A Family of IFN-γ–Inducible 65-kD GTPases Protects Against Bacterial Infection

Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria

Singh, S. B., Davis, A. S., Taylor, G. A., & Deretic, V. (2006) · Science · doi:10.1126/science.1129577 · Cited by 915 · see citing works

Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47

MacMicking, J. D., Taylor, G. A., & McKinney, J. D. (2003) · Science · doi:10.1126/science.1088063 · Cited by 685 · see citing works

An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure

Fujita, N., Hayashi, M., Fukumoto, H., Omori, H., Yamamoto, A., Noda, T., & Yoshimori, T. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-03-0312 · Cited by 527 · see citing works

p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

Itakura, E., & Mizushima, N. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201009067 · Cited by 415 · see citing works

Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis

Sever, S., Muhlberg, A. B., & Schmid, S. L. (1999) · Nature · doi:10.1038/19024 · Cited by 369 · see citing works

Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins

Prakash, B., Praefcke, G. J. K., Renault, L., Wittinghofer, A., & Herrmann, C. (2000) · Nature · doi:10.1038/35000617 · Cited by 325 · see citing works

Inborn errors of interferon (IFN)‐mediated immunity in humans: insights into the respective roles of IFN‐α/β, IFN‐γ, and IFN‐λ in host defense

Zhang, S., Boisson‐Dupuis, S., Chapgier, A. L. A., Yang, K., Bustamante, J. C., Puel, A., Pïcard, C., Abel, L., Jouanguy, E., & Casanova, J. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00698.x · Cited by 320 · see citing works

Lysosomal killing of <i>Mycobacterium</i> mediated by ubiquitin-derived peptides is enhanced by autophagy

Alonso, S., Pethe, K., Russell, D. G., & Purdy, G. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700036104 · Cited by 318 · see citing works

Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties

Ponpuak, M., Davis, A. S., Roberts, E. A., Delgado, M. A., Dinkins, C., Zhao, Z., Virgin, H. W., Kyei, G. B., Johansen, T., Vergne, I., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.009 · Cited by 308 · see citing works

The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage

Bekpen, C., Hunn, J. P., Rohde, C., Parvanova, I., Guethlein, L., Dunn, D. M., Glowalla, E., Leptin, M., & Howard, J. C. (2005) · Genome biology · doi:10.1186/gb-2005-6-11-r92 · Cited by 294 · see citing works

Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease

Bustamante, J., Arias, A. A., Vogt, G., Picard, C., Galicia, L. B., Prando, C., Grant, A. V., Marchal, C. C., Hubeau, M., Chapgier, A., et al. (2011) · Nature Immunology · doi:10.1038/ni.1992 · Cited by 287 · see citing works

Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria

Singh, S., Ornatowski, W., Vergne, I., Naylor, J., Delgado, M. A., Roberts, E. A., Ponpuak, M., Master, S. S., Pilli, M., White, E., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2119 · Cited by 257 · see citing works

Extensive Characterization of IFN-Induced GTPases mGBP1 to mGBP10 Involved in Host Defense

Degrandi, D., Konermann, C., Beuter-Gunia, C., Kresse, A., Wuerthner, J., Kurig, S., Beer, S., & Pfeffer, K. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7729 · Cited by 209 · see citing works

The Interferon-Inducible GTPases

Martens, S., & Howard, J. C. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104619 · Cited by 162 · see citing works

In Silico Genomic Analysis of the Human and Murine Guanylate-Binding Protein (GBP) Gene Clusters

Olszewski, M. A., Gray, J. C., & Vestal, D. J. (2006) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.26.328 · Cited by 160 · see citing works

Antiviral effects of the interferon‐induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein†

Itsui, Y., Sakamoto, N., Kakinuma, S., Nakagawa, M., Sekine‐Osajima, Y., Tasaka‐Fujita, M., Nishimura‐Sakurai, Y., Suda, G., Karakama, Y., Mishima, K., et al. (2009) · Hepatology · doi:10.1002/hep.23195 · Cited by 159 · see citing works

Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii

Hunn, J. P., Könen‐Waisman, S., Papic, N., Schroëder, N., Pawlowski, N., Lange, R., Kaiser, F., Zerrahn, J., Martens, S., & Howard, J. C. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.176 · Cited by 157 · see citing works

Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P2 and PtdIns(3,4,5)P3 promotes immunity to mycobacteria

Tiwari, S., Choi, H.-P., Matsuzawa, T., Pypaert, M., & MacMicking, J. D. (2009) · Nature Immunology · doi:10.1038/ni.1759 · Cited by 130 · see citing works

Human Guanylate Binding Proteins Potentiate the Anti-Chlamydia Effects of Interferon-γ

Tietzel, I., El-Haibi, C. P., & Carabeo, R. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006499 · Cited by 104 · see citing works

ESCRT factors restrict mycobacterial growth

Philips, J. A., Porto, M., Wang, H., Rubin, E. J., & Perrimon, N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707206105 · Cited by 89 · see citing works

Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-γ-inducible cofactor

Modiano, N., Lu, Y. E., & Cresswell, P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503227102 · Cited by 76 · see citing works

Induction of Guanylate Binding Protein 5 by Gamma Interferon Increases Susceptibility toSalmonella entericaSerovar Typhimurium-Induced Pyroptosis in RAW 264.7 Cells

Rupper, A. C., & Cardelli, J. A. (2008) · Infection and Immunity · doi:10.1128/iai.01437-07 · Cited by 52 · see citing works

Autophagy in infection, inflammation and immunity

Deretic, V., Saitoh, T., & Akira, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3532 · Cited by 1,919 · see citing works

Pathways of Antigen Processing

Blum, J. S., Wearsch, P. A., & Cresswell, P. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095910 · Cited by 1,561 · see citing works

Macrophage defense mechanisms against intracellular bacteria

Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989 · see citing works

Dynamin, a membrane-remodelling GTPase

Ferguson, S. M., & Camilli, P. V. D. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3266 · Cited by 977 · see citing works

Interferon-gamma (IFN-γ): Exploring its implications in infectious diseases

Kak, G., Raza, M., & Tiwari, B. K. (2018) · BioMolecular Concepts · doi:10.1515/bmc-2018-0007 · Cited by 624 · see citing works

Innate immunity to intracellular LPS

Rathinam, V. A. K., Zhao, Y., & Shao, F. (2019) · Nature Immunology · doi:10.1038/s41590-019-0368-3 · Cited by 608 · see citing works

Interferon-inducible effector mechanisms in cell-autonomous immunity

MacMicking, J. D. (2012) · Nature reviews. Immunology · doi:10.1038/nri3210 · Cited by 564 · see citing works

Modulation of innate immunity by Toxoplasma gondii virulence effectors

Hunter, C. A., & Sibley, L. D. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2858 · Cited by 570 · see citing works

GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals

Shenoy, A. R., Wellington, D. A., Kumar, P., Kassa, H. T., Booth, C. J., Cresswell, P., & MacMicking, J. D. (2012) · Science · doi:10.1126/science.1217141 · Cited by 512 · see citing works

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

Meunier, E., Dick, M. S., Dreier, R. F., Schürmann, N., Broz, D. K., Warming, S., Roose-Girma, M., Bumann, D., Kayagaki, N., Takeda, K., et al. (2014) · Nature · doi:10.1038/nature13157 · Cited by 485 · see citing works

Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation

Castillo, E. F., Dekonenko, A., Arko‐Mensah, J., Mandell, M. A., Dupont, N., Jiang, S., Delgado-Vargas, M., Timmins, G. S., Bhattacharya, D., Yang, H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210500109 · Cited by 451 · see citing works

Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies

Thakur, A., Mikkelsen, H., & Jungersen, G. (2019) · Journal of Immunology Research · doi:10.1155/2019/1356540 · Cited by 404 · see citing works

Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages

Chen, X., Barozzi, I., Termanini, A., Prosperini, E., Recchiuti, A., Dalli, J., Mietton, F., Matteoli, G., Hiebert, S., & Natoli, G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121131109 · Cited by 397 · see citing works

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

Man, S. M., Karki, R., Malireddi, R. K. S., Neale, G., Vogel, P., Yamamoto, M., Lamkanfi, M., & Kanneganti, T.-D. (2015) · Nature Immunology · doi:10.1038/ni.3118 · Cited by 380 · see citing works

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

Meunier, É., Wallet, P., Dreier, R. F., Costanzo, S., Anton, L., Rühl, S., Dussurgey, S., Dick, M. S., Kistner, A., Mélanie, R., et al. (2015) · Nature Immunology · doi:10.1038/ni.3119 · Cited by 353 · see citing works

Immune response and immunopathology during toxoplasmosis

Dupont, C. D., Christian, D. A., & Hunter, C. A. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0339-3 · Cited by 364 · see citing works

Interferon-induced guanylate-binding proteins: Guardians of host defense in health and disease

Tretina, K., Park, E., Mamińska, A., & MacMicking, J. D. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20182031 · Cited by 323 · see citing works

A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

Yamamoto, M., Okuyama, M., Su, J., Kimura, T., Kamiyama, N., Saiga, H., Ohshima, J., Sasai, M., Kayama, H., Okamoto, T., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.06.009 · Cited by 330 · see citing works

Autophagy and the Immune System

Kuballa, P., Nolte, W. M., Castoreno, A. B., & Xavier, R. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074948 · Cited by 326 · see citing works

Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors

Deretic, V. P. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.10.006 · Cited by 294 · see citing works

Cellular Self-Defense: How Cell-Autonomous Immunity Protects Against Pathogens

Randow, F., MacMicking, J. D., & James, L. C. (2013) · Science · doi:10.1126/science.1233028 · Cited by 294 · see citing works

Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms

Wandel, M. P., Kim, B.-H., Park, E., Boyle, K. B., Nayak, K., Lagrange, B., Herod, A., Henry, T., Zilbauer, M., Rohde, J. R., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0697-2 · Cited by 282 · see citing works

IFN-Inducible GTPases in Host Cell Defense

Kim, B.-H., Shenoy, A. R., Kumar, P., Bradfield, C. J., & MacMicking, J. D. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.09.007 · Cited by 278 · see citing works

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

Naujoks, J., Tabeling, C., Dill, B. D., Hoffmann, C., Brown, A. S., Kunze, M., Kempa, S., Peter, A., Mollenkopf, H.-J., Dorhoi, A., et al. (2016) · PLOS Pathogens · doi:10.1371/journal.ppat.1005408 · Cited by 261 · see citing works

Latent Tuberculosis Infection: Myths, Models, and Molecular Mechanisms

Dutta, N. K., & Karakousis, P. C. (2014) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00010-14 · Cited by 248 · see citing works

Human GBP1 is a microbe‐specific gatekeeper of macrophage apoptosis and pyroptosis

Fisch, D., Bando, H., Clough, B., Hornung, V., Yamamoto, M., Shenoy, A. R., & Frickel, E. (2019) · The EMBO Journal · doi:10.15252/embj.2018100926 · Cited by 222 · see citing works

HIF-1α Is an Essential Mediator of IFN-γ–Dependent Immunity to Mycobacterium tuberculosis

Braverman, J., Sogi, K. M., Benjamin, D. I., Nomura, D. K., & Stanley, S. A. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600266 · Cited by 233 · see citing works

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

Brunette, R. L., Young, J. M., Whitley, D. G., Brodsky, I. E., Malik, H. S., & Stetson, D. B. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20121960 · Cited by 223 · see citing works

Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense

Knight, M., Braverman, J., Asfaha, K., Gronert, K., & Stanley, S. A. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006874 · Cited by 219 · see citing works

