Cited by 1,287Cancer, Stress, Anesthesia, and Immune ResponseProstate Cancer Treatment and ResearchVagus Nerve Stimulation Research

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Autonomic Nerve Development Contributes to Prostate Cancer Progression

Magnon, Claire, Hall, Simon J., Lin, Juan, Xue, Xiaonan, Gerber, Leah, Freedland, Stephen J., Frenette, Paul S.·2013·Science

DOI 10.1126/science.1236361

Open this paper in CoChat — free account

Abstract

Cancer Hits a Nerve: Solid tumors sculpt their microenvironment to maximize their growth and metastatic potential. This concept is illustrated most famously by tumor angiogenesis, a process whereby tumors induce the growth of new blood vessels to boost their supply of oxygen and blood-borne nutrients. Magnon et al. (p. 10.1126/science.1236361 ; see the Perspective by Isaacs ) now highlight the important contribution made by another microenvironmental component—developing autonomic nerve fibers—to tumor growth and metastasis. In mouse models of prostate cancer, surgical or chemical destruction of sympathetic nerves prevented early-stage growth of tumors, whereas pharmacological inhibition of parasympathetic nerves inhibited tumor dissemination. In a small study of human prostate cancer specimens, the presence of a high density of nerve fibers in and around the tumor tissue was found to correlate with poor clinical outcome. These results raise the possibility that drugs targeting the autonomic nervous system may have therapeutic potential for prostate cancer.

Integrity signals

Registry

Crossref · 10.1126/science.1236361

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer.
D'Amico, A., Whittington, R., Malkowicz, S., Schultz, D., Blank, K., Broderick, G., Tomaszewski, J., Renshaw, A., Kaplan, I., Beard, C., et al. (1998) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.280.11.969 · Cited by 2,697
A Population-Based Study
Christakis, D., Richards, J. A., Zimmerman, F. J., Garrison, M. M., Xu, D., & Yapanel, U. H. (2009) · Cited by 2,290
Radical Prostatectomy versus Observation for Localized Prostate Cancer
Wilt, T. J., Brawer, M. K., Jones, K. M., Barry, M. J., Aronson, W. J., Fox, S., Gingrich, J. R., Wei, J. T., Gilhooly, P. E., Grob, B. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1113162 · Cited by 1,767
Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow
Katayama, Y., Battista, M., Kao, W.-M., Hidalgo, A., Peired, A. J., Thomas, S. A., & Frenette, P. S. (2006) · Cell · doi:10.1016/j.cell.2005.10.041 · Cited by 1,412
Self-citation
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320
Haematopoietic stem cell release is regulated by circadian oscillations
Méndez‐Ferrer, S., Lucas, D., Battista, M., & Frenette, P. S. (2008) · Nature · doi:10.1038/nature06685 · Cited by 1,310
Self-citation
Muscarinic Receptors—Characterization, coupling and function
Caulfield, M. P. (1993) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(93)90027-b · Cited by 1,284
Perineural invasion in cancer
Liebig, C., Ayala, G., Wilks, J. A., Berger, D. H., & Albo, D. (2009) · Cancer · doi:10.1002/cncr.24396 · Cited by 1,243
Common mechanisms of nerve and blood vessel wiring
Carmeliet, P., & Tessier-Lavigne, M. (2005) · Nature · doi:10.1038/nature03875 · Cited by 1,085
TNM classification of malignant tumors, fifth edition (1997)
Sobin, L. H., & Fleming, I. D. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19971101)80:9 · Cited by 996

Flagged first, then by citations

Show all 36 references

Research works printed but not linked: 4

10.1200/JCO.2010.33.4441 · DOI
10.1016/j.cell.2005.10.041 · DOI · Paper page
L. Wecker L. Crespo G. Dunaway S. Watts Brody’s Human Pharmacology (Mosby Elsevier Philadelphia ed. 5 2010).
10.1016/0024-3205(88)90345-1 · DOI

