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Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells
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Stem Cell Expansion: The ability to expand hematopoietic stem cells (HSCs) during ex-vivo culture has been an important goal for over 20 years. Using a high-throughput chemical screen, Boitano et al. (p. 1345 , published online 5 August; see the Perspective by Sauvageau and Humphries ) found that a purine derivative, StemRegenin1 (SR1), promoted the expansion of human HSCs. Treatment of HSCs with SR1 (which blocked the activity of the aryl hydrocarbon receptor) led to the expansion of CD34 + cells and a 12 to 17-fold increase in the number of HSCs that engraft immune deficient mice.
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Metadata
- Authors
- Boitano, A. E., Wang, J., Romeo, R., Bouchez, L. C., Parker, A. E., Sutton, S. E., Walker, J. R., Flaveny, C. A., Perdew, G. H., Denison, M. S., Schultz, P. G., & Cooke, M. P.
- Venue
- Science
- Published
- 2010-09-10
- Volume
- 329
- Issue
- 5997
- Pages
- 1345-1348
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2040568539
- Cited by
- 1,047
- References
- 2
- FWCI
- 36.10
- Type
- journal article
- Language
- en
- Open access
- green
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