Cited by 374T-cell and B-cell ImmunologyImmune Cell Function and InteractionDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Reprogramming of T Cells to Natural Killer–Like Cells upon Bcl11b Deletion

Open access

Li, Peng, Burke, Shannon, Wang, Juexuan, Chen, Xiongfeng, Ortiz, Mariaestela, Lee, Song-Choon, Lu, Dong, Campos, Lia, Goulding, David, Ng, Bee Ling, Dougan, Gordon, Huntly, Brian, Gottgens, Bertie, Jenkins, Nancy A., Copeland, Neal G., Colucci, Francesco, Liu, Pentao·2010·Science

DOI 10.1126/science.1188063PMC PMC3628452

Open this paper in CoChat — free account

Abstract

One Two T: T cells develop in the thymus, where they proceed through several developmental stages, losing alternative lineage potential as they progress. The molecular regulation of this developmental process, however, is not fully understood (see the Perspective by Di Santo ). P. Li et al. (p. 85 , published online 10 June), L. Li et al. (p. 89 ), and Ikawa et al. (p. 93 ) now identify expression of the zinc finger transcription factor Bcl11b as the earliest checkpoint in T cell development in mice. Genetic deletion of Bcl11b in developing T cells inhibited commitment to the T cell lineage. Under conditions that should have stimulated T lineage differentiation, Bcl11b -deficient T cell progenitors failed to up-regulate genes associated with lineage-committed T cells and maintained stem cell– and progenitor cell–associated gene expression. In both developing and committed T cells, loss of Bcl11b resulted in the generation of cells that resembled natural killer (NK) cells in both phenotype and function. These NK-like cells could be expanded easily in vitro and possessed antitumor cytotoxicity, but they did not exhibit cytotoxicity against normal cells and were not tumorigenic. Because T cells are much easier to obtain from human patients than NK cells, deletion of Bcl11b in T cells may thus provide a source of easy-to-grow NK cells for cell-based antitumor therapies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1126/science.1188063

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy
Kärre, K., Ljunggren, H., Piontek, G., & Kiessling, R. (1986) · Nature · doi:10.1038/319675a0 · Cited by 2,333
Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro
Schmitt, T. M., & Zúñiga-Pflücker, J. C. (2002) · Immunity · doi:10.1016/s1074-7613(02)00474-0 · Cited by 1,120
Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism.
Ljunggren, H., & Kärre, K. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.162.6.1745 · Cited by 741
Launching the T-cell-lineage developmental programme
Rothenberg, E. V., Moore, J. E., & Yui, M. A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2232 · Cited by 514
Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46
Walzer, T., Bléry, M., Chaix, J., Fuséri, N., Chasson, L., Robbins, S. H., Jaeger, S., André, P., Gauthier, L., Daniel, L., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609692104 · Cited by 496
A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127
Vosshenrich, C. A. J., García‐Ojeda, M. E., Samson, S., Pasqualetto, V., Enault, L., Goff, O. R.-L., Corcuff, E., Guy‐Grand, D., Rocha, B., Cumano, A., et al. (2006) · Nature Immunology · doi:10.1038/ni1395 · Cited by 475
The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development
Gascoyne, D. M., Long, E., Veiga‐Fernandes, H., de Boer, J., Williams, O., Seddon, B. P., Coles, M. C., Kioussis, D., & Brady, H. J. M. (2009) · Nature Immunology · doi:10.1038/ni.1787 · Cited by 446
Naive T cell homeostasis: from awareness of space to a sense of place
Takada, K., & Jameson, S. C. (2009) · Nature reviews. Immunology · doi:10.1038/nri2657 · Cited by 393
Bcl11b is required for differentiation and survival of αβ T lymphocytes
Wakabayashi, Y., Watanabe, H., Inoue, J., Takeda, N., Sakata, J., Mishima, Y., Hitomi, J., Yamamoto, T., Utsuyama, M., Niwa, O., et al. (2003) · Nature Immunology · doi:10.1038/ni927 · Cited by 372
