The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Increased Mutagenesis and Unique Mutation Signature Associated with Mitotic Gene Conversion
Open accessAbstract
Dodgy Repair: A double-strand break (DSB) in genomic DNA poses a serious threat to genome stability, and yet vertebrate cells may suffer 10 or more DSBs every time the genome is replicated. Pathways have thus evolved that can recognize and repair DSBs before they reek havoc in the cell. Hicks et al. (p. 82 ) show that this repair can come at a price. DSBs were induced in the budding yeast genome. Repair of a break was accompanied by a massive increase in the rate of mutation in the vicinity of the break. The mutations generated displayed a specific “signature” that included the copying of divergent sequences from other chromosomes.
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Cites
Mechanisms of change in gene copy number
Hastings, P. J., Lupski, J. R., Rosenberg, S. M., & Ira, G. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2593 · Cited by 1,316
Bitterman, K. J., Anderson, R. M., Cohen, H. Y., Latorre-Esteves, M., & Sinclair, D. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205670200 · Cited by 1,002
Estimating the Per-Base-Pair Mutation Rate in the Yeast Saccharomyces cerevisiae
Lang, G. I., & Murray, A. W. (2008) · Genetics · doi:10.1534/genetics.107.071506 · Cited by 344
Payen, C., Koszul, R., Dujon, B., & Fischer, G. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000175 · Cited by 200
Kunkel, T. A., Pavlov, Y. I., & Bebenek, K. (2003) · DNA Repair · doi:10.1016/s1568-7864(02)00224-0 · Cited by 125
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Nik-Zainal, S., Alexandrov, L. B., Wedge, D. C., Van Loo, P., Greenman, C. D., Raine, K., Jones, D., Hinton, J., Marshall, J., Stebbings, L. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.024 · Cited by 1,909
DNA double-strand break repair-pathway choice in somatic mammalian cells
Scully, R., Panday, A., Elango, R., & Willis, N. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0152-0 · Cited by 1,457
Ranjha, L., Howard, S. M., & Cejka, P. (2018) · Chromosoma · doi:10.1007/s00412-017-0658-1 · Cited by 325
Inflammation-Induced Cell Proliferation Potentiates DNA Damage-Induced Mutations In Vivo
Kiraly, O., Gong, G., Olipitz, W., Muthupalani, S., & Engelward, B. P. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1004901 · Cited by 169
DNA replication fidelity and cancer
Preston, B. D., Albertson, T. M., & Herr, A. J. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.10.009 · Cited by 160
Metadata
- Authors
- Hicks, W. M., Kim, M., & Haber, J. E.
- Venue
- Science
- Published
- 2010-07-02
- Volume
- 329
- Issue
- 5987
- Pages
- 82-85
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966568350
- Cited by
- 232
- References
- 5
- FWCI
- 9.33
- Type
- journal article
- Language
- en
- Open access
- green
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