Cited by 322Stroke Rehabilitation and RecoveryNerve injury and regenerationSpinal Cord Injury Research

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Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke

Wahl, A. S., Omlor, W., Rubio, J. C., Chen, J. L., Zheng, H., Schröter, A., Gullo, M., Weinmann, O., Kobayashi, K., Helmchen, F., Ommer, B., Schwab, M. E.·2014·Science

DOI 10.1126/science.1253050

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Abstract

Improving stroke recovery by timing treatment: Patients recovering from strokes often fight a long uphill battle, with mixed results. Studying the effect of physical training on regeneration from damaged nerves in a model of stroke in rats, Wahl et al. show that timing matters. First, the researchers gave the rats a stroke, which damaged their ability to reach for food pellets with their forelimbs. The researchers then gave them physical training and treated them with an antibody to encourage neural regeneration. The rats improved more when the researchers waited until after the antibody treatment to start the training. Damaged circuits, it seems, need a little time to regrow before being called into action. Science , this issue p. 1250

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Authors: Wahl, A. S., Omlor, W., Rubio, J. C., Chen, J. L., Zheng, H., Schröter, A., Gullo, M., Weinmann, O., Kobayashi, K., Helmchen, F., Ommer, B., & Schwab, M. E.
Affiliations: University of Zurich (CH)
Heidelberg University (DE)
Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland.
National Institute for Physiological Sciences (JP)
Corresponding author: Wahl, A. S.
Schwab, M. E.
ORCID: Wahl, A. S.
Omlor, W.
Rubio, J. C.
Chen, J. L.
Zheng, H.
Gullo, M.
Weinmann, O.
Kobayashi, K.
Helmchen, F.
Ommer, B.
Schwab, M. E.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2014-06-13
Volume: 344
Issue: 6189
Pages: 1250-1255
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1253050
OpenAlex: W2001165604
Cited by: 322
References: 34
Citations by year: 2026: 7 · 2025: 25 · 2024: 11 · 2023: 23 · 2022: 30 · 2021: 28 · 2020: 23 · 2019: 35 · 2018: 29 · 2017: 42 · 2016: 33 · 2015: 26 · 2014: 10
FWCI: 35.92
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Funders: Japan Society for the Promotion of Science (25560436)
Topics: Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
Keywords: stroke, corticospinal tract, motor recovery, immunotherapy, neurite outgrowth inhibition, axonal sprouting, forelimb function, motor rehabilitation, intensive training, spinal cord, pharmacogenetics, functional recovery
MeSH terms: Nogo Proteins, Stroke Rehabilitation, Animals, Female, Immunotherapy, Motor Cortex, Myelin Proteins, Physical Conditioning, Animal, Pyramidal Tracts, Prosencephalon, Recovery of Function, Rats, Long-Evans, Rats

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Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke

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