The sleep–wake Cycle and Alzheimer’s Disease: What do We know?
Open accessAbstract
Sleep-wake disturbances are a highly prevalent and often disabling feature of Alzheimer's disease (AD). A cardinal feature of AD includes the formation of amyloid plaques, associated with the extracellular accumulation of the amyloid-β (Aβ) peptide. Evidence from animal and human studies suggests that Aβ pathology may disrupt the sleep-wake cycle, in that as Aβ accumulates, more sleep-wake fragmentation develops. Furthermore, recent research in animal and human studies suggests that the sleep-wake cycle itself may influence Alzheimer's disease onset and progression. Chronic sleep deprivation increases amyloid plaque deposition, and sleep extension results in fewer plaques in experimental models. In this review geared towards the practicing clinician, we discuss possible mechanisms underlying the reciprocal relationship between the sleep-wake cycle and AD pathology and behavior, and present current approaches to therapy for sleep disorders in AD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Agitation is common in Alzheimer's disease, with 60% of people with MCI and 76% of people with Alzheimer's dementia experiencing agitation.
“Agitation is common in Alzheimer's disease, with 60% of people with MCI and 76% of people with Alzheimer's dementia experiencing agitation.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [63]
The Conclusion & future perspective section describes sundowning as a common feature of Alzheimer’s dementia, and the References identify sundowning as an agitation state. However, the paper does not report that agitation affects 60% of people with MCI or 76% of people with Alzheimer’s dementia; its 25–60% figure in the Abstract concerns sleep and circadian disturbances, not agitation. (LLM, conf=0.78)
Experimental — accuracy not yet measuredIncreases in beta-amyloid and tau may interrupt the sleep-wake cycle, leading to increased sleep fragmentation and wakefulness and decreased slow-wave sleep.
“For example, increases in beta‐amyloid and tau may interrupt the sleep‐wake cycle, 217 leading to increased sleep fragmentation and wakefulness and decreased slow‐wave sleep. 63”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [63]
Enhancing normal sleep patterns may alleviate AD pathogenesis, as extension of sleep duration decreases plaque deposition in animal models.
“In contrast to SD, enhancing normal sleep patterns may alleviate AD pathogenesis, as extension of sleep duration decreases plaque deposition in animal models [574].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [574]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155 · see citing works
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411 · see citing works
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814 · see citing works
Self-citationAmyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565 · see citing works
Self-citationAlzheimer’s Disease: The Challenge of the Second Century
Holtzman, D. M., Morris, J. C., & Goate, A. M. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002369 · Cited by 1,424 · see citing works
Self-citationEEG dynamics in patients with Alzheimer's disease
Jeong, J. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.01.001 · Cited by 1,346 · see citing works
Why Sleep Is Important for Health: A Psychoneuroimmunology Perspective
Irwin, M. R. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115205 · Cited by 1,325 · cited 2× · see citing works
“86 Irwin MR. Why sleep Is important for health: a psychoneuroimmunology perspective. Annu. Rev. Psychol doi:10.1146/ annurevpsych010213115205 (2014) (Epub ahed of print).”
BackgroundInfluentialSynaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
Cirrito, J. R., Yamada, K. A., Finn, M. B., Sloviter, R. S., Bales, K. R., May, P. C., Schoepp, D. D., Paul, S. M., Mennerick, S., & Holtzman, D. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.028 · Cited by 1,265 · see citing works
Self-citationFagan, A. M., Mintun, M. A., Mach, R. H., Lee, S., Dence, C. S., Shah, A. R., LaRossa, G. N., Spinner, M. L., Klunk, W. E., Mathis, C. A., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20730 · Cited by 1,246 · see citing works
Self-citationThe role of sleep in learning and memory
Maquet, P. (2001) · Science · doi:10.1126/science.1062856 · Cited by 1,177 · see citing works
Walker, M. P., & Stickgold, R. (2006) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070307 · Cited by 1,075 · see citing works
Epidemiology of Alzheimer DiseasePreprint
Mayeux, R. P., & Stern, Y. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006239 · Cited by 1,070 · see citing works
ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y. D., Karlo, J. C., Zinn, A. E., Casali, B. T., Restivo, J. L., Goebel, W. D., James, M. J., et al. (2012) · Science · doi:10.1126/science.1217697 · Cited by 1,050 · see citing works
Use it or lose it: Engaged lifestyle as a buffer of cognitive decline in aging?
Hultsch, D. F., Hertzog, C. K., Small, B. J., & Dixon, R. A. (1999) · Psychology and Aging · doi:10.1037//0882-7974.14.2.245 · Cited by 1,023 · see citing works
Use it or lose it: Engaged lifestyle as a buffer of cognitive decline in aging?
Hultsch, D. F., Hertzog, C., Small, B. J., & Dixon, R. A. (1999) · Psychology and Aging · doi:10.1037/0882-7974.14.2.245 · Cited by 1,023 · see citing works
Sleep and Alzheimer disease pathology--a bidirectional relationship
Ju, Y.-E. S., Lucey, B. P., & Holtzman, D. M. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.269 · Cited by 996 · see citing works
Self-citationNeuronal activity regulates the regional vulnerability to amyloid-β deposition
Bero, A. W., Yan, P., Roh, J. H., Cirrito, J. R., Stewart, F. R., Raichle, M. E., Lee, J.-M., & Holtzman, D. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2801 · Cited by 880 · see citing works
Self-citationLim, A. S. P., Kowgier, M., Yu, L., Buchman, A. S., & Bennett, D. A. (2013) · Sleep · doi:10.5665/sleep.2802 · Cited by 793 · see citing works
Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease
Holtzman, D. M., Herz, J., & Bu, G. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006312 · Cited by 782 · see citing works
Self-citationPrion-like mechanisms in neurodegenerative diseases
Frost, B., & Diamond, M. I. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2786 · Cited by 776 · see citing works
Sleep Quality and Preclinical Alzheimer Disease
Ju, Y.-E. S., McLeland, J. S., Toedebusch, C. D., Xiong, C., Fagan, A. M., Duntley, S. P., Morris, J. C., & Holtzman, D. M. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.2334 · Cited by 744 · see citing works
Self-citationPellerin, L., & Magistretti, P. J. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.149 · Cited by 726 · see citing works
A network diffusion model of disease progression in dementia
Raj, A., Kuceyeski, A., & Weiner, M. (2012) · Neuron · doi:10.1016/j.neuron.2011.12.040 · Cited by 723 · see citing works
How (and why) the immune system makes us sleep
Imeri, L., & Opp, M. R. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2576 · Cited by 710 · see citing works
Decoupling of the brain's default mode network during deep sleep
Horovitz, S. G., Braun, A. R., Carr, W. S., Picchioni, D., Balkin, T. J., Fukunaga, M., & Duyn, J. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901435106 · Cited by 685 · see citing works
Cytokines and cognition–the case for a head-to-toe inflammatory paradigm.
