The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment
Open accessAbstract
The lateral habenula (LHb), a key regulator of monoaminergic brain regions, is activated by negatively valenced events. Its hyperactivity is associated with depression. Although enhanced excitatory input to the LHb has been linked to depression, little is known about inhibitory transmission. We discovered that γ-aminobutyric acid (GABA) is co-released with its functional opponent, glutamate, from long-range basal ganglia inputs (which signal negative events) to limit LHb activity in rodents. At this synapse, the balance of GABA/glutamate signaling is shifted toward reduced GABA in a model of depression and increased GABA by antidepressant treatment. GABA and glutamate co-release therefore controls LHb activity, and regulation of this form of transmission may be important for determining the effect of negative life events on mood and behavior.
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“The excitatory/ inhibitory ratio at each synapse can be adjusted independently by regulating the activity of the vesicular transporters 26,41 or adjusting the composition of postsynaptic receptors.”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [26]
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“Later, they were found to simultaneously transmit both glutamate and GABA and to be capable of both exciting and inhibiting LHb neurons 40,26 (Figure 1A).”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [26]
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Cites
Millisecond-timescale, genetically targeted optical control of neural activity
Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 5,015
How Inhibition Shapes Cortical Activity
Isaacson, J. S., & Scanziani, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.027 · Cited by 1,678
Lateral habenula as a source of negative reward signals in dopamine neurons
Matsumoto, M., & Hikosaka, O. (2007) · Nature · doi:10.1038/nature05860 · Cited by 1,292
Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning
Tsai, H.-C., Zhang, F., Adamantidis, A., Stuber, G. D., Bonci, A., de Lecea, L., & Deisseroth, K. (2009) · Science · doi:10.1126/science.1168878 · Cited by 1,266
Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons
Vong, L., Ye, C., Yang, Z., Choi, B. J., Chua, S. C., & Lowell, B. B. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.028 · Cited by 1,237
The habenula: from stress evasion to value-based decision-making
Hikosaka, O. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2866 · Cited by 955
Herkenham, M. A., & Nauta, W. J. H. (1977) · The Journal of Comparative Neurology · doi:10.1002/cne.901730107 · Cited by 798
Synaptic potentiation onto habenula neurons in the learned helplessness model of depression
Li, B., Piriz, J., Mirrione, M., Chung, C., Proulx, C. D., Schulz, D., Henn, F., & Malinow, R. (2011) · Nature · doi:10.1038/nature09742 · Cited by 634
Self-citationSartorius, A., Kiening, K. L., Kirsch, P., von Gall, C. C., Haberkorn, U., Unterberg, A. W., Henn, F. A., & Meyer-Lindenberg, A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.027 · Cited by 611
Hyttel, J. (1982) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(82)80179-6 · Cited by 585
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Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression
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Metadata
- Authors
- Shabel, S. J., Proulx, C. D., Piriz, J., & Malinow, R.
- Affiliations
- University of California San Diego (US)
- Grupo de Neurociencia de Sistemas, Instituto de Fisiología y Biofísica Houssay (CONICET-UBA), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
- Corresponding author
- Shabel, Steven J.
- Venue
- Science
- Published
- 2014-09-19
- Volume
- 345
- Issue
- 6203
- Pages
- 1494-1498
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4305433
- OpenAlex
- W2046270739
- Cited by
- 369
- References
- 44
- Citations by year
- 2026: 25 · 2025: 23 · 2024: 24 · 2023: 28 · 2022: 43 · 2021: 29 · 2020: 23 · 2019: 28 · 2018: 41 · 2017: 34 · 2016: 37 · 2015: 28 · 2014: 5
- FWCI
- 15.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Conicet (submittedVersion, cc-by-nc-sa)
- Funders
- National Institute of Mental Health (R01MH091119)
- National Institute of Neurological Disorders and Stroke (NS047101, P30NS047101)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- lateral habenula, glutamate co-release, synaptic inhibition, depression, antidepressant treatment
- MeSH terms
- Channelrhodopsins, Animals, Antidepressive Agents, Depression, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Male, Mice, Inbred C57BL, Synaptic Transmission, Neurons, Rats, Sprague-Dawley, Glutamic Acid, Habenula, Entopeduncular Nucleus, Vesicular Glutamate Transport Protein 2, Mice, Rats
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