The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells
Open accessAbstract
Stem Cell Expansion: The ability to expand hematopoietic stem cells (HSCs) during ex-vivo culture has been an important goal for over 20 years. Using a high-throughput chemical screen, Boitano et al. (p. 1345 , published online 5 August; see the Perspective by Sauvageau and Humphries ) found that a purine derivative, StemRegenin1 (SR1), promoted the expansion of human HSCs. Treatment of HSCs with SR1 (which blocked the activity of the aryl hydrocarbon receptor) led to the expansion of CD34 + cells and a 12 to 17-fold increase in the number of HSCs that engraft immune deficient mice.
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Cites
Ligand Selectivity and Gene Regulation by the Human Aryl Hydrocarbon Receptor in Transgenic Mice
Flaveny, C. A., Murray, I. A., Chiaro, C. R., & Perdew, G. H. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.054825 · Cited by 124
Self-citationDefinition of a Dioxin Receptor Mutant That Is a Constitutive Activator of Transcription
McGuire, J., Okamoto, K., Whitelaw, M. L., Tanaka, H., & Poellinger, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105607200 · Cited by 102
Cited by
Regulation of the immune response by the aryl hydrocarbon receptor
Gutiérrez-Vázquez, C., & Quintana, F. J. (2018) · Immunity · doi:10.1016/j.immuni.2017.12.012 · Cited by 985
The aryl hydrocarbon receptor: multitasking in the immune system
Stockinger, B., Meglio, P. D., Gialitakis, M., & Duarte, J. H. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120245 · Cited by 909
Hematopoiesis: a human perspective
Doulatov, S., Notta, F., Laurenti, E., & Dick, J. E. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.01.006 · Cited by 895
Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., & Zhao, B. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr218 · Cited by 748
Self-citationJoubert, B. R., Håberg, S. E., Nilsen, R. M., Wang, X., Vollset, S. E., Murphy, S. K., Huang, Z., Hoyo, C., Midttun, Ø., Cupul-Uicab, L. A., et al. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1205412 · Cited by 716
Metadata
- Authors
- Boitano, A. E., Wang, J., Romeo, R., Bouchez, L. C., Parker, A. E., Sutton, S. E., Walker, J. R., Flaveny, C. A., Perdew, G. H., Denison, M. S., Schultz, P. G., & Cooke, M. P.
- Venue
- Science
- Published
- 2010-09-10
- Volume
- 329
- Issue
- 5997
- Pages
- 1345-1348
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2040568539
- Cited by
- 1,047
- References
- 2
- FWCI
- 36.10
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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