Wilson, C. J., Finch, C. E., & Cohen, H. J. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50619.x · Cited by 637 · see citing works
Microglial dysfunction in brain aging and Alzheimer's disease
Mosher, K. I., & Wyss-Coray, T. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.008 · Cited by 618 · see citing works
Human amyloid-β synthesis and clearance rates as measured in cerebrospinal fluid in vivo
Bateman, R. J., Munsell, L. Y., Morris, J. C., Swarm, R., Yarasheski, K. E., & Holtzman, D. M. (2006) · Nature Medicine · doi:10.1038/nm1438 · Cited by 599 · see citing works
Self-citationRoh, J. H., Huang, Y., Bero, A. W., Kasten, T., Stewart, F. R., Bateman, R. J., & Holtzman, D. M. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004291 · Cited by 563 · see citing works
Self-citationSleep deprivation selectively impairs memory consolidation for contextual fear conditioning
Graves, L. A., Heller, E. A., Pack, A. I., & Abel, T. (2003) · Learning & Memory · doi:10.1101/lm.48803 · Cited by 476 · see citing works
Ooms, S., Overeem, S., Besse, K., Rikkert, M. O., Verbeek, M., & Claassen, J. A. H. R. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.1173 · Cited by 438 · see citing works
Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer’s Disease
Fagan, A. M., Xiong, C., Jasielec, M. S., Bateman, R. J., Goate, A. M., Benzinger, T. L. S., Ghetti, B., Martins, R. N., Masters, C. L., Mayeux, R., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007901 · Cited by 434 · see citing works
Self-citationA Multicenter, Placebo-controlled Trial of Melatonin for Sleep Disturbance in Alzheimer's Disease
Singer, C., Tractenberg, R. E., Kaye, J., Schafer, K., Gamst, A., Grundman, M., Thomas, R., & Thal, L. J. (2003) · Sleep · doi:10.1093/sleep/26.7.893 · Cited by 407 · see citing works
de Haan, W., Pijnenburg, Y. A. L., STRIJERS, R. L. M., van der Made, Y., van der Flier, W. M., Scheltens, P., & Stam, C. J. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-101 · Cited by 404 · see citing works
Development of the Brain's Default Mode Network from Wakefulness to Slow Wave Sleep
Sämann, P. G., Wehrle, R., Hoehn, D., Spoormaker, V. I., Peters, H., Tully, C., Holsboer, F., & Czisch, M. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq295 · Cited by 399 · see citing works
Guarnieri, B., Adorni, F., Musicco, M., Appollonio, I. M., Bonanni, E., Caffarra, P., Caltagirone, C., Cerroni, G., Concari, L., Cosentino, F., et al. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000335363 · Cited by 381 · see citing works
Ancoli‐Israel, S., Palmer, B. W., Cooke, J. R., Corey‐Bloom, J., Fiorentino, L., Natarajan, L., Liu, L., Ayalon, L., He, F., & Loredo, J. S. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01934.x · Cited by 379 · see citing works
Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?
Braak, H., & Tredici, K. D. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0825-z · Cited by 359 · see citing works
Use of Wrist Activity for Monitoring Sleep/Wake in Demented Nursing-Home Patients
Ancoli‐Israel, S., Clopton, P., Klauber, M. R., Fell, R. L., & Mason, W. J. (1997) · SLEEP · doi:10.1093/sleep/20.1.24 · Cited by 348 · see citing works
Sleep disturbance in mild to moderate Alzheimer's disease
MORAN, M., LYNCH, C., Walsh, C., Coen, R. F., Coakley, D., & LAWLOR, B. A. (2005) · Sleep Medicine · doi:10.1016/j.sleep.2004.12.005 · Cited by 337 · see citing works
Bondareff, W. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92657-x · Cited by 332 · see citing works
Harris, J. A., Devidze, N., Verret, L., Ho, K., Halabisky, B., Thwin, M. T., Kim, D., Hamto, P., Lo, I., Yu, G.-Q., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.020 · Cited by 319 · see citing works
Dowling, G. A., Burr, R. L., Someren, E. J. W. V., Hubbard, E. M., Luxenberg, J. S., Mastick, J., & Cooper, B. A. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01543.x · Cited by 313 · see citing works
Heneka, M. T., Ramanathan, M., Jacobs, A. H., Dumitrescu-Ozimek, L., Bilkei-Gorzo, A., Debeir, T., Sastre, M., Galldiks, N., Zimmer, A., Hoehn, M., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4236-05.2006 · Cited by 305 · see citing works
Ancoli‐Israel, S., Klauber, M. R., Jones, D. W., Kripke, D. F., Martin, J. L., Mason, W. J., Pat‐Horenczyk, R., & Fell, R. L. (1997) · SLEEP · doi:10.1093/sleep/20.1.18 · Cited by 302 · see citing works
Sleep Quality and 1-Year Incident Cognitive Impairment in Community-Dwelling Older Adults
Potvin, O., Lorrain, D., Forget, H., Dubé, M., Grenier, S., Préville, M., & Hudon, C. (2012) · SLEEP · doi:10.5665/sleep.1732 · Cited by 267 · see citing works
Hernández, F., & Ávila, J. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7220-x · Cited by 263 · see citing works
Illumination levels in nursing home patients: effects on sleep and activity rhythms
Shochat, T., Martin, J., Marler, M., & Ancoli‐Israel, S. (2000) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2000.00221.x · Cited by 262 · see citing works
Lim, A. S. P., Yu, L., Kowgier, M. E., Schneider, J. A., Buchman, A. S., & Bennett, D. A. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.4215 · Cited by 260 · see citing works
BLACKWELL, T. L., Yaffe, K. S., Ancoli‐Israel, S., Redline, S. S., Ensrud, K. E., Stefanick, M. L., Laffan, A. M., Stone, K. L., & for the Osteoporotic Fractures in Men (MrOS) Study Group (2011) · SLEEP · doi:10.5665/sleep.1276 · Cited by 256 · see citing works
Hypocretin (orexin) loss in Alzheimer's disease
Fronczek, R., van Geest, S., Frölich, M., Overeem, S., Roelandse, F. W. C., Lammers, G. J., & Swaab, D. F. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.014 · Cited by 254 · see citing works