Role of NK cells in the control of metastatic spread and growth of tumor cells in mice
Gorelik, E., Wiltrout, R. H., Okumura, K., Habu, S., & Herberman, R. B. (1982) · International Journal of Cancer · doi:10.1002/ijc.2910300118 · Cited by 366

Flagged first, then by citations

Show all 26 references

Sorted by citations

T cells in health and disease
Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,153
NK cell development, homeostasis and function: parallels with CD8+ T cells
Sun, J. C.-Y., & Lanier, L. L. (2011) · Nature reviews. Immunology · doi:10.1038/nri3044 · Cited by 728
Plasmacytoid Dendritic Cells: Recent Progress and Open Questions
Reizis, B., Bunin, A., Ghosh, H. S., Lewis, K. L. T., & Sisirak, V. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101345 · Cited by 680
A critical role for TCF-1 in T-lineage specification and differentiation
Weber, B., Chi, A. W. S., Chavez, A., Yashiro–Ohtani, Y., Yang, Q., Shestova, O. E., & Bhandoola, A. (2011) · Nature · doi:10.1038/nature10279 · Cited by 433
Direct Lineage Reprogramming: Strategies, Mechanisms, and Applications
Xu, J., Du, Y., & Deng, H. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.01.013 · Cited by 434
β 2 -adrenergic receptor–mediated negative regulation of group 2 innate lymphoid cell responses
Moriyama, S., Brestoff, J. R., Flamar, A.-L., Moeller, J. B., Klose, C. S. N., Rankin, L. C., Yudanin, N. A., Monticelli, L. A., Putzel, G., Rodewald, H.-R., et al. (2018) · Science · doi:10.1126/science.aan4829 · Cited by 379
Developmental gene networks: a triathlon on the course to T cell identity
Yui, M. A., & Rothenberg, E. V. (2014) · Nature Reviews Immunology · doi:10.1038/nri3702 · Cited by 342
Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate
Isoda, T., Moore, A. J., He, Z., Chandra, V. K., Aida, M., Denholtz, M., van Hamburg, J. P., Fisch, K. M., Chang, A. N., Fahl, S. P., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.001 · Cited by 323
Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate
Lin, Y. C., Benner, C., Mansson, R., Heinz, S., Miyazaki, K., Miyazaki, M., Chandra, V., Bossen, C., Glass, C. K., & Murre, C. (2012) · Nature Immunology · doi:10.1038/ni.2432 · Cited by 281
The transcriptional landscape of αβ T cell differentiation
Mingueneau, M., Kreslavsky, T., Gray, D. H. D., Heng, T. S. P., Cruse, R., Ericson, J., Bendall, S. C., Spitzer, M. H., Nolan, G. P., Kobayashi, K. S., et al. (2013) · Nature Immunology · doi:10.1038/ni.2590 · Cited by 267
Skint-1 Identifies a Common Molecular Mechanism for the Development of Interferon-γ-Secreting versus Interleukin-17-Secreting γδ T Cells
Turchinovich, G., & Hayday, A. (2011) · Immunity · doi:10.1016/j.immuni.2011.04.018 · Cited by 269
How transcription factors drive choice of the T cell fate
Hosokawa, H., & Rothenberg, E. V. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-00426-6 · Cited by 250
An Overview of the Intrathymic Intricacies of T Cell Development
Shah, D., & Zúñiga‐Pflücker, J. C. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302259 · Cited by 236
Transcriptional Control of Early T and B Cell Developmental Choices
Rothenberg, E. V. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100024 · Cited by 245
Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity
Xing, S., Li, F., Zeng, Z., Zhao, Y., Yu, S., Shan, Q., Li, Y., Phillips, F. C., Maina, P. K., Qi, H. H., et al. (2016) · Nature Immunology · doi:10.1038/ni.3456 · Cited by 226
Bcl11a is essential for lymphoid development and negatively regulates p53
Yu, Y., Wang, J., Khaled, W. T., Burke, S., Li, P., Chen, X., Yang, W., Jenkins, N. A., Copeland, N. G., Zhang, S., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20121846 · Cited by 223
Self-citation
miR-150 regulates the development of NK and iNKT cells
