The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The Big and the Small: Challenges of Imaging the Brain’s Circuits
Abstract
The relation between the structure of the nervous system and its function is more poorly understood than the relation between structure and function in any other organ system. We explore why bridging the structure-function divide is uniquely difficult in the brain. These difficulties also explain the thrust behind the enormous amount of innovation centered on microscopy in neuroscience. We highlight some recent progress and the challenges that remain.
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“The central tenet of connectomics is capturing both big and small scales: reconstructing individual synaptic connections in volumes large enough to encompass neural circuits (57).”
From A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution (2024) · cites this paper as [57]
Citations
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Cited by
Sorted by citations
Structural and Functional Brain Networks: From Connections to Cognition
Park, H.-J., & Friston, K. (2013) · Science · doi:10.1126/science.1238411 · Cited by 2,106
Neuromodulation of neuronal circuits: back to the future
Marder, E. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.010 · Cited by 904
Distinct Profiles of Myelin Distribution Along Single Axons of Pyramidal Neurons in the Neocortex
Tomassy, G. S., Berger, D. R., Chen, H.-H., Kasthuri, N., Hayworth, K. J., Vercelli, A., Seung, H. S., Lichtman, J. W., & Arlotta, P. (2014) · Science · doi:10.1126/science.1249766 · Cited by 600
Self-citationNeuronal wiring diagram of an adult brain
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“Scepti-cism has flourished largely owing to a lack of technologies that could reconstruct such wiring diagrams 16,17 , so obtaining such diagrams has remained hypothetical.”
BackgroundSuper-multiplex vibrational imaging
Wei, L., Chen, Z., Shi, L., Long, R., Anzalone, A. V., Zhang, L., Hu, F., Yuste, R., Cornish, V. W., & Min, W. (2017) · Nature · doi:10.1038/nature22051 · Cited by 514
Metadata
- Authors
- Lichtman, J. W., & Denk, W.
- Affiliations
- Molecular and Cellular Biology and Center for Brain Science Harvard University, Cambridge, MA 02138, USA.
- Max-Planck Institute for Medical Research, Department of Biomedical Optics, 69120 Heidelberg, Germany.
- Venue
- Science
- Published
- 2011-11-04
- Volume
- 334
- Issue
- 6056
- Pages
- 618-623
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 370
- References
- 7
- Language
- en
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