The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
Open accessAbstract
On the Origin of Tumor T regs: The tumor microenvironment is often seeded with regulatory T cells (T regs ), which inhibit antitumor immunity. Using mice with genetically driven prostate cancer, Malchow et al. (p. 1219 ; see the Perspective by Joshi and Jacks ) found a population of T regs that were enriched in the prostate of tumor-bearing mice. Surprisingly, these cells were also present in female mice and were found to be specific, not for a tumor-specific antigen, but rather for an antigen normally expressed in the prostate. Prostate antigen–specific T regs arose in the thymus and their selection was dependent on Aire, a protein that drives the expression of tissue-specific antigens in the thymus. Thus, T regs that seed tumors likely arise in the thymus, are not necessarily tumor-specific, and are recruited and/or expand in an organ when a tumor arises.
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Regulatory T cells: mechanisms of differentiation and function
Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866
Yadav, M., Louvet, C., Davini, D., Gardner, J. M., Martinez-Llordella, M., Bailey-Bucktrout, S., Anthony, B. A., Sverdrup, F. M., Head, R., Kuster, D. J., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120822 · Cited by 649
Induced CD4+Foxp3+Regulatory T Cells in Immune Tolerance
Bilate, A. M., & Lafaille, J. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075043 · Cited by 569
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Tay, C., Tanaka, A., & Sakaguchi, S. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.014 · Cited by 580
T cell receptor signalling in the control of regulatory T cell differentiation and function
Li, M. O., & Rudensky, A. Y. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.26 · Cited by 493
Autoimmune Polyendocrine Syndromes
Husebye, E. S., Anderson, M. S., & Kämpe, O. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1713301 · Cited by 466
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June, C. H., Warshauer, J. T., & Bluestone, J. A. (2017) · Nature Medicine · doi:10.1038/nm.4321 · Cited by 445
Principles of regulatory T cell function
Dikiy, S., & Rudensky, A. Y. (2023) · Immunity · doi:10.1016/j.immuni.2023.01.004 · Cited by 445
Metadata
- Authors
- Malchow, S., Leventhal, D. S., Nishi, S., Fischer, B. I., Shen, L., Paner, G. P., Amit, A. S., Kang, C., Geddes, J. E., Allison, J. P., Socci, N. D., & Savage, P. A.
- Venue
- Science
- Published
- 2013-03-08
- Volume
- 339
- Issue
- 6124
- Pages
- 1219-1224
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2069545220
- Cited by
- 328
- References
- 3
- FWCI
- 18.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Malchow, S., Leventhal, D. S., Nishi, S., Fischer, B. I., Shen, L., Paner, G. P., Amit, A. S., Kang, C., Geddes, J. E., Allison, J. P., Socci, N. D., & Savage, P. A. (2013). Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells. Science. https://doi.org/10.1126/science.1233913
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