Bezman, N., Chakraborty, T., Bender, T. P., & Lanier, L. L. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20111386 · Cited by 234
CD4 Helper and CD8 Cytotoxic T Cell Differentiation
Taniuchi, I. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053411 · Cited by 249
T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling
Germar, K., Dose, M., Konstantinou, T., Zhang, J., Wang, H., Lobry, C., Arnett, K. L., Blacklow, S. C., Aifantis, I., Aster, J. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110230108 · Cited by 225
NK cells and immune “memory”
Sun, J. C., López-Vergès, S., Kim, C. C., Derisi, J., & Lanier, L. (2011) · Journal of Immunology · doi:10.4049/jimmunol.1003035 · Cited by 215
NOTCH1 Nuclear Interactome Reveals Key Regulators of Its Transcriptional Activity and Oncogenic Function
Yatim, A., Benne, C., Sobhian, B., Laurent‐Chabalier, S., Déas, O., Judde, J., Lelièvre, J., Lévy, Y., & Benkirane, M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.022 · Cited by 207
Transformation of Accessible Chromatin and 3D Nucleome Underlies Lineage Commitment of Early T Cells
Hu, G., Cui, K., Fang, D., Hirose, S., Wang, X., Wangsa, D., Jin, W., Ried, T., Liu, P., Zhu, J., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.013 · Cited by 199
Self-citation
Historical origins of transdifferentiation and reprogramming
Graf, T. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.11.012 · Cited by 194
The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia
Gutiérrez, A., Kentsis, A., Sanda, T., Holmfeldt, L., Chen, S.-C., Zhang, J., Protopopov, A. I., Chin, L., Dahlberg, S. E., Neuberg, D. S., et al. (2011) · Blood · doi:10.1182/blood-2010-11-318873 · Cited by 192
Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells
Califano, D., Cho, J. J., Uddin, M. N., Lorentsen, K. J., Yang, Q., Bhandoola, A., Li, H., & Avram, D. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.005 · Cited by 179
Recent advances in understanding the Th1/Th2 effector choice
Butcher, M. J., & Zhu, J. (2021) · Faculty Reviews · doi:10.12703/r/10-30 · Cited by 191
Transcriptional control of T-cell development
Naito, T., Tanaka, H., Naoe, Y., & Taniuchi, I. (2011) · International Immunology · doi:10.1093/intimm/dxr078 · Cited by 168
Bcl11b is essential for group 2 innate lymphoid cell development
Walker, J. A., Oliphant, C. J., Englezakis, A., Yu, Y., Clare, S., Rodewald, H.-R., Belz, G. T., Liu, P., Fallon, P. G., & McKenzie, A. N. J. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20142224 · Cited by 166
Self-citation
Transcriptional Regulation of Innate and Adaptive Lymphocyte Lineages
Obaldia, M. E. D., & Bhandoola, A. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112032 · Cited by 167
The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development
Yu, Y., Wang, C., Clare, S., Wang, J., Lee, S.-C., Brandt, C., Burke, S., Lu, L., He, D., Jenkins, N. A., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20142318 · Cited by 163
Self-citation
Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells
Hudspeth, K. L., Silva‐Santos, B., & Mavilio, D. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00069 · Cited by 176
Maintaining differentiated cellular identity
Holmberg, J., & Perlmann, T. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3209 · Cited by 166
An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials
Xu, W., Cherrier, D. E., Chea, S., Vosshenrich, C. A. J., Serafini, N., Petit, M., Liu, P., Golub, R., & Santo, J. P. D. (2019) · Immunity · doi:10.1016/j.immuni.2019.02.022 · Cited by 157
Self-citation
TGF-β family signaling in stem cells
Sakaki‐Yumoto, M., Katsuno, Y., & Derynck, R. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.08.008 · Cited by 163
Development and maturation of natural killer cells
Geiger, T. L., & Sun, J. C.-Y. (2016) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.01.007 · Cited by 155
Human NK Cell Development: One Road or Many?