Recognition of nucleic acids by pattern‐recognition receptors and its relevance in autoimmunity

Kawasaki, T., Kawai, T., & Akira, S. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01048.x · Cited by 216 · see citing works

Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease

Pilla-Moffett, D. M., Barber, M. F., Taylor, G. A., & Coers, J. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.04.032 · Cited by 216 · see citing works

IL-1β Promotes Antimicrobial Immunity in Macrophages by Regulating TNFR Signaling and Caspase-3 Activation

Jayaraman, P., Sada‐Ovalle, I., Nishimura, T., Anderson, A. C., Kuchroo, V. K., Remold, H. G., & Behar, S. M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202688 · Cited by 217 · see citing works

The role of ‘eat-me’ signals and autophagy cargo receptors in innate immunity

Boyle, K. B., & Randow, F. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.03.010 · Cited by 204 · see citing works

Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence

Li, P., Jiang, W., Yu, Q., Liu, W., Zhou, P., Li, J., Xu, J., Xu, B., Wang, F., & Shao, F. (2017) · Nature · doi:10.1038/nature24467 · Cited by 206 · see citing works

Regulation of the NADPH Oxidase and Associated Ion Fluxes During Phagocytosis

Nunes, P., Demaurex, N., & Dinauer, M. C. (2013) · Traffic · doi:10.1111/tra.12115 · Cited by 204 · see citing works

The Innate Immune Response to Mycobacterium tuberculosis Infection

Ravesloot-Chávez, M. M., Dis, E. S. V., & Stanley, S. A. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-010426 · Cited by 208 · see citing works

Host immune responses to <i>Toxoplasma gondii</i>

Sasai, M., Pradipta, A., & Yamamoto, M. (2018) · International Immunology · doi:10.1093/intimm/dxy004 · Cited by 202 · see citing works

Murine Guanylate Binding Protein 2 (mGBP2) controls Toxoplasma gondii replication

Degrandi, D., Kravets, E., Konermann, C., Beuter-Gunia, C., Klümpers, V., Lahme, S., Rasch, E., Mausberg, A. K., Beer‐Hammer, S., & Pfeffer, K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205635110 · Cited by 196 · see citing works

Safety and immunogenicity of the recombinant BCG vaccine VPM1002 in a phase 1 open-label randomized clinical trial

Grode, L., Ganoza, C. A., Brohm, C., Weiner, J. M., Eisele, B., & Kaufmann, S. H. E. (2013) · Vaccine · doi:10.1016/j.vaccine.2012.12.053 · Cited by 196 · see citing works

GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8

Wandel, M. P., Pathe, C., Werner, E., Ellison, C. J., Boyle, K. B., von der Malsburg, A., Rohde, J. R., & Randow, F. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.09.007 · Cited by 185 · see citing works

Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondii

Selleck, E. M., Fentress, S. J., Beatty, W. L., Degrandi, D., Pfeffer, K., Virgin, H. W., MacMicking, J. D., & Sibley, L. D. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003320 · Cited by 189 · see citing works

IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins

Haldar, A. K., Saka, H. A., Piro, A. S., Dunn, J. D., Henry, S. C., Taylor, G. A., Frickel, E., Valdivia, R. H., & Coers, J. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003414 · Cited by 185 · see citing works

The Parasitophorous Vacuole Membrane of Toxoplasma gondii Is Targeted for Disruption by Ubiquitin-like Conjugation Systems of Autophagy

Choi, J., Park, S., Biering, S. B., Selleck, E. M., Liu, C. Y., Zhang, X., Fujita, N., Saitoh, T., Akira, S., Yoshimori, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.006 · Cited by 181 · see citing works

The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18

Behnke, M. S., Fentress, S. J., Mashayekhi, M., Li, L. X., Taylor, G. A., & Sibley, L. D. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002992 · Cited by 179 · see citing works

