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Autonomic Nerve Development Contributes to Prostate Cancer Progression
Abstract
Cancer Hits a Nerve: Solid tumors sculpt their microenvironment to maximize their growth and metastatic potential. This concept is illustrated most famously by tumor angiogenesis, a process whereby tumors induce the growth of new blood vessels to boost their supply of oxygen and blood-borne nutrients. Magnon et al. (p. 10.1126/science.1236361 ; see the Perspective by Isaacs ) now highlight the important contribution made by another microenvironmental component—developing autonomic nerve fibers—to tumor growth and metastasis. In mouse models of prostate cancer, surgical or chemical destruction of sympathetic nerves prevented early-stage growth of tumors, whereas pharmacological inhibition of parasympathetic nerves inhibited tumor dissemination. In a small study of human prostate cancer specimens, the presence of a high density of nerve fibers in and around the tumor tissue was found to correlate with poor clinical outcome. These results raise the possibility that drugs targeting the autonomic nervous system may have therapeutic potential for prostate cancer.
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“SNS dysfunction is closely associated with metabolic syndrome, oncogenic activation, neoplastic growth and tumor initiation (Lee et al., 2010; Magnon et al., 2013; Tentolouris et al., 2006).”
From Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis (2016) · cites this paper as Magnon et al., 2013
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“both of which have been linked to oncogenic activation and increased risk of cancer (Kettner NM, 2016; Lee et al., 2010; Magnon et al., 2013).”
From Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis (2016) · cites this paper as Magnon et al., 2013
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Cites
D'Amico, A., Whittington, R., Malkowicz, S., Schultz, D., Blank, K., Broderick, G., Tomaszewski, J., Renshaw, A., Kaplan, I., Beard, C., et al. (1998) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.280.11.969 · Cited by 2,697
Christakis, D., Richards, J. A., Zimmerman, F. J., Garrison, M. M., Xu, D., & Yapanel, U. H. (2009) · Cited by 2,290
Radical Prostatectomy versus Observation for Localized Prostate Cancer
Wilt, T. J., Brawer, M. K., Jones, K. M., Barry, M. J., Aronson, W. J., Fox, S., Gingrich, J. R., Wei, J. T., Gilhooly, P. E., Grob, B. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1113162 · Cited by 1,767
Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow
Katayama, Y., Battista, M., Kao, W.-M., Hidalgo, A., Peired, A. J., Thomas, S. A., & Frenette, P. S. (2006) · Cell · doi:10.1016/j.cell.2005.10.041 · Cited by 1,412
Self-citationChronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320
Haematopoietic stem cell release is regulated by circadian oscillations
Méndez‐Ferrer, S., Lucas, D., Battista, M., & Frenette, P. S. (2008) · Nature · doi:10.1038/nature06685 · Cited by 1,310
Self-citationMuscarinic Receptors—Characterization, coupling and function
Caulfield, M. P. (1993) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(93)90027-b · Cited by 1,284
Liebig, C., Ayala, G., Wilks, J. A., Berger, D. H., & Albo, D. (2009) · Cancer · doi:10.1002/cncr.24396 · Cited by 1,243
Common mechanisms of nerve and blood vessel wiring
Carmeliet, P., & Tessier-Lavigne, M. (2005) · Nature · doi:10.1038/nature03875 · Cited by 1,085
TNM classification of malignant tumors, fifth edition (1997)
Sobin, L. H., & Fleming, I. D. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19971101)80:9 · Cited by 996
Research works printed but not linked: 4
- 10.1200/JCO.2010.33.4441 · DOI
- 10.1016/j.cell.2005.10.041 · DOI · Paper page
- L. Wecker L. Crespo G. Dunaway S. Watts Brody’s Human Pharmacology (Mosby Elsevier Philadelphia ed. 5 2010).