Cichocki, F. M., Grzywacz, B. J., & Miller, J. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02078 · Cited by 161
Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment
Kueh, H. Y., Yui, M. A., Ng, K. K. H., Pease, S., Zhang, J. A., Damle, S. S., Freedman, G., Siu, S., Bernstein, I. D., Elowitz, M. B., et al. (2016) · Nature Immunology · doi:10.1038/ni.3514 · Cited by 138
Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow
Walker, J. A., Clark, P. A., Crisp, A., Barlow, J. L., Szeto, A. C. H., Ferreira, A. C. F., Rana, B. M. J., Jolin, H. E., Rodríguez‐Rodríguez, N., Sivasubramaniam, M., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.05.002 · Cited by 129
Dendritic cell fate is determined by BCL11A
Ippolito, G. C., Dekker, J. D., Wang, Y., Lee, B., Shaffer, A. L., Lin, J. X., Wall, J. K., Lee, B.-S., Staudt, L. M., Liu, Y., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319228111 · Cited by 133
BCL11B mutations in patients affected by a neurodevelopmental disorder with reduced type 2 innate lymphoid cells
Lessel, D., Gehbauer, C., Bramswig, N. C., Schluth‐Bolard, C., Venkataramanappa, S., van Gassen, K. L. I., Hempel, M., Haack, T. B., Barešić, A., Genetti, C. A., et al. (2018) · Brain · doi:10.1093/brain/awy173 · Cited by 124
Self-citation
Critical roles of Bcl11b in T‐cell development and maintenance of T‐cell identity
Liu, P., Li, P., & Burke, S. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00953.x · Cited by 125
Self-citation
A far downstream enhancer for murine Bcl11b controls its T-cell specific expression
Li, L., Zhang, J. A., Dose, M., Kueh, H. Y., Mosadeghi, R., Gounari, F., & Rothenberg, E. V. (2013) · Blood · doi:10.1182/blood-2012-08-447839 · Cited by 115
A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis
Simon, R., Brylka, H., Schwegler, H., Venkataramanappa, S., Andratschke, J., Wiegreffe, C., Liu, P., Fuchs, E., Jenkins, N., Copeland, N., et al. (2012) · EMBO Journal · doi:10.1038/emboj.2012.142 · Cited by 113
Self-citation
T‐cell lineage determination
Yang, Q., Bell, J. J., & Bhandoola, A. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00956.x · Cited by 116
Transdifferentiation and reprogramming: Overview of the processes, their similarities and differences
Cieślar‐Pobuda, A., Knoflach, V., Ringh, M. V., Stark, J., Likus, W., Siemianowicz, K., Ghavami, S., Hudecki, A., Green, J. L., & Łoś, M. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.04.017 · Cited by 117
New views on natural killer cell-based immunotherapy for melanoma treatment
Burke, S., Lakshmikanth, T., Colucci, F., & Carbone, E. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.06.003 · Cited by 107
Self-citation
Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16
Hosokawa, H., Romero-Wolf, M., Yui, M. A., Ungerbäck, J., Quiloan, M. L. G., Matsumoto, M., Nakayama, K. I., Tanaka, T., & Rothenberg, E. V. (2018) · Nature Immunology · doi:10.1038/s41590-018-0238-4 · Cited by 110
GATA-3 promotes T-cell specification by repressing B-cell potential in pro–T cells in mice
García‐Ojeda, M. E., Wolterink, R. G. J. K., Lemaı̂tre, F., Goff, O. R.-L., Hasan, M., Hendriks, R. W., Cumano, A., & Santo, J. P. D. (2013) · Blood · doi:10.1182/blood-2012-06-440065 · Cited by 105
A Quiescent Bcl11b High Stem Cell Population Is Required for Maintenance of the Mammary Gland
Cai, S., Tomer Kalisky, C., Sahoo, D., Dalerba, P. D., Feng, W., Lin, Y., Qian, D., Kong, A., Yu, J. J., Wang, F., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.11.007 · Cited by 105
