Cited by 145Autophagy in Disease and TherapyMicroRNA in disease regulationRNA Interference and Gene Delivery

MicroRNA-137 Is a Novel Hypoxia-responsive MicroRNA That Inhibits Mitophagy via Regulation of Two Mitophagy Receptors FUNDC1 and NIX

Open access
Li, Wen, Zhang, Xingli, Zhuang, Haixia, Chen, He-ge, Chen, Yinqin, Tian, Weili, Wu, Wenxian, Li, Ying +8 more·2014·Journal of Biological Chemistry

Abstract

Mitophagy receptors mediate the selective recognition and targeting of damaged mitochondria by autophagosomes. The mechanism for the regulation of these receptors remains unknown. Here, we demonstrated that a novel hypoxia-responsive microRNA, microRNA-137 (miR-137), markedly inhibits mitochondrial degradation by autophagy without affecting global autophagy. miR-137 targets the expression of two mitophagy receptors NIX and FUNDC1. Impaired mitophagy in response to hypoxia caused by miR-137 is reversed by re-expression of FUNDC1 and NIX expression vectors lacking the miR-137 recognition sites at their 3' UTR. Conversely, miR-137 also suppresses the mitophagy induced by fundc1 (CDS+3'UTR) but not fundc1 (CDS) overexpression. Finally, we found that miR-137 inhibits mitophagy by reducing the expression of the mitophagy receptor thereby leads to inadequate interaction between mitophagy receptor and LC3. Our results demonstrated the regulatory role of miRNA to mitophagy receptors and revealed a novel link between miR-137 and mitophagy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1074/jbc.m113.537050

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

2 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Li, W., Zhang, X., Zhuang, H., Chen, H.-G., Chen, Y., Tian, W., Wu, W., Li, Y., Wang, S., Zhang, L., Chen, Y., Li, L., Zhao, B., Sui, S., Hu, Z., & Feng, D.
Affiliations
  • Guangdong Medical College (CN)
  • Tsinghua University (CN)
Corresponding author
  • Hu, Zhe
  • Feng, Du
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2014-04
Volume
289
Issue
15
Pages
10691-10701
ISSN
0021-9258 (ISSN-L)
OpenAlex
W1969728632
Cited by
145
References
55
Citations by year
2026: 7 · 2025: 8 · 2024: 9 · 2023: 7 · 2022: 15 · 2021: 23 · 2020: 16 · 2019: 6 · 2018: 14 · 2017: 15 · 2016: 10 · 2015: 11 · 2014: 4
FWCI
10.10
Type
journal article
Language
en
Open access
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords
microRNA-137, mitophagy, hypoxia, FUNDC1, Nix, mitophagy receptors, LC3, 3' UTR regulation, mitochondrial degradation, autophagy
MeSH terms
Animals, Autophagy, Fibroblasts, Gene Expression Regulation, Genetic Vectors, HeLa Cells, Humans, Membrane Proteins, Mice, Inbred C57BL, Mitochondria, Phagosomes, Cell Hypoxia, 3' Untranslated Regions, Mitochondrial Proteins, MicroRNAs, Mice, HEK293 Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review