Cited by 121Genomics and Chromatin DynamicsAutophagy in Disease and TherapyHematopoietic Stem Cell Transplantation

A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy

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Barde, Isabelle, Rauwel, Benjamin, Marin-Florez, Ray Marcel, Corsinotti, Andrea, Laurenti, Elisa, Verp, Sonia, Offner, Sandra, Marquis, Julien +3 more·2013·Science

Abstract

Red in Cell and Marrow: About one hundred billion new red cells are released every day from the adult human bone marrow—the result of a complex differentiation pathway. Barde et al. (p. 350 , published online 14 March) show that an essential step in this process, the elimination of mitochondria from maturing erythroblasts through mitophagy, is controlled through the timely induction of specific members of the large family of KRAB-containing zinc finger proteins (KRAB-ZFPs), which, together with their cofactor KAP1, repress the expression of micro-RNAs targeting the transcripts of mitophagy effector genes. This multilayered and combinatorial regulation system provides a level of modularity that may be shared by other physiological processes.

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Authors
Barde, I., Rauwel, B., Marin-Florez, R. M., Corsinotti, A., Laurenti, E., Verp, S., Offner, S., Marquis, J., Kapopoulou, A., Vanicek, J., & Trono, D.
Affiliations
  • École Polytechnique Fédérale de Lausanne (CH)
  • School of Basic Sciences, EPFL, 1015 Lausanne, Switzerland.
Corresponding author
Trono, Didier
Venue
Science
Published
2013-04-19
Volume
340
Issue
6130
Pages
350-353
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1989966286
Cited by
111
References
39
Citations by year
2026: 5 · 2025: 1 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 11 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 12 · 2016: 10 · 2015: 11 · 2014: 17 · 2013: 6
FWCI
6.57
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
  • IRIS (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders
  • National Science Foundation
  • Cincinnati Children's Hospital Medical Center
  • École Polytechnique Fédérale de Lausanne
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords
KRAB zinc finger proteins, KAP1, mitophagy, erythropoiesis, microRNA regulation, erythroblasts, hypoproliferative anemia, hematopoiesis, transcriptional repression, chromatin modifiers, mitochondrial clearance
MeSH terms
Tripartite Motif-Containing Protein 28, Anemia, Animals, Autophagy, Erythroblasts, Erythropoiesis, Female, Male, Membrane Proteins, Mice, Inbred C57BL, Mitochondria, Nuclear Proteins, Repressor Proteins, Transcription Factors, Zinc Fingers, Mice, Knockout, Mitochondrial Proteins, MicroRNAs, Mice

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