Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

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Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection

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Macromolecular Modeling with Rosetta

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Generative design of therapeutics that bind and modulate protein states

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Elucidation of potential sites for antibody engineering by fluctuation editing

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Accurately Predicting Disordered Regions of Proteins Using Rosetta ResidueDisorder Application

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Synthetic biology approaches to dissecting linear motor protein function: towards the design and synthesis of artificial autonomous protein walkers

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Deep Mutational Scanning of Viral Glycoproteins and Their Host Receptors

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MHCEpitopeEnergy, a Flexible Rosetta-Based Biotherapeutic Deimmunization Platform

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Structurally Conserved Binding Sites of Hemagglutinin as Targets for Influenza Drug and Vaccine Development

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An integrated device for the rapid and sensitive detection of the influenza hemagglutinin

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Multi-scale structural analysis of proteins by deep semantic segmentation

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Applications of Deep Mutational Scanning in Virology

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Mapping of the Binding Landscape for a Picomolar Protein-Protein Complex through Computation and Experiment

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Computational Design of Helical Peptides Targeting TNFα

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Structural Insight into a Human Neutralizing Antibody against Influenza Virus H7N9

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Are natural proteins special? Can we do that?

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Beyond Thermodynamic Constraints: Evolutionary Sampling Generates Realistic Protein Sequence Variation

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The SARS-CoV-2 Spike Harbours a Lipid Binding Pocket Which Modulates Stability of the Prefusion TrimerPreprint

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Discovery of binding proteins for a protein target using protein-protein docking-based virtual screening

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Molecular insight on the altered membrane trafficking of TrkA kinase dead mutants

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Improved flexible refinement of protein docking in CAPRI rounds 22–27

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Data driven flexible backbone protein design

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Design-driven, multi-use research agendas to enable applied synthetic biology for global health

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A “building block” approach to the new influenza A virus entry inhibitors with reduced cellular toxicities

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Using Molecular Dynamics Simulations as an Aid in the Prediction of Domain Swapping of Computationally Designed Protein Variants

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Sensitive Protein Detection and Quantification in Paper-Based Microfluidics for the Point of Care

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Applications of cell free protein synthesis in protein design

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Committing the Oldest Sins in the Newest Kind of Ways—Antibodies Targeting the Influenza Virus Type A Hemagglutinin Globular Head

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Amino-acid site variability among natural and designed proteins

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Tertiary motifs as building blocks for the design of protein‐binding peptides

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Protein engineering and the use of molecular modeling and simulation: The case of heterodimeric Fc engineering

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De novo design of immunoreactive conformation-specific HIV-1 epitopes based on Top7 scaffold

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Redesigning the Specificity of Protein–DNA Interactions with Rosetta

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Structure-Guided Design of a Peptide Lock for Modular Peptide Binders

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Influenza Virus Specific CD8+T Cells Exacerbate Infection Following High Dose Influenza Challenge of Aged Mice

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Binding Affinities Controlled by Shifting Conformational Equilibria: Opportunities and Limitations

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Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma

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Antiviral compound screening, peptide designing, and protein network construction of influenza a virus (strain a/Puerto Rico/8/1934 H1N1)

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Design of novel granulopoietic proteins by topological rescaffolding

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Targeting Viral Surface Proteins through Structure-Based Design

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Deciphering interaction fingerprints from protein molecular surfacesPreprint

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Targeting Ras with protein engineering

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ProBAN : Neural network algorithm for predicting binding affinity in protein–protein complexes

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New Insights into the Interdependence between Amino Acid Stereochemistry and Protein Structure

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Mutagenesis Studies of the H5 Influenza Hemagglutinin Stem Loop Region

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An Atomistic Statistically Effective Energy Function for Computational Protein Design

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Metalloprotein Design

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Grafting of functional motifs onto protein scaffolds identified by PDB screening – an efficient route to design optimizable protein binders

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Stabilization and Improvement of a Promising Influenza Antiviral: Making a PAIN PAINless

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Dynamics of hemagglutinin-mediated membrane fusion

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Design of High-Affinity Metal-Controlled Protein Dimers

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Inhibition of a malaria host–pathogen interaction by a computationally designed inhibitor

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From Computational Design to a Protein That Binds

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Robust de novo design of protein binding proteins from target structural information alonePreprint

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Protein engineering via sequence-performance mapping

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De novo design of D-peptide ligands: Application to influenza virus hemagglutinin

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EPI-peptide designer: a tool for designing peptide ligand libraries based on epitope–paratope interactions

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High-resolution genetic profile of viral genomes: why it matters

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Combined computational design of a zinc‐binding site and a protein–protein interaction: One open zinc coordination site was not a robust hotspot for de novo ubiquitin binding

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Structural Insights for Anti-Influenza Vaccine Design

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A conserved histidine in Group-1 influenza subtype hemagglutinin proteins is essential for membrane fusion activity

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Consistency principle for protein design

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A novel strategy for molecular interfaces optimization: The case of Ferritin-Transferrin receptor interaction

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De Novo Protein Design Using the Blueprint Builder in Rosetta

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A fragment-based protein interface design algorithm for symmetric assemblies

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Inhibition of H1 and H5 Influenza A Virus Entry by Diverse Macrocyclic Peptides Targeting the Hemagglutinin Stem Region

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Targeting Ras-binding domain of ELMO1 by computational nanobody design

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ProfileGrids solve the large alignment visualization problem: influenza hemagglutinin example

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Collective repacking reveals that the structures of protein cores are uniquely specified by steric repulsive interactions

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Integrating linear optimization with structural modeling to increase HIV neutralization breadth

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Asymmetric protein design from conserved supersecondary structures

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Current directions in combining simulation-based macromolecular modeling approaches with deep learning

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Victory for crowdsourced biomolecule design

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What Can De Novo Protein Design Bring to the Treatment of Hematological Disorders?

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