- 10.1016/0024-3205(88)90345-1 · DOI
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Pinho, S., & Frenette, P. S. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0103-9 · Cited by 1,064
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Venkatesh, H. S., Johung, T., Caretti, V., Noll, A., Tang, Y., Nagaraja, S., Gibson, E. M., Mount, C., Polepalli, J. S., Mitra, S. S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.012 · Cited by 1,011
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Wang, G., Zhao, D., Spring, D. J., & DePinho, R. A. (2018) · Genes & Development · doi:10.1101/gad.315739.118 · Cited by 814
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Zhao, C., Hayakawa, Y., Kodama, Y., Muthupalani, S., Westphalen, C. B., Andersen, G. T., Flatberg, A., Johannessen, H., Friedman, R. A., Renz, B. W., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009569 · Cited by 687
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Venkatesh, H. S., Tam, L. T., Woo, P. J., Lennon, J., Nagaraja, S., Gillespie, S. M., Ni, J., Duveau, D. Y., Morris, P. J., Zhao, J. J., et al. (2017) · Nature · doi:10.1038/nature24014 · Cited by 623
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Hayakawa, Y., Sakitani, K., Konishi, M., Asfaha, S., Niikura, R., Tomita, H., Renz, B. W., Tailor, Y. H., Macchini, M., Middelhoff, M. A., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.11.005 · Cited by 577
Cancer neuroscience: State of the field, emerging directions
Winkler, F., Venkatesh, H. S., Amit, M., Batchelor, T. T., Demir, İ. E., Deneen, B., Gutmann, D. H., Hervey‐Jumper, S. L., Kuner, T., Mabbott, D., et al. (2023) · Cell · doi:10.1016/j.cell.2023.02.002 · Cited by 602
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Cole, S. W., Nagaraja, A. S., Lutgendorf, S. K., Green, P. A., & Sood, A. K. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3978 · Cited by 576
Vanharanta, S., & Massagué, J. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.09.007 · Cited by 563
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Hiller, J. G., Perry, N. J., Poulogiannis, G., Riedel, B., & Sloan, E. K. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.194 · Cited by 556
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Zahalka, A. H., Arnal-Estapé, A., Maryanovich, M., Nakahara, F., Cruz, C. D., Finley, L. W. S., & Frenette, P. S. (2017) · Science · doi:10.1126/science.aah5072 · Cited by 548
Self-citationβ2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer
Renz, B. W., Takahashi, R., Tanaka, T., Macchini, M., Hayakawa, Y., Dantes, Z., Maurer, H. C., Chen, X., Jiang, Z., Westphalen, C. B., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2017.11.007 · Cited by 543
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Khalaf, K., Hana, D., Chou, J. T.-T., Singh, C., Mackiewicz, A. A., & Kaczmarek, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.656364 · Cited by 551
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Kettner, N. M., Voicu, H., Finegold, M. J., Coarfa, C., Sreekumar, A., Putluri, N., Katchy, C. A., Lee, C., Moore, D. D., & Fu, L. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.007 · Cited by 508
“…develop NAFLD in response to chronic metabolic stress and progress to NAFLD-initiated liver injury, inflammation, fibrosis and HCC as observed in obese human subjects has significantly impaired the study on the mechanism of metabolic syndromeinduced hepatocarcinogenesis (Michelotti et al., 2013).”
BackgroundLoss of p53 drives neuron reprogramming in head and neck cancer
Amit, M., Takahashi, H., Dragomir, M. P., Lindemann, A., Gleber-Netto, F. O., Pickering, C. R., Anfossi, S., Osman, A. A., Cai, Y., Wang, R., et al. (2020) · Nature · doi:10.1038/s41586-020-1996-3 · Cited by 483
Zahalka, A. H., & Frenette, P. S. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0237-2 · Cited by 470
Self-citationMuscarinic acetylcholine receptors: novel opportunities for drug development
Kruse, A. C., Kobilka, B. K., Gautam, D., Sexton, P. M., Christopoulos, A., & Wess, J. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4295 · Cited by 437
Saloman, J. L., Albers, K. M., Li, D., Hartman, D. J., Crawford, H. C., Muha, E. A., Rhim, A. D., & Davis, B. M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512603113 · Cited by 415