Cooke, J. R., Ayalon, L., Palmer, B. W., Loredo, J. S., Corey‐Bloom, J., Natarajan, L., Liu, L., & Ancoli‐Israel, S. (2009) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27538 · Cited by 244 · see citing works
Animal models in the drug discovery pipeline for Alzheimer's disease
Dam, D. V., & Deyn, P. P. D. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01299.x · Cited by 228 · see citing works
Lifespan brain activity, β-amyloid, and Alzheimer's disease
Jagust, W. J., & Mormino, E. C. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.09.004 · Cited by 221 · see citing works
Age-related changes in the cognitive function of sleep
Pace-Schott, E. F., & Spencer, R. M. C. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53752-2.00012-6 · Cited by 220 · see citing works
Sleep disorders in aging and dementia
Bombois, S., Derambure, P., Pasquier, F., & Monaca, C. C. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0052-7 · Cited by 220 · see citing works
Bonanni, E., Maestri, M., Tognoni, G., Fabbrini, M., Nucciarone, B., Manca, M. L., Gori, S., Iudice, A., & Murri, L. (2005) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2005.00462.x · Cited by 213 · see citing works
Di Meco, A., Joshi, Y. B., & Praticò, D. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.011 · Cited by 205 · see citing works
Kim, J., Jiang, H., Park, S., Eltorai, A. E. M., Stewart, F. R., Yoon, H., Basak, J. M., Finn, M. B., & Holtzman, D. M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3773-11.2011 · Cited by 199 · see citing works
Self-citationSleep deprivation and neurobehavioral dynamics
Basner, M., Rao, H., Goel, N., & Dinges, D. F. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.02.008 · Cited by 192 · see citing works
Gehrman, P., Connor, D. J., Martin, J. L., Shochat, T., Corey‐Bloom, J., & Ancoli‐Israel, S. (2009) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e318187de18 · Cited by 189 · see citing works
Serfaty, M. A., Kennell-Webb, S. A., Warner, J. P., Blizard, R., & Raven, P. (2002) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.760 · Cited by 182 · see citing works
Bidirectional Relationship between Functional Connectivity and Amyloid-β Deposition in Mouse Brain
Bero, A. W., Bauer, A. Q., Stewart, F. R., White, B. R., Cirrito, J. R., Raichle, M. E., Culver, J. P., & Holtzman, D. M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5845-11.2012 · Cited by 181 · see citing works
Self-citationFunctional Consequences of Locus Coeruleus Degeneration in Alzheimers Disease
Weinshenker, D. (2008) · Current Alzheimer Research · doi:10.2174/156720508784533286 · Cited by 180 · see citing works
Sleep/wake patterns In Alzheimer's disease: relationships with cognition and function
Moe, K. E., Vitiello, M. V., Larsen, L. H., & Prinz, P. N. (1995) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1995.tb00145.x · Cited by 175 · see citing works
Jackson, C. E., & Snyder, P. J. (2007) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2007.10.008 · Cited by 171 · see citing works
Wisor, J. P., Edgar, D. M., Yesavage, J. A., Ryan, H. S., McCormick, C. M., Lapustea, N., & Murphy, G. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.018 · Cited by 169 · see citing works
Sleep disturbances in older adults with mild cognitive impairment
Beaulieu‐Bonneau, S., & Hudon, C. (2009) · International Psychogeriatrics · doi:10.1017/s1041610209009120 · Cited by 167 · see citing works
Camargos, E. F., Louzada, L. L., Quintas, J. L., Naves, J. O. S., Louzada, F. M., & Nóbrega, O. D. T. (2014) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.12.174 · Cited by 165 · see citing works
Fitz, N. F., Cronican, A. A., Lefterov, I., & Koldamova, R. (2013) · Science · doi:10.1126/science.1235809 · Cited by 151 · see citing works
Chong, M. S., Ayalon, L., Marler, M., Loredo, J. S., Corey‐Bloom, J., Palmer, B. W., Liu, L., & Ancoli‐Israel, S. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00694.x · Cited by 142 · see citing works
Prince, T.-M., Wimmer, M., Choi, J., Havekes, R., Aton, S., & Abel, T. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.11.021 · Cited by 142 · see citing works
Abnormal Cognition, Sleep, EEG and Brain Metabolism in a Novel Knock-In Alzheimer Mouse, PLB1
Platt, B., Drever, B. D., Koss, D. J., Stoppelkamp, S., Jyoti, A., Plano, A., Utan, A., Merrick, G., Ryan, D., Melis, V., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027068 · Cited by 141 · see citing works
Price, A. R., Xu, G., Siemienski, Z. B., Smithson, L. A., Borchelt, D. R., Golde, T. E., & Felsenstein, K. M. (2013) · Science · doi:10.1126/science.1234089 · Cited by 138 · see citing works
Circadian Misalignment and Sleep Disruption in Mild Cognitive Impairment
Naismith, S. L., Hickie, I. B., Terpening, Z., Rajaratnam, S. M. W., Hodges, J. R., Bolitho, S., Rogers, N. L., & Lewis, S. J. G. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-131217 · Cited by 136 · see citing works
Veeraraghavalu, K., Zhang, C., Miller, S., Hefendehl, J. K., Rajapaksha, T. W., Ulrich, J., Jucker, M., Holtzman, D. M., Tanzi, R. E., Vassar, R., et al. (2013) · Science · doi:10.1126/science.1235505 · Cited by 133 · see citing works
Self-citationRudelli, R. D., Ambler, M. W., & Wı́sniewski, H. M. (1984) · Acta Neuropathologica · doi:10.1007/bf00690393 · Cited by 129 · see citing works
Tesseur, I., Lo, A. C., Roberfroid, A., Dietvorst, S., Van Broeck, B., Borgers, M., Gijsen, H., Moechars, D., Mercken, M., Kemp, J., et al. (2013) · Science · doi:10.1126/science.1233937 · Cited by 128 · see citing works
Cognitive activity and the cognitive morbidity of Alzheimer disease
Wilson, R. S., Barnes, L. L., Aggarwal, N. T., Boyle, P. A., Hebert, L. E., de Leon, C. F. M., & Evans, D. A. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f25b5e · Cited by 125 · see citing works
“Sundowning” and Other Temporally Associated Agitation States in Dementia Patients