Sorted by citations

Items 201–300 of 1,000

Schwann cells shape the neuro-immune environs and control cancer progression
Martyn, G. V., Shurin, G. V., Keskinov, A. A., Bunimovich, Y. L., & Shurin, M. R. (2019) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-018-02296-3 · Cited by 80
Role of stress in the pathogenesis of cancer (Review)
Lempesis, I. G., Georgakopoulou, V., Papalexis, P., Chrousos, G. P., & Spandidos, D. A. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5572 · Cited by 82
Long-range gap junctional signaling controls oncogene-mediated tumorigenesis in Xenopus laevis embryos
Chernet, B. T., Fields, C., & Levin, M. G. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2014.00519 · Cited by 80
Tumor-neuroglia interaction promotes pancreatic cancer metastasis
Su, D., Guo, X., Huang, L., Ye, H., Li, Z., Lin, L., Chen, R., & Zhou, Q. (2020) · Theranostics · doi:10.7150/thno.42440 · Cited by 80
Nerve input to tumours: Pathophysiological consequences of a dynamic relationship
Hutchings, C., Phillips, J. A., & Djamgoz, M. B. A. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188411 · Cited by 79
Tumorigenesis as a process of gradual loss of original cell identity and gain of properties of neural precursor/progenitor cells
Cao, Y. (2017) · Cell & Bioscience · doi:10.1186/s13578-017-0188-9 · Cited by 78
Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer
You, H., Shang, W., Min, X., Weinreb, J. C., Li, Q., Leapman, M., Wang, L., & Tian, J. (2020) · Science Advances · doi:10.1126/sciadv.aax6040 · Cited by 77
Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance
Zhang, Y., Guo, Y., Liu, Z., Sun, Y., Xi, Y., Chen, M., Feng, G., Lin, C., Wang, Y., Zhang, Z., et al. (2025) · Cell · doi:10.1016/j.cell.2025.09.029 · Cited by 79
Prostate Cancer and Neuroendocrine Differentiation: More Neuronal, Less Endocrine?
Grigore, A. D., Ben‐Jacob, E., & Farach‐Carson, M. C. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00037 · Cited by 78
A MYC and RAS co-activation signature in localized prostate cancer drives bone metastasis and castration resistance
Arriaga, J. M., Panja, S., Alshalalfa, M., Zhao, J., Zou, M., Giacobbe, A., Madubata, C. J., Kim, J. Y., Rodrı́guez, A., Coleman, I. M., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-00125-0 · Cited by 79
Carvedilol blocks neural regulation of breast cancer progression in vivo and is associated with reduced breast cancer mortality in patients
Gillis, R. D., Botteri, E., Chang, A., Ziegler, A. I., Chung, N.-C., Pon, C. K., Shackleford, D. M., Andreassen, B. K., Halls, M. L., Baker, J. G., et al. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.01.029 · Cited by 76
Differentiation of the tumor microenvironment: are CAFs the Organizer?
Kochetkova, M., & Samuel, M. S. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.11.008 · Cited by 76
A brain-tumor neural circuit controls breast cancer progression in mice
Xiong, S., Wen, H., Dai, L., Lou, Y.-X., Wang, Z.-Q., Yi, Y.-L., Yan, X.-J., Wu, Y., Sun, W. M., Chen, P., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci167725 · Cited by 80
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling
Drexler, R., Drinnenberg, A., Gavish, A., Yalçın, B., Shamardani, K., Rogers, A. E., Mancusi, R. A., Trivedi, V., Taylor, K. R., Kim, Y. S., et al. (2025) · Cell · doi:10.1016/j.cell.2025.05.031 · Cited by 82
Role of the autonomic nervous system in tumorigenesis and metastasis
Magnon, C. (2015) · Molecular & Cellular Oncology · doi:10.4161/23723556.2014.975643 · Cited by 78
Self-citation
Tumor-specific cholinergic CD4+ T lymphocytes guide immunosurveillance of hepatocellular carcinoma
Zheng, C., Snow, B. E., Elia, A. J., Nechanitzky, R., Dominguez-Brauer, C., Liu, S., Tong, Y., Cox, M. A., Focaccia, E., Wakeham, A. C., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00624-w · Cited by 75
Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System
