The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke
Abstract
Improving stroke recovery by timing treatment: Patients recovering from strokes often fight a long uphill battle, with mixed results. Studying the effect of physical training on regeneration from damaged nerves in a model of stroke in rats, Wahl et al. show that timing matters. First, the researchers gave the rats a stroke, which damaged their ability to reach for food pellets with their forelimbs. The researchers then gave them physical training and treated them with an antibody to encourage neural regeneration. The rats improved more when the researchers waited until after the antibody treatment to start the training. Damaged circuits, it seems, need a little time to regrow before being called into action. Science , this issue p. 1250
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In the citing paper
“There have been many studies of the molecules that block axonal sprouting after CNS injury, such as myelin proteins or chondroitin sulfate proteoglycans (CSPGs)8–10”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [10]
In the citing paper
“After stroke, axonal sprouting has been demonstrated in mice, rats and non-human primates1–4,10,38.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [10]
In the citing paper
“Much scientific study has focused on the molecular components of the injury response that block axonal sprouting, such as the glial growth inhibitors NogoA and the chondroitin sulfate proteoglycans8–10.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [10]
Citations
Cites
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Plasticity during stroke recovery: from synapse to behaviour
Murphy, T. H., & Corbett, D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2735 · Cited by 1,938
Recommendations for Standards Regarding Preclinical Neuroprotective and Restorative Drug Development
Roundtable, S. T. A. I. (1999) · Stroke · doi:10.1161/01.str.30.12.2752 · Cited by 1,256
Alexander, G. M., Rogan, S. C., Abbas, A. I., Armbruster, B. N., Pei, Y., Allen, J., Nonneman, R. J., Hartmann, J. F., Moy, S. S., Nicolelis, M. A. L., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.014 · Cited by 1,019
Neuroplasticity in the context of motor rehabilitation after stroke
Dimyan, M. A., & Cohen, L. G. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.200 · Cited by 732
The “staircase test”: a measure of independent forelimb reaching and grasping abilities in rats
Montoya, C. P., Campbell-Hope, L. J., Pemberton, K. D., & Dunnett, S. B. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90048-5 · Cited by 610
Cellular and molecular mechanisms of neural repair after stroke: making waves
Carmichael, S. T. (2006) · Annals of Neurology · doi:10.1002/ana.20845 · Cited by 595
Getting Neurorehabilitation Right: What Can Be Learned From Animal Models?
Krakauer, J. W., Carmichael, S. T., Corbett, D., & Wittenberg, G. F. (2012) · Neurorehabilitation and Neural Repair · doi:10.1177/1545968312440745 · Cited by 591
Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation
García‐Alías, G., Barkhuysen, S., Buckle, M., & Fawcett, J. W. (2009) · Nature Neuroscience · doi:10.1038/nn.2377 · Cited by 474
The interaction between training and plasticity in the poststroke brain
Zeiler, S. R., & Krakauer, J. W. (2013) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000025 · Cited by 436
Cited by
Sorted by citations
Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities
Candelario‐Jalil, E., Dijkhuizen, R. M., & Magnus, T. U. (2022) · Stroke · doi:10.1161/strokeaha.122.036946 · Cited by 1,007
Intrinsic Control of Axon Regeneration
He, Z., & Jin, Y. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.022 · Cited by 654
Shrinkage-mediated imaging of entire organs and organisms using uDISCO
Pan, C., Cai, R., Quacquarelli, F. P., Ghasemigharagoz, A., Lourbopoulos, A. I., Matryba, P., Plesnila, N., Dichgans, M., Hellal, F., & Ertürk, A. (2016) · Nature Methods · doi:10.1038/nmeth.3964 · Cited by 621
Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration
Kadoya, K., Lu, P., Nguyen, K., Lee-Kubli, C. A., Kumamaru, H., Yao, L., Knackert, J. A., Poplawski, G. H. D., Dulin, J. N., Strobl, H., et al. (2016) · Nature Medicine · doi:10.1038/nm.4066 · Cited by 399
Restoring function after spinal cord injury: towards clinical translation of experimental strategies
Ramer, L. M., Ramer, M. S., & Bradbury, E. J. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70144-9 · Cited by 330
Metadata
- Authors
- Wahl, A. S., Omlor, W., Rubio, J. C., Chen, J. L., Zheng, H., Schröter, A., Gullo, M., Weinmann, O., Kobayashi, K., Helmchen, F., Ommer, B., & Schwab, M. E.
- Affiliations
- University of Zurich (CH)
- Heidelberg University (DE)
- Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland.
- National Institute for Physiological Sciences (JP)
- Corresponding author
- Wahl, A. S.
- Schwab, M. E.
- ORCID
- Venue
- Science
- Published
- 2014-06-13
- Volume
- 344
- Issue
- 6189
- Pages
- 1250-1255
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2001165604
- Cited by
- 322
- References
- 34
- Citations by year
- 2026: 7 · 2025: 25 · 2024: 11 · 2023: 23 · 2022: 30 · 2021: 28 · 2020: 23 · 2019: 35 · 2018: 29 · 2017: 42 · 2016: 33 · 2015: 26 · 2014: 10
- FWCI
- 35.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (25560436)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Keywords
- stroke, corticospinal tract, motor recovery, immunotherapy, neurite outgrowth inhibition, axonal sprouting, forelimb function, motor rehabilitation, intensive training, spinal cord, pharmacogenetics, functional recovery
- MeSH terms
- Nogo Proteins, Stroke Rehabilitation, Animals, Female, Immunotherapy, Motor Cortex, Myelin Proteins, Physical Conditioning, Animal, Pyramidal Tracts, Prosencephalon, Recovery of Function, Rats, Long-Evans, Rats
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