E4BP4: an unexpected player in the immune response
Male, V. H., Nisoli, I., Gascoyne, D. M., & Brady, H. J. M. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.10.002 · Cited by 102
Cellular Adjuvant Properties, Direct Cytotoxicity of Re-differentiated Vα24 Invariant NKT-like Cells from Human Induced Pluripotent Stem Cells
Kitayama, S., Zhang, R., Liu, T., Ueda, N., Iriguchi, S., Yasui, Y., Kawai, Y., Tatsumi, M., Hirai, N., Mizoro, Y., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.01.005 · Cited by 99
CTIP2 is a negative regulator of P-TEFb
Cherrier, T., Douce, V. L., Eilebrecht, S., Riclet, R., Marban, C., Dequiedt, F., Goumon, Y., Paillart, J., Mericskay, M., Parlakian, A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220136110 · Cited by 97
The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation
Holmes, T. D., Pandey, R. V., Helm, E. Y., Schlums, H., Han, H., Campbell, T. M., Drashansky, T. T., Chiang, S. C. C., Wu, C.-Y., Tao, C., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abc9801 · Cited by 100
The Multifaceted Roles of Bcl11b in Thymic and Peripheral T Cells: Impact on Immune Diseases
Avram, D., & Califano, D. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400930 · Cited by 98
Role of TCF‐1 in differentiation, exhaustion, and memory of CD8 + T cells: A review
Zhang, J., Lyu, T., Cao, Y., & Feng, H. (2021) · The FASEB Journal · doi:10.1096/fj.202002566r · Cited by 109
Surprising new roles for PU.1 in the adaptive immune response
Carotta, S., Wu, L., & Nutt, S. L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00955.x · Cited by 93
Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress
Malcolm, T. I. M., Villarèse, P., Fairbairn, C., Lamant, L., Trinquand, A., Hook, C. E., Burke, G. A. A., Brugières, L., Hughes, K., Payet‐Bornet, D., et al. (2016) · Nature Communications · doi:10.1038/ncomms10087 · Cited by 90
Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network
Longabaugh, W. J. R., Zeng, W., Zhang, J. A., Hosokawa, H., Jansen, C. S., Li, L., Romero-Wolf, M., Liu, P., Kueh, H. Y., Mortazavi, A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610617114 · Cited by 89
Self-citation
T Cell Lineage Commitment: Identity and Renunciation
Rothenberg, E. V. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003703 · Cited by 96
A map for lineage restriction of progenitors during hematopoiesis: the essence of the myeloid‐based model
Kawamoto, H., Ikawa, T., Masuda, K., Wada, H., & Katsura, Y. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00959.x · Cited by 96
Transcriptional Control of Natural Killer Cell Development and Function
Hesslein, D. G. T., & Lanier, L. L. (2011) · Advances in immunology · doi:10.1016/b978-0-12-387664-5.00002-9 · Cited by 85
RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus
Ferreira, A. C. F., Szeto, A. C. H., Heycock, M. W. D., Clark, P. A., Walker, J. A., Crisp, A., Barlow, J. L., Kitching, S., Lim, A., Gogoi, M., et al. (2021) · Nature Immunology · doi:10.1038/s41590-020-00833-w · Cited by 87
Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease
VanValkenburgh, J., Albu, D. I., Bapanpally, C., Casanova, S., Califano, D., Jones, D., Ignatowicz, L., Kawamoto, S., Fagarasan, S., Jenkins, N. A., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102683 · Cited by 84
Self-citation
Multilayered specification of the T-cell lineage fate.