The cytoskeleton in cell-autonomous immunity: structural determinants of host defence

Mostowy, S., & Shenoy, A. R. (2015) · Nature reviews. Immunology · doi:10.1038/nri3877 · Cited by 175 · see citing works

Interferon- γ and infectious diseases: Lessons and prospects

Casanova, J., MacMicking, J. D., & Nathan, C. (2024) · Science · doi:10.1126/science.adl2016 · Cited by 179 · see citing works

IFN-γ Elicits Macrophage Autophagy via the p38 MAPK Signaling Pathway

Matsuzawa, T., Kim, B.-H., Shenoy, A. R., Kamitani, S., Miyake, M., & MacMicking, J. D. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102041 · Cited by 173 · see citing works

A phase-separated nuclear GBPL circuit controls immunity in plants

Huang, S., Zhu, S., Kumar, P., & MacMicking, J. D. (2021) · Nature · doi:10.1038/s41586-021-03572-6 · Cited by 171 · see citing works

Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins

Haldar, A. K., Foltz, C., Finethy, R., Piro, A. S., Feeley, E. M., Pilla-Moffett, D. M., Komatsu, M., Frickel, E., & Coers, J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515966112 · Cited by 169 · see citing works

Autophagy Protein Rubicon Mediates Phagocytic NADPH Oxidase Activation in Response to Microbial Infection or TLR Stimulation

Yang, C., Lee, J., Rodgers, M. A., Min, C., Lee, J., Kim, H. J., Lee, K.-H., Kim, C., Oh, B., Zandi, E., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.01.018 · Cited by 163 · see citing works

Macrophage Autophagy and Bacterial Infections

Bah, A., & Vergne, I. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01483 · Cited by 166 · see citing works

Interferon-induced guanylate-binding proteins in inflammasome activation and host defense

Kim, B.-H., Chee, J., Bradfield, C. J., Park, E., Kumar, P., & MacMicking, J. D. (2016) · Nature Immunology · doi:10.1038/ni.3440 · Cited by 161 · see citing works

Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins

Finethy, R., Luoma, S., Orench‐Rivera, N., Feeley, E. M., Haldar, A. K., Yamamoto, M., Kanneganti, T., Kuehn, M. J., & Coers, J. (2017) · mBio · doi:10.1128/mbio.01188-17 · Cited by 154 · see citing works

Inducible antibacterial responses in macrophages

Sweet, M. J., Ramnath, D., Singhal, A., & Kapétanovic, R. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01080-y · Cited by 163 · see citing works

Molecular basis of mycobacterial survival in macrophages

Awuh, J. A., & Flo, T. H. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2422-8 · Cited by 155 · see citing works

Autophagy: An Emerging Immunological Paradigm

Deretic, V. P. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102108 · Cited by 154 · see citing works

Cellular and Molecular Connections between Autophagy and Inflammation

Lapaquette, P., Guzzo, J., Brétillon, L., & Bringer, M.-A. (2015) · Mediators of Inflammation · doi:10.1155/2015/398483 · Cited by 151 · see citing works

Host-Directed Therapeutics for Tuberculosis: Can We Harness the Host?

Hawn, T. R., Matheson, A. I., Maley, S. N., & Vandal, O. H. (2013) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00032-13 · Cited by 150 · see citing works

Guanylate Binding Proteins Enable Rapid Activation of Canonical and Noncanonical Inflammasomes in Chlamydia-Infected Macrophages

Finethy, R., Jørgensen, I., Haldar, A. K., de Zoete, M. R., Strowig, T., Flavell, R. A., Yamamoto, M., Nagarajan, U. M., Miao, E. A., & Coers, J. (2015) · Infection and Immunity · doi:10.1128/iai.00856-15 · Cited by 147 · see citing works

Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems

Feeley, E. M., Pilla-Moffett, D. M., Zwack, E. E., Piro, A. S., Finethy, R., Kolb, J. P., Martinez, J., Brodsky, I. E., & Coers, J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615771114 · Cited by 148 · see citing works

