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Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes

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The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments

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A Novel ES Cell Line, TT2, with High Germline-Differentiating Potency

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Dom34 Rescues Ribosomes in 3′ Untranslated Regions

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Translational Pausing Ensures Membrane Targeting and Cytoplasmic Splicing of XBP1u mRNA

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Widespread Regulation of Translation by Elongation Pausing in Heat Shock

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Dom34:Hbs1 Promotes Subunit Dissociation and Peptidyl-tRNA Drop-Off to Initiate No-Go Decay

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Translational regulation by ribosome-associated quality control in neurodegenerative disease, cancer, and viral infection

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Functions of unconventional mammalian translational GTPases GTPBP1 and GTPBP2Preprint

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Cell type–specific analysis by single-cell profiling identifies a stable mammalian tRNA–mRNA interface and increased translation efficiency in neuronsPreprint

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Genome-wide profiling of tRNA modifications by Induro-tRNAseq reveals coordinated changes

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Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation

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tRNAArg-Derived Fragments Can Serve as Arginine Donors for Protein Arginylation

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Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology

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A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription

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Eukaryotic ribosome quality control system: a potential therapeutic target for human diseases

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Biallelic inactivating variants in the GTPBP2 gene cause a neurodevelopmental disorder with severe intellectual disability

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Weighted gene co-expression network analysis reveals specific modules and biomarkers in Parkinson’s disease

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Assessing cell-specific effects of genetic variations using tRNA microarrays

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Conserved functions of human Pelota in mRNA quality control of nonstop mRNA

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Gabra2 is a genetic modifier of Dravet syndrome in mice

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The trinity of ribosome-associated quality control and stress signaling for proteostasis and neuronal physiology

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hnRNPs and ELAVL1 cooperate with uORFs to inhibit protein translation

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Overlapping spectrums: The clinicogenetic commonalities between Charcot-Marie-Tooth and other neurodegenerative diseases

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Optimization of ribosome profiling using low-input brain tissue from fragile X syndrome model mice

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Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay

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Distinct types of translation termination generate substrates for ribosome-associated quality control

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Cellular models of Batten disease

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Human DDX6 regulates translation and decay of inefficiently translated mRNAs

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Measuring mRNA translation in neuronal processes and somata by tRNA-FRET

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Global identification and characterization of tRNA-derived RNA fragment landscapes across human cancers

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New insights into RNA processing by the eukaryotic tRNA splicing endonuclease

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Liquid–liquid phase separation in diseases

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Translation suppresses exogenous target RNA-mediated microRNA decay

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Transfer RNA processing – from a structural and disease perspective

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Protein synthesis as an integral quality control mechanism during ageing

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A dual fluorescent reporter for the investigation of methionine mistranslation in live cells

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Polysome Profiling in Leishmania, Human Cells and Mouse Testis

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BiP/GRP78 Mediates ERAD Targeting of Proteins Produced by Membrane-Bound Ribosomes Stalled at the STOP-Codon

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Dysregulated ribosome quality control in human diseases

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Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1

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Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches

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Clinical delineation of GTPBP2‐associated neuro‐ectodermal syndrome: Report of two new families and review of the literature

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The tRNA Epitranscriptome and Diabetes: Emergence of tRNA Hypomodifications as a Cause of Pancreatic β-Cell Failure

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Mutations in the anticodon stem of tRNA cause accumulation and Met22-dependent decay of pre-tRNA in yeast

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Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil

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Nuclear and cytoplasmic RNA exosomes and PELOTA1 prevent miRNA-induced secondary siRNA production in Arabidopsis

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Rebirth of the translational machinery: The importance of recycling ribosomes

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Dengue virus preferentially uses human and mosquito non-optimal codons

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Functional Interplay between Small Non-Coding RNAs and RNA Modification in the Brain

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Posttranscriptional Gene Regulation of the GABA Receptor to Control Neuronal Inhibition

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Subcellular relocalization and nuclear redistribution of the RNA methyltransferases TRMT1 and TRMT1L upon neuronal activation

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Analysis of Parkinson's disease pathophysiology using an integrated genomics-bioinformatics approach

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The E3 ligase OsHel2 impedes readthrough of stalled mRNAs to regulate male fertility in thermosensitive genic male sterile rice

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Epigenetic modifications of DNA and RNA in Alzheimer’s disease

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Unraveling RNA Conformation Dynamics in Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episode Syndrome with Solid-State Nanopores

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Transfer RNA acetylation regulates in vivo mammalian stress signaling

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A Pelota-like gene regulates root development and defence responses in rice

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Ubiquitination of stalled ribosomes enables mRNA decay via HBS-1 and NONU-1 in vivo

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Molecular Highway Patrol for Ribosome Collisions

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Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery

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Premature termination codon readthrough in Drosophila varies in a developmental and tissue-specific manner

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Zinc-finger protein Zpr1 is a bespoke chaperone essential for eEF1A biogenesis

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Emerging roles of transfer RNA fragments in the CNS

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Structural basis for impaired 5′ processing of a mutant tRNA associated with defects in neuronal homeostasis

Lai, L. B., Lai, S. M., Szymanski, E. S., Kapur, M., Choi, E. K., Al‐Hashimi, H. M., Ackerman, S. L., & Gopalan, V. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2119529119 · Cited by 16

Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis

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Emerging Role of GCN1 in Disease and Homeostasis

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RNA-binding protein dysfunction in neurodegeneration

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Effects of regulatory BC1 RNA deletion on synaptic plasticity, learning, and memoryPreprint

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Polyglycine-mediated aggregation of FAM98B disrupts tRNA processing in GGC repeat disorders

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The interplay between translational efficiency, poly(A) tails, microRNAs, and neuronal activation

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Aminoacylation‐defective bi‐allelic mutations in human EPRS1 associated with psychomotor developmental delay, epilepsy, and deafness

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Run, Ribosome, Run: From Compromised Translation to Human Health

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Ribosome inactivation regulates translation elongation in neurons

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Metabolism Meets Translation: Dietary and Metabolic Influences on tRNA Modifications and Codon Biased Translation

Rashad, S., & Marahleh, A. (2025) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.70011 · Cited by 14

Insights Into Translatomics in the Nervous System

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A ubiquitin language communicates ribosomal distress

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Quantitative Nucleotide Level Analysis of Regulation of Translation in Response to Depolarization of Cultured Neural Cells

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Upstream ORFs Prevent MAVS Spontaneous Aggregation and Regulate Innate Immune Homeostasis

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Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2–encoded Nsp1

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Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin

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Ribosome rescue and neurodegeneration

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Chronic BMAA exposure combined with TDP-43 mutation elicits motor neuron dysfunction phenotypes in mice

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Human Tissues Exhibit Diverse Composition of Translation Machinery

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Proteostasis regulation through ribosome quality control and no‐go‐decay

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Human organoid model of pontocerebellar hypoplasia 2a recapitulates brain region-specific size differences

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Co-Translational Folding: A Novel Modulator of Local Protein Expression in Mammalian Neurons?

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Translation from the Ribosome to the Clinic: Implication in Neurological Disorders and New Perspectives from Recent Advances

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