The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Sleep promotes branch-specific formation of dendritic spines after learning
Open accessAbstract
To sleep, perchance to remember: Many researchers believe sleep helps us consolidate our memories, but no one knows quite how. Yang et al. investigated the precise role of sleep in changing mouse brain structures (see the Perspective by Euston and Steenland). When mice learned motor tasks, small protuberances—or “spines”—formed on some of the dendritic branches of specific brain neurons. These spines represent the physical correlate of a memory. But the neurons grew and retained these spines better when the mice slept after learning the task. Neurons that fired during learning fired again during subsequent slow-wave sleep, allowing the mice to conserve the newly formed spines—and memories. Science , this issue p. 1173 ; see also p. 1087
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“(C) Sleep downscaling also entails a reduction of dendritic synaptic spines, with branches involved in prior learning (red) being spared (assessed by two-photon imaging, 164 left).”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [164]
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“At the morphological level, there is evidence that synaptic downscaling during sleep is not ubiquitous but may spare some select synapses that are particularly large or were involved in prior encoding, resulting in increased connectivity at these synapses 163,164,228,231 (Figure 2C).”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [164]
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“On a morphological level, SWS following motor task training was found to support branch-specific spine formation in a subset of cells in motor cortex.164”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [164]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Thus, similar to spine formation during learning, also spine formation during post-training SWS only pertained to select dendritic branches of motor cortex pyramidal cells.164”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [164]
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Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474
Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760
Reactivation of hippocampal ensemble memories during sleep
Wilson, M. A., & McNaughton, B. L. (1994) · Science · doi:10.1126/science.8036517 · Cited by 3,118
Sleep-dependent memory consolidation
Stickgold, R. (2005) · Nature · doi:10.1038/nature04286 · Cited by 1,857
Coordinated memory replay in the visual cortex and hippocampus during sleep
Ji, D., & Wilson, M. A. (2007) · Nature Neuroscience · doi:10.1038/nn1825 · Cited by 1,669
Roffwarg, H. P., Muzio, J. N., & Dement, W. C. (1966) · Science · doi:10.1126/science.152.3722.604 · Cited by 1,559
Sleep and synaptic homeostasis: a hypothesis
Tononi, G., & Cirelli, C. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.09.004 · Cited by 1,217
Long-term dendritic spine stability in the adult cortex
Grutzendler, J., Kasthuri, N., & Gan, W.-B. (2002) · Nature · doi:10.1038/nature01276 · Cited by 1,198
Self-citationStably maintained dendritic spines are associated with lifelong memories
Yang, G., Pan, F., & Gan, W.-B. (2009) · Nature · doi:10.1038/nature08577 · Cited by 1,182
Self-citationThe role of sleep in learning and memory
Maquet, P. (2001) · Science · doi:10.1126/science.1062856 · Cited by 1,177
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Overcoming catastrophic forgetting in neural networks
Kirkpatrick, J., Pascanu, R., Rabinowitz, N., Veness, J., Desjardins, G., Rusu, A. A., Milan, K., Quan, J., Ramalho, T., Grabska-Barwinska, A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611835114 · Cited by 7,899
Mechanisms of systems memory consolidation during sleep
Klinzing, J. G., Niethard, N., & Born, J. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0467-3 · Cited by 1,176
Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits
Südhof, T. C. (2017) · Cell · doi:10.1016/j.cell.2017.10.024 · Cited by 810
The Consolidation and Transformation of Memory
Dudai, Y., Karni, A., & Born, J. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.004 · Cited by 741
Sleep spindles: mechanisms and functions
Fernandez, L. M. J., & Lüthi, A. (2020) · Physiological Reviews · doi:10.1152/physrev.00042.2018 · Cited by 716
Metadata
- Authors
- Yang, G., Lai, C. S. W., Cichon, J., Ma, L., Li, W., & Gan, W.-B.
- Affiliations
- New York University (US)
- Peking University (CN)
- Corresponding author
- Gan, Wen-Biao
- Venue
- Science
- Published
- 2014-06-06
- Volume
- 344
- Issue
- 6188
- Pages
- 1173-1178
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4447313
- OpenAlex
- W2088321899
- Semantic Scholar
- 0a583ef013a40265cc574b8f97597b48824ef580
- Cited by
- 616
- References
- 43
- Citations by year
- 2026: 31 · 2025: 39 · 2024: 42 · 2023: 37 · 2022: 54 · 2021: 55 · 2020: 63 · 2019: 61 · 2018: 56 · 2017: 63 · 2016: 50 · 2015: 49 · 2014: 14
- FWCI
- 32.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- U.S. Department of Agriculture
- Utah State University
- Louisiana State University
- National Institute of Neurological Disorders and Stroke (R01NS047325, P01NS074972)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- sleep, dendritic spines, motor learning, motor cortex, layer 5 pyramidal neurons, synaptogenesis, memory consolidation, NREM sleep
- MeSH terms
- Animals, Female, Learning, Male, Mice, Mutant Strains, Motor Cortex, Sleep, REM, Dendritic Spines, Mice
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