Bachman, D., & Rabins, P. V. (2005) · Annual Review of Medicine · doi:10.1146/annurev.med.57.071604.141451 · Cited by 119 · see citing works
Pharmacotherapies for sleep disturbances in Alzheimer's disease
McCleery, J. M., Cohen, D. A., & Sharpley, A. L. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009178.pub2 · Cited by 116 · see citing works
Lactate as a biomarker for sleep
Naylor, E., Aillon, D. V., Barrett, B. S., Wilson, G. S., Johnson, D. A., Johnson, D. A., Harmon, H. P., Gabbert, S., & Petillo, P. A. (2012) · SLEEP · doi:10.5665/sleep.2072 · Cited by 112 · see citing works
Sleep and immune function: glial contributions and consequences of aging
Ingiosi, A. M., Opp, M. R., & Krueger, J. M. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.02.003 · Cited by 104 · see citing works
Immunotherapy for Alzheimer's disease
Wısnıewskı, T., & Goñi, F. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.020 · Cited by 99 · see citing works
Anesthesia with Isoflurane Increases Amyloid Pathology in Mice Models of Alzheimer'S Disease
Perucho, J., Rubio, I., Casarejos, M. J., Gómez, A., Rodríguez‐Navarro, J. A., Solano, R. M., de Yébenes, J. G., & Mena, M. A. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1318 · Cited by 97 · see citing works
Zhang, B., Veasey, S. C., Wood, M. A., Leng, L. Z., Kaminski, C., Leight, S., Abel, T. G., Lee, V. M. ‐., & Trojanowski, J. Q. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61223-0 · Cited by 95 · see citing works
Alterations in the histaminergic system in Alzheimer's disease: a postmortem study
Shan, L., Bossers, K., Unmehopa, U., Bao, A.-M., & Swaab, D. F. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.026 · Cited by 84 · see citing works
Cooke, J. R., Ancoli‐Israel, S., Liu, L., Loredo, J. S., Natarajan, L., Palmer, B. S., He, F., & Corey‐Bloom, J. (2009) · Sleep Medicine · doi:10.1016/j.sleep.2008.12.016 · Cited by 79 · see citing works
β-Amyloid Dynamics in Human Plasma
Huang, Y., Potter, R. C., Sigurdson, W. C., Kasten, T. P., Connors, R., Morris, J. C., Benzinger, T. L. S., Mintun, M. A., Ashwood, T. J., Ferm, M. T., et al. (2012) · JAMA Neurology · doi:10.1001/archneurol.2012.18107 · Cited by 77 · see citing works
Gaweł, M., Zalewska, E., Szmidt-Sałkowska, E., & Kowalski, J. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.332 · Cited by 76 · see citing works
Landreth, G. E., Cramer, P. E., Lakner, M. M., Cirrito, J. R., Wesson, D. W., Brunden, K. R., & Wilson, D. A. (2013) · Science · doi:10.1126/science.1234114 · Cited by 73 · see citing works
Brain ERP components predict which individuals progress to Alzheimer's disease and which do not
Chapman, R. M., McCrary, J. W., Gardner, M. N., Sandoval, T. C., Guillily, M. D., Reilly, L. A., & DeGrush, E. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.11.010 · Cited by 68 · see citing works
Slats, D., Claassen, J. A. H. R., Lammers, G. J., Melis, R. J. F., Verbeek, M. M., & Overeem, S. (2012) · Current Alzheimer Research · doi:10.2174/156720512804142840 · Cited by 68 · see citing works
Genetically Increased Risk of Sleep Disruption in Alzheimer's Disease
Craig, D., Hart, D. J., & Passmore, A. P. (2006) · SLEEP · doi:10.1093/sleep/29.8.1003 · Cited by 66 · see citing works
Christoffersson, G., Vågesjö, E., Pettersson, U. S., Massena, S., Nilsson, E., Broman, J., Schiöth, H. B., Benedict, C., & Phillipson, M. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.05.010 · Cited by 62 · see citing works
Gerstner, J. R., Vanderheyden, W. M., LaVaute, T. M., Westmark, C. J., Rouhana, L., Pack, A. I., Wickens, M., & Landry, C. F. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3228-11.2012 · Cited by 61 · see citing works
Self-citationAnesthesia in presymptomatic Alzheimer's disease: A study using the triple‐transgenic mouse model
Tang, J. X., Mardini, F., Caltagarone, B. M., Garrity, S. T., Li, R. Q., Bianchi, S. L., Gomes, O., LaFerla, F. M., Eckenhoff, R. G., & Eckenhoff, M. F. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.10.003 · Cited by 57 · see citing works
Age-related loss of noradrenergic neurons in the brains of triple transgenic mice
Manaye, K. F., Mouton, P. R., Xu, G., Drew, A., Lei, D.-L., Sharma, Y., Rebeck, G. W., & Turner, S. (2013) · AGE · doi:10.1007/s11357-011-9343-0 · Cited by 54 · see citing works
Casement, M. D., Broussard, J. L., Mullington, J. M., & Press, D. Z. (2005) · Biological Psychology · doi:10.1016/j.biopsycho.2005.11.002 · Cited by 51 · see citing works
Simoncini, M., Gatti, A., Quirico, P. E., Balla, S., Capellero, B., Obialero, R., D’Agostino, S., Sandri, N., & Pernigotti, L. M. (2014) · Aging Clinical and Experimental Research · doi:10.1007/s40520-014-0244-9 · Cited by 47 · see citing works
Hypocretin in cerebrospinal fluid is positively correlated with Tau and pTau
Deuschle, M., Schilling, C., Leweke, F. M., Enning, F., Pollmächer, T., Esselmann, H., Wiltfang, J., Frölich, L., & Heuser, I. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.12.036 · Cited by 39 · see citing works
Age trends in the sleep EEG of healthy older men and women
Larsen, L. H., Moe, K. E., Vitiello, M. V., & Prinz, P. N. (1995) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1995.tb00165.x · Cited by 37 · see citing works
Pharmacotherapies for sleep disturbances in Alzheimer's disease
McCleery, J. M., Cohen, D. A., & Sharpley, A. L. (2015) · BJPsych Advances · doi:10.1192/apt.21.4.218 · Cited by 23 · see citing works
The Nexus of Aβ, Aging, and Sleep
Gerstner, J. R., Perron, I. J., & Pack, A. I. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004815 · Cited by 19 · see citing works
Self-citationA Hypnic Hypothesis of Alzheimer's Disease
Clark, C. N., & Warren, J. D. (2013) · Neurodegenerative Diseases · doi:10.1159/000350060 · Cited by 15 · see citing works