Roles for Hedgehog signaling in adult organ homeostasis and repair
Petrova, R., & Joyner, A. L. (2014) · Development · doi:10.1242/dev.083691 · Cited by 415
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Kok, V. C., & Yu, C. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s272378 · Cited by 409
Roadmap for the Emerging Field of Cancer Neuroscience
Monje, M., Borniger, J. C., D’Silva, N. J., Deneen, B., Dirks, P. B., Fattahi, F., Frenette, P. S., Garzia, L., Gutmann, D. H., Hanahan, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.034 · Cited by 402
Self-citationTumor microenvironment: barrier or opportunity towards effective cancer therapy
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Maryanovich, M., Zahalka, A. H., Pierce, H., Pinho, S., Nakahara, F., Asada, N., Wei, Q., Wang, X., Ciero, P., Xu, J., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0030-x · Cited by 411
Self-citationNociceptor neurons affect cancer immunosurveillance
Balood, M., Ahmadi, M., Eichwald, T., Ahmadi, A., Majdoubi, A., Roversi, K., Roversi, K., Lucido, C. T., Restaino, A. C., Huang, S., et al. (2022) · Nature · doi:10.1038/s41586-022-05374-w · Cited by 405
Hanoun, M., Zhang, D., Mizoguchi, T., Pinho, S., Pierce, H., Kunisaki, Y., Lacombe, J., Armstrong, S. A., Dührsen, U., & Frenette, P. S. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.06.020 · Cited by 381
Self-citationNiches for Hematopoietic Stem Cells and Their Progeny
Wei, Q., & Frenette, P. S. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.024 · Cited by 398
Self-citationA genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies
Jing, M., Zhang, P., Wang, G., Feng, J., Mesik, L., Zeng, J., Jiang, H., Wang, S., Looby, J. C., Guagliardo, N. A., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4184 · Cited by 392
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Massagué, J., & Ganesh, K. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0010 · Cited by 372
Renz, B. W., Tanaka, T., Sunagawa, M., Takahashi, R., Jiang, Z., Macchini, M., Dantes, Z., Valenti, G., White, R. A., Middelhoff, M. A., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0046 · Cited by 374
Mancusi, R. A., & Monje, M. (2023) · Nature · doi:10.1038/s41586-023-05968-y · Cited by 388
Unsworth, S. P., Eberl, M., Vagnozzi, A. N., Belkadi, A., Veniaminova, N. A., Verhaegen, M. E., Bichakjian, C. K., Ward, N. L., Dlugosz, A. A., & Wong, S. Y. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.02.006 · Cited by 366
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Mauffrey, P., Tchitchek, N., Barroca, V., Bemelmans, A., Firlej, V., Allory, Y., Roméo, P., & Magnon, C. (2019) · Nature · doi:10.1038/s41586-019-1219-y · Cited by 362
Self-citationChronic stress in mice remodels lymph vasculature to promote tumour cell dissemination
Le, C. P., Nowell, C. J., Kim-Fuchs, C., Botteri, E., Hiller, J. G., Ismail, H., Pimentel, M. A., Chai, M. G., Karnezis, T., Rotmensz, N., et al. (2016) · Nature Communications · doi:10.1038/ncomms10634 · Cited by 354
Stress and cancer: mechanisms, significance and future directions
Eckerling, A., Ricon-Becker, I., Sorski, L., Sandbank, E., & Ben-Eliyahu, S. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-021-00395-5 · Cited by 348
Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer
Lei, Y., Tang, L., Xie, Y., Xianyu, Y., Zhang, L., Wang, P., Hamada, Y., Jiang, K., Zheng, W., & Jiang, X. (2017) · Nature Communications · doi:10.1038/ncomms15130 · Cited by 340
Mohammadpour, H., MacDonald, C. R., Qiao, G., Chen, M., Dong, B., Hylander, B. L., McCarthy, P. L., Abrams, S. I., & Repasky, E. A. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129502 · Cited by 328
Cancer hallmarks intersect with neuroscience in the tumor microenvironment
Hanahan, D., & Monje, M. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.012 · Cited by 340
Mechanisms of cancer dissemination along nerves
Amit, M., Na’ara, S., & Gil, Z. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.38 · Cited by 314
Cancer exosomes induce tumor innervation
Madeo, M., Colbert, P. L., Vermeer, D. W., Lucido, C. T., Cain, J. T., Vichaya, E. G., Grossberg, A. J., Muirhead, D., Rickel, A. P., Hong, Z., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06640-0 · Cited by 313