Duchalais, É., Guilluy, C., Nédellec, S., Touvron, M. S., Bessard, A., Touchefeu, Y., Bossard, C., Boudin, H., Louarn, G., Neunlist, M., et al. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.10.002 · Cited by 75
Insights and opportunities at the crossroads of cancer and neuroscience
Pan, C., & Winkler, F. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00978-w · Cited by 75
Tumor innervation and clinical outcome in pancreatic cancer
Ferdoushi, A., Griffin, N., Marsland, M., Xu, X., Faulkner, S., Gao, F., Liu, H., King, S., Denham, J. W., Helden, D. F. V., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-86831-w · Cited by 78
The Interplay of the Extracellular Matrix and Stromal Cells as a Drug Target in Stroma-Rich Cancers
Kozlova, N., Grossman, J. E., Iwanicki, M. P., & Muranen, T. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.01.001 · Cited by 73
Redefining Perineural Invasion: Integration of Biology With Clinical Outcome
Schmitd, L. B., Beesley, L. J., Russo, N., Bellile, E. L., Inglehart, R. C., Liu, M., Romanowicz, G. E., Wolf, G. T., Taylor, J. M. G., & D’Silva, N. J. (2018) · Neoplasia · doi:10.1016/j.neo.2018.04.005 · Cited by 73
An active role for neurons in glioma progression: making sense of Scherer’s structures
Gillespie, S. M., & Monje, M. (2018) · Neuro-Oncology · doi:10.1093/neuonc/noy083 · Cited by 74
β-Adrenergic Receptor Signaling in Prostate Cancer
Braadland, P. R., Ramberg, H., Grytli, H. H., & TaskÃ©n, K. A. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2014.00375 · Cited by 72
Molecular model for neuroendocrine prostate cancer progression
Chen, R., Dong, X., & Gleave, M. E. (2018) · British Journal of Urology · doi:10.1111/bju.14207 · Cited by 71
Autocrine Activation of CHRM3 Promotes Prostate Cancer Growth and Castration Resistance via CaM/CaMKK–Mediated Phosphorylation of Akt
Wang, N., Yao, M., Xu, J., Quan, Y., Zhang, K., Yang, R., & Gao, W. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-3163 · Cited by 71
Sympathetic and parasympathetic innervation in hepatocellular carcinoma
Zhang, L., Wu, L. L., Huan, H.-B., Chen, X., Wen, X. D., Yang, D. P., & Xia, F. (2017) · Neoplasma · doi:10.4149/neo_2017_605 · Cited by 70
Stem cell division theory of cancer
López‐Lázaro, M. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1062330 · Cited by 70
Perineural Invasion in Adenoid Cystic Carcinoma of the Salivary Glands: Where We Are and Where We Need to Go
Liu, X., Yang, X., Zhan, C., Zhang, Y., Hou, J. L., & Yin, X. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01493 · Cited by 69
The Role of Perineural Invasion in Prostate Cancer and Its Prognostic Significance
Niu, Y., Förster, S., & Muders, M. H. (2022) · Cancers · doi:10.3390/cancers14174065 · Cited by 69
Ion channels expression and function are strongly modified in solid tumors and vascular malformations
Biasiotta, A., D’Arcangelo, D., Passarelli, F., Nicodemi, E. M., & Facchiano, A. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1038-y · Cited by 70
Expression of PD‐L1 in tumor‐associated nerves correlates with reduced CD8+ tumor‐associated lymphocytes and poor prognosis in prostate cancer
Mo, R., Han, Z., Liang, Y., Ye, J., Wu, S., Lin, S. X. H., Zhang, Y., Song, S., Jiang, F., Zhong, W., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.32061 · Cited by 70
In vitro modeling of the prostate cancer microenvironment
Ellem, S. J., De-Juan-Pardo, E. M., & Risbridger, G. P. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.04.008 · Cited by 68
Cellular determinants and microenvironmental regulation of prostate cancer metastasis
Rycaj, K., Li, H., Zhou, J., Chen, X., & Tang, D. G. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.03.009 · Cited by 69
Implantable pre-metastatic niches for the study of the microenvironmental regulation of disseminated human tumour cells
Carpenter, R., Kwak, J., Peyton, S. R., & Lee, J. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0307-x · Cited by 69
