The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages
Open accessAbstract
Dissecting SNARE Zippering: The SNARE complex is critical for vesicle fusion, notably during release of neurotransmitters at synapses. Understanding the biophysics of SNARE assembly has been the object of several structural studies, and yet much remains to be understood about the mechanisms. Now, Gao et al. (p. 1340 , published online 16 August; see the Perspective by Rizo ) describe the results of cell-free experiments using optical tweezers to elucidate assembly and disassembly of the SNARE complex. Direct observations of SNARE intermediates revealed multiple steps of the assembly process, along with the associated energetics and kinetics. Applying forces similar to those occurring during fusion, an intermediate was stabilized, and the derived mechanism indicates how neurotransmitter release may be regulated.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A tutorial on hidden Markov models and selected applications in speech recognition
Rabiner, L. R. (1989) · Proceedings of the IEEE · doi:10.1109/5.18626 · Cited by 22,743
SNAP receptors implicated in vesicle targeting and fusion
Söllner, T., Whiteheart, S. W., Brunner, M., Erdjument-Bromage, H., Geromanos, S., Tempst, P., & Rothman, J. E. (1993) · Nature · doi:10.1038/362318a0 · Cited by 3,237
Self-citationSNAREpins: Minimal Machinery for Membrane Fusion
Weber, T., Zemelman, B. V., McNew, J. A., Westermann, B., Gmachl, M., Parlati, F., Söllner, T. H., & Rothman, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81404-x · Cited by 2,475
Self-citationCrystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417
Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy
Neuman, K. C., & Nagy, A. (2008) · Nature Methods · doi:10.1038/nmeth.1218 · Cited by 2,406
Marko, J. F., & Siggia, E. D. (1995) · Macromolecules · doi:10.1021/ma00130a008 · Cited by 2,307
Entropic Elasticity of λ-Phage DNA
Bustamante, C., Marko, J. F., Siggia, E. D., & Smith, S. (1994) · Science · doi:10.1126/science.8079175 · Cited by 2,154
Membrane Fusion: Grappling with SNARE and SM Proteins
Südhof, T. C., & Rothman, J. E. (2009) · Science · doi:10.1126/science.1161748 · Cited by 2,027
Self-citationTheory of the Phase Transition between Helix and Random Coil in Polypeptide Chains
Zimm, B. H., & Bragg, J. K. (1959) · The Journal of Chemical Physics · doi:10.1063/1.1730390 · Cited by 1,785
Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones
Bennett, M. K., Calakos, N., & Scheller, R. H. (1992) · Science · doi:10.1126/science.1321498 · Cited by 1,263
Cited by
Brain temperature and its fundamental properties: a review for clinical neuroscientists
Wang, H., Wang, B., Normoyle, K. P., Jackson, K., Spitler, K., Sharrock, M. F., Miller, C. M., Best, C., Llano, D., & Du, R. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00307 · Cited by 356
Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis
Zhou, Q., Lai, Y., Bacaj, T., Zhao, M., Lyubimov, A. Y., Uervirojnangkoorn, M., Zeldin, O. B., Brewster, A. S., Sauter, N. K., Cohen, A. E., et al. (2015) · Nature · doi:10.1038/nature14975 · Cited by 348
The Synaptic Vesicle Release Machinery
Rizo, J., & Xu, J. (2015) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-060414-034057 · Cited by 339
Synaptic vesicle recycling: steps and principles
Rizzoli, S. O. (2014) · The EMBO Journal · doi:10.1002/embj.201386357 · Cited by 317
The Multifaceted Role of SNARE Proteins in Membrane Fusion
Han, J., Pluhackova, K., & Böckmann, R. A. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00005 · Cited by 285
Metadata
- Authors
- Gao, Y., Zorman, S., Gundersen, G., Xi, Z., Ma, L., Sirinakis, G., Rothman, J. E., & Zhang, Y.
- Venue
- Science
- Published
- 2012-09-14
- Volume
- 337
- Issue
- 6100
- Pages
- 1340-1343
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2040025072
- Cited by
- 405
- References
- 61
- FWCI
- 14.64
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages. https://app.cochat.ai/papers/10.1126/science.1224492
- The paper
- Gao, Y., Zorman, S., Gundersen, G., Xi, Z., Ma, L., Sirinakis, G., Rothman, J. E., & Zhang, Y. (2012). Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages. Science. https://doi.org/10.1126/science.1224492
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