Rothenberg, E. V., Zhang, J., & Li, L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00964.x · Cited by 81
GATA-3 Dose-Dependent Checkpoints in Early T Cell Commitment
Scripture-Adams, D. D., Damle, S. S., Li, L., Elihu, K. J., Qin, S., Arias, A. M., Butler, R. R., Champhekar, A., Zhang, J. A., & Rothenberg, E. V. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301663 · Cited by 81
Transcriptional drivers of the T-cell lineage program
Rothenberg, E. V. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.12.012 · Cited by 80
Cytokines, Transcription Factors, and the Initiation of T-Cell DevelopmentPreprint
Hosokawa, H., & Rothenberg, E. V. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028621 · Cited by 89
A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment
Ng, K. K. H., Yui, M. A., Mehta, A., Siu, S., Irwin, B., Pease, S., Hirose, S., Elowitz, M. B., Rothenberg, E. V., & Kueh, H. Y. (2018) · eLife · doi:10.7554/elife.37851 · Cited by 79
Terminally Differentiated Effector Memory CD8+ T Cells Identify Kidney Transplant Recipients at High Risk of Graft Failure
Jacquemont, L., Tilly, G., Yap, M., Doan-Ngoc, T.-M., Danger, R., Guérif, P., Delbos, F., Martinet, B., Giral, M., Foucher, Y., et al. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2019080847 · Cited by 78
E proteins and the regulation of early lymphocyte development
de Pooter, R. F., & Kee, B. L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00957.x · Cited by 77
Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling
Hassler, M. R., Pulverer, W., Lakshminarasimhan, R., Redl, E., Hacker, J., Garland, G. D., Merkel, O., Schiefer, A., Simonitsch‐Klupp, I., Kenner, L., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.018 · Cited by 76
Human T‐Lymphoid Progenitors Generated in a Feeder‐Cell‐Free Delta‐Like‐4 Culture System Promote T‐Cell Reconstitution in NOD/SCID/γc −/− Mice
Reimann, C., Six, E. M., Cortivo, L. D., Schiavo, A. A., Appourchaux, K., Lagresle‐Peyrou, C., Demerens, C., Ternaux, B., Coulombel, L., Beldjord, K., et al. (2012) · Stem Cells · doi:10.1002/stem.1145 · Cited by 76
Programming for T-lymphocyte fates: modularity and mechanismsPreprint
Rothenberg, E. V. (2019) · Genes & Development · doi:10.1101/gad.327163.119 · Cited by 75
Bcl11b/Ctip2 Controls the Differentiation of Vomeronasal Sensory Neurons in Mice
Enomoto, T., Ohmoto, M., Iwata, T., Uno, A., Saitou, M., Yamaguchi, T., Kominami, R., Matsumoto, I., & Hirota, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1245-11.2011 · Cited by 74
Role of the transcription factor Bcl11b in development and lymphomagenesis
Kominami, R. (2012) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.88.72 · Cited by 75
IFN-γ–Producing and IL-17–Producing γδ T Cells Differentiate at Distinct Developmental Stages in Murine Fetal Thymus
Shibata, K., Yamada, H., Nakamura, M., Hatano, S., Katsuragi, Y., Kominami, R., & Yoshikai, Y. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302145 · Cited by 72
Coordinated Regulation of Transcription Factor Bcl11b Activity in Thymocytes by the Mitogen-activated Protein Kinase (MAPK) Pathways and Protein Sumoylation
Zhang, L., Vogel, W., Liu, X., Topark‐Ngarm, A., Arbogast, B. L., Maier, C. S., Filtz, T. M., & Leid, M. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.344176 · Cited by 74
Distinct human circulating NKp30 + FcεRIγ + CD8 + T cell population exhibiting high natural killer-like antitumor potential
Correia, M. P., Stojanovic, A., Bauer, K., Juraeva, D., Tykocinski, L., Lorenz, H., Brors, B., & Cerwenka, A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720564115 · Cited by 69
The Genetics and Mechanisms of T-Cell Acute Lymphoblastic LeukemiaPreprint
Gianni, F., Belver, L., & Ferrando, A. A. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a035246 · Cited by 69
