Exploring genetic interactions and networks with yeast

A haplotype map of the human genome

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A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae

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Functional profiling of the Saccharomyces cerevisiae genome

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Functional Characterization of the <i>S. cerevisiae</i> Genome by Gene Deletion and Parallel Analysis

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Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

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A comprehensive two-hybrid analysis to explore the yeast protein interactome

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Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

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Proteome survey reveals modularity of the yeast cell machinery

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New heterologous modules for classical or PCR‐based gene disruptions in Saccharomyces cerevisiae

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Scale-Free Networks

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Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants

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Global Mapping of the Yeast Genetic Interaction Network

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Global Analysis of Protein Activities Using Proteome Chips

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Sequencing and comparison of yeast species to identify genes and regulatory elements

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Genetic Control of the Cell Division Cycle in Yeast

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The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes

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Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray Profile

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Principles for the buffering of genetic variation

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Principles for the Buffering of Genetic Variation

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Finding Functional Features in Saccharomyces Genomes by Phylogenetic Footprinting

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Multicomponent therapeutics for networked systems

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Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway

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Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

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Mapping Pathways and Phenotypes by Systematic Gene Overexpression

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Bni1p, a Yeast Formin Linking Cdc42p and the Actin Cytoskeleton During Polarized Morphogenesis

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Systematic discovery of multicomponent therapeutics

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Exploration of Essential Gene Functions via Titratable Promoter Alleles

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The landscape of genetic complexity across 5,700 gene expression traits in yeast

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Modular epistasis in yeast metabolism

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A DNA Integrity Network in the Yeast Saccharomyces cerevisiae

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Mechanisms of Haploinsufficiency Revealed by Genome-Wide Profiling in Yeast

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Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast

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Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways

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Discovering Modes of Action for Therapeutic Compounds Using a Genome-Wide Screen of Yeast Heterozygotes

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Biochemical and genetic analysis of the yeast proteome with a movable ORF collectionPreprint

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The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae

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Systematic interpretation of genetic interactions using protein networks

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Use of a screen for synthetic lethal and multicopy suppressee mutants to identify two new genes involved in morphogenesis in Saccharomyces cerevisiae.

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GENETICS OF NATURAL POPULATIONS. XIII. RECOMBINATION AND VARIABILITY IN POPULATIONS OF DROSOPHILA PSEUDOOBSCURA

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Assessing experimentally derived interactions in a small world

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High-throughput RNAi screening in cultured cells: a user's guide

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SEX AND THE SINGLE CELL. I. ON THE ACTION OF MAJOR LOCI AFFECTING SEX DETERMINATION IN DROSOPHILA MELANOGASTER

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Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae

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A Robust Toolkit for Functional Profiling of the Yeast Genome

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A strategy for extracting and analyzing large-scale quantitative epistatic interaction data

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Genetic interactions between polymorphisms that affect gene expression in yeast

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Exploring the etiology of haploinsufficiency

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Suppressors of yeast actin mutations.

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The Language of Gene Interaction

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Genome-Wide Prediction of C. elegans Genetic Interactions

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The art and design of genetic screens: yeast

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Activation of the yeast HO gene by release from multiple negative controls

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Genome-Wide Detection of Polymorphisms at Nucleotide Resolution with a Single DNA Microarray

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Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo

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The centrosome in human genetic disease

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Ordering gene function: the interpretation of epistasis in regulatory hierarchies

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Combining biological networks to predict genetic interactions

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Synthetic enhancement in gene interaction: a genetic tool come of age

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The synthetic genetic interaction spectrum of essential genes

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Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiaePreprint

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Building mammalian signalling pathways with RNAi screens

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Plasticity of genetic interactions in metabolic networks of yeast

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Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiaeinteraction network

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Establishing Genetic Interactions by a Synthetic Dosage Lethality Phenotype

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Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss

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Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation

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Gene function prediction from congruent synthetic lethal interactions in yeast

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Genetic basis of individual differences in the response to small-molecule drugs in yeast

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Derivation of genetic interaction networks from quantitative phenotype data

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Functional genomics and proteomics: charting a multidimensional map of the yeast cell

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NOBEL LECTURE: Yeast and Cancer

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Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway

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Synthetic Lethal Analysis Implicates Ste20p, a p21-activated Protein Kinase, in Polarisome Activation

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A HIGHLY SPECIFIC COMPLEMENTARY LETHAL SYSTEM IN DROSOPHILA MELANOGASTER

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Yeast and Cancer

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From large networks to small molecules

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Yeast-based functional genomics and proteomics technologies: the first 15 years and beyond

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Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficienciesPreprint

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Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions

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Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality

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Changing perspectives in yeast research nearly a decade after the genome sequencePreprint

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Heat‐Inducible Degron and the Making of Conditional Mutants

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Ordering gene function: the interpretation of epistasis in regulatory hierarchies

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The promise of functional genomics: completing the encyclopedia of a cell

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Synthetic Interactions of the Post-Golgi sec Mutations of Saccharomyces cerevisiae

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Mutation load, functional overlap, and synthetic lethality in the evolution and treatment of cancer

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Network medicine: a network-based approach to human disease

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Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

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Interactome Networks and Human Disease

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Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems

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Synergistic drug combinations tend to improve therapeutically relevant selectivity

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Evolution by gene loss

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