Cited by 165Genetics, Aging, and Longevity in Model OrganismsAnimal Behavior and ReproductionNeurobiology and Insect Physiology Research

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Males Shorten the Life Span of C. elegans Hermaphrodites via Secreted Compounds

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Maures, Travis J., Booth, Lauren N., Benayoun, Bérénice A., Izrayelit, Yevgeniy, Schroeder, Frank C., Brunet, Anne·2014·Science

DOI 10.1126/science.1244160PMC PMC4126796

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Abstract

Battle of the Sexes: In many species, males compete with one another to propagate their own DNA, often to the detriment of females (see the Perspective by Promislow and Kaeberlein ). Shi and Murphy (p. 536 , published online 19 December) discovered that mating in Caenorhabditis species causes mothers to shrink and die soon after they have ceased producing progeny. Males appear to hijack the longevity and stress resistance pathways normally employed by the mothers to slow reproduction and somatic aging in times of stress. Maures et al. (p. 541 , published online 29 November) explored why the presence of abundant mating-competent males causes a decrease in the life span of nematodes of the opposite sex and found that a secreted substance, possibly a pheromone, reproduced the effect of the males when transferred in the culture medium. Detection of pheromones from a female fruit fly is enough to cause changes in metabolism, reduce resistance to starvation, and shorten the life span of male flies. Gendron et al. (p. 544 , published online 29 November) report that the signals from the female appear to be recognized by sensory receptors on the legs of male flies.

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Authors: Maures, T. J., Booth, L. N., Benayoun, B. A., Izrayelit, Y., Schroeder, F. C., & Brunet, A.
Affiliations: Stanford University (US)
Cornell University (US)
Corresponding author: Brunet, Anne
ORCID: Maures, Travis J.
Booth, Lauren N.
Benayoun, Bérénice A.
Schroeder, Frank C.
Brunet, Anne
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2014-01-31
Volume: 343
Issue: 6170
Pages: 541-544
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1244160
PMC: PMC4126796
OpenAlex: W2057579138
Cited by: 165
References: 37
Citations by year: 2026: 5 · 2025: 12 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 12 · 2020: 8 · 2019: 17 · 2018: 13 · 2017: 18 · 2016: 21 · 2015: 15 · 2014: 13
FWCI: 5.80
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (F32AG37254, DP1AG044848, F32AG037254, R01AG031198)
National Human Genome Research Institute (K22HG000044, T32HG000044)
National Institute of General Medical Sciences (T32GM008500, R01GM088290)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: male-male competition, Caenorhabditis elegans, pheromones, somatic aging, stress tolerance, longevity, Drosophila, starvation resistance, reproductive aging
MeSH terms: Animals, Carrier Proteins, Biological Evolution, Female, Gene Expression Regulation, Longevity, Male, Culture Media, Conditioned, Caenorhabditis elegans, Genes, Helminth, Caenorhabditis elegans Proteins, RNA Interference, Peptide Hormones

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Males Shorten the Life Span of C. elegans Hermaphrodites via Secreted Compounds

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