Cited by 1,287Cancer, Stress, Anesthesia, and Immune ResponseProstate Cancer Treatment and ResearchVagus Nerve Stimulation Research

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Autonomic Nerve Development Contributes to Prostate Cancer Progression

Magnon, Claire, Hall, Simon J., Lin, Juan, Xue, Xiaonan, Gerber, Leah, Freedland, Stephen J., Frenette, Paul S.·2013·Science

DOI 10.1126/science.1236361

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Abstract

Cancer Hits a Nerve: Solid tumors sculpt their microenvironment to maximize their growth and metastatic potential. This concept is illustrated most famously by tumor angiogenesis, a process whereby tumors induce the growth of new blood vessels to boost their supply of oxygen and blood-borne nutrients. Magnon et al. (p. 10.1126/science.1236361 ; see the Perspective by Isaacs ) now highlight the important contribution made by another microenvironmental component—developing autonomic nerve fibers—to tumor growth and metastasis. In mouse models of prostate cancer, surgical or chemical destruction of sympathetic nerves prevented early-stage growth of tumors, whereas pharmacological inhibition of parasympathetic nerves inhibited tumor dissemination. In a small study of human prostate cancer specimens, the presence of a high density of nerve fibers in and around the tumor tissue was found to correlate with poor clinical outcome. These results raise the possibility that drugs targeting the autonomic nervous system may have therapeutic potential for prostate cancer.

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Authors: Magnon, C., Hall, S. J., Lin, J., Xue, X., Gerber, L., Freedland, S. J., & Frenette, P. S.
Affiliations: Albert Einstein College of Medicine (US)
Icahn School of Medicine at Mount Sinai (US)
Duke University (US)
Corresponding author: Magnon, Claire
Frenette, Paul S.
ORCID: Magnon, Claire
Hall, Simon J.
Lin, Juan
Xue, Xiaonan
Freedland, Stephen J.
Frenette, Paul S.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2013-07-12
Volume: 341
Issue: 6142
Pages: 1236361-1236361
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1236361
OpenAlex: W2049959255
Cited by: 1,287
References: 36
Citations by year: 2026: 136 · 2025: 128 · 2024: 127 · 2023: 119 · 2022: 116 · 2021: 120 · 2020: 120 · 2019: 85 · 2018: 78 · 2017: 66 · 2016: 66 · 2015: 56 · 2014: 46 · 2013: 23
FWCI: 45.11
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL069438, HL097819, R01HL069438, R01HL097819)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056638, DK056638)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords: prostate cancer, autonomic nerves, tumor microenvironment, sympathetic nerves, parasympathetic nerves, cholinergic fibers, adrenergic receptors, muscarinic receptors, metastasis, tumor invasion
MeSH terms: Adenocarcinoma, Adrenergic Fibers, Animals, Autonomic Nervous System, Cell Transformation, Neoplastic, Cholinergic Fibers, Humans, Male, Mice, Transgenic, Neoplasm Invasiveness, Neoplasm Transplantation, Nerve Net, Parasympathetic Nervous System, Promoter Regions, Genetic, Prostate, Prostatic Neoplasms, Genes, myc, Disease Progression, Cell Line, Tumor, Mice, Neurogenesis

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Autonomic Nerve Development Contributes to Prostate Cancer Progression

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