New pathways of protective and pathological host defense to mycobacteria

Ottenhoff, T. H. M. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2012.06.002 · Cited by 140 · see citing works

Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection

Sasai, M., & Yamamoto, M. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0353-9 · Cited by 149 · see citing works

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

Rosain, J., Neehus, A., Manry, J., Yang, R., Pen, J. L., Daher, W., Liu, Z., Chan, Y., Tahuil, N., Türel, Ö., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.038 · Cited by 140 · see citing works

Impact of lactobacilli on orally acquired listeriosis

Archambaud, C., Nahori, M., Soubigou, G., Bécavin, C., Laval, L., Lechat, P., Smokvina, T., Langella, P., Lecuit, M., & Cossart, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212809109 · Cited by 133 · see citing works

New Function of Type I IFN: Induction of Autophagy

Schmeisser, H., Bekisz, J., & Zoon, K. C. (2014) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2013.0128 · Cited by 129 · see citing works

Inflammation in tuberculosis: interactions, imbalances and interventions

Kaufmann, S. H. E., & Dorhoi, A. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.05.005 · Cited by 135 · see citing works

Autophagy and bacterial infectious diseases

Yuk, J., Yoshimori, T., & Jo, E. (2012) · Experimental & Molecular Medicine · doi:10.3858/emm.2012.44.2.032 · Cited by 127 · see citing works

Bacterial recognition pathways that lead to inflammasome activation

Storek, K. M., & Monack, D. M. (2015) · Immunological Reviews · doi:10.1111/imr.12289 · Cited by 129 · see citing works

Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility

Piro, A. S., Hernandez, D., Luoma, S., Feeley, E. M., Finethy, R., Yirga, A., Frickel, E., Lesser, C. F., & Coers, J. (2017) · mBio · doi:10.1128/mbio.01979-17 · Cited by 125 · see citing works

Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins

Tyrkalska, S. D., Candel, S., Angosto-Bazarra, D., Gómez-Abellán, V., Martín‐Sánchez, F., García‐Moreno, D., Perez, R. Z., Sánchez‐Ferrer, Á., Sepulcre, M. P., Pelegrı́n, P., et al. (2016) · Nature Communications · doi:10.1038/ncomms12077 · Cited by 124 · see citing works

Interferon-inducible GTPases in cell autonomous and innate immunity

Meunier, É., & Brož, P. (2015) · Cellular Microbiology · doi:10.1111/cmi.12546 · Cited by 118 · see citing works

Autophagy and Its Interaction With Intracellular Bacterial Pathogens

Siqueira, M. D. S., Ribeiro, R. D. M., & Travassos, L. H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00935 · Cited by 120 · see citing works

Role of Mouse and Human Autophagy Proteins in IFN-γ–Induced Cell-Autonomous Responses against Toxoplasma gondii

Ohshima, J., Lee, Y., Sasai, M., Saitoh, T., Su, J., Kamiyama, N., Matsuura, Y., Pann-Ghill, S., Hayashi, M., Ebisu, S., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302822 · Cited by 120 · see citing works

Roles of Autophagy-Related Genes in the Pathogenesis of Inflammatory Bowel Disease

Kim, S., Eun, H. S., & Jo, E. (2019) · Cells · doi:10.3390/cells8010077 · Cited by 120 · see citing works

Primary macrophages and J774 cells respond differently to infection with Mycobacterium tuberculosis

Andreu, N., Phelan, J. E., de Sessions, P. F., Cliff, J. M., Clark, T. G., & Hibberd, M. L. (2017) · Scientific Reports · doi:10.1038/srep42225 · Cited by 118 · see citing works

Regulation of innate immune functions by guanylate-binding proteins

Praefcke, G. J. K. (2017) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2017.10.013 · Cited by 118 · see citing works

Guanylate-Binding Protein 1: An Emerging Target in Inflammation and Cancer

Honkala, A. T., Tailor, D., & Malhotra, S. V. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03139 · Cited by 118 · see citing works

Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response

Subbian, S., Tsenova, L., Yang, G., O’Brien, P. E., Parsons, S. D. C., Peixoto, B., Taylor, L., Fallows, D. A., & Kaplan, G. (2011) · Open Biology · doi:10.1098/rsob.110016 · Cited by 118 · see citing works

Autophagy restrictsChlamydia trachomatisgrowth in human macrophages via IFNG-inducible guanylate binding proteins

Al‐Zeer, M. A., Al‐Younes, H. M., Lauster, D. C., Lubad, M. A., & Meyer, T. F. (2012) · Autophagy · doi:10.4161/auto.22482 · Cited by 117 · see citing works

Memory-T-Cell-Derived Interferon-γ Instructs Potent Innate Cell Activation for Protective Immunity

Soudja, S. M., Chandrabos, C., Yakob, E., Veenstra, M., Palliser, D., & Lauvau, G. S. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.005 · Cited by 116 · see citing works

Autophagy in inflammation, infection, neurodegeneration and cancer

Arroyo, D. S., Gaviglio, E. A., Ramos, J. M. P., Bussi, C., Rodriguez‐Galán, M. C., & Iribarren, P. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.11.001 · Cited by 112 · see citing works

Innate Immunity to Intracellular Pathogens: Balancing Microbial Elimination and Inflammation

Mitchell, G., & Isberg, R. R. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.07.005 · Cited by 107 · see citing works

A human apolipoprotein L with detergent-like activity kills intracellular pathogens

Gaudet, R. G., Zhu, S., Halder, A., Kim, B.-H., Bradfield, C. J., Huang, S., Xu, D., Mamińska, A., Nguyen, T. N., Lazarou, M., et al. (2021) · Science · doi:10.1126/science.abf8113 · Cited by 111 · see citing works

Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation

Man, S. M., Place, D. E., Kuriakose, T., & Kanneganti, T. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.4mr0516-223r · Cited by 108 · see citing works

Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death

Fisch, D., Clough, B., Domart, M., Encheva, V., Bando, H., Snijders, A. P., Collinson, L., Yamamoto, M., Shenoy, A. R., & Frickel, E. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108008 · Cited by 110 · see citing works

Nonstructural Protein 1 of Influenza A Virus Interacts with Human Guanylate-Binding Protein 1 to Antagonize Antiviral Activity

Zhu, Z., Shi, Z., Yan, W., Wei, J., Shao, D., Deng, X., Wang, S., Li, B., Tong, G., & Ma, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055920 · Cited by 108 · see citing works

Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation

Franco, M. M. C., Marim, F. M., Guimarães, E. S., Assis, N. R. G., Cerqueira, D. M., Alves‐Silva, J., Harms, J. S., Splitter, G. A., Smith, J. A., Kanneganti, T., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700725 · Cited by 104 · see citing works

A new splice variant of the human guanylate‐binding protein 3 mediates anti‐influenza activity through inhibition of viral transcription and replication

Nordmann, A., Wixler, L., Boergeling, Y., Wixler, V., & Ludwig, S. (2011) · The FASEB Journal · doi:10.1096/fj.11-189886 · Cited by 102 · see citing works

The role of autophagy in host defence against Mycobacterium tuberculosis infection

Songane, M., Kleinnijenhuis, J., Netea, M. G., & van Crevel, R. (2012) · Tuberculosis · doi:10.1016/j.tube.2012.05.004 · Cited by 101 · see citing works

The Macrophage Response to Mycobacterium tuberculosis and Opportunities for Autophagy Inducing Nanomedicines for Tuberculosis Therapy

Maphasa, R. E., Meyer, M., & Dube, A. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.618414 · Cited by 100 · see citing works

Single cell RNA sequencing identifies an early monocyte gene signature in acute respiratory distress syndrome