Sleep Evaluation by Actigraphy for Patients With Alzheimer Disease—Reply
Ju, Y. S., & Holtzman, D. M. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.3490 · Cited by 12 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [74]Naylor E Aillon DV Barrett BS Lactate as a biomarker for sleep Sleep 35 9 1209 1222 2012 22942499 PMC3413798
Cited by
Sorted by citations
2024 Alzheimer's disease facts and figures
(2024) · Alzheimer's & Dementia · doi:10.1002/alz.13809 · Cited by 2,536 · see citing works
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works
Wang, C., & Holtzman, D. M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0478-5 · Cited by 589 · see citing works
Self-citation2025 Alzheimer's disease facts and figures
(2025) · Alzheimer s & Dementia · doi:10.1002/alz.70235 · Cited by 569 · see citing works
Sleep Loss Promotes Astrocytic Phagocytosis and Microglial Activation in Mouse Cerebral Cortex
Bellesi, M., de Vivo, L., Chini, M., Gilli, F., Tononi, G., & Cirelli, C. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3981-16.2017 · Cited by 417 · see citing works
Microglia-Mediated Synapse Loss in Alzheimer's Disease
Rajendran, L., & Paolicelli, R. C. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1136-17.2017 · Cited by 355 · see citing works
Monoaminergic neuropathology in Alzheimer’s disease
Šimić, G., Leko, M. B., Wray, S., Harrington, C. R., Delalle, I., Milošević, N. J., Bažadona, D., Buée, L., de Silva, R., Giovanni, G. D., et al. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.001 · Cited by 289 · see citing works
Sleep architecture and the risk of incident dementia in the community
Pase, M. P., Himali, J. J., Grima, N., Beiser, A., Satizábal, C. L., Aparicio, H. J., THOMAS, R. J., Gottlieb, D. J., Auerbach, S. H., & Seshadri, S. S. (2017) · Neurology · doi:10.1212/wnl.0000000000004373 · Cited by 233 · see citing works
Sleep in Alzheimer’s disease: a systematic review and meta-analysis of polysomnographic findings
Zhang, Y., Ren, R., Yang, L., Zhang, H., Shi, Y., Okhravi, H. R., Vitiello, M. V., Sanford, L. D., & Tang, X. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01897-y · Cited by 211 · see citing works
Cedernaes, J., Osorio, R. S., Varga, A. W., Kam, K., Schiöth, H. B., & Benedict, C. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.02.002 · Cited by 200 · see citing works
Vercruysse, P., Vieau, D., Blum, D., Petersén, Å., & Dupuis, L. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00002 · Cited by 172 · see citing works
Boespflug, E. L., & Iliff, J. J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.031 · Cited by 171 · see citing works
Sleep in Alzheimer's Disease–Beyond Amyloid
Holth, J. K., Patel, T. K., & Holtzman, D. M. (2016) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2016.08.002 · Cited by 165 · see citing works
Self-citationThe hypocretin (orexin) system: from a neural circuitry perspective
Li, S., & de Lecea, L. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.107993 · Cited by 130 · see citing works
Behavioral and psychological symptoms in Alzheimer's dementia and vascular dementia
Deardorff, W. J., & Grossberg, G. T. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64012-3.00002-2 · Cited by 124 · see citing works
Figueiro, M. G., Plitnick, B., Roohan, C., Sahin, L., Kalsher, M. J., & Rea, M. S. (2019) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.8078 · Cited by 116 · see citing works
Alzheimer’s disease: The state of the art in resting-state magnetoencephalography
Engels, M. M. A., van der Flier, W. M., Stam, C. J., Hillebrand, A., Scheltens, P., & van Straaten, E. C. W. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.05.012 · Cited by 99 · see citing works
(2020) · International Review of Neurobiology · doi:10.1016/bs.irn.2020.02.006 · Cited by 87 · see citing works
Sleep disruption and the sequelae associated with traumatic brain injury
Lucke-Wold, B. P., Smith, K. E., Nguyen, L., Turner, R. C., Logsdon, A. F., Jackson, G. J., Huber, J. D., Rosen, C. L., & Miller, D. B. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.010 · Cited by 93 · see citing works
EEG alterations during wake and sleep in mild cognitive impairment and Alzheimer's disease
D’Atri, A., Scarpelli, S., Gorgoni, M., Truglia, I., Lauri, G., Cordone, S., Ferrara, M., Marra, C., Rossini, P. M., & Gennaro, L. D. (2021) · iScience · doi:10.1016/j.isci.2021.102386 · Cited by 92 · see citing works
Sleep, major depressive disorder, and Alzheimer disease
Huang, J. V., Zuber, V., Matthews, P. M., Elliott, P., Tzoulaki, I., & Dehghan, A. (2020) · Neurology · doi:10.1212/wnl.0000000000010463 · Cited by 84 · see citing works
Pistollato, F., Cano, S. S., Elío, I., Vergara, M. M., Giampieri, F., & Battino, M. A. (2016) · Advances in Nutrition · doi:10.3945/an.115.011775 · Cited by 81 · see citing works
Alzheimer’s disease: Neurotransmitters of the sleep-wake cycle
Erum, J. V., Dam, D. V., & Deyn, P. P. D. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.07.019 · Cited by 81 · see citing works
Pistollato, F., Ohayon, E. L., Lam, A., Langley, G. R., Novak, T. J., Pamies, D., Perry, G. L., Trushina, E. V., Williams, R. S. B., Roher, A. E., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9175 · Cited by 78 · see citing works
Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study
Eser, R. A., Ehrenberg, A. J., Petersen, C., Dunlop, S. R., Mejia, M. B., Suemoto, C. K., Walsh, C. M., Rajana, H., Oh, J. Y., Theofilas, P., et al. (2018) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx113 · Cited by 71 · see citing works
Miller, M. A. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00224 · Cited by 73 · see citing works
A Growing Link between Circadian Rhythms, Type 2 Diabetes Mellitus and Alzheimer’s Disease