The Emerging Role of Nerves and Glia in Colorectal Cancer
Schonkeren, S. L., Thijssen, M. S., Vaes, N., Boesmans, W., & Melotte, V. (2021) · Cancers · doi:10.3390/cancers13010152 · Cited by 71
Sympathetic activity in breast cancer and metastasis: partners in crime
Conceição, F., Sousa, D. M., Paredes, J., & Lamghari, M. (2021) · Bone Research · doi:10.1038/s41413-021-00137-1 · Cited by 73
Histamine receptor 1 inhibition enhances antitumor therapeutic responses through extracellular signal-regulated kinase (ERK) activation in breast cancer
Fernández‐Nogueira, P., Noguera‐Castells, A., Fuster, G., Recalde‐Percaz, L., Moragas, N., López‐Plana, A., Enreig, E., Jáuregui, P., Carbó, N., Almendro, V., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.03.014 · Cited by 68
Beyond Wrapping: Canonical and Noncanonical Functions of Schwann Cells
Taveggia, C., & Feltri, M. L. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110920-030610 · Cited by 72
The role of perineural invasion in predicting survival in patients with primary operable colorectal cancer: A systematic review
Wyk, H. C. V., Going, J. J., Horgan, P. G., & McMillan, D. C. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.02.005 · Cited by 66
How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes: A Summary of Current State of Evidence
Forget, P., Aguirre, J. A., Benčić, I., Borgeat, A., Cama, A., Condron, C. M., Eintrei, C., Eroles, P., Gupta, A. K., Hales, T. G., et al. (2019) · Cancers · doi:10.3390/cancers11050592 · Cited by 66
New insights into perineural invasion of pancreatic cancer: More than pain
Liang, D., Shi, S., Xu, J., Zhang, B., Qin, Y., Ji, S., Xu, W., Liu, J., Liu, L., Liu, C., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.01.002 · Cited by 66
β 3 ‐Adrenoceptor as a potential immuno‐suppressor agent in melanoma
Calvani, M., Bruno, G., Monte, M. D., Nassini, R., Fontani, F., Casini, A., Cavallini, L., Becatti, M., Bianchini, F., Logu, F. D., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14660 · Cited by 66
Neuronal signatures in cancer
Jung, E., Alfonso, J., Monyer, H., Wick, W., & Winkler, F. (2020) · International Journal of Cancer · doi:10.1002/ijc.33138 · Cited by 70
Immunomodulation by Schwann cells in disease
Zhang, S. H., Shurin, G. V., Khosravi, H., Kazi, R., Kruglov, O., Shurin, M. R., & Bunimovich, Y. L. (2019) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-019-02424-7 · Cited by 65
Perineural invasion is associated with poor prognosis of colorectal cancer: a retrospective cohort study
Cao, Y., Deng, S., Yan, L., Gu, J., Jiang, L., Wu, K., & Cai, K. (2020) · International Journal of Colorectal Disease · doi:10.1007/s00384-020-03566-2 · Cited by 65
The Tumor Microenvironment of Bladder Cancer
Hatogai, K., & Sweis, R. F. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-59038-3_17 · Cited by 67
Exosomal Induction of Tumor Innervation
Vermeer, P. D. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3995 · Cited by 66
Mindfulness-Based Movement: A Polyvagal Perspective
Lucas, A. R., Klepin, H. D., Porges, S. W., & Rejeski, W. J. (2016) · Integrative Cancer Therapies · doi:10.1177/1534735416682087 · Cited by 67
Chronic stress induces pulmonary epithelial cells to produce acetylcholine that remodels lung pre-metastatic niche of breast cancer by enhancing NETosis
Pan, J., Zhang, L., Wang, X., Li, L., Yang, C., Wang, Z., Su, K., Hu, X., Zhang, Y., Ren, G., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02836-5 · Cited by 64
Hijacking of the nervous system in cancer: mechanism and therapeutic targets
Zhang, Y., Liao, Q., Wen, X., Fan, J., Yuan, T., Tong, X., Jia, R., Chai, P., & Fan, X. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02246-5 · Cited by 67
Landscape of extracellular vesicles in the tumour microenvironment: Interactions with stromal cells and with non-cell components, and impacts on metabolic reprogramming, horizontal transfer of neoplastic traits, and the emergence of therapeutic resistance
