Cited by 240T-cell and Retrovirus StudiesXenotransplantation and immune responseViral-associated cancers and disorders

Recombinant Origin of the Retrovirus XMRV

Open access
Paprotka, Tobias, Delviks-Frankenberry, Krista A., Cingöz, Oya, Martinez, Anthony, Kung, Hsing-Jien, Tepper, Clifford G., Hu, Wei-Shau, Fivash, Matthew J. +2 more·2011·Science

Abstract

Analysis of the origin of XMRV suggests that links between the virus and human disease are due to laboratory contamination.

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Registry

Crossref · 10.1126/science.1205292

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25 of 25 references verified0 citation errors · 0 not checkable

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  • XMRV, an MLV-like virus thought to be associated with prostate cancer and chronic fatigue syndrome, turned out to be a recombinant between two endogenous MLVs acquired during passage of a human xenograft in nude mice.

    “most recently with the discovery of xenotropic murine leukemia virus–related virus (XMRV), an MLV-like virus thought to be associated with prostate cancer and chronic fatigue syndrome (99, 100), which turned out to be a recombinant between two endogenous MLVs acquired during passage of a human xenograft in nude mice (101).”

    From The Discovery of Reverse Transcriptase (2016) · cites this paper as [101]

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Authors
Paprotka, T., Delviks-Frankenberry, K. A., Cingöz, O., Martinez, A., Kung, H.-J., Tepper, C. G., Hu, W.-S., Fivash, M. J., Coffin, J. M., & Pathak, V. K.
Affiliations
  • Frederick National Laboratory for Cancer Research (US)
  • Viral Mutation Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
  • Tufts University (US)
  • University of California, Davis (US)
  • National Cancer Institute (US)
Corresponding author
Pathak, Vinay K.
Venue
Science
Published
2011-07
Volume
333
Issue
6038
Pages
97-101
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2067387759
Cited by
240
References
25
Citations by year
2026: 3 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 12 · 2016: 14 · 2015: 12 · 2014: 16 · 2013: 26 · 2012: 68
FWCI
23.97
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (R37CA089441, R01CA150197, ZIABC011339, P30CA093373)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
  • Health Sciences › Medicine › Surgery › Xenotransplantation and immune response
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords
XMRV, viral recombination, provirus, prostate cancer cell lines, tumor xenografts, chronic fatigue syndrome, sample contamination
MeSH terms
Animals, DNA, Viral, Humans, Male, Mice, Nude, Neoplasm Transplantation, Prostatic Neoplasms, Proviruses, Recombination, Genetic, Transplantation, Heterologous, Fatigue Syndrome, Chronic, Genes, gag, Genes, env, Polymerase Chain Reaction, Gammaretrovirus, Endogenous Retroviruses, Cell Line, Tumor, Mice, Xenotropic murine leukemia virus-related virus, DNA Contamination

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