The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Radio-Wave Heating of Iron Oxide Nanoparticles Can Regulate Plasma Glucose in Mice
Open accessAbstract
Gene Expression by Remote Control: Techniques that allow remote, noninvasive activation of specific genes in specific tissues could one day be applied to regulate expression of therapeutic proteins in a clinical setting. In a proof-of-concept study, Stanley et al. (p. 604 ) showed that heating of iron oxide nanoparticles by radiowaves can remotely activate insulin gene expression in cultured cells and in a mouse model. Heating of membrane-targeted nanoparticles induced opening of a temperature-sensitive membrane channel in the cells and triggered calcium entry. The intracellular calcium signal in turn stimulated expression of an engineered insulin gene, leading to the synthesis and release of insulin. In experiments with mice bearing tumors that expressed the engineered insulin gene, exposure to radiowaves promoted secretion of insulin from the tumors and lowered blood glucose levels in the animals.
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Metadata
- Authors
- Stanley, S. A., Gagner, J. E., Damanpour, S., Yoshida, M., Dordick, J. S., & Friedman, J. M.
- Venue
- Science
- Published
- 2012-05-04
- Volume
- 336
- Issue
- 6081
- Pages
- 604-608
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2074327258
- Cited by
- 490
- References
- 1
- FWCI
- 17.07
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