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies
Cervantes‐Villagrana, R. D., Albores‐García, D., Cervantes-Villagrana, A. R., & García-Acevez, S. J. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0205-z · Cited by 311
Schwann cells induce cancer cell dispersion and invasion
Deborde, S., Omelchenko, T., Lyubchik, A., Zhou, Y., He, S., McNamara, W. F., Chernichenko, N., Lee, S., Barajas, F., Chen, C., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci82658 · Cited by 305
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Boilly, B., Faulkner, S., Jobling, P., & Hondermarck, H. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.02.005 · Cited by 295
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Silverman, D. A., Martinez, V. K., Dougherty, P. M., Myers, J. N., Călin, G. A., & Amit, M. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-2793 · Cited by 304
Bucsek, M. J., Qiao, G., MacDonald, C. R., Giridharan, T., Evans, L., Niedzwecki, B., Liu, H., Kokolus, K. M., Eng, J. W.-L., Messmer, M. N., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0546 · Cited by 294
Kamiya, A., Hayama, Y., Kato, S., Shimomura, A., Shimomura, T., Irie, K., Kaneko, R., Yanagawa, Y., Kobayashi, K., & Ochiya, T. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0430-3 · Cited by 287
RetractedNerve–Cancer Cell Cross-talk: A Novel Promoter of Tumor Progression
Jobling, P., Pundavela, J., Oliveira, S. M. R., Roselli, S., Walker, M. M., & Hondermarck, H. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3180 · Cited by 272
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Faulkner, S., Jobling, P., March, B., Jiang, C. C., & Hondermarck, H. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1398 · Cited by 275
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Hanoun, M., Maryanovich, M., Arnal-Estapé, A., & Frenette, P. S. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.026 · Cited by 265
Self-citationChronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2
Zhang, X., Zhang, Y., He, Z., Yin, K., Li, B., Zhang, L., & Xu, Z. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-2030-2 · Cited by 261
Host tissue determinants of tumour immunity
Salmon, H., Remark, R., Gnjatic, S., & Mérad, M. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0125-9 · Cited by 263
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Demir, İ. E., Frieß, H., & Ceyhan, G. O. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.166 · Cited by 256
Treweek, J. B., Chan, K. Y., Flytzanis, N. C., Yang, B., Deverman, B. E., Greenbaum, A., Lignell, A., Xiao, C., Cai, L., Ladinsky, M. S., et al. (2015) · Nature Protocols · doi:10.1038/nprot.2015.122 · Cited by 261
Pavlov, V. A., & Tracey, K. J. (2015) · Immunologic Research · doi:10.1007/s12026-015-8718-1 · Cited by 254
Wrapped to Adapt: Experience-Dependent Myelination
Mount, C., & Monje, M. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.009 · Cited by 262
Wu, F., Fang, T., Yu, L., Lv, G., Lv, H., Dong, L., Li, T., Wang, C., Tan, Y., Ding, J., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.04.019 · Cited by 248
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Mohanta, S. K., Peng, L., Li, Y., Lu, S., Sun, T., Carnevale, L., Perrotta, M., Ma, Z., Förstera, B., Stanic, K., et al. (2022) · Nature · doi:10.1038/s41586-022-04673-6 · Cited by 249
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Filbin, M. G., & Monje, M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0383-9 · Cited by 258
Neurotransmitters: emerging targets in cancer
Jiang, S., Hu, L.-P., Wang, X., Li, J., & Zhang, Z. (2019) · Oncogene · doi:10.1038/s41388-019-1006-0 · Cited by 239
Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories
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Tumor innervation: peripheral nerves take control of the tumor microenvironment
Gysler, S. M., & Drapkin, R. (2021) · Journal of Clinical Investigation · doi:10.1172/jci147276 · Cited by 230
Zhang, D., Park, D., Zhong, Y., Lu, Y., Rycaj, K., Gong, S., Chen, X., Liu, X., Chao, H., Whitney, P., et al. (2016) · Nature Communications · doi:10.1038/ncomms10798 · Cited by 225
Hallmarks of cancer—the new testament
Senga, S. S., & Grose, R. P. (2021) · Open Biology · doi:10.1098/rsob.200358 · Cited by 245
Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis
Schulz, M., Salamero‐Boix, A., Niesel, K., Alekseeva, T., & Sevenich, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01713 · Cited by 226
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Dubois, C., Abeele, F. V., Lehen’kyi, V., Gkika, D., Guarmit, B., Lepage, G., Slomianny, C., Borowiec, A., Bidaux, G., Benahmed, M., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.025 · Cited by 217
Inflammation amplifier, a new paradigm in cancer biology
Atsumi, T., Singh, R., Sabharwal, L., Bando, H., Meng, J., Arima, Y., Yamada, M., Harada, M., Jiang, J.-J., Kamimura, D., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2322 · Cited by 217
Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma
Stopczynski, R. E., Normolle, D. P., Hartman, D. J., Ying, H., DeBerry, J. J., Bielefeldt, K., Rhim, A. D., DePinho, R. A., Albers, K. M., & Davis, B. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2050 · Cited by 216
Neuronal substance P drives metastasis through an extracellular RNA–TLR7 axis
Padmanaban, V., Keller, I., Seltzer, E. S., Ostendorf, B. N., Kerner, Z. J., & Tavazoie, S. F. (2024) · Nature · doi:10.1038/s41586-024-07767-5 · Cited by 223
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Torrano, V., Valcárcel-Jiménez, L., Cortázar, A. R., Liu, X., Urosevic, J., Castillo-Martín, M., Fernández‐Ruiz, S., Morciano, G., Caro‐Maldonado, A., Guiu, M., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3357 · Cited by 220
Nerves in Bone: Evolving Concepts in Pain and Anabolism
Brazill, J. M., Beeve, A. T., Craft, C. S., Ivanusic, J. J., & Scheller, E. L. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3822 · Cited by 218
Yang, M., Tao, L., Jiang, Y., Yang, J., Huo, Y., Liu, D., Li, J., Fu, X., He, R., Lin, C., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-2689 · Cited by 208
Ren, S., Wei, G., Liu, D., Wang, L., Hou, Y., Zhu, S., Peng, L., Zhang, Q., Cheng, Y., Su, H. L., et al. (2017) · European Urology · doi:10.1016/j.eururo.2017.08.027 · Cited by 198
Jiang, S.-H., Zhu, L., Zhang, M., Li, R., Yang, Q., Yan, J., Zhang, C., Yang, J., Dong, F., Dai, M., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317479 · Cited by 197
Remote neuronal activity drives glioma progression through SEMA4F
Huang-Hobbs, E., Cheng, Y.-T., Ko, Y., Luna-Figueroa, E., Lozzi, B., Taylor, K. R., McDonald, M. F., He, P., Chen, H., Yang, Y., et al. (2023) · Nature · doi:10.1038/s41586-023-06267-2 · Cited by 205
Li, W., Wang, Y., Liu, R., Kasinski, A. L., Shen, H., Slack, F. J., & Tang, D. G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.640587 · Cited by 198
Tumor Abnormality-Oriented Nanomedicine Design
Zhou, Q., Xiang, J., Qiu, N., Wang, Y., Piao, Y., Shao, S., Tang, J., Zhou, Z., & Shen, Y. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00062 · Cited by 203
Eng, J. W. ‐., Kokolus, K. M., Reed, C. B., Hylander, B. L., Ma, W. W., & Repasky, E. A. (2014) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-014-1617-9 · Cited by 197
Critical Neurotransmitters in the Neuroimmune Network
Hodo, T., de Aquino, M. T. P., Shimamoto, A., & Shanker, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01869 · Cited by 192
Metabolic heterogeneity in cancer
Demicco, M., Liu, X., Leithner, K., & Fendt, S. (2024) · Nature Metabolism · doi:10.1038/s42255-023-00963-z · Cited by 186
Linking Heart Failure to Cancer
Bertero, E., Canepa, M., Maack, C., & Ameri, P. (2018) · Circulation · doi:10.1161/circulationaha.118.033603 · Cited by 184
Pundavela, J., Roselli, S., Faulkner, S., Attia, J., Scott, R. J., Thorne, R. F., Forbes, J., Bradshaw, R. A., Walker, M. M., Jobling, P., et al. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.05.001 · Cited by 181
Rajasethupathy, P., Ferenczi, E., & Deisseroth, K. A. (2016) · Cell · doi:10.1016/j.cell.2016.03.047 · Cited by 183
Qiao, G., Chen, M., Mohammadpour, H., MacDonald, C. R., Bucsek, M. J., Hylander, B. L., Barbi, J. J., & Repasky, E. A. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0445 · Cited by 181
Guo, X., Pan, Y., Xiong, M., Sanapala, S., Anastasaki, C., Cobb, O. M., Dahiya, S. M., & Gutmann, D. H. (2020) · Nature Communications · doi:10.1038/s41467-020-15770-3 · Cited by 175
Modulation of anti-tumor immunity by the brain’s reward system
