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A High-Coverage Genome Sequence from an Archaic Denisovan Individual
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Ancient Genomics: The Denisovans were archaic humans closely related to Neandertals, whose populations overlapped with the ancestors of modern-day humans. Using a single-stranded library preparation method, Meyer et al. (p. 222 , published online 30 August) provide a detailed analysis of a high-quality Denisovan genome. The genomic sequence provides evidence for very low rates of heterozygosity in the Denisova, probably not because of recent inbreeding, but instead because of a small population size. The genome sequence also illuminates the relationships between humans and archaics, including Neandertals, and establishes a catalog of genetic changes within the human lineage.
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“However, recent discoveries of relatively intact macromolecular organic material in fossils and sub-fossils challenge this view.”
From Cretaceous dinosaur bone contains recent organic material and provides an environment conducive to microbial communities (2019) · cites this paper as Meyer et al., 2012
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Moreover, the introgressing Neanderthals were probably from populations that were separated both in time and space from the three archaic individuals who have so far been sequenced to high coverage-hereafter referred to as DAV (Denisovan, Altai Neanderthal and Vindija Neanderthal) 1,17,18 .”
From The nature of Neanderthal introgression revealed by 27,566 Icelandic genomes (2020) · cites this paper as [17]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Introgression from extinct Neanderthal and Denisovan human species has been shown to contribute to the genetic pool of modern human populations and their phenotypic spectrum.”
From Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations (2022) · cites this paper as [13]
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“While NE ancestry is relatively uniform among modern Eurasian populations (1, 2), it is approximately 8 to 24% higher in East Asia than in Europe (5, 10, 12, 13).”
From Past human expansions shaped the spatial pattern of Neanderthal ancestry (2023) · cites this paper as [12]
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“This second range expansion is essential for explaining the pattern currently observed of lower NE ancestry in western Europe than in East Asia (5, 10, 12, 13).”
From Past human expansions shaped the spatial pattern of Neanderthal ancestry (2023) · cites this paper as [12]
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“In particular, non-African populations show 1% to 2% of Neanderthal ancestry in their genomes (Green et al. 2010; Prüfer et al. 2014) and Melanesians and East Asians display 3% and 0.2%, respectively, from Denisovans ancestry (Green et al. 2010; Meyer et al. 2012; Prüfer et al. 2014).”
From The Human Accelerated Region HAR202 Controls NPAS3 Expression in the Developing Forebrain Displaying Differential Enhancer Activity Between Modern and Archaic Human Sequences (2024) · cites this paper as Meyer et al. 2012
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“These archaic hominins diverged from AMHs around 700 ka (Meyer et al. 2012; Prüfer et al. 2014, 2017; Nielsen et al. 2017; Gómez-Robles 2019; Mafessoni et al. 2020)”
From Archaic Introgression Shaped Human Circadian Traits (2023) · cites this paper as Meyer et al. 2012
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“West Eurasians harbour significantly less Neanderthal ancestry than East Asians19-21, which could be explained if West Eurasians (but not East Asians) have partial ancestry from a source diluting their Neanderthal inheritance22.”
From Genomic insights into the origin of farming in the ancient Near East (2016) · cites this paper as [20]
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“The mapping approaches employed in this study are consistent with those used in previous research [2, 6].”
From A refined analysis of Neanderthal-introgressed sequences in modern humans with a complete reference genome (2025) · cites this paper as [6]
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“These findings corroborated the theory that the Denisovans (and presumably also the Neandertals) had shared the fused HSA2 with modern humans.”
From Revised time estimation of the ancestral human chromosome 2 fusion (2022) · cites this paper as [17]
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“After modern humans left Africa more than 60,000 years ago, genetic evidence suggests multiple admixture events ~55,000 years [9] between modern humans and now extinct archaic humans including Neandertals [10–12] and Denisovans [13, 14].”
From Neandertal introgression partitions the genetic landscape of neuropsychiatric disorders and associated behavioral phenotypes (2022) · cites this paper as [13]
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“Admixture with extinct hominins (Neanderthals and Denisovans) resulted in the introgression of archaic alleles into the human gene pool51–53.”
From Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders (2017) · cites this paper as [52]
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“Perhaps surprisingly, Neanderthals, Denisovans and modern humans share an identical FOXP2 protein (Meyer et al., 2012; Noonan et al., 2006).”