Jiang, Y., Rosborough, B. R., Chen, J., Das, S., Kitsios, G. D., McVerry, B. J., Mallampalli, R. K., Lee, J. S., Ray, A., Chen, W., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.135678 · Cited by 97 · see citing works

Interferons in health and disease

Boehmer, D. F. R., & Zanoni, I. (2025) · Cell · doi:10.1016/j.cell.2025.06.044 · Cited by 101 · see citing works

The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons

Dussurget, O., Bierne, H., & Cossart, P. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00050 · Cited by 93 · see citing works

Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense

Sasai, M., Sakaguchi, N., Su, J., Nakamura, S., Kawabata, T., Bando, H., Lee, Y., Saitoh, T., Akira, S., Iwasaki, A., et al. (2017) · Nature Immunology · doi:10.1038/ni.3767 · Cited by 94 · see citing works

Inflammatory Stimuli Reprogram Macrophage Phagocytosis to Macropinocytosis for the Rapid Elimination of Pathogens

Dasgupta, S. B., & Pieters, J. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003879 · Cited by 90 · see citing works

Guanylate-Binding Protein 1, an Interferon-Induced GTPase, Exerts an Antiviral Activity against Classical Swine Fever Virus Depending on Its GTPase Activity

Li, L., Yu, J., Li, Y., Wang, J., Li, S., Zhang, L., Xia, S.-L., Yang, Q., Wang, X., Yu, S., et al. (2016) · Journal of Virology · doi:10.1128/jvi.02718-15 · Cited by 91 · see citing works

Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns

Dubey, S. R., Turnbull, C., Pandey, A., Zhao, A., Kurera, M., Al-Zidan, R. N., Shen, C. X., Gautam, M., Mahajan, S., Jadhav, P. S., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01354-y · Cited by 97 · see citing works

Apoptosis-Associated Speck–like Protein Containing a Caspase Recruitment Domain Inflammasomes Mediate IL-1β Response and Host Resistance to Trypanosoma cruzi Infection

Silva, G. K., Sesti‐Costa, R., Silveira, T. N., Caetano, B. C., Horta, C. V., Gutierrez, F. R. S., Guedes, P. M. D. M., Andrade, W. A., Niz, M. D., Gazzinelli, R. T., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203293 · Cited by 90 · see citing works

Immune correlates of tuberculosis disease and risk translate across species

Ahmed, M., Thirunavukkarasu, S., Rosa, B. A., Thomas, K. A., Das, S., Rangel-Moreno, J., Lu, L., Mehra, S., Mbandi, S. K., Thackray, L. B., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay0233 · Cited by 89 · see citing works

Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-γ and alpha B-crystallin

Bsibsi, M., Peferoen, L., Holtman, I., Nacken, P., Gerritsen, W., Witte, M., van Horssen, J., Eggen, B., van der Valk, P., Amor, S., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1317-8 · Cited by 87 · see citing works

This Week in Science

(2011) · Science · doi:10.1126/science.2011.332.6030.twis

A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

Yamamoto, M., Okuyama, M., Su, J., Kimura, T., Kamiyama, N., Saiga, H., Ohshima, J., Sasai, M., Kayama, H., Okamoto, T., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.06.009 · Cited by 330 · see citing works

Extensive Characterization of IFN-Induced GTPases mGBP1 to mGBP10 Involved in Host Defense

Degrandi, D., Konermann, C., Beuter-Gunia, C., Kresse, A., Wuerthner, J., Kurig, S., Beer, S., & Pfeffer, K. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7729 · Cited by 209 · see citing works

ID: 165

Pfeffer, K., Degrandi, D., & Kravets, E. (2015) · Cytokine · doi:10.1016/j.cyto.2015.08.036

IFN-Inducible GTPases in Host Cell Defense

Kim, B.-H., Shenoy, A. R., Kumar, P., Bradfield, C. J., & MacMicking, J. D. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.09.007 · Cited by 278 · see citing works