ATP-Dependent Lon Protease Controls Tumor Bioenergetics by Reprogramming Mitochondrial Activity
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We generated mice deficient in Lon protease (LONP1), a major enzyme of the mitochondrial quality control machinery. Homozygous deletion of Lonp1 causes early embryonic lethality, whereas its haploinsufficiency protects against colorectal and skin tumors. Furthermore, LONP1 knockdown inhibits cellular proliferation and tumor and metastasis formation, whereas its overexpression increases tumorigenesis. Clinical studies indicate that high levels of LONP1 are a poor prognosis marker in human colorectal cancer and melanoma. Additionally, functional analyses show that LONP1 plays a key role in metabolic reprogramming by remodeling OXPHOS complexes and protecting against senescence. Our findings demonstrate the relevance of LONP1 for cellular and organismal viability and identify this protease as a central regulator of mitochondrial activity in oncogenesis.
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The matrix mitochondrial protease LonP1 is necessary for maintenance of mitochondrial matrix proteostasis.
“The matrix mitochondrial protease LonP1 is necessary for the maintenance of mitochondrial matrix proteostasis.”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [161]
In mice, homozygous deletion of LonP1 causes early embryonic death.
“In mice, the homozygous deletion of LonP1 causes early embryonic death [161].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [161]
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Self-citation
- Authors
- Quirós, P. M., Español, Y., Acín-Pérez, R., Rodríguez, F., Bárcena, C., Watanabe, K., Calvo, E., Loureiro, M., Fernández-García, M. S., Fueyo, A., Vázquez, J., Enríquez, J. A., & López-Otín, C.
- Affiliations
- Universidad de Oviedo (ES)
- Spanish National Centre for Cardiovascular Research (ES)
- Hospital Universitario Central de Asturias (ES)
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 8
- Issue
- 2
- Pages
- 542-556
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2078704533
- Cited by
- 233
- References
- 62
- Citations by year
- 2026: 15 · 2025: 29 · 2024: 14 · 2023: 19 · 2022: 24 · 2021: 23 · 2020: 25 · 2019: 18 · 2018: 24 · 2017: 15 · 2016: 15 · 2015: 10 · 2014: 2
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- Lon protease, LONP1, mitochondrial quality control, tumor bioenergetics, metabolic reprogramming, oxidative phosphorylation complexes, cellular senescence, colorectal cancer, melanoma, carcinogenesis, haploinsufficiency, ATP-dependent proteolysis, metastasis
- MeSH terms
- Animals, Homozygote, Humans, Melanoma, Mitochondria, Oxidative Phosphorylation, Skin Neoplasms, Colorectal Neoplasms, Cellular Senescence, Gene Deletion, HCT116 Cells, ATP-Dependent Proteases, Cell Proliferation, Mice, HEK293 Cells, Haploinsufficiency
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