Cited by 452Fungal and yeast genetics researchDNA Repair MechanismsBioinformatics and Genomic Networks

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Rewiring of Genetic Networks in Response to DNA Damage

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Bandyopadhyay, Sourav, Mehta, Monika, Kuo, Dwight, Sung, Min-Kyung, Chuang, Ryan, Jaehnig, Eric J., Bodenmiller, Bernd, Licon, Katherine, Copeland, Wilbert, Shales, Michael, Fiedler, Dorothea, Dutkowski, Janusz, Guénolé, Aude, van Attikum, Haico, Shokat, Kevan M., Kolodner, Richard D., Huh, Won-Ki, Aebersold, Ruedi, Keogh, Michael-Christopher, Krogan, Nevan J., Ideker, Trey·2010·Science

DOI 10.1126/science.1195618PMC PMC3006187

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Abstract

DNA Damage Pathways Revealed: Despite the dynamic nature of cellular responses, the genetic networks that govern these responses have been mapped primarily as static snapshots. Bandyopadhyay et al. (p. 1385 ; see the Perspective by Friedman and Schuldiner ) report a comparison of large genetic interactomes measured among all yeast kinases, phosphatases, and transcription factors, as the cell responded to DNA damage. The interactomes revealed were highly dynamic structures that changed dramatically with changing conditions. These dynamic interactions reveal genetic relationships that can be more effective than classical “static” interactions (for example, synthetic lethals and epistasis maps) in identifying pathways of interest.

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Authors: Bandyopadhyay, S., Mehta, M., Kuo, D., Sung, M.-K., Chuang, R., Jaehnig, E. J., Bodenmiller, B., Licon, K., Copeland, W., Shales, M., Fiedler, D., Dutkowski, J., Guénolé, A., van Attikum, H., Shokat, K. M., Kolodner, R. D., Huh, W.-K., Aebersold, R., Keogh, M.-C., Krogan, N. J., & Ideker, T.
Affiliations: University of California San Diego (US)
Albert Einstein College of Medicine (US)
Seoul National University (KR)
University of Zurich (CH)
University of California, San Francisco (US)
Howard Hughes Medical Institute (US)
Leiden University Medical Center (NL)
Department of Toxicogenetics, Leiden University Medical Center, Leiden, Netherlands.
Corresponding author: Keogh, Michael-Christopher
Krogan, Nevan J.
Ideker, Trey
ORCID: Bandyopadhyay, Sourav
Mehta, Monika
Kuo, Dwight
Sung, Min-Kyung
Chuang, Ryan
Jaehnig, Eric J.
Bodenmiller, Bernd
Copeland, Wilbert
Fiedler, Dorothea
Shokat, Kevan M.
Kolodner, Richard D.
Huh, Won-Ki
Aebersold, Ruedi
Keogh, Michael-Christopher
Krogan, Nevan J.
Ideker, Trey
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2010-12-03
Volume: 330
Issue: 6009
Pages: 1385-1389
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1195618
PMC: PMC3006187
OpenAlex: W1988263223
Cited by: 447
References: 23
Citations by year: 2026: 7 · 2025: 5 · 2024: 12 · 2023: 10 · 2022: 17 · 2021: 18 · 2020: 31 · 2019: 40 · 2018: 22 · 2017: 42 · 2016: 28 · 2015: 37 · 2014: 55 · 2013: 51 · 2012: 41
FWCI: 15.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Leiden Repository (Leiden University) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Cancer Institute (P30CA013330)
National Institute of General Medical Sciences (R01GM084448, P50GM081879, R01GM084279, R37GM026017, R01GM026017)
National Institute of Environmental Health Sciences (R01ES014811)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Keywords: DNA damage response, genetic interaction networks, phosphatase, transcription factors, DNA repair pathways, protein complex stability, network rewiring
MeSH terms: Chromatin, DNA Damage, DNA Repair, DNA, Fungal, Epistasis, Genetic, Genes, Fungal, Histones, Methyl Methanesulfonate, Mutagens, Mutation, Phosphoprotein Phosphatases, Saccharomyces cerevisiae, Transcription Factors, Signal Transduction, Protein Serine-Threonine Kinases, Mitogen-Activated Protein Kinases, Protein Interaction Mapping, Saccharomyces cerevisiae Proteins, Gene Regulatory Networks

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Rewiring of Genetic Networks in Response to DNA Damage

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