GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment

Millisecond-timescale, genetically targeted optical control of neural activity

Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 5,015

How Inhibition Shapes Cortical Activity

Isaacson, J. S., & Scanziani, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.027 · Cited by 1,678

Lateral habenula as a source of negative reward signals in dopamine neurons

Matsumoto, M., & Hikosaka, O. (2007) · Nature · doi:10.1038/nature05860 · Cited by 1,292

Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

Tsai, H.-C., Zhang, F., Adamantidis, A., Stuber, G. D., Bonci, A., de Lecea, L., & Deisseroth, K. (2009) · Science · doi:10.1126/science.1168878 · Cited by 1,266

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

Vong, L., Ye, C., Yang, Z., Choi, B. J., Chua, S. C., & Lowell, B. B. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.028 · Cited by 1,237

The habenula: from stress evasion to value-based decision-making

Hikosaka, O. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2866 · Cited by 955

Afferent connections of the habenular nuclei in the rat. A horseradish peroxidase study, with a note on the fiber‐of‐passage problem

Herkenham, M. A., & Nauta, W. J. H. (1977) · The Journal of Comparative Neurology · doi:10.1002/cne.901730107 · Cited by 798

Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

Li, B., Piriz, J., Mirrione, M., Chung, C., Proulx, C. D., Schulz, D., Henn, F., & Malinow, R. (2011) · Nature · doi:10.1038/nature09742 · Cited by 634

Remission of major depression under deep brain stimulation of the lateral habenula in a therapy-refractory patient

Sartorius, A., Kiening, K. L., Kirsch, P., von Gall, C. C., Haberkorn, U., Unterberg, A. W., Henn, F. A., & Meyer-Lindenberg, A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.027 · Cited by 611

Citalopram — Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity

Hyttel, J. (1982) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(82)80179-6 · Cited by 585

Neuronal circuits for fear and anxiety

Tovote, P., Fadok, J. P., & Lüthi, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3945 · Cited by 1,786

Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region

Moffitt, J. R., Bambah-Mukku, D., Eichhorn, S. W., Vaughn, E., Shekhar, K., Perez, J. D., Rubinstein, N. D., Hao, J., Regev, A., Dulac, C., et al. (2018) · Science · doi:10.1126/science.aau5324 · Cited by 1,365

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

Yang, Y., Cui, Y., Sang, K., Dong, Y., Ni, Z., Ma, S., & Hu, H. (2018) · Nature · doi:10.1038/nature25509 · Cited by 1,036

Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

Cui, Y., Yang, Y., Ni, Z., Dong, Y., Cai, G., Foncelle, A., Ma, S., Sang, K., Tang, S., Li, Y., et al. (2018) · Nature · doi:10.1038/nature25752 · Cited by 597

Molecularly defined and spatially resolved cell atlas of the whole mouse brain

Zhang, M., Pan, X., Jung, W., Halpern, A. R., Eichhorn, S. W., Lei, Z., Cohen, L., Smith, K. A., Tasic, B., Yao, Z., et al. (2023) · Nature · doi:10.1038/s41586-023-06808-9 · Cited by 531

Circuits and functions of the lateral habenula in health and in disease

Hu, H., Cui, Y., & Yang, Y. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0292-4 · Cited by 489

A neural circuit for comorbid depressive symptoms in chronic pain

Zhou, W., Jin, Y., Meng, Q., Zhu, X., Bai, T., Tian, Y., Mao, Y., Wang, L., Xie, W., Zhong, H., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0468-2 · Cited by 353

Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward

Stamatakis, A. M., van Swieten, M. M. H., Basiri, M. L., Blair, G. A., Kantak, P. A., & Stuber, G. D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1202-15.2016 · Cited by 331

Mechanisms and functions of GABA co-release

Tritsch, N. X., Granger, A. J., & Sabatini, B. L. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2015.21 · Cited by 276

Neuronal Dynamics Regulating Brain and Behavioral State Transitions

Andalman, A. S., Burns, V. M., Lovett-Barron, M., Broxton, M. J., Poole, B., Yang, S., Grosenick, L., Lerner, T. N., Chen, R., Benster, T., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.037 · Cited by 253

Lateral habenula in the pathophysiology of depression

Yang, Y., Wang, H., Hu, J., & Hu, H. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.10.024 · Cited by 254