Cell type–specific actions of Bcl11b in early T-lineage and group 2 innate lymphoid cells
Hosokawa, H., Romero-Wolf, M., Yang, Q., Motomura, Y., Levanon, D., Groner, Y., Moro, K., Tanaka, T., & Rothenberg, E. V. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190972 · Cited by 67
Modulation of Signal Strength Switches Notch from an Inducer of T Cells to an Inducer of ILC2
Gentek, R., Munneke, J. M., Helbig, C., Blom, B., Hazenberg, M. D., Spits, H., & Amsen, D. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00334 · Cited by 67
Human cytomegalovirus expands a CD8 + T cell population with loss of BCL11B expression and gain of NK cell identity
Sottile, R., Panjwani, M. K., Lau, C. M., Daniyan, A. F., Tanaka, K., Barker, J. N., Brentjens, R. J., Sun, J. C.-Y., Luduec, J.-B. L., & Hsu, K. C. (2021) · Science Immunology · doi:10.1126/sciimmunol.abe6968 · Cited by 67
GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate
de Walle, I. V., Dolens, A., Durinck, K., Katrien De Mulder, A., Loocke, W. V., Damle, S. S., Waegemans, E., Medts, J. D., Velghe, I., Smedt, M. D., et al. (2016) · Nature Communications · doi:10.1038/ncomms11171 · Cited by 65
Forging T-Lymphocyte Identity
Rothenberg, E. V., Ungerbäck, J., & Champhekar, A. (2016) · Advances in Immunology · doi:10.1016/bs.ai.2015.09.002 · Cited by 61
The 'T-cell-ness' of NK cells: unexpected similarities between NK cells and T cells
Narni-Mancinelli, É., Vivier, É., & Kerdiles, Y. M. (2011) · International Immunology · doi:10.1093/intimm/dxr035 · Cited by 60
On becoming a T cell, a convergence of factors kick it up a Notch along the way
Thompson, P. K., & Zúñiga‐Pflücker, J. C. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.08.007 · Cited by 59
Expression of mesenchyme-specific gene signatures by follicular dendritic cells: insights from the meta-analysis of microarray data from multiple mouse cell populations
Mabbott, N. A., Baillie, J. K., Kobayashi, A., Donaldson, D. S., Ohmori, H., Yoon, S.-O., Freedman, A. S., Freeman, T. C., & SUMMERS, K. M. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03461.x · Cited by 59
Notch Signaling During Human T cell Development
Taghon, T., Waegemans, E., & de Walle, I. V. (2012) · Current topics in microbiology and immunology · doi:10.1007/82_2012_230 · Cited by 58
Cell Fate Reprogramming in the Era of Cancer Immunotherapy
Zimmermannova, O., Caiado, I., Ferreira, A. G., & Pereira, C.-F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.714822 · Cited by 56
Single-cell deletion analyses show control of pro–T cell developmental speed and pathways by Tcf7, Spi1, Gata3, Bcl11a, Erg, and Bcl11b
Zhou, W., Gao, F., Romero-Wolf, M., Jo, S., & Rothenberg, E. V. (2022) · Science Immunology · doi:10.1126/sciimmunol.abm1920 · Cited by 52
Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes
Kojo, S., Tanaka, H., Endo, T. A., Muroi, S., Liu, Y., Seo, W., Tenno, M., Kakugawa, K., Naoe, Y., Nair, K., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00768-1 · Cited by 57
Bcl11b, a novel GATA3-interacting protein, suppresses Th1 while limiting Th2 cell differentiation
Fang, D., Cui, K., Hu, G., Gurram, R. K., Zhong, C., Oler, A. J., Yagi, R., Zhao, M., Sharma, S., Liu, P., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20171127 · Cited by 56
Self-citation
Regulatory mechanisms of thymus and T cell development
Ma, D., Wei, Y., & Liu, F. (2011) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2011.12.013 · Cited by 60
Increased expression of miR-221 is associated with shorter overall survival in T-cell acute lymphoid leukemia
Teixeira, H. L. G., Lucena-Araujo, A. R., dos Santos, G. A., Zanette, D. L., Scheucher, P. S., de Oliveira, L. C. O., Dalmazzo, L. F. F., Silva, W. A., Falcão, R. P., & Rego, E. M. (2013) · Experimental Hematology and Oncology · doi:10.1186/2162-3619-2-10 · Cited by 55
Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes
Zhang, M., Dong, Y., Hu, F., Yang, D., Zhao, Q., Lv, C., Wang, Y., Xia, C., Weng, Q., Liu, X., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0046-x · Cited by 53
Self-citation
Runx1 and Runx3 drive progenitor to T-lineage transcriptome conversion in mouse T cell commitment via dynamic genomic site switching
Shin, B., Hosokawa, H., Romero-Wolf, M., Zhou, W., Masuhara, K., Tobin, V. R., Levanon, D., Groner, Y., & Rothenberg, E. V. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2019655118 · Cited by 51
The role of BCL11B in hematological malignancy
Huang, X., Du, X., & Li, Y. (2012) · Experimental Hematology and Oncology · doi:10.1186/2162-3619-1-22 · Cited by 52
Transcription factor networks in dendritic cell development
Satpathy, A. T., MURPHY, K. M. M., & Wumesh, K. C. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.08.009 · Cited by 57
Diverting T helper cell trafficking through increased plasticity attenuates autoimmune encephalomyelitis
Califano, D., Sweeney, K. J., Le, H., VanValkenburgh, J., Yager, E. J., O’Connor, W., Kennedy, J. S., Jones, D. M., & Avram, D. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70103 · Cited by 51
The development of adult innate lymphoid cells
Yang, Q., & Bhandoola, A. (2016) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.01.006 · Cited by 50

Authors: Li, P., Burke, S., Wang, J., Chen, X., Ortiz, M., Lee, S.-C., Lu, D., Campos, L., Goulding, D., Ng, B. L., Dougan, G., Huntly, B., Gottgens, B., Jenkins, N. A., Copeland, N. G., Colucci, F., & Liu, P.
Affiliations: Wellcome Sanger Institute (GB)
Babraham Institute (GB)
National Cancer Institute (US)
Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK.
Wellcome Trust (GB)
Cambridge Institute for Medical Research, Wellcome Trust–MRC Building, Hills Road, Cambridge CB2 0XY, UK.
Institute of Molecular and Cell Biology (SG)
Corresponding author: Liu, Pentao
ORCID: Li, Peng
Burke, Shannon
Chen, Xiongfeng
Lu, Dong
Campos, Lia
Goulding, David
Ng, Bee Ling
Huntly, Brian
Jenkins, Nancy A.
Colucci, Francesco
Liu, Pentao
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2010-07-02
Volume: 329
Issue: 5987
Pages: 85-89
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1188063
PMC: PMC3628452
OpenAlex: W2010957709
Cited by: 374
References: 26
Citations by year: 2026: 16 · 2025: 22 · 2024: 28 · 2023: 11 · 2022: 17 · 2021: 28 · 2020: 16 · 2019: 26 · 2018: 24 · 2017: 14 · 2016: 27 · 2015: 20 · 2014: 21 · 2013: 24 · 2012: 26
FWCI: 14.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders: Wellcome Trust (077186, 076962)
National Centre for the Replacement, Refinement and Reduction of Animals in Research (G0900729/1)
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: BCL11B, T cell development, NK-like cells, lineage commitment, thymus development, zinc finger transcription factor, T cell progenitors, tumor cytotoxicity, NK cell expansion
MeSH terms: Animals, Cells, Cultured, Cytotoxicity, Immunologic, Killer Cells, Natural, Melanoma, Experimental, Mice, Inbred C57BL, Repressor Proteins, T-Lymphocytes, Tamoxifen, Signal Transduction, Receptors, Antigen, T-Cell, alpha-beta, Stromal Cells, Gene Deletion, Mice, Knockout, Gene Expression Regulation, Developmental, Coculture Techniques, Cell Lineage, Genes, T-Cell Receptor beta, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Tumor Suppressor Proteins, Lymphopoiesis, Cell Line, Tumor, Mice, Precursor Cells, T-Lymphoid, Gene Knock-In Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Reprogramming of T Cells to Natural Killer–Like Cells upon Bcl11b Deletion

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks