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The Big and the Small: Challenges of Imaging the Brain’s Circuits
Abstract
The relation between the structure of the nervous system and its function is more poorly understood than the relation between structure and function in any other organ system. We explore why bridging the structure-function divide is uniquely difficult in the brain. These difficulties also explain the thrust behind the enormous amount of innovation centered on microscopy in neuroscience. We highlight some recent progress and the challenges that remain.
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“The central tenet of connectomics is capturing both big and small scales: reconstructing individual synaptic connections in volumes large enough to encompass neural circuits (57).”
From A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution (2024) · cites this paper as [57]
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“Then we randomly sampled neurons from each list and queried: (1) All L2 IDs from the ChunkedGraph, (2) All volume measurements from the L2 Cache for these L2 IDs.”
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Metadata
- Authors
- Lichtman, J. W., & Denk, W.
- Affiliations
- Molecular and Cellular Biology and Center for Brain Science Harvard University, Cambridge, MA 02138, USA.
- Max-Planck Institute for Medical Research, Department of Biomedical Optics, 69120 Heidelberg, Germany.
- Venue
- Science
- Published
- 2011-11-04
- Volume
- 334
- Issue
- 6056
- Pages
- 618-623
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 370
- References
- 7
- Language
- en
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