Reward and aversion

Hu, H. (2016) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-014106 · Cited by 253

Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress

Milior, G., Lecours, C., Samson, L., Bisht, K., Poggini, S., Pagani, F., Deflorio, C., Lauro, C., Alboni, S., Limatola, C., et al. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.07.024 · Cited by 259

Anhedonia and the Brain Reward Circuitry in Depression

Heshmati, M., & Russo, S. J. (2015) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-015-0044-3 · Cited by 254

Diagnosis of major depressive disorder based on changes in multiple plasma neurotransmitters: a targeted metabolomics study

Pan, J.-X., Xia, J.-J., Deng, F.-L., Liang, W., Wu, J., Yin, B., Dong, M.-X., Chen, J., Ye, F., Wang, H., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0183-x · Cited by 239

Basal ganglia circuit loops, dopamine and motivation: a review and enquiry

Ikemoto, S., Yang, C., & Tan, A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.018 · Cited by 226

Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons

Kim, J.-I., Ganesan, S., Luo, S. X., Wu, Y.-W., Park, E., Huang, E. J., Chen, L., & Ding, J. B. (2015) · Science · doi:10.1126/science.aac4690 · Cited by 217

Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum

Faget, L. C., Zell, V., Souter, E. A., McPherson, A. D., Ressler, R. L., Gutierrez-Reed, N. A., Yoo, J. H., Dulcis, D., & Hnasko, T. S. (2018) · Nature Communications · doi:10.1038/s41467-018-03125-y · Cited by 223

Disrupted habenula function in major depression

Lawson, R. P., Nord, C. L., Seymour, B., Thomas, D. L., Dayan, P., Pilling, S., & Roiser, J. P. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.81 · Cited by 210

Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement

Yoo, J. H., Zell, V., Gutierrez-Reed, N. A., Wu, J., Ressler, R. L., Shenasa, M. A., Johnson, A. B., Fife, K. H., Faget, L. C., & Hnasko, T. S. (2016) · Nature Communications · doi:10.1038/ncomms13697 · Cited by 223

Genetically distinct parallel pathways in the entopeduncular nucleus for limbic and sensorimotor output of the basal ganglia

Wallace, M. L., Saunders, A., Huang, K. W., Philson, A. C., Goldman, M., Macosko, E. Z., McCarroll, S. A., & Sabatini, B. L. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.017 · Cited by 205

Corelease of acetylcholine and GABA from cholinergic forebrain neurons

Saunders, A., Granger, A. J., & Sabatini, B. L. (2015) · eLife · doi:10.7554/elife.06412 · Cited by 200

The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders

Sanacora, G., Yan, Z., & Popoli, M. (2022) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00540-x · Cited by 197

Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors

Cerniauskas, I., Winterer, J., de Jong, J. W., Lukacsovich, D., Yang, H., Khan, F., Peck, J. R., Obayashi, S. K., Lilascharoen, V., Lim, B. K., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.005 · Cited by 187

The Neurobiology of Fear Generalization

Asok, A., Kandel, E. R., & Rayman, J. B. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00329 · Cited by 201

A hypothalamus-habenula circuit controls aversion

Lazaridis, I., Tzortzi, O., Weglage, M., Märtin, A., Xuan, Y., Parent, M. A., Johansson, Y., Fuzik, J., Fürth, D., Fenno, L. E., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0369-5 · Cited by 187

Rescue of GABAB and GIRK function in the lateral habenula by protein phosphatase 2A inhibition ameliorates depression-like phenotypes in mice

Lecca, S., Pelosi, A., Tchenio, A., Moutkine, I., Lujan, R., Hervé, D., & Mameli, M. (2016) · Nature Medicine · doi:10.1038/nm.4037 · Cited by 176

Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse

Meye, F. J., Soiza-Reilly, M., Smit, T., Diana, M. A., Schwarz, M. K., & Mameli, M. (2016) · Nature Neuroscience · doi:10.1038/nn.4334 · Cited by 173

Wakefulness Is Governed by GABA and Histamine Cotransmission

Yu, X., Ye, Z., Houston, C. M., Zecharia, A. Y., Ma, Y., Zhang, Z., Uygun, D. S., Parker, S., Vyssotski, A. L., Yustos, R., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.003 · Cited by 171

Anterior cingulate cortex and its input to the basolateral amygdala control innate fear response

Jhang, J., Lee, H., Kang, M. S., Lee, H.-S., Park, H., & Han, J. (2018) · Nature Communications · doi:10.1038/s41467-018-05090-y · Cited by 180

Opposing Contributions of GABAergic and Glutamatergic Ventral Pallidal Neurons to Motivational Behaviors

Stephenson‐Jones, M., Bravo-Rivera, C., Ahrens, S., Furlan, A., Xiao, X., Fernandes-Henriques, C., & Li, B. (2020) · Neuron · doi:10.1016/j.neuron.2019.12.006 · Cited by 165

Neuroanatomic differences associated with stress susceptibility and resilience

Anacker, C., Scholz, J., O’Donnell, K. J., Allemang-Grand, R., Diorio, J., Bagot, R. C., Nestler, E. J., Hen, R., Lerch, J. P., & Meaney, M. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.009 · Cited by 167

Transcriptional and spatial resolution of cell types in the mammalian habenula

Hashikawa, Y., Hashikawa, K., Rossi, M. A., Basiri, M. L., Liu, Y., Johnston, N. L., Ahmad, O. R., & Stuber, G. D. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.011 · Cited by 167

The Claustrum Supports Resilience to Distraction

Atlan, G., Terem, A., Peretz‐Rivlin, N., Sehrawat, K., Gonzales, B. J., Pozner, G., Tasaka, G., Goll, Y., Refaeli, R., Zviran, O., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.06.068 · Cited by 160

Translating the habenula-from rodents to humans

Boulos, L.-J., Darcq, E., & Kieffer, B. L. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.003 · Cited by 164

The Lateral Habenula Circuitry: Reward Processing and Cognitive Control

Baker, P. M., Jhou, T. C., Li, B., Matsumoto, M., Mizumori, S. J. Y., Stephenson‐Jones, M., & Vicentic, A. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2350-16.2016 · Cited by 164

Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders

Jean-Richard-Dit-Bressel, P., Killcross, S., & McNally, G. P. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0047-3 · Cited by 160

Selective brain distribution and distinctive synaptic architecture of dual glutamatergic-GABAergic neurons

Root, D. H., Zhang, S., Barker, D. J., Miranda-Barrientos, J., Liu, B., Wang, H.-L., & Morales, M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.063 · Cited by 153

Hypothalamus-habenula potentiation encodes chronic stress experience and drives depression onset

Zheng, Z., Guo, C., Li, M., Yang, L., Liu, P., Zhang, X., Liu, Y., Guo, X., Cao, S., Dong, Y., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.011 · Cited by 142

The habenula

Namboodiri, V. M. K., Rodríguez-Romaguera, J., & Stuber, G. D. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.051 · Cited by 143

Local Corticotropin-Releasing Factor Signaling in the Hypothalamic Paraventricular Nucleus

Jiang, Z., Rajamanickam, S., & Justice, N. J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1492-17.2017 · Cited by 146

Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry

Zhu, H., Zou, G., Wang, N., Zhuang, M., Xiong, W., & Huang, G. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615557114 · Cited by 133

Lateral Preoptic Control of the Lateral Habenula through Convergent Glutamate and GABA Transmission

Barker, D. J., Miranda-Barrientos, J. A., Zhang, S., Root, D. H., Wang, H.-L., Liu, B., Calipari, E. S., & Morales, M. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.066 · Cited by 125

Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome

Ure, K., Lü, H., Wang, W., Ito, A., Wu, Z., He, L.-J., Sztainberg, Y., Chen, W., Tang, J., & Zoghbi, H. Y. (2016) · eLife · doi:10.7554/elife.14198 · Cited by 133

Implication of cerebral astrocytes in major depression: A review of fine neuroanatomical evidence in humans

O’Leary, L. A., & Mechawar, N. (2021) · Glia · doi:10.1002/glia.23994 · Cited by 126

Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner

Granger, A. J., Wang, W., Robertson, K., El-Rifai, M., Zanello, A. F., Bistrong, K., Saunders, A., Chow, B. W., Nuñez, V., Turrero García, M., et al. (2020) · eLife · doi:10.7554/elife.57749 · Cited by 124