Peng, X., Fan, R., Xie, L., Shi, X., Dong, K., Zhang, S., Tao, J., Xu, W., Ma, D., Chen, J., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010504 · Cited by 68 · see citing works
Alzheimer's Disease and Sleep–Wake Disturbances: Amyloid, Astrocytes, and Animal Models
Vanderheyden, W. M., Lim, M. M., Musiek, E. S., & Gerstner, J. R. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1135-17.2017 · Cited by 63 · see citing works
Self-citationGreen, T. R. F., Ortiz, J. B., Wonnacott, S., Williams, R. J., & Rowe, R. K. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00894 · Cited by 63 · see citing works
Closed-loop auditory stimulation of sleep slow oscillations: Basic principles and best practices
Esfahani, M. J., Farboud, S., Ngo, H.-V. V., Schneider, J., Weber, F. D., Talamini, L. M., & Dresler, M. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105379 · Cited by 65 · see citing works
Air pollution, glymphatic impairment, and Alzheimer's disease
Hussain, R., Graham, U. M., Elder, A. C. P., & Nedergaard, M. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.08.010 · Cited by 60 · see citing works
Sleep and circadian rhythm disruption and stress intersect in Alzheimer's disease
Phan, T., & Malkani, R. G. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.10.001 · Cited by 64 · see citing works
Sleep Deprivation Induced Plasma Amyloid-β Transport Disturbance in Healthy Young Adults
Meng, W., Zhao, B., Huo, K., Deng, Y., Shang, S., Liu, J., Li, Y., Ma, L., Jiang, Y., Dang, L., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161213 · Cited by 56 · see citing works
Genetic Risk of Alzheimer's Disease and Sleep Duration in Non‐Demented Elders
Leng, Y., Ackley, S. F., Glymour, M. M., Yaffe, K. S., & Brenowitz, W. D. (2020) · Annals of Neurology · doi:10.1002/ana.25910 · Cited by 55 · see citing works
Piantino, J. A., Iliff, J. J., & Lim, M. M. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.06.025 · Cited by 55 · see citing works
Self-citationZhou, G., Liu, S., Yu, X., Zhao, X., Ma, L., & Shan, P. (2019) · Medicine · doi:10.1097/md.0000000000018405 · Cited by 54 · see citing works
Stanhope, B. A., Jaggard, J. B., Gratton, M., Brown, E., & Keene, A. C. (2020) · Current Biology · doi:10.1016/j.cub.2020.02.057 · Cited by 51 · see citing works
Sleep disruption and quality of life in persons with dementia: A state-of-the-art review
Petrovsky, D., McPhillips, M., Li, J., Brody, A., Caffeé, L., & Hodgson, N. A. (2018) · Geriatric Nursing · doi:10.1016/j.gerinurse.2018.04.014 · Cited by 52 · see citing works
Does sleep disturbance affect the amyloid clearance mechanisms in A lzheimer's disease?
Yuluğ, B., Hanoğlu, L., & Kılıç, E. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12539 · Cited by 52 · see citing works
Kim, M., Subramanian, M., Cho, Y.-H., Kim, G.-H., Lee, E., & Park, J. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.12.021 · Cited by 51 · see citing works
Sleep deficiency promotes Alzheimer's disease development and progression
Lv, Y.-N., Cui, Y., Zhang, B., & Huang, S.-M. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.1053942 · Cited by 50 · see citing works
Brain Inflammation Connects Cognitive and Non-Cognitive Symptoms in Alzheimer’s Disease
Sellés, M. C., Oliveira, M. M., & Ferreira, S. T. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179925 · Cited by 50 · see citing works
Frost, P. S., Barros‐Aragão, F. G. Q., da Silva, R. T., Venancio, A. M., Matias, I. C. P., Silva, N. M. L. E., Kincheski, G. C., Pimentel‐Coelho, P. M., Felice, F. G. D., Gomes, F. C. A., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1529-x · Cited by 50 · see citing works
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease
Kron, J. O.-Z. J., Keenan, R. J., Hoyer, D., & Jacobson, L. H. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-040323-031929 · Cited by 47 · see citing works
Circadian Insights into Motivated Behavior
Antle, M. C., & Silver, R. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_384 · Cited by 47 · see citing works
Separability of calcium slow waves and functional connectivity during wake, sleep, and anesthesia
Brier, L. M., Landsness, E. C., Snyder, A. Z., Wright, P. W., Baxter, G. A., Bauer, A. Q., Lee, J., & Culver, J. P. (2019) · Neurophotonics · doi:10.1117/1.nph.6.3.035002 · Cited by 45 · see citing works
Santacruz Escudero, J. M., Beltrán, J., Palacios, Á., Chimbí, C. M., Matallana, D., Reyes, P., Perez-Sola, V., & Santamaría-García, H. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00176 · Cited by 41 · see citing works
Xiong, Y., Tvedt, J., Åkerstedt, T., Cadar, D., & Wang, H. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115760 · Cited by 43 · see citing works
Self-reported sleep disturbance and incidence of dementia in ageing men
Luojus, M. K., Lehto, S. M., Tolmunen, T., Brem, A.-K., Lönnroos, E., & Kauhanen, J. (2017) · Journal of Epidemiology and Community Health · doi:10.1136/jech-2016-207764 · Cited by 42 · see citing works
Guarnieri, B., Maestri, M., Cucchiara, F., Gerfo, A. L., Schirru, A., Arnaldi, D., Mattioli, P., Nobili, F. M., Lombardi, G., Cerroni, G., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200632 · Cited by 42 · see citing works
Gerstner, J. R., Lenz, O., Vanderheyden, W. M., Chan, M. T., Pfeiffenberger, C., & Pack, A. I. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23778 · Cited by 40 · see citing works
Self-citation2026 Alzheimer's disease facts and figures
(2026) · Alzheimer s & Dementia · doi:10.1002/alz.71345 · Cited by 61 · see citing works
Review Paper: Tau Pathology of Alzheimer Disease: Possible Role of Sleep Deprivation
Ahmadian, N., Hejazi, S., Mahmoudi, J., & Talebi, M. (2018) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.9.5.307 · Cited by 38 · see citing works
Havekes, R., Heckman, P. R. A., Wams, E. J., Stasiukonytė, N., Meerlo, P., & Eisel, U. L. M. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109420 · Cited by 34 · see citing works
The Role of Sleep in Cognitive Function: The Value of a Good Night’s Rest
Gilley, R. R. (2022) · Clinical EEG and Neuroscience · doi:10.1177/15500594221090067 · Cited by 34 · see citing works
Sleep Disturbance and the Risk of Cognitive Decline or Clinical Conversion in the ADNI Cohort
Mecca, A. P., Michalak, H. R., McDonald, J. W., Kemp, E. C., Pugh, E., Becker, M. L., Mecca, M. C., van Dyck, C. H., & (ADNI), T. A. D. N. I. (2018) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000488671 · Cited by 32 · see citing works
Amyloid-β–Induced Changes in Molecular Clock Properties and Cellular Bioenergetics
Schmitt, K., Grimm, A., & Eckert, A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00124 · Cited by 32 · see citing works
Melatonin and Sleep Disturbances in Alzheimer’s Disease
Prodhan, A. H. M. S. U., Cavestro, C., Kamal, M. A., & Islam, M. A. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210804155617 · Cited by 30 · see citing works
A Dichotomous Role for FABP7 in Sleep and Alzheimer’s Disease Pathogenesis: A Hypothesis
Needham, H., Torpey, G., Flores, C. C., Davis, C. J., Vanderheyden, W. M., & Gerstner, J. R. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.798994 · Cited by 28 · see citing works
Self-citationSleep deprivation: A risk factor for the pathogenesis and progression of Alzheimer's disease
Han, Z., Yang, X., & Huang, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28819 · Cited by 27 · see citing works
Sanfilippo, C., Giuliano, L., Castrogiovanni, P., Imbesi, R., Ulivieri, M., Fazio, F., Blennow, K., Zetterberg, H., & Rosa, M. D. (2022) · Current Neuropharmacology · doi:10.2174/1570159x21666221207091209 · Cited by 20 · see citing works
Sharma, A., Muresanu, D. F., Ozkızılcık, A., Tian, Z. R., Lafuente, J. V., Manzhulo, I., Mössler, H., & Sharma, H. S. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.03.002 · Cited by 24 · see citing works
Uslaner, J. M., Herring, W. J., & Coleman, P. J. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00110 · Cited by 24 · see citing works
A Human-Based Integrated Framework forAlzheimer’s Disease Research
Pistollato, F., Cavanaugh, S. E., & Chandrasekera, P. C. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150281 · Cited by 20 · see citing works
Ahnaou, A., & Drinkenburg, W. H. I. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.039 · Cited by 23 · see citing works
Purinergic signaling in cognitive impairment and neuropsychiatric symptoms of Alzheimer's disease
Ribeiro, D. E., Petiz, L. L., Glaser, T., Oliveira‐Giacomelli, Á., Andrejew, R., Saab, F. D. A. R., Milanis, M. D. S., Campos, H. C., Arnaud-Sampaio, V. F., de Oliveira, S. L. B., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109371 · Cited by 20 · see citing works
New directions in sleep and memory research: the role of autonomic activity
Whitehurst, L. N., Chen, P., Naji, M., & Mednick, S. C. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.11.001 · Cited by 20 · see citing works
Zhao, P., You, Y., Wang, Z., Zhou, Y., Chai, G., Yan, G., Jin, Z., Wang, Q., & Sun, H. (2022) · Brain Structure and Function · doi:10.1007/s00429-021-02447-w · Cited by 19 · see citing works
Nakagawa, Y., & Yamada, S. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01234-3 · Cited by 19 · see citing works
Matsuoka, T., Imai, A., Fujimoto, H., Kato, Y., Shibata, K., Nakamura, K., Yokota, H., Yamada, K., & Narumoto, J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171169 · Cited by 19 · see citing works
Unraveling the Neurobiology of Sleep and Sleep Disorders Using Drosophila
Chakravarti, L. J., Moscato, E. H., & Kayser, M. S. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.07.010 · Cited by 16 · see citing works
Neuropathology of the Brainstem to Mechanistically Understand and to Treat Alzheimer’s Disease
Patthy, Á., Murai, J., Hanics, J., Pintér, A., Zahola, P., Hökfelt, T. G. M., Harkany, T., & Alpár, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081555 · Cited by 18 · see citing works
A meta-analysis of the relationship between sleep and β-Amyloid biomarkers in Alzheimer’s disease
Harenbrock, J., Holling, H., Reid, G., & Koychev, I. G. (2023) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2023.100068 · Cited by 18 · see citing works
Keenan, R. J., Daykin, H. J., Metha, J. A., Cornthwaite‐Duncan, L., Wright, D. K., Clarke, K. M., Oberrauch, S., Brian, M. L., Stephenson, S. E. M., Nowell, C. J., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16212 · Cited by 18 · see citing works
Exploring the nexus: Sleep disorders, circadian dysregulation, and Alzheimer’s disease
Khandayataray, P., & Murthy, M. K. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.03.066 · Cited by 18 · see citing works
Song, J., Cui, S., Cui, X., Hu, X., Ma, Y., Ding, H., Ye, H., & Zhang, Y.-H. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0125-y · Cited by 16 · see citing works
Bedward, A., Kaur, J., Seedat, S., Donohue, H., Kow, C. S., Rasheed, M. K., Javed, A., & Hasan, S. S. (2024) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2024.2341004 · Cited by 15 · see citing works
Keenan, R. J., Oberrauch, S., Bron, R., Nowell, C. J., Challis, L. M., Hoyer, D., & Jacobson, L. H. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-201177 · Cited by 15 · see citing works
Cui, S., Song, J., Cui, X., Hu, X., Ma, Y., Shi, Y., Luo, Y., Ge, Y., Ding, H., Ye, H., et al. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13032 · Cited by 15 · see citing works
Cassar, M., Law, A. D., Chow, E. S., Giebultowicz, J. M., & Kretzschmar, D. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00232 · Cited by 14 · see citing works
Keenan, R. J., Daykin, H. J., Chu, J., Cornthwaite‐Duncan, L., Allocca, G., Hoyer, D., & Jacobson, L. H. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15813 · Cited by 13 · see citing works
Genesis of the Master Circadian Pacemaker in Mice
Cheng, A. H., & Cheng, H. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.659974 · Cited by 13 · see citing works
Panda, S. P., Sinha, S., Kesharwani, A., Kumar, S., Singh, M., Kondepudi, G. M., Samuel, A., Sanghi, A. K., Thapliyal, S., Chaubey, K. K., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116794 · Cited by 13 · see citing works
Grounding the Body Improves Sleep Quality in Patients with Mild Alzheimer’s Disease: A Pilot Study
Lin, C., Tseng, S.-T., Chuang, Y., Kuo, C. A., & Chen, N.-C. (2022) · Healthcare · doi:10.3390/healthcare10030581 · Cited by 13 · see citing works
Yusof, N. I. S. M., & Fauzi, F. M. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105738 · Cited by 12 · see citing works
Xiang, W., Shen, Y., Chen, S., Tan, H., Cao, Q., & Xu, L. (2024) · Sleep Medicine · doi:10.1016/j.sleep.2024.06.007 · Cited by 12 · see citing works
Determinants of Change in Objectively Assessed Sleep Duration Among Older Men
Smagula, S. F., Harrison, S. L., Cauley, J. A., Ancoli‐Israel, S., Cawthon, P. M., Cummings, S., & Stone, K. L. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kwx014 · Cited by 12 · see citing works
Classification of Rest and Active Periods in Actigraphy Data Using PCA
Wagner-Muns, I. M., Lad, Y. D., Guardiola, I. G., & Thimgan, M. S. (2017) · Procedia Computer Science · doi:10.1016/j.procs.2017.09.041 · Cited by 11 · see citing works
Akinci, M., Peña-Gómez, C., Operto, G., Fuentes‐Julián, S., Deulofeu, C., Sánchez‐Benavides, G., Milà‐Alomà, M., Grau‐Rivera, O., Gramunt, N., Navarro, A., et al. (2022) · Neurology · doi:10.1212/wnl.0000000000200948 · Cited by 11 · see citing works
Zhai, Z., Xie, D., Qin, T., Zhong, Y., Xu, Y., & Sun, T. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.09.012 · Cited by 11 · see citing works
Acero, N., Ortega, T., Villagrasa, V., Leon, G., Mingarro, D. M., Castillo, E., González‐Rosende, M. E., Borrás, S., Rı́os, J. L., Bosch‐Morell, F., et al. (2023) · Phytotherapy Research · doi:10.1002/ptr.7727 · Cited by 13 · see citing works
Öz, P., GÖKALP, H. K., Göver, T., & Uzbay, T. I. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.002 · Cited by 11 · see citing works
A Single Channel EEG-based All AASM Sleep Stages Classifier for Neurodegenerative Disorder
Zamin, S. A., Altaf, M. A. B., & Saadeh, W. (2019) · IEEE Biomedical Circuits and Systems Conference (BioCAS) · doi:10.1109/biocas.2019.8918738 · Cited by 11 · see citing works
Sleep in Normal Aging, Alzheimer's Disease, and Mild Cognitive Impairment
Gagnon, J., Lafrenière, A., Rauchs, G., Petit, D., & Carrier, J. (2019) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-813743-7.00045-1 · Cited by 10 · see citing works
Atayde, A. L., Fischer, C. E., Schweizer, T. A., & Muñoz, D. G. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215276 · Cited by 10 · see citing works
Sleep is Essential for Mental Health: Potential Role of Slow Oscillations
Aquino, G., Alfì, G., Riemann, D. W., Laurino, M., Menicucci, D., Piarulli, A., Palagini, L., & Gemignani, A. (2024) · Current Sleep Medicine Reports · doi:10.1007/s40675-024-00277-w · Cited by 11 · see citing works
Relationship between Cortical Thickness and EEG Alterations during Sleep in the Alzheimer’s Disease
D’Atri, A., Gorgoni, M., Scarpelli, S., Cordone, S., Alfonsi, V., Marra, C., Ferrara, M., Rossini, P. M., & Gennaro, L. D. (2021) · Brain Sciences · doi:10.3390/brainsci11091174 · Cited by 10 · see citing works
The Glymphatic System and Brain Interstitial Fluid Homeostasis
Iliff, J. J., Thrane, A. S., & Nedergaard, M. (2017) · Primer on Cerebrovascular Diseases · doi:10.1016/b978-0-12-803058-5.00003-5 · Cited by 9 · see citing works
The core pattern of Chinese herbal formulae and drug–herb concurrent usage in patients with dementia
Lin, S., Tzeng, J., & Lai, J. (2019) · Medicine · doi:10.1097/md.0000000000013931 · Cited by 9 · see citing works
Irmen, R. E., Turner, S. M., Snipes, J. A., Schloss, K. H., Wang, X., Williams, H. C., Velmurugan, G. V., Hunt, J. B., Li, J., Sullivan, P. G., et al. (2026) · npj Dementia · doi:10.1038/s44400-025-00054-8 · Cited by 10 · see citing works
- Authors
- Lim, M. M., Gerstner, J. R., & Holtzman, D. M.
- Affiliations
- Oregon Health & Science University (US)
- Washington State University Spokane (US)
- Washington University in St. Louis (US)
- Venue
- Neurodegenerative Disease Management
- Publisher
- Informa UK Limited
- Published
- 2014-10
- Volume
- 4
- Issue
- 5
- Pages
- 351-362
- ISSN
- 1758-2024 (ISSN-L)
- 1758-2032
- PMC
- PMC4257134
- OpenAlex
- W1984375619
- Cited by
- 168
- References
- 105
- Citations by year
- 2026: 17 · 2025: 15 · 2024: 15 · 2023: 8 · 2022: 20 · 2021: 14 · 2020: 16 · 2019: 16 · 2018: 17 · 2017: 14 · 2016: 11 · 2015: 4
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurodegenerative Disease Management (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P01 AG0 3991, P01AG003991)
- National Heart, Lung, and Blood Institute (T32HL007713)
- National Institute of Neurological Disorders and Stroke (P01NS080675, 1P01NS074969-A1, P01NS074969)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, sleep-wake cycle, sleep-wake disturbances, amyloid-beta, amyloid plaques, sleep fragmentation, chronic sleep deprivation, sleep extension, disease progression
- MeSH terms
- Alzheimer Disease, Animals, Brain, Disease Models, Animal, Humans, Sleep, Amyloid beta-Peptides, Disease Progression, Sleep Disorders, Circadian Rhythm, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