Ben-Shaanan, T. L., Schiller, M., Azulay‐Debby, H., Korin, B., Boshnak, N., Koren, T., Krot, M., Shakya, J., Rahat, M. A., Hakim, F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05283-5 · Cited by 175
Nerve-to-cancer transfer of mitochondria during cancer metastasis
Hoover, G., Gilbert, S., Curley, O., Obellianne, C., Lin, M. T., Hixson, W., Pierce, T. W., Andrews, J., ALEXEYEV, M. F., Ding, Y., et al. (2025) · Nature · doi:10.1038/s41586-025-09176-8 · Cited by 177
The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease
Ordovás-Montañés, J., Rakoff-Nahoum, S., Huang, S., Riol‐Blanco, L., Barreiro, O., & von Andrian, U. H. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.007 · Cited by 178
Reprogrammed Schwann Cells Organize into Dynamic Tracks that Promote Pancreatic Cancer Invasion
Deborde, S., Gusain, L., Powers, A. E., Marcadis, A. R., Yu, Y., Chen, C.-H., Frants, A., Kao, E., Tang, L. H., Vakiani, E., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-1690 · Cited by 170
Adrenergic Signaling: A Targetable Checkpoint Limiting Development of the Antitumor Immune Response
Qiao, G., Chen, M., Bucsek, M. J., Repasky, E. A., & Hylander, B. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00164 · Cited by 172
Mohammadpour, H., MacDonald, C. R., McCarthy, P. L., Abrams, S. I., & Repasky, E. A. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109883 · Cited by 166
Role of the nervous system in cancers: a review
Wang, H., Zheng, Q., Lu, Z., Wang, L., Ding, L., Xia, L., Zhang, H., Wang, M., Chen, Y.-C., & Li, G. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00450-y · Cited by 171
Olfactory sensory experience regulates gliomagenesis via neuronal IGF1
Chen, P., Wang, W., Liu, R., Lyu, J., Zhang, L., Li, B., Qiu, B., Tian, A., Jiang, W., Ying, H., et al. (2022) · Nature · doi:10.1038/s41586-022-04719-9 · Cited by 166
McCullough, D. J., Stabley, J. N., Siemann, D. W., & Behnke, B. J. (2014) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/dju036 · Cited by 159
Eng, J. W. ‐., Reed, C. B., Kokolus, K. M., Pitoniak, R., Utley, A. T., Bucsek, M. J., Ma, W. W., Repasky, E. A., & Hylander, B. L. (2015) · Nature Communications · doi:10.1038/ncomms7426 · Cited by 157
Mast Cell-Mediated Mechanisms of Nociception
Aich, A., Afrin, L. B., & Gupta, K. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226151 · Cited by 159
Li, J., Yang, X., Wang, Y., Feng, M., Liu, X., Zhang, Y., Huang, S., Wu, Z., Xue, F., Qin, W., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.02.025 · Cited by 155
Engineering of magnetic nanoparticles as magnetic particle imaging tracers
Lu, C., Han, L., Wang, J., Wan, J., Song, G., & Rao, J. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00260g · Cited by 156
Metadata
- Authors
- Magnon, C., Hall, S. J., Lin, J., Xue, X., Gerber, L., Freedland, S. J., & Frenette, P. S.
- Affiliations
- Albert Einstein College of Medicine (US)
- Icahn School of Medicine at Mount Sinai (US)
- Duke University (US)
- Corresponding author
- Magnon, Claire
- Frenette, Paul S.
- Venue
- Science
- Published
- 2013-07-12
- Volume
- 341
- Issue
- 6142
- Pages
- 1236361-1236361
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2049959255
- Cited by
- 1,287
- References
- 36
- Citations by year
- 2026: 136 · 2025: 128 · 2024: 127 · 2023: 119 · 2022: 116 · 2021: 120 · 2020: 120 · 2019: 85 · 2018: 78 · 2017: 66 · 2016: 66 · 2015: 56 · 2014: 46 · 2013: 23
- FWCI
- 45.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL069438, HL097819, R01HL069438, R01HL097819)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056638, DK056638)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- prostate cancer, autonomic nerves, tumor microenvironment, sympathetic nerves, parasympathetic nerves, cholinergic fibers, adrenergic receptors, muscarinic receptors, metastasis, tumor invasion
- MeSH terms
- Adenocarcinoma, Adrenergic Fibers, Animals, Autonomic Nervous System, Cell Transformation, Neoplastic, Cholinergic Fibers, Humans, Male, Mice, Transgenic, Neoplasm Invasiveness, Neoplasm Transplantation, Nerve Net, Parasympathetic Nervous System, Promoter Regions, Genetic, Prostate, Prostatic Neoplasms, Genes, myc, Disease Progression, Cell Line, Tumor, Mice, Neurogenesis
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