Neurochemical Heterogeneity Among Lateral Hypothalamic Hypocretin/Orexin and Melanin-Concentrating Hormone Neurons Identified Through Single-Cell Gene Expression Analysis

Mickelsen, L. E., Kolling, F. W., Chimileski, B. R., Fujita, A., Norris, C., Chen, K., Nelson, C. E., & Jackson, A. C. (2017) · eNeuro · doi:10.1523/eneuro.0013-17.2017 · Cited by 121

A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling

Zhang, L., Hernández, V. S., Swinny, J. D., Verma, A. K., Giesecke, T., Emery, A. C., Mutig, K., García‐Segura, L. M., & Eiden, L. E. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0099-5 · Cited by 120

Organization of Functional Long-Range Circuits Controlling the Activity of Serotonergic Neurons in the Dorsal Raphe Nucleus

Zhou, L., Liu, M., Li, Q., Deng, J., Mu, D., & Sun, Y.-G. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.077 · Cited by 120

A neural pathway controlling motivation to exert effort

Proulx, C. D., Aronson, S., Milivojevic, D., Molina, C., Loi, A., Monk, B., Shabel, S. J., & Malinow, R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801837115 · Cited by 119

Left Habenula Mediates Light-Preference Behavior in Zebrafish via an Asymmetrical Visual Pathway

Zhang, B.-B., Yao, Y.-Y., Zhang, H.-F., Kawakami, K., & Du, J.-L. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.011 · Cited by 115

Neurotransmitter Switching in the Developing and Adult Brain

Spitzer, N. C. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031204 · Cited by 109

Dual-transmitter systems regulating arousal, attention, learning and memory

Ma, S., Hangya, B., Leonard, C. S., Wisden, W., & Gundlach, A. L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.009 · Cited by 107

Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms

Tchenio, A., Lecca, S., Valentinova, K., & Mameli, M. (2017) · Nature Communications · doi:10.1038/s41467-017-01192-1 · Cited by 106

Cotransmission of acetylcholine and GABA

Granger, A. J., Mulder, N., Saunders, A. B., & Sabatini, B. L. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.07.031 · Cited by 101

Synaptic Mechanisms Regulating Mood State Transitions in Depression

Parekh, P. K., Johnson, S. B., & Liston, C. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110920-040422 · Cited by 101

Segregated glycine-glutamate co-transmission from vGluT3 amacrine cells to contrast-suppressed and contrast-enhanced retinal circuits

Lee, S., Zhang, Y., Chen, M., & Zhou, Z. J. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.023 · Cited by 101

An essential role of acetylcholine-glutamate synergy at habenular synapses in nicotine dependence

Frahm, S., Antolin-Fontes, B., Görlich, A., Zander, J.-F., Ahnert-Hilger, G., & Ibañez-Tallon, I. (2015) · eLife · doi:10.7554/elife.11396 · Cited by 98

Multiplexed neurochemical signaling by neurons of the ventral tegmental area

Barker, D. J., Root, D. H., Zhang, S., & Morales, M. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2015.12.016 · Cited by 105

Afferent Connectivity of the Zebrafish Habenulae

Turner, K. J., Hawkins, T. A., Yáñez, J., Anadón, R., Wilson, S. W., & Folgueira, M. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00030 · Cited by 98

Mixed selectivity: Cellular computations for complexity

Tye, K. M., Miller, E. K., Taschbach, F., Benna, M. K., Rigotti, M., & Fusi, S. (2024) · Neuron · doi:10.1016/j.neuron.2024.04.017 · Cited by 117

Neurotransmitter Switching? No Surprise

Spitzer, N. C. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.028 · Cited by 96

Multi-transmitter neurons in the mammalian central nervous system

Granger, A. J., Wallace, M. L., & Sabatini, B. L. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.04.007 · Cited by 95

Dysregulation of the Lateral Habenula in Major Depressive Disorder

Browne, C. A., Hammack, R. J., & Lucki, I. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00046 · Cited by 95

Diversity and function of corticopetal and corticofugal GABAergic projection neurons

Melzer, S., & Monyer, H. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0344-9 · Cited by 101

Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation

Harraz, M. M., Tyagi, R., Cortés, P., & Snyder, S. H. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.211 · Cited by 94

Wiring the depressed brain: optogenetic and chemogenetic circuit interrogation in animal models of depression

Muir, J., Lopez, J., & Bagot, R. C. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0291-6 · Cited by 97

Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output

Hashimotodani, Y., Karube, F., Yanagawa, Y., Fujiyama, F., & Kano, M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.016 · Cited by 92

The habenula in psychiatric disorders: More than three decades of translational investigation

Fakhoury, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.010 · Cited by 92

Review of the cytology and connections of the lateral habenula, an avatar of adaptive behaving

Zahm, D. S., & Root, D. H. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.06.004 · Cited by 96

A Central Role for Mixed Acetylcholine/GABA Transmission in Direction Coding in the Retina

Sethuramanujam, S., McLaughlin, A. J., deRosenroll, G., Hoggarth, A., Schwab, D. J., & Awatramani, G. B. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.041 · Cited by 86

Circuit-based frameworks of depressive behaviors: The role of reward circuitry and beyond

Knowland, D., & Lim, B. K. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.12.010 · Cited by 89

The lateral habenula and the serotonergic system

Metzger, M., Bueno, D., & Lima, L. B. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.05.007 · Cited by 86

Neurotransmitter phenotype switching by spinal excitatory interneurons regulates locomotor recovery after spinal cord injury

Bertels, H., Vicente-Ortiz, G., Kanbi, K. E., & Takeoka, A. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01067-9 · Cited by 81

Habenula volume increases with disease severity in unmedicated major depressive disorder as revealed by 7T MRI

Schmidt, F. M., Schindler, S., Adamidis, M., Strauß, M., Tränkner, A., Trampel, R., Walter, M., Hegerl, U., Turner, R., Geyer, S., et al. (2016) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-016-0675-8 · Cited by 76

Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism

Eriksen, J., Chang, R., McGregor, M., Silm, K., Suzuki, T., & Edwards, R. H. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.026 · Cited by 76

VTA Projection Neurons Releasing GABA and Glutamate in the Dentate Gyrus

Ntamati, N. R., & Lüscher, C. (2016) · eNeuro · doi:10.1523/eneuro.0137-16.2016 · Cited by 78

Habenular connections with the dopaminergic and serotonergic system and their role in stress‐related psychiatric disorders

Metzger, M., Souza, R., Lima, L. B., Bueno, D., Gonçalves, L., Sego, C., Donato, J., & Shammah‐Lagnado, S. J. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14647 · Cited by 82

Understanding the habenula: A major node in circuits regulating emotion and motivation

Ables, J. L., Park, K., & Ibáñez-Tallon, I. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106734 · Cited by 79

Glutamate Cotransmission in Cholinergic, GABAergic and Monoamine Systems: Contrasts and Commonalities

Trudeau, L., & Mestikawy, S. E. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00113 · Cited by 83

Rescue of glutamate transport in the lateral habenula alleviates depression- and anxiety-like behaviors in ethanol-withdrawn rats

Kang, S., Li, J., Bekker, A., & Ye, J.-H. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.013 · Cited by 75

Ongoing behavioral state information signaled in the lateral habenula guides choice flexibility in freely moving rats

Baker, P. M., Oh, S., Kidder, K. S., & Mizumori, S. J. Y. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00295 · Cited by 76

Dorsal raphe projection inhibits the excitatory inputs on lateral habenula and alleviates depressive behaviors in rats

Zhang, H., Li, K., Chen, H., Gao, S., Xia, Z., Zhang, J., Wang, F., & Chen, J. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1623-3 · Cited by 75

A role for corticotropin-releasing factor signaling in the lateral habenula and its modulation by early-life stress

Authement, M. E., Langlois, L. D., Shepard, R. D., Browne, C. A., Lucki, I., Kassis, H., & Nugent, F. S. (2018) · Science Signaling · doi:10.1126/scisignal.aan6480 · Cited by 69

Exposure to Stressors Facilitates Long-Term Synaptic Potentiation in the Lateral Habenula

Park, H.-Y., Rhee, J., Park, K., Han, J., Malinow, R., & Chung, C. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2281-16.2017 · Cited by 71

From controlled to compulsive drug-taking: The role of the habenula in addiction

Mathis, V., & Kenny, P. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.06.018 · Cited by 73

Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3

Upmanyu, N., Jin, J., Emde, H. V. D., Ganzella, M., Bösche, L., Malviya, V. N., Zhuleku, E., Politi, A. Z., Ninov, M., Silbern, I., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.02.008 · Cited by 69

Target selectivity of septal cholinergic neurons in the medial and lateral entorhinal cortex

Desikan, S., Koser, D. E., Neitz, A., & Monyer, H. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716531115 · Cited by 72

Mu Opioid Receptor Actions in the Lateral Habenula

Margolis, E. B., & Fields, H. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159097 · Cited by 68

The Lateral Habenula Directs Coping Styles Under Conditions of Stress via Recruitment of the Endocannabinoid System

Berger, A. L., Henricks, A. M., Lugo, J. M., Wright, H. R., Warrick, C. R., Sticht, M. A., Morena, M., Río, I. B., Laredo, S. A., Craft, R. M., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.04.018 · Cited by 66

Beneficial effect of antidepressants against rotenone induced Parkinsonism like symptoms in rats

Sharma, N., Jamwal, S., & Kumar, P. (2016) · Pathophysiology · doi:10.1016/j.pathophys.2016.03.002 · Cited by 66

Boramino acid as a marker for amino acid transporters

Liu, Z., Chen, H., Chen, K., Shao, Y., Kiesewetter, D. O., Niu, G., & Chen, X. S. (2015) · Science Advances · doi:10.1126/sciadv.1500694 · Cited by 64

Why depression and pain often coexist and mutually reinforce: Role of the lateral habenula

Li, J., Li, Y., Zhang, B., Shen, X., & Zhao, H. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.08.010 · Cited by 63

An emerging role for the lateral habenula in aggressive behavior

Flanigan, M. E., Aleyasin, H., Takahashi, A., Golden, S. A., & Russo, S. J. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.05.003 · Cited by 61

Activation of serotonin2C receptors in the lateral habenular nucleus increases the expression of depression-related behaviors in the hemiparkinsonian rat

Han, L., Zhang, L., Li, L., Sun, Y., Wang, Y., Chen, L., Guo, Y., Zhang, Y., Zhang, Q.-J., & Liu, J. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.024 · Cited by 63

Hippocampal‐like circuitry in the pallium of an electric fish: Possible substrates for recursive pattern separation and completion

Elliott, S. B., Harvey‐Girard, E., Giassi, A. C. C., & Maler, L. (2017) · Journal of Comparative Neurology · doi:10.1002/cne.24060 · Cited by 61

Depletion of the Microbiome Alters the Recruitment of Neuronal Ensembles of Oxycodone Intoxication and Withdrawal

Simpson, S., Kimbrough, A., Boomhower, B., Mclellan, R., Hughes, M., Shankar, K., de Guglielmo, G., & George, O. (2020) · eNeuro · doi:10.1523/eneuro.0312-19.2020 · Cited by 60

Optogenetics enlightens neuroscience drug discovery

Song, C., & Knöpfel, T. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.15 · Cited by 63

Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula

Nuno‐Perez, A., Trusel, M., Lalive, A. L., Congiu, M., Gastaldo, D., Tchenio, A., Lecca, S., Soiza‐Reilly, M., Bagni, C., & Mameli, M. (2021) · Neuron · doi:10.1016/j.neuron.2021.01.008 · Cited by 58

Multiplexed Monitoring of Neurochemicals via Electrografting-Enabled Site-Selective Functionalization of Aptamers on Field-Effect Transistors

Gao, Z. J., Wu, G., Song, Y., Li, H., Zhang, Y., Schneider, M. J., Qiang, Y., Kaszas, J., Weng, Z., Sun, H., et al. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c05531 · Cited by 60

A pathway that controls our mood

Stern, P. (2014) · Science · doi:10.1126/science.345.6203.1463-m

Glutamatergic Dysfunction of Lateral Habenula Promotes Depression

Hu, B., & Fitzgerald, R. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000507 · Cited by 2

On the Lateral Habenula: Neurotransmitter Co-Release and a Neural Circuit Controlling Discouragement.

Aronson, S. (2019) · eScholarship (California Digital Library)

Transmission takes two

Yates, D. M. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3848

5HT1B receptor-mediated pre-synaptic depression of excitatory inputs to the rat lateral habenula

Hwang, E.-K., & Chung, J.-M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.046 · Cited by 46