The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish
Open accessAbstract
Eye to Eyeless: To what extent does adaptation rely on de novo mutation, as opposed to preexisting variation? It has been proposed that heat shock protein 90 (HSP90) can act to maintain cryptic variation by correcting misfolded proteins, until the system is taxed under stress conditions. Focusing on the cavefish Astyanax mexicanus , Rohner et al. (p. 1372 ) provide evidence that this mechanism contributed to morphological evolution in a natural setting where cryptic variation in eye size was masked by HSP90 in the ancestral river but revealed when the fish were reared and selected in caves.
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Cites
CANALIZATION OF DEVELOPMENT AND THE INHERITANCE OF ACQUIRED CHARACTERS
WADDINGTON, C. H. (1942) · Nature · doi:10.1038/150563a0 · Cited by 3,255
Hsp90 as a capacitor for morphological evolution
Rutherford, S. L., & Lindquist, S. (1998) · Nature · doi:10.1038/24550 · Cited by 2,270
Self-citationWidespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles.
Colosimo, P. F., Hosemann, K. E., Balabhadra, S., Villarreal, G., Dickson, M., Grimwood, J., Schmutz, J., Myers, R. M., Schluter, D., & Kingsley, D. M. (2005) · Science · doi:10.1126/science.1107239 · Cited by 1,448
Hsp90 as a capacitor of phenotypic variation
Queitsch, C., Sangster, T. A., & Lindquist, S. (2002) · Nature · doi:10.1038/nature749 · Cited by 1,372
Self-citationQuantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition
Taipale, M., Krykbaeva, I., Koeva, M., Kayatekin, C., Westover, K. D., Karras, G. I., & Lindquist, S. (2012) · Cell · doi:10.1016/j.cell.2012.06.047 · Cited by 879
Self-citationHsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi
Cowen, L. E., & Lindquist, S. (2005) · Science · doi:10.1126/science.1118370 · Cited by 698
Self-citationEvidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution
Sollars, V., Lu, X., Xiao, L., Wang, X., Garfinkel, M. D., & Ruden, D. M. (2003) · Nature Genetics · doi:10.1038/ng1067 · Cited by 409
Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation
Jarosz, D. F., & Lindquist, S. (2010) · Science · doi:10.1126/science.1195487 · Cited by 346
Self-citationRegressive Evolution in Astyanax Cavefish
Jeffery, W. R. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134216 · Cited by 298
Self-citationHedgehog signalling controls eye degeneration in blind cavefish
Yamamoto, Y., Stock, D. W., & Jeffery, W. R. (2004) · Nature · doi:10.1038/nature02864 · Cited by 274
Self-citation
Cited by
Schopf, F. H., Biebl, M. M., & Buchner, J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.20 · Cited by 1,540
Cryptic genetic variation: evolution's hidden substrate
Paaby, A. B., & Rockman, M. V. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3688 · Cited by 500
Schlichting, C. D., & Wund, M. A. (2014) · Evolution · doi:10.1111/evo.12348 · Cited by 285
Evolution of heat‐shock protein expression underlying adaptive responses to environmental stress
Chen, B., Feder, M. E., & Kang, L. (2018) · Molecular Ecology · doi:10.1111/mec.14769 · Cited by 267
Joel, D., & McCarthy, M. M. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.79 · Cited by 158
Metadata
- Authors
- Rohner, N., Jarosz, D. F., Kowalko, J. E., Yoshizawa, M., Jeffery, W. R., Borowsky, R. L., Lindquist, S., & Tabin, C. J.
- Venue
- Science
- Published
- 2013-12-13
- Volume
- 342
- Issue
- 6164
- Pages
- 1372-1375
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1585630096
- Cited by
- 353
- References
- 12
- FWCI
- 26.22
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish. https://app.cochat.ai/papers/10.1126/science.1240276
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- Rohner, N., Jarosz, D. F., Kowalko, J. E., Yoshizawa, M., Jeffery, W. R., Borowsky, R. L., Lindquist, S., & Tabin, C. J. (2013). Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish. Science. https://doi.org/10.1126/science.1240276
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