From Genetic Changes Shaping the Human Brain (2015) · cites this paper as Meyer et al., 2012
In the citing paper
“For the Neanderthal sequence, we removed all sites with genotype quality < 40, and mapping quality < 30, as done previously 67 .”
From A Chronological Atlas of Natural Selection in the Human Genome during the Past Half-million Years (2015) · cites this paper as [67]
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Cites
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Self-citationFast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
Self-citationThe Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
McKenna, A., Hanna, M., Banks, E., Sivachenko, A., Cibulskis, K., Kernytsky, A., Garimella, K., Altshuler, D., Gabriel, S., Daly, M., et al. (2010) · Genome Research · doi:10.1101/gr.107524.110 · Cited by 27,895
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
Wang, K., Li, M., & Hakonarson, H. H. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq603 · Cited by 14,724
A method and server for predicting damaging missense mutations.
Adzhubei, I. A., Schmidt, S., Peshkin, L., Ramensky, V. E., Gerasimova, A., Bork, P., Kondrashov, A. S., & Sunyaev, S. R. (2010) · Nature Methods · doi:10.1038/nmeth0410-248 · Cited by 13,194
A framework for variation discovery and genotyping using next-generation DNA sequencing data
DePristo, M. A., Banks, E., Poplin, R. E., Garimella, K. V., Maguire, J., Hartl, C., Philippakis, A., del Angel, G., Rivas, M. A., Hanna, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.806 · Cited by 11,457
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366
A map of human genome variation from population-scale sequencing.
The 1000 Genomes Project Consortium (2010) · Nature · doi:10.1038/nature09534 · Cited by 7,877
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- J. A. Coyne H. A. Orr in Speciation and its Consequences D. Otte and J. A. Endler Eds. (Wiley New York 1989) pp. 180–207.
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Climer, S., Templeton, A. R., & Zhang, W. (2015) · Nature Communications · doi:10.1038/ncomms7534 · Cited by 14
DNA fingerprinting in anthropological genetics: past, present, future
Crawford, M. H., & Beaty, K. G. (2013) · Investigative Genetics · doi:10.1186/2041-2223-4-23 · Cited by 13
Archaic hominin genomics provides a window into gene expression evolution
Yan, S. M., & McCoy, R. C. (2020) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2020.05.014 · Cited by 13
A human-specific VNTR in the TRIB3 promoter causes gene expression variation between individuals
Örd, T., Puurand, T., Örd, D., Annilo, T., Möls, M., Remm, M., & Örd, T. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008981 · Cited by 16
Synapses, Language, and Being Human
LIEBERMAN, P. H. (2013) · Science · doi:10.1126/science.1247515 · Cited by 14
Yoshida, K., Schuenemann, V. J., Cano, L. M., Pais, M., Mishra, B., Sharma, R., Lanz, C., Martin, F. N., Kamoun, S., Krause, J., et al. (2013) · eLife · doi:10.7554/elife.01108 · Cited by 14
A high-coverage genome from a 200,000-year-old DenisovanPreprint
Peyrégne, S., Massilani, D., Swiel, Y., Boyle, M. J., Iasi, L. N. M., Sümer, A. P., Mesa, A. B., de Filippo, C., Viola, B., Essel, E., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.20.683404 · Cited by 19
Self-citationA cautionary note on using STRUCTURE to detect hybridization in a phylogenetic context
Pang, X., & Zhang, D. (2025) · Journal of Systematics and Evolution · doi:10.1111/jse.70013 · Cited by 13
The contribution of ancient hominin genomes from Siberia to our understanding of human evolution
Pääbo, S. (2015) · Herald of the Russian Academy of Sciences · doi:10.1134/s1019331615050081 · Cited by 13
Self-citationHow did language evolve in the lineage of higher primates?