Zhang, D. X., Vu, L. T., Ismail, N. N., Le, M. T. N., & Grimson, A. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.01.007 · Cited by 64
Sensory Nerves Impede the Formation of Tertiary Lymphoid Structures and Development of Protective Antimelanoma Immune Responses
Vats, K., Kruglov, O., Sahoo, B., Soman, V., Zhang, J., Shurin, G. V., Chandran, U. R., Skums, P., Shurin, M. R., Zelikovsky, A., et al. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0110 · Cited by 63
Neurotransmitter Receptor HTR2B Regulates Lipid Metabolism to Inhibit Ferroptosis in Gastric Cancer
Tu, R., Wu, S.-Z., Huang, Z.-N., Zhong, Q., Ye, Y., Zheng, C., Xie, J., Wang, J., Lin, J., Chen, Q., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-1012 · Cited by 63
Self-citation
Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment
Huang, Q., Hu, B., Ping, Z., Yuan, Y., Yue, S., Chen, X., Liang, J., Tang, Z., & Zhang, B. (2025) · Molecular Cancer · doi:10.1186/s12943-024-02219-0 · Cited by 68
Repurposing antipsychotics as glioblastoma therapeutics: Potentials and challenges
Lee, J., Nam, D., & Lee, J. (2016) · Oncology Letters · doi:10.3892/ol.2016.4074 · Cited by 63
Adrenergic-mediated increases in INHBA drive CAF phenotype and collagens
Nagaraja, A. S., Dood, R. L., Armaiz-Peña, G. N., Kang, Y., Wu, S. Y., Allen, J. K., Jennings, N. B., Mangala, L. S., Pradeep, S., Lyons, Y., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.93076 · Cited by 63
Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G1 arrest independent of DRD2
Tegowski, M., Fan, C., & Baldwin, A. S. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003719 · Cited by 63
Multiple cancer cell types release LIF and Gal3 to hijack neural signals
Xu, Q., Cao, Y., Kong, F., Liu, J., Chen, X., Zhao, Y., Lai, C., Zhou, X., Hu, H., Fu, W., et al. (2024) · Cell Research · doi:10.1038/s41422-024-00946-z · Cited by 61
Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis
Wei, H. K., Yu, C. D., Hu, B., Zeng, X., Ichise, H., Li, L., Wang, Y., Wang, R., Germain, R. N., Chang, R. B., et al. (2026) · Nature · doi:10.1038/s41586-025-10028-8 · Cited by 62
Tumor progression: the neuronal input
Arese, M., Bussolino, F., Pergolizzi, M., Bizzozero, L., & Pascal, D. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.01.01 · Cited by 61
Histone-Related Genes Are Hypermethylated in Lung Cancer and Hypermethylated HIST1H4F Could Serve as a Pan-Cancer Biomarker
Dong, S., Li, W., Wang, L., Hu, J., Song, Y., Zhang, B., Ren, X., Ji, S., Li, J., Xu, P., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1019 · Cited by 63
Role of sensory neurons, neuroimmune pathways, and transient receptor potential vanilloid 1 (TRPV1) channels in a murine model of breast cancer metastasis
Erin, N. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-019-02463-0 · Cited by 64
The Neuroimmune Axis in the Tumor Microenvironment
Shurin, M. R., Shurin, G. V., Zlotnikov, S. B., & Bunimovich, Y. L. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900828 · Cited by 61
The tumor organismal environment: Role in tumor development and cancer immunotherapy
Dieterich, L. C., & Bikfalvi, A. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.12.021 · Cited by 61
Sympathectomy reduces tumor weight and affects expression of tumor-related genes in melanoma tissue in the mouse
Horváthová, Ľ., Padová, A., Tillinger, A., Osacká, J., Bízik, J., & Mravec, B. (2016) · Stress · doi:10.1080/10253890.2016.1213808 · Cited by 60
Systemic Depletion of Nerve Growth Factor Inhibits Disease Progression in a Genetically Engineered Model of Pancreatic Ductal Adenocarcinoma
Saloman, J. L., Singhi, A. D., Hartman, D. J., Normolle, D. P., Albers, K. M., & Davis, B. M. (2018) · Pancreas · doi:10.1097/mpa.0000000000001090 · Cited by 59
Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression
Costa, P. A. C., da Silva, W. N., Prazeres, P. H. D. M., Picoli, C. C., Guardia, G. D. A., Costa, A. C., Oliveira, M. D. A., Guimarães, P. P. G., Gonçalves, R., Pinto, M. C. X., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01273-9 · Cited by 59
Biobehavioral Pathways and Cancer Progression: Insights for Improving Well-Being and Cancer Outcomes
Chang, A., Sloan, E. K., Antoni, M. H., Knight, J. M., Telles, R., & Lutgendorf, S. K. (2022) · Integrative Cancer Therapies · doi:10.1177/15347354221096081 · Cited by 61
Vagotomy and Gastric Tumorigenesis
Rabben, H.-L., Zhao, C., Hayakawa, Y., Wang, T. C., & Chen, D. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160121114854 · Cited by 59
Schwann cells: a new player in the tumor microenvironment
Bunimovich, Y. L., Keskinov, A. A., Shurin, G. V., & Shurin, M. R. (2016) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-016-1929-z · Cited by 61
The role of enteric neurons in the development and progression of colorectal cancer
Rademakers, G., Vaes, N., Schonkeren, S. L., Koch, A., Sharkey, K. A., & Melotte, V. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.08.003 · Cited by 59
The systemic hallmarks of cancer
Paul, D. (2020) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2020.63 · Cited by 59
Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance
Chen, W., Wen, Y., Lin, S., Yeh, H.-L., Jiang, K.-C., Chen, W., Lin, Y.-S., Zhang, Q., Liew, P., Hsiao, M., et al. (2021) · Communications Biology · doi:10.1038/s42003-020-01549-1 · Cited by 60
An on-chip model for investigating the interaction between neurons and cancer cells
Lei, Y., Li, J., Wang, N., Yang, X., Hamada, Y., Li, Q., Zheng, W., & Jiang, X. (2016) · Integrative Biology · doi:10.1039/c5ib00309a · Cited by 58
Selective Induction of Human Autonomic Neurons Enables Precise Control of Cardiomyocyte Beating
Takayama, Y., Kushige, H., Akagi, Y., Suzuki, Y., Kumagai, Y., & Kida, Y. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-66303-3 · Cited by 57
Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases
Kaduri, M., Sela, M., Kagan, S., Poley, M., Abumanhal-Masarweh, H., Mora‐Raimundo, P., Ouro, A., Dahan, N., Hershkovitz, D., Shklover, J., et al. (2021) · Science Advances · doi:10.1126/sciadv.abj5435 · Cited by 58
Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance
Nouri, M., Caradec, J., Lubik, A. A., Li, N., Hollier, B. G., Takhar, M. M., Altamirano-Dimas, M., Chen, M., Roshan‐Moniri, M., Butler, M. S., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14850 · Cited by 57
ADRB2-Targeting Therapies for Prostate Cancer
Kulik, G. (2019) · Cancers · doi:10.3390/cancers11030358 · Cited by 56
Increased Nerve Density Adversely Affects Outcome in Oral Cancer
Perez‐Pacheco, C., Schmitd, L. B., Furgal, A. K. C., Bellile, E. L., Liu, M., Fattah, A., Gonzalez-Maldonado, L., Unsworth, S. P., Wong, S. Y., Rozek, L. S., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-3496 · Cited by 56
Nano-formulations in disease therapy: designs, advances, challenges, and future directions
Shi, Y., Li, X., Li, Z., Sun, J., Gao, T., Wei, G., & Guo, Q. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03442-7 · Cited by 58
The tumor-nerve circuit in breast cancer
Cui, Q., Jiang, D., Zhang, Y., & Chen, C. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10095-1 · Cited by 55
Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis
Fu, Y., Shen, K., Wang, H., Wang, S., Wang, X., Zhu, L., Zheng, Y., Zou, T., Ci, H., Dong, Q., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01761-z · Cited by 55
IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer
van Baarle, L., Simone, V. D., Schneider, L. H., Santhosh, S., Abdurahiman, S., Biscu, F., Schneider, R., Zanoletti, L., de Mello, R. S., Verbandt, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50438-2 · Cited by 55
Dopamine receptor antagonist thioridazine inhibits tumor growth in a murine breast cancer model
Yin, T., He, S., Shen, G., Ye, T., Guo, F., & Wang, Y. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3967 · Cited by 55
DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance
Huber, R. M., Lucas, J. M., Gomez-Sarosi, L., Coleman, I. M., Zhao, S. Q., COLEMAN, R. T., & Nelson, P. S. (2014) · Oncotarget · doi:10.18632/oncotarget.3040 · Cited by 57
Stimulation of hypothalamic oxytocin neurons suppresses colorectal cancer progression in mice
Pan, S., Yin, K., Tang, Z., Wang, S., Chen, Z., Wang, Y., Zhu, H., Han, Y., Liu, M., Jiang, M., et al. (2021) · eLife · doi:10.7554/elife.67535 · Cited by 54
Impact of the Sensory Neurons on Melanoma Growth In Vivo
Keskinov, A. A., Tapias, V., Watkins, S. C., Ma, Y., Shurin, M. R., & Shurin, G. V. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156095 · Cited by 54
Muscarinic acetylcholine receptor M1 mediates prostate cancer cell migration and invasion through hedgehog signaling
Xu, C., Yin, Q., Xu, L.-H., & Zhang, M. (2018) · Asian Journal of Andrology · doi:10.4103/aja.aja_55_18 · Cited by 54
Emerging experimental models for assessing perineural invasion in human cancers
Jiang, S., Zhang, S., Wang, H., Xue, J., & Zhang, Z. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215610 · Cited by 54
Triiodothyronine Attenuates Prostate Cancer Progression Mediated by β-Adrenergic Stimulation
Delgado-González, E., Tusie, A. A. S., Morales, G., Aceves, C., & Anguiano, B. (2016) · Molecular Medicine · doi:10.2119/molmed.2015.00047 · Cited by 53
Autonomic nervous infiltration positively correlates with pathological risk grading and poor prognosis in patients with lung adenocarcinoma
Shao, J., Wang, B., Yao, Y., Pan, Z., Shen, Q., & Zhou, J. (2016) · Thoracic Cancer · doi:10.1111/1759-7714.12374 · Cited by 53
The Sympathetic Nervous System Drives Tumor Angiogenesis
Hondermarck, H., & Jobling, P. (2018) · Trends in Cancer · doi:10.1016/j.trecan.2017.11.008 · Cited by 55
Cancer-nervous system crosstalk: from biological mechanism to therapeutic opportunities
Huang, S., Zhu, J., Yu, L., Huang, Y., & Hu, Y. H. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02336-4 · Cited by 54
Autonomic nerve development contributes to prostate cancer progression
Bauman, J., & McVary, K. T. (2013) · Asian Journal of Andrology · doi:10.1038/aja.2013.113 · Cited by 52
Cholinergic Receptors as Target for Cancer Therapy in a Systems Medicine Perspective
Russo, P., Bufalo, A. D., Milić, M., Salinaro, G., Fini, M., & Cesario, A. (2014) · Current Molecular Medicine · doi:10.2174/1566524014666141015152601 · Cited by 52
Use of Phosphodiesterase Type 5 Inhibitors May Adversely Impact Biochemical Recurrence after Radical Prostatectomy
Michl, U. H. G., Molfenter, F., Graefen, M., Tennstedt, P., Ahyai, S., Beyer, B., Budäus, L., Haese, A., Hans Heinzer, A., Oh, S. J., et al. (2014) · The Journal of Urology · doi:10.1016/j.juro.2014.08.111 · Cited by 52
Symptoms of Lower Urinary Tract Dysfunction Research Network
Yang, C. C., Weinfurt, K. P., Merion, R. M., Kırkalı, Z., & LURN Study Group Cindy Amundsen MD, K. W. P. (2016) · The Journal of Urology · doi:10.1016/j.juro.2016.01.007 · Cited by 52
MACC1 mediates acetylcholine-induced invasion and migration by human gastric cancer cells
Yang, T., He, W., Cui, F., Xia, J., Zhou, R., Wu, Z., Zhao, Y., & Shi, M. (2016) · Oncotarget · doi:10.18632/oncotarget.7634 · Cited by 52
Parasympathetic neurogenesis is strongly associated with tumor budding and correlates with an adverse prognosis in pancreatic ductal adenocarcinoma
Zhang, L., Guo, L., Tao, M., Fu, W., & Xiu, D. (2016) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2016.02.05 · Cited by 52
Denervation leads to volume regression in breast cancer
Kappos, E. A., Engels, P. E., Tremp, M., Sieber, P. K., von Felten, S., Madduri, S., zu Schwabedissen, M. M., Fischmann, A., Schaefer, D. J., & Kalbermatten, D. F. (2018) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2018.03.012 · Cited by 52

