Adaptive evolution of multiple traits through multiple mutations at a single gene

Linnen, Catherine R.; Poh, Yu-Ping; Peterson, Brant K.; Barrett, Rowan D. H.; Larson, Joanna G.; Jensen, Jeffrey D.; Hoekstra, Hopi E.

doi:10.1126/science.1233213

Cited by 292Evolution and Genetic DynamicsGenetic diversity and population structureAnimal Behavior and Reproduction

Adaptive evolution of multiple traits through multiple mutations at a single gene

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Linnen, Catherine R., Poh, Yu-Ping, Peterson, Brant K., Barrett, Rowan D. H., Larson, Joanna G., Jensen, Jeffrey D., Hoekstra, Hopi E.·2013·Science

DOI 10.1126/science.1233213PMC PMC3836219

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Abstract

The identification of precise mutations is required for a complete understanding of the underlying molecular and evolutionary mechanisms driving adaptive phenotypic change. Using plasticine models in the field, we show that the light coat color of deer mice that recently colonized the light-colored soil of the Nebraska Sand Hills provides a strong selective advantage against visually hunting predators. Color variation in an admixed population suggests that this light Sand Hills phenotype is composed of multiple traits. We identified distinct regions within the Agouti locus associated with each color trait and found that only haplotypes associated with light trait values have evidence of selection. Thus, local adaptation is the result of independent selection on many mutations within a single locus, each with a specific effect on an adaptive phenotype, thereby minimizing pleiotropic consequences.

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Variation in gene expression mediated by cis-regulatory elements plays an important role in evolutionary phenotypic change.
“Variation in gene expression mediated by cis-REs plays an important role in evolutionary phenotypic change (32, 42–46).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [43]

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Authors: Linnen, C. R., Poh, Y.-P., Peterson, B. K., Barrett, R. D. H., Larson, J. G., Jensen, J. D., & Hoekstra, H. E.
Affiliations: University of Kentucky (US)
SIB Swiss Institute of Bioinformatics (CH)
Harvard University (US)
Corresponding author: Linnen, Catherine R.
Hoekstra, Hopi E.
ORCID: Linnen, Catherine R.
Peterson, Brant K.
Barrett, Rowan D. H.
Larson, Joanna G.
Jensen, Jeffrey D.
Hoekstra, Hopi E.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2013-03-15
Volume: 339
Issue: 6125
Pages: 1312-1316
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1233213
PMC: PMC3836219
OpenAlex: W1977765763
Cited by: 292
References: 45
Citations by year: 2026: 6 · 2025: 7 · 2024: 7 · 2023: 21 · 2022: 11 · 2021: 25 · 2020: 17 · 2019: 24 · 2018: 30 · 2017: 27 · 2016: 31 · 2015: 27 · 2014: 41 · 2013: 18
FWCI: 25.88
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Keywords: local adaptation, agouti locus, coat color, deer mouse, Nebraska Sandhills, visual predation, predation selection, pleiotropy, haplotype selection, color polymorphism, phenotypic plasticity
MeSH terms: Adaptation, Physiological, Animals, Color, Biological Evolution, Mutation, Organic Chemicals, Peromyscus, Pigmentation, Selection, Genetic, Food Chain, Multifactorial Inheritance, Agouti Signaling Protein

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