Cited by 125DNA Repair MechanismsDNA and Nucleic Acid ChemistryGenetic factors in colorectal cancer

Functions of human DNA polymerases η, κ and ι suggested by their properties, including fidelity with undamaged DNA templates

Kunkel, Thomas A, Pavlov, Youri I, Bebenek, Katarzyna·2003·DNA Repair

Abstract

Human DNA polymerases eta, kappa and iota are template-dependent, Y-family DNA polymerases that have been implicated in translesion DNA synthesis (TLS) in human cells. Here, we briefly review evidence that these exonuclease-deficient polymerases copy undamaged DNA with very low fidelity and unusual error specificity. Based on the base substitution specificity and other biochemical properties of DNA polymerases eta and iota, we consider the possibility that they participate in specialized DNA transactions that repair damaged DNA and/or generate mutations in the variable regions of immunoglobulin genes.

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Crossref · 10.1016/s1568-7864(02)00224-0

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  • Translesion synthesis (TLS) polymerases copy past lesions in DNA that block the major replicative polymerases.

    “Translesion synthesis (TLS) polymerases copy past lesions in DNA that block the major replicative polymerases (7)(8)(9)(10)(11).”

    From DNA Replication Fidelity (2004) · cites this paper as [8]

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Authors
Kunkel, T. A., Pavlov, Y. I., & Bebenek, K.
Affiliations
  • National Institutes of Health (US)
  • National Institute of Environmental Health Sciences (US)
Corresponding author
Kunkel, Thomas A
Venue
DNA Repair
Publisher
Elsevier BV
Published
2003-02
Volume
2
Issue
2
Pages
135-149
ISSN
  • 1568-7856 (ISSN-L)
  • 1568-7864
OpenAlex
W2078840215
Cited by
125
References
102
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2016: 3 · 2014: 3 · 2013: 3 · 2012: 8
FWCI
1.66
Type
journal article
Language
en
Open access
closed
Locations
  • DNA repair (publishedVersion)
  • PubMed (publishedVersion)
Funders
Francis Crick Institute
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords
DNA polymerase eta, DNA polymerase kappa, DNA polymerase iota, Y-family DNA polymerases, translesion synthesis, DNA replication fidelity, immunoglobulin gene rearrangement
MeSH terms
DNA Polymerase iota, Y-Family DNA Polymerases, DNA, DNA-Directed DNA Polymerase, Humans, Immunoglobulins, Mutation

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