Authors: Magnon, C., Hall, S. J., Lin, J., Xue, X., Gerber, L., Freedland, S. J., & Frenette, P. S.
Affiliations: Albert Einstein College of Medicine (US)
Icahn School of Medicine at Mount Sinai (US)
Duke University (US)
Corresponding author: Magnon, Claire
Frenette, Paul S.
ORCID: Magnon, Claire
Hall, Simon J.
Lin, Juan
Xue, Xiaonan
Freedland, Stephen J.
Frenette, Paul S.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2013-07-12
Volume: 341
Issue: 6142
Pages: 1236361-1236361
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1236361
OpenAlex: W2049959255
Cited by: 1,287
References: 36
Citations by year: 2026: 136 · 2025: 128 · 2024: 127 · 2023: 119 · 2022: 116 · 2021: 120 · 2020: 120 · 2019: 85 · 2018: 78 · 2017: 66 · 2016: 66 · 2015: 56 · 2014: 46 · 2013: 23
FWCI: 45.11
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL069438, HL097819, R01HL069438, R01HL097819)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056638, DK056638)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords: prostate cancer, autonomic nerves, tumor microenvironment, sympathetic nerves, parasympathetic nerves, cholinergic fibers, adrenergic receptors, muscarinic receptors, metastasis, tumor invasion
MeSH terms: Adenocarcinoma, Adrenergic Fibers, Animals, Autonomic Nervous System, Cell Transformation, Neoplastic, Cholinergic Fibers, Humans, Male, Mice, Transgenic, Neoplasm Invasiveness, Neoplasm Transplantation, Nerve Net, Parasympathetic Nervous System, Promoter Regions, Genetic, Prostate, Prostatic Neoplasms, Genes, myc, Disease Progression, Cell Line, Tumor, Mice, Neurogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Autonomic Nerve Development Contributes to Prostate Cancer Progression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks