Decoding Human Cytomegalovirus
Open accessAbstract
Dissecting HCMV Gene Expression: Most of us are infected with human cytomegalovirus (HCMV), but severe disease is almost always limited to immunocompromised individuals or newborn infants. The virus has a relatively large (∼240 kb) DNA genome and shows a complex pattern of gene transcription, hinting at a complex regulatory and coding capacity. Stern-Ginossar et al. (p. 1088 ) mapped ribosome positions on HCMV transcripts during the course of viral infection of human fibroblast cells. The data suggest the presence of novel open reading frames (ORFs) lying within existing ORFs; very short ORFs upstream of canonical ORFs; ORFs antisense to canonical ORFs; and short, conserved ORFs encoded by long RNAs. Select ORFs were translated, dramatically expanding the coding capacity of the HCMV genome.
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Sequences of uncharacterized proteins and transcripts mapped to nonannotated or overlapping annotated human cytomegalovirus genomic loci and corresponded with alternative splicing or translation sites within known viral gene transcripts.
“Sequences of uncharacterized proteins and transcripts could be mapped to nonannotated or overlapping annotated HCMV genomic loci and corresponded with alternative splicing or translation sites within known HCMV gene transcripts.”
From The Impact of Mass Spectrometry–Based Proteomics on Fundamental Discoveries in Virology (2014) · cites this paper as [101]
Mass spectrometry and ribosome occupancy profiling identified and temporally resolved more than 50 previously unreported human cytomegalovirus polypeptides and more than 550 transcripts during infection.
“Recently, MS and ribosome occupancy profiling were used to identify and temporally resolve unique, previously unreported HCMV polypeptides (>50) and transcripts (>550) during infection (101).”
From The Impact of Mass Spectrometry–Based Proteomics on Fundamental Discoveries in Virology (2014) · cites this paper as [101]
Mass spectrometry approaches are necessary to reveal the true genetic complexity and protein diversity of even well-studied viruses.
“This study highlighted the necessity of MS approaches to reveal the true genetic complexity and protein diversity of even well-studied viruses.”
From The Impact of Mass Spectrometry–Based Proteomics on Fundamental Discoveries in Virology (2014) · cites this paper as [101]
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- Authors
- Stern-Ginossar, N., Weisburd, B., Michalski, A., Le, V. T. K., Hein, M. Y., Huang, S.-X., Ma, M., Shen, B., Qian, S.-B., Hengel, H., Mann, M., Ingolia, N. T., & Weissman, J. S.
- Affiliations
- Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisico, CA 94158, USA.
- Howard Hughes Medical Institute (US)
- Max Planck Institute of Biochemistry (DE)
- Institut für Virologie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.
- Scripps Research Institute (US)
- Cornell University (US)
- Heinrich Heine University Düsseldorf (DE)
- Corresponding author
- Michalski, Annette
- Weissman, Jonathan S.
- ORCID
- Venue
- Science
- Published
- 2012-11-23
- Volume
- 338
- Issue
- 6110
- Pages
- 1088-1093
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3817102
- OpenAlex
- W2010005720
- Cited by
- 589
- References
- 23
- Citations by year
- 2026: 14 · 2025: 21 · 2024: 30 · 2023: 31 · 2022: 28 · 2021: 64 · 2020: 48 · 2019: 49 · 2018: 38 · 2017: 45 · 2016: 56 · 2015: 56 · 2014: 72 · 2013: 35 · 2012: 2
- FWCI
- 39.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Cancer Institute (R01CA106150)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- human cytomegalovirus, viral genome, open reading frames, ribosome profiling, temporal gene expression, viral protein expression, transcriptome
- MeSH terms
- Cytomegalovirus Infections, Cytomegalovirus, Humans, Transcription, Genetic, Protein Biosynthesis, Genetic Variation, Open Reading Frames, Genome, Viral, Alternative Splicing, Sequence Analysis, DNA, Proteome
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