Hillert, D. G. (2021) · Lingua · doi:10.1016/j.lingua.2021.103158 · Cited by 13
Doña, J., & Johnson, K. P. (2023) · Evolution Letters · doi:10.1093/evlett/qrad026 · Cited by 13
Finlayson, C., Zollikofer, C. P. E., de León, M. S. P., Finlayson, G., Carrión, J. S., Finlayson, S., Guzmán, F. G., & Shea, J. J. (2023) · Quaternary Science Reviews · doi:10.1016/j.quascirev.2023.108307 · Cited by 14
Loh, L., Saunders, P. M., Faoro, C., Font‐Porterias, N., Nemat‐Gorgani, N., Harrison, G. F., Sadeeq, S., Hensen, L., Wong, S. C., Widjaja, J. M. L., et al. (2024) · Cell · doi:10.1016/j.cell.2024.10.005 · Cited by 15
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Jacobs, Z. L., Zavala, E. I., Li, B., O’Gorman, K., Shunkov, M. V., Kozlikin, M. B., Derevianko, A. P., Uliyanov, V. A., Goldberg, P. S., Agadjanian, A. K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60140-6 · Cited by 15
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Swali, P., Booth, T. J., Tan, C. C. S., McCabe, J., Anastasiadou, K., Barrington, C., Borrini, M., Bricking, A., Buckberry, J., Büster, L., et al. (2025) · Science · doi:10.1126/science.adr2147 · Cited by 14
Robertson, K. M., Minich, J. J., Bowman, A. J., et al. (2013) · Conservation Genetics Resources · doi:10.1007/s12686-013-9934-4 · Cited by 13
Elhaik, E., Yusuf, L. H., Anderson, A. I. J., Pirooznia, M., Arnellos, D., Vilshansky, G., Ercal, G., Lu, Y., Webster, T. A., Baird, M. L., et al. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx237 · Cited by 13
Improving Species Identification of Ancient Mammals Based on Next-Generation Sequencing Data
Lan, T., Lin, Y., Ngatia, J. N., Guo, X., Li, R., Li, H., Sahu, S. K., Xie, W., Yang, X., Guo, H., et al. (2019) · Genes · doi:10.3390/genes10070509 · Cited by 12
Self-citationHarnessing epigenetics to study human evolution
Mathov, Y., Batyrev, D., Meshorer, E., & Carmel, L. (2020) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2020.05.023 · Cited by 15
ABO Genetic Variation in Neanderthals and Denisovans
Villanea, F. A., Huerta‐Sánchez, E., & Fox, K. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab109 · Cited by 15
Millennia-Old Coral Holobiont DNA Provides Insight into Future Adaptive Trajectories
Scott, C. B., Cárdenas, A., Mah, M., Narasimhan, V. M., Rohland, N., Toth, L. T., Voolstra, C. R., Reich, D., & Matz, M. V. (2021) · Molecular Ecology · doi:10.1111/mec.16642 · Cited by 14
Self-citationFlegontov, P., Işıldak, U., Maier, R., Yüncü, E., Changmai, P., & Reich, D. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010931 · Cited by 14
Self-citationMitochondrial DNA haplogroup phylogeny of the dog: Proposal for a cladistic nomenclature
Fregel, R., Suárez, N. M., Betancor, E., González, A. M., Cabrera, V. M., & Pestano, J. (2015) · Mitochondrion · doi:10.1016/j.mito.2015.04.001 · Cited by 13
Multiple loss-of-function variants of taste receptors in modern humans
Fujikura, K. (2015) · Scientific Reports · doi:10.1038/srep12349 · Cited by 16
Evolution of genetic diversity and human diseases
Степанов, В. А. (2016) · Russian Journal of Genetics · doi:10.1134/s1022795416070103 · Cited by 14
Intragenus (Homo) variation in a chemokine receptor gene (CCR5)
Hoover, K. C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204989 · Cited by 13
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Vangenot, C., Gagneux, P., de Groot, N. G., Baumeyer, A., Mouterde, M., Crouau‐Roy, B., Darlu, P., Sanchez‐Mazas, A., Sabbagh, A., & Poloni, E. S. (2019) · G3 Genes Genomes Genetics · doi:10.1534/g3.119.400223 · Cited by 13
Construction of JRG (Japanese reference genome) with single-molecule real-time sequencing
Nagasaki, M., Kuroki, Y., Shibata, T. F., Katsuoka, F., Mimori, T., Kawai, Y., Minegishi, N., Hozawa, A., Kuriyama, S., Suzuki, Y., et al. (2019) · Human Genome Variation · doi:10.1038/s41439-019-0057-7 · Cited by 11
Adaptive Landscape of Protein Variation in Human Exomes
Patel, R., Scheinfeldt, L., Sanderford, M. D., Lanham, T. R., Tamura, K., Platt, A., Glicksberg, B. S., Xu, K., Dudley, J. T., & Kumar, S. (2018) · Molecular Biology and Evolution · doi:10.1093/molbev/msy107 · Cited by 11
Reproducible, portable, and efficient ancient genome reconstruction with nf-core/eager
Yates, J. A. F., Lamnidis, T. C., Borry, M., Valtueña, A. A., Fagernäs, Z., Clayton, S., Garcia, M. U., Neukamm, J., & Peltzer, A. (2021) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-202801 · Cited by 13
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Hempel, E., Bibi, F., Faith, J. T., Brink, J. S., Kalthoff, D. C., Kamminga, P., Paijmans, J. L. A., Westbury, M. V., Hofreiter, M., & Zachos, F. E. (2021) · Scientific Reports · doi:10.1038/s41598-020-80142-2 · Cited by 13
Past human expansions shaped the spatial pattern of Neanderthal ancestry
Quilodrán, C. S., Rio, J., Tsoupas, A., & Currat, M. (2023) · Science Advances · doi:10.1126/sciadv.adg9817 · Cited by 12
Metadata
- Authors
- Meyer, M., Kircher, M., Gansauge, M.-T., Li, H., Racimo, F., Mallick, S., Schraiber, J. G., Jay, F., Prüfer, K., de Filippo, C., Sudmant, P. H., Alkan, C., Fu, Q., Do, R., Rohland, N., Tandon, A., Siebauer, M., Green, R. E., Bryc, K., Briggs, A. W., Stenzel, U., Dabney, J., Shendure, J., Kitzman, J., Hammer, M. F., Shunkov, M. V., Derevianko, A. P., Patterson, N., Andrés, A. M., Eichler, E. E., Slatkin, M., Reich, D., Kelso, J., & Pääbo, S.
- Affiliations
- Max Planck Institute for Evolutionary Anthropology (DE)
- Max Planck Society (DE)
- Broad Institute (US)
- University of California, Berkeley (US)
- Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.
- University of Washington (US)
- Bilkent University (TR)
- Chinese Academy of Sciences (CN)
- University of California, Santa Cruz (US)
- Harvard University (US)
- University of Arizona (US)
- Russian Academy of Sciences (RU)
- Palaeolithic Department, Institute of Archaeology and Ethnography, Russian Academy of Sciences, Siberian Branch, 630090 Novosibirsk, Russia.
- Howard Hughes Medical Institute (US)
- Corresponding author
- Meyer, Matthias
- Kircher, Martin
- Reich, David
- Pääbo, Svante
- ORCID
- Meyer, Matthias
- Kircher, Martin
- Gansauge, Marie-Theres
- Li, Heng
- Racimo, Fernando
- Mallick, Swapan
- Schraiber, Joshua G.
- Jay, Flora
- Prüfer, Kay
- Sudmant, Peter H.
- Alkan, Can
- Fu, Qiaomei
- Do, Ron
- Rohland, Nadin
- Green, Richard E.
- Bryc, Katarzyna
- Briggs, Adrian W.
- Dabney, Jesse
- Shendure, Jay
- Kitzman, Jacob
- Hammer, Michael F.
- Shunkov, Michael V.
- Patterson, Nick
- Andrés, Aida M.
- Eichler, Evan E.
- Slatkin, Montgomery
- Reich, David
- Kelso, Janet
- Pääbo, Svante
- Venue
- Science
- Published
- 2012-10-12
- Volume
- 338
- Issue
- 6104
- Pages
- 222-226
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3617501
- OpenAlex
- W2038686775
- Semantic Scholar
- 914243876fdc3842f1f9e33432ada3dcf130ad10
- Cited by
- 1,967
- References
- 200
- Citations by year
- 2026: 97 · 2025: 104 · 2024: 113 · 2023: 138 · 2022: 115 · 2021: 179 · 2020: 161 · 2019: 146 · 2018: 158 · 2017: 146 · 2016: 166 · 2015: 145 · 2014: 164 · 2013: 118 · 2012: 14
- FWCI
- 658.14
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Bilkent University Institutional Repository (Bilkent University) (submittedVersion)
- Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of General Medical Sciences (R01GM040282, GM100233, R01GM100233)
- Topics
- Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- Denisovans, archaic humans, DNA library preparation, heterozygosity, genetic diversity, Denisovan admixture, modern human populations, positive selection, human evolution
- MeSH terms
- Alleles, Animals, Base Sequence, Fossils, Heterozygote, Humans, Molecular Sequence Data, Genetic Variation, Gene Library, Genome, Human, Sequence Analysis, DNA, Gene Flow, Neanderthals
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