Recombinant Origin of the Retrovirus XMRV
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Analysis of the origin of XMRV suggests that links between the virus and human disease are due to laboratory contamination.
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XMRV, an MLV-like virus thought to be associated with prostate cancer and chronic fatigue syndrome, turned out to be a recombinant between two endogenous MLVs acquired during passage of a human xenograft in nude mice.
“most recently with the discovery of xenotropic murine leukemia virus–related virus (XMRV), an MLV-like virus thought to be associated with prostate cancer and chronic fatigue syndrome (99, 100), which turned out to be a recombinant between two endogenous MLVs acquired during passage of a human xenograft in nude mice (101).”
From The Discovery of Reverse Transcriptase (2016) · cites this paper as [101]
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- Authors
- Paprotka, T., Delviks-Frankenberry, K. A., Cingöz, O., Martinez, A., Kung, H.-J., Tepper, C. G., Hu, W.-S., Fivash, M. J., Coffin, J. M., & Pathak, V. K.
- Affiliations
- Frederick National Laboratory for Cancer Research (US)
- Viral Mutation Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
- Tufts University (US)
- University of California, Davis (US)
- National Cancer Institute (US)
- Corresponding author
- Pathak, Vinay K.
- Venue
- Science
- Published
- 2011-07
- Volume
- 333
- Issue
- 6038
- Pages
- 97-101
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3278917
- OpenAlex
- W2067387759
- Cited by
- 240
- References
- 25
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 12 · 2016: 14 · 2015: 12 · 2014: 16 · 2013: 26 · 2012: 68
- FWCI
- 23.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R37CA089441, R01CA150197, ZIABC011339, P30CA093373)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Health Sciences › Medicine › Surgery › Xenotransplantation and immune response
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- XMRV, viral recombination, provirus, prostate cancer cell lines, tumor xenografts, chronic fatigue syndrome, sample contamination
- MeSH terms
- Animals, DNA, Viral, Humans, Male, Mice, Nude, Neoplasm Transplantation, Prostatic Neoplasms, Proviruses, Recombination, Genetic, Transplantation, Heterologous, Fatigue Syndrome, Chronic, Genes, gag, Genes, env, Polymerase Chain Reaction, Gammaretrovirus, Endogenous Retroviruses, Cell Line, Tumor, Mice, Xenotropic murine leukemia virus-related virus, DNA Contamination
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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