineage Decision during Early T-cell Development
    Del Real · 2013 · CaltechTHESIS (California Institute of Technology)
  15. cancer tumorigenesis changes underlying pregnancy protection of breast Mammary gland morphological and gene expression
    Feng‐Qi Zhao, Yogi Misra, Pamela A. Bentley, Jeffrey P. Bond, Scott W. Tighe, Tim Hunter · 2012
  16. Les progéniteurs multipotents exprimant Flt3 source des précurseurs T extra-thymiques
    Vanessa Zepponi · 2012 · theses.fr (ABES)
  17. The Role of T-box Transcription Factors in the Development and Plasticity of Natural Killer Cell Lineages
    Olga Pikovskaya · 2016
  18. Molecular Pathogenesis of T Lymphoblastic Lymphomas in an Atm-deficient Mouse Model
    Peggy P. C. Wong · 2013 · TSpace (University of Toronto)
  19. Transcriptional Regulation of T Cell Lineage Commitment
    Ellen V. Rothenberg · 2016 · Elsevier eBooks
  20. Generation and Regeneration of T Cells
    Hiroshi Kawamoto, Tomokatsu Ikawa, Takuya Maeda, Kyoko Masuda · 2016 · Springer eBooks
  21. REGULATION OF EARLY T-CELL DEVELOPMENT AND COMMITMENT BY HEB
    Marsela Braunstein · 2011 · TSpace (University of Toronto)
  22. The Role of the E-protein HEBAlt in T-Cell Development
    Kogulan Yoganathan · 2020 · TSpace (University of Toronto)
  23. The comprehensive roadmaps of reprogramming and transformation unveiled antagonistic roles for bHLH transcription factors in the control of cellular plasticity
    Aurélia Huyghe, Giacomo Furlan, Jan Schröder, J. Stüder, F. Mugnier, Lorena Matteo, J. Wang, Yong Yu, Nicolas Rama, Benjamin Gibert et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  24. Molecular regulation of cellular function
    Marsela Braunstein, John M.S. Bartlett · 2015
  25. In vitro determination and functional maturation of natural killer cells from umbilical cord blood progenitor cells
    Maria João Pinho · 2012 · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
  26. Faculty Opinions recommendation of A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.
    Christopher J. Gregg, Wei-Chao Huang · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  27. Blood Cells
    Marc Thiriet · 2012 · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems
  28. Single-cell CRISPR screening characterizes transcriptional deregulation in T-cell acute lymphoblastic leukemia
    Sarah Meyers, Olga Gielen, Jan Cools, Sofie Demeyer · 2023 · Research Square
  29. High-resolution mapping of cell cycle dynamics during T-cell development and regeneration in vivo
    Heike Kunze‐Schumacher, Nikita A. Verheyden, Zoe Grewers, Michael Meyer‐Hermann, Victor Greiff, Philippe Auguste Robert, Andreas Krueger · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  30. T-cell commitment inheritance – an agent-based multi-scale model
    Victor Olariu, Emil Andersson, Ellen V. Rothenberg, Carsten Peterson · 2023 · Research Square
  31. Single-cell CRISPR screening characterizes transcriptional deregulation in T-cell acute lymphoblastic leukemia
    Sarah Meyers, Olga Gielen, Jan Cools, Sofie Demeyer · 2023 · Research Square
  32. Transcriptional Regulation of T-Cell Lineage Commitment
    Ellen V. Rothenberg · 2024 · Elsevier eBooks
  33. Development of adaptive immune cells
    Antonio La Cava · 2024 · Elsevier eBooks
  34. Inborn errors of immunity caused by dominant negative interference by a BCL11B variant
    2024 · Nature Immunology
  35. Immuno-moodulin is Differentially Expressed in T Cells and Plasma in Obsessive-Compulsive Disorder Patients
    Isobel Alice Blacksell, Matteo E.M. Vismara, Christine Maria Lim, Bernardo Maria Dell’Osso, Stefano Pallanti, Eric Hollander, Michele Vendruscolo, Claudio D’Addario, Dianne Cooper, Fulvio D’Acquisto · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  36. PreTCR Interaction With Self-pMHC: Expanding the Repertoire of Thymocytes During β Selection While Maintaining Developmental Fidelity
    Jonathan S. Duke‐Cohan, Aoi Akitsu, Robert J. Mallis, Kristine N. Brazin, Kemin Tan, Wonmuk Hwang, Matthew J. Lang, Ellis L. Reinherz · 2025 · Elsevier eBooks
  37. Early Progenitors of Innate Lymphoid Cells (ILC)
    Arundhoti Das, Yi Ding, Avinash Bhandoola · 2024 · Elsevier eBooks
  38. Natural Killer Cell Development
    Ansel P. Nalin, Michael A. Caligiuri, Jianhua Yu, Aharon G. Freud · 2025 · Springer eBooks
  39. Ex vivo-generated lymphoid progenitors encompass both T cell and innate lymphoid cell fates
    Pierre Gaudeaux, Juliette Paillet, Monah Abou Alezz, Ranjita Devi Moirangthem, Sara Cascione, Marta Martin Corredera, Anne‐Catherine Dolens, Katrien De Mulder A, Imke Velghe, Bart Vandekerckhove et al. · 2025 · Frontiers in Immunology
  40. Paxbp1 restrains cytotoxic and innate cell programs in CD4+ T cells to promote Th2 differentiation
    Danielle A. Chisolm, Yuki Morimoto, Hiroyuki Nagashima, Stephen R. Brooks, Ijeoma C. Meremikwu, Micala Hammond, Jian Sun, Ebru Ermis, Rachael Laura Philips, Vijender Chaitankar et al. · 2025 · Research Square
  41. Zinc-mediated multimerization of the N-terminal CCHC zinc finger domain of BCL11B: a key to stability and a potential therapeutic target
    Anne Susemihl, Felix Nagel, Piotr Grabarczyk, Christian Andreas Schmidt, Mihaela Delcea · 2025 · Physical Chemistry Chemical Physics
  42. Pioneer Transcription Factors Differentially Co-opt Bcl11a and Bcl11b to orchestrate Reprogramming
    Aneta Trajkova, Emile Zakiev, Maria Grazia Mendoza-Ferri, Ines Messahli, M. Ruel, Imène Krossa, Yann Tapponnier, E. Dejonckere, Emma Hunter, Léo Claret et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  43. Natural and Artificial Hematopoietic Cell Reprogramming
    Dong Hun Yu, Wenpei Liu, Feng Liu, Lei Cheng · 2026 · Cellular Reprogramming
  44. Epigenetic landscape of normal and malignant lympho-hematopoiesis : interplays between chromatin signature and tissue specific gene expression
    Aleksandra Pękowska · 2011 · theses.fr (ABES)
  45. Détection des anomalies génétiques dans les LAL-T : de la biologie à la clinique
    Raouf Ben Abdelali · 2011 · theses.fr (ABES)
  46. Etude du rôle des régulateurs Post-transcriptionnels Pumilio dans les cellules souches hématopoïétiques humaines
    Ayda Miri-Nezhad · 2013 · theses.fr (ABES)
  47. Etude des rôles des voies Notch et du couple IL-7 / IL-7R au cours des étapes précoces de la différenciation lymphoïde T chez l’Homme
    Maymouna Magri · 2011 · theses.fr (ABES)
  48. The role of human Natural Killer cells (NK) in anti-tumour immune responses
    Giulia Fregni · 2011
  49. NOTCH1 Nuclear Interactome Reveals Key Regulators of Its Transcriptional Activity and Oncogenic Function
    Ahmad Yatim · 2013 · theses.fr (ABES)
  50. Etude du développement lymphoïde T à partir des progéniteurs hématopoïétiques CD34+ chez les patients infectés par le VIH-1 et traités par une thérapie antirétrovirale
    Inna Menkova · 2016
  51. Étude de la migration thymique : vers une reconstitution optimale du compartiment T
    Victoria Michaels Lopez · 2017 · theses.fr (ABES)
  52. Le suppresseur de tumeur HIC1 est une nouvelle cible directe de la kinase ATM et un acteur multifonctionnel de la réponse cellulaire aux cassures double brin (DSBs) de l’ADN
    Sonia Paget · 2016 · theses.fr (ABES)
  53. Rôle des récepteurs NK dans les lymphoproliférations T matures. Exemple des leucémies/lymphomes T de l'adulte associés à l'HTLV-1 et des lymphoproliférations T intestinales primitives
    Morgane Cheminant · 2018
  54. KAP1 : un nouveau facteur répresseur de la transcription du VIH-1
    Amina Aït-Ammar · 2018 · theses.fr (ABES)
  55. Rôles de la stimulation chronique du TCR et de la reprogrammation cellulaire dans les lymphomes T périphériques
    Sylvain Carras · 2018 · theses.fr (ABES)
  56. Regulation of innate lymphoid cells development by transcription factors : a multi-transcription factors reporter mouse model approach
    Dylan E. Cherrier · 2020 · theses.fr (ABES)
  57. Variations du développement thymique des lymphocytes T régulateurs : influence de l’âge et de la génétique
    Julie Darrigues · 2018 · theses.fr (ABES)
  58. Ontogeny of hematopoietic progenitor cells seeding the embryonic thymus
    Ramy Elsaid · 2019 · theses.fr (ABES)
  59. Rôle du facteur de transcription Bcl11b dans l’homéostasie et le remodelage cardiaque
    Marie‐Thérèse Daher · 2019 · theses.fr (ABES)
  60. Dissecting the non-cell autonomous impact of cellular senescence on cellular reprogramming
    Mathieu von Joest · 2019 · theses.fr (ABES)
  61. Etude de nouvelles cibles thérapeutiques dans les lymphomes compliquant la maladie cœliaque
    Sofia Berrabah · 2021
  62. Regulation of IL-17A expression during Toxoplasma gondii infection
    Faïza Bittich-Fahmi · 2020 · theses.fr (ABES)
  63. Etude bioinformatique intégrative : déterminants et dynamique des interactions chromosomiques à longue distance
    Alexandre Heurteau · 2019 · theses.fr (ABES)
  64. Development of a protocol to produce Natural Killer cells for therapeutic purposes
    Marta Martin Corredera · 2024 · theses.fr (ABES)
  65. Bipartite DNA binding domain of transcription factor BCL11B binds clustered short DNA sequence motifs
    Jisun Lee, Jujun Zhou, John R. Horton, Meigen Yu, Munachi Daniella Muoghalu, Faizan Ahmed Khan, Xiaotian Zhang, Yun Huang, Robert Blumenthal, Xiaodong Cheng et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  66. Signaling and transcriptional control of thymocyte differentiation
    Ichiro Taniuchi · 2026 · International Immunology
  67. The Bcl11–Cxxc1 axis regulates stage-specific chromatin accessibility during lymphocyte development
    Kazuki Okuyama, Wooseok Seo, Hirotaka Takahashi, Sawako Muroi, Ning Hou, Shinsuke Ito, Tatsuya Sawasaki, Haruhiko Koseki, Yibo Wu, Ichiro Taniuchi · 2026 · Genes & Development
  68. Hematopoietic Cell Fate Reprogramming in the Context of Pathological Processes and Translational Opportunities
    Branko Cirovic · 2026 · Cellular Reprogramming
  69. Bcl11b dose-dependently regulates positive selection of CD8 T cells to the virtual memory fate
    Tom Sidwell, Ellen V. Rothenberg · 2026 · eLife
  70. BCL11B targeting in tumor CD8 + T cells amplifies anti-tumor response by blocking exhaustion while promoting stemness and cytotoxicity
    Leonardo Silvane, Τόμας Ζελένκα, Divya Priyanka Talada, Valeriu Bogdan Cismasiu, Shamima Islam, Raghwendra P. Singh, Zefanias Ngove, Sayan Chakraborty, MacLean S. Hall, Jamie L. Blauvelt et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  71. BCL11B predetermines a persister state in breast cancer that is reversed by TNFα
    Zhen Qi, G. Gulati, Rachel Gleyzer, Angera H. Kuo, Shaheen S. Sikandar, Hui-Ru Bai, W. H. D. Ho, Da-Long Qian, F. Dirbas, Aaron M. Newman et al. · 2026 · Science Advances
  72. Upregulation of CD90 correlates with T lineage commitment at the DN2a stage of T cell development
    Dhruti Parikh, Karen Gu, Sara Tomei, Tom S. Weber, Shalin H. Naik, Mark M. W. Chong · 2026 · Frontiers in Immunology
  73. RNA-seq-based transcriptome analysis identifies TCR-expressing B1 cells as a multipotent lymphoid intermediate
    Jeong-Eun Seon, Su‐Min Yee, Sung-Gwon Lee, Ha-Rim Choi, Jungwoo Lee, Jae-Eun Seo, Seo-Hee Moon, Hae-Jin Seo, Hyun-Su Koo, PARK Chungoo et al. · 2026 · Biochemical and Biophysical Research Communications
  74. Next-generation natural killer cell therapy: bench to bedside and beyond
    Aiqi Zhao, Jing Xu, Wenhai Deng, Minghuan Zhang, Yanping Shao, Yu Liu, Aibin Liang, Xiaobing Wang, Ting Niu, Wenbin Qian · 2026 · Signal Transduction and Targeted Therapy