The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke
Abstract
Improving stroke recovery by timing treatment: Patients recovering from strokes often fight a long uphill battle, with mixed results. Studying the effect of physical training on regeneration from damaged nerves in a model of stroke in rats, Wahl et al. show that timing matters. First, the researchers gave the rats a stroke, which damaged their ability to reach for food pellets with their forelimbs. The researchers then gave them physical training and treated them with an antibody to encourage neural regeneration. The rats improved more when the researchers waited until after the antibody treatment to start the training. Damaged circuits, it seems, need a little time to regrow before being called into action. Science , this issue p. 1250
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There have been many studies of the molecules that block axonal sprouting after CNS injury, such as myelin proteins or chondroitin sulfate proteoglycans (CSPGs)8–10”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [10]
In the citing paper
“After stroke, axonal sprouting has been demonstrated in mice, rats and non-human primates1–4,10,38.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [10]
In the citing paper
“Much scientific study has focused on the molecular components of the injury response that block axonal sprouting, such as the glial growth inhibitors NogoA and the chondroitin sulfate proteoglycans8–10.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [10]
Citations
Cites
Langhorne, P., Bernhardt, J., & Kwakkel, G. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60325-5 · Cited by 2,726
Plasticity during stroke recovery: from synapse to behaviour
Murphy, T. H., & Corbett, D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2735 · Cited by 1,938
Recommendations for Standards Regarding Preclinical Neuroprotective and Restorative Drug Development
Roundtable, S. T. A. I. (1999) · Stroke · doi:10.1161/01.str.30.12.2752 · Cited by 1,256
Alexander, G. M., Rogan, S. C., Abbas, A. I., Armbruster, B. N., Pei, Y., Allen, J., Nonneman, R. J., Hartmann, J. F., Moy, S. S., Nicolelis, M. A. L., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.014 · Cited by 1,019
Neuroplasticity in the context of motor rehabilitation after stroke
Dimyan, M. A., & Cohen, L. G. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.200 · Cited by 732
The “staircase test”: a measure of independent forelimb reaching and grasping abilities in rats
Montoya, C. P., Campbell-Hope, L. J., Pemberton, K. D., & Dunnett, S. B. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90048-5 · Cited by 610
Cellular and molecular mechanisms of neural repair after stroke: making waves
Carmichael, S. T. (2006) · Annals of Neurology · doi:10.1002/ana.20845 · Cited by 595
Getting Neurorehabilitation Right: What Can Be Learned From Animal Models?
Krakauer, J. W., Carmichael, S. T., Corbett, D., & Wittenberg, G. F. (2012) · Neurorehabilitation and Neural Repair · doi:10.1177/1545968312440745 · Cited by 591
Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation
García‐Alías, G., Barkhuysen, S., Buckle, M., & Fawcett, J. W. (2009) · Nature Neuroscience · doi:10.1038/nn.2377 · Cited by 474
The interaction between training and plasticity in the poststroke brain
Zeiler, S. R., & Krakauer, J. W. (2013) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000025 · Cited by 436
Ferguson, S. M., Eskenazi, D., Ishikawa, M., Wanat, M. J., Phillips, P. E. M., Dong, Y., Roth, B. L., & Neumaier, J. F. (2011) · Nature Neuroscience · doi:10.1038/nn.2703 · Cited by 418
Nogo-A Inhibits Neurite Outgrowth and Cell Spreading with Three Discrete Regions
Oertle, T., van der Haar, M. E., Bandtlow, C. E., Robeva, A., Burfeind, P., Buss, A., Huber, A. B., Simonen, M., Schnell, L., Brösamle, C., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05393.2003 · Cited by 416
Self-citationUsing contours to detect and localize junctions in natural images
Maire, M., Arbeláez, P., Fowlkes, C. C., & Malik, J. (2008) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr.2008.4587420 · Cited by 403
Skilled reaching relies on a V2a propriospinal internal copy circuit
Azim, E., Jiang, J., Alstermark, B., & Jessell, T. M. (2014) · Nature · doi:10.1038/nature13021 · Cited by 355
Engineering GPCR signaling pathways with RASSLs
Conklin, B. R., Hsiao, E. C., Claeysen, S., Dumuis, A., Srinivasan, S., Forsayeth, J., Guettier, J., Chang, W. C., Pei, Y., McCarthy, K. D., et al. (2008) · Nature Methods · doi:10.1038/nmeth.1232 · Cited by 262
Genetic dissection of the circuit for hand dexterity in primates
Kinoshita, M., Matsui, R., Kato, S., Hasegawa, T., Kasahara, H., Isa, K., Watakabe, A., Yamamori, T., Nishimura, Y., Alstermark, B., et al. (2012) · Nature · doi:10.1038/nature11206 · Cited by 259
Self-citationWiessner, C., Bareyre, F. M., Allegrini, P. R., Mir, A. K., Frentzel, S., Zurini, M., Schnell, L., Oertle, T., & Schwab, M. E. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200302000-00003 · Cited by 209
Self-citationBrus‐Ramer, M., Carmel, J. B., Chakrabarty, S., & Martin, J. H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3489-07.2007 · Cited by 199
Constraint-Induced Movement Therapy in the Adult Rat after Unilateral Corticospinal Tract Injury
Maier, I. C., Baumann, K., Thallmair, M., Weinmann, O., Scholl, J., & Schwab, M. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1697-08.2008 · Cited by 184
Self-citationRewiring of the corticospinal tract in the adult rat after unilateral stroke and anti-Nogo-A therapy
Lindau, N. T., Bänninger, B. J., Gullo, M., Good, N., Bachmann, L. C., Starkey, M. L., & Schwab, M. E. (2013) · Brain · doi:10.1093/brain/awt336 · Cited by 178
Self-citationPetruska, J. C., Ichiyama, R. M., Jindrich, D. L., Crown, E. D., Tansey, K. E., Roy, R. R., Edgerton, V. R., & Mendell, L. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2302-06.2007 · Cited by 151
Soleman, S., Yip, P. K., Duricki, D. A., & Moon, L. D. F. (2012) · Brain · doi:10.1093/brain/aws027 · Cited by 123
Kato, S., Kuramochi, M., Kobayashi, K., Fukabori, R., Okada, K., Uchigashima, M., Watanabe, M., Tsutsui, Y., & Kobayashi, K. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4005-11.2011 · Cited by 95
Self-citationAlaverdashvili, M. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.11.007 · Cited by 94
Back seat driving: hindlimb corticospinal neurons assume forelimb control following ischaemic stroke
Starkey, M. L., Bleul, C., Zörner, B., Lindau, N. T., Mueggler, T., Rudin, M., & Schwab, M. E. (2012) · Brain · doi:10.1093/brain/aws270 · Cited by 93
Self-citationEmerick, A. J., Neafsey, E. J., Schwab, M. E., & Kartje, G. L. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-04826.2003 · Cited by 86
Self-citationTsai, S., Markus, T. M., Andrews, E. M., Cheatwood, J. L., Emerick, A. J., Mir, A. K., Schwab, M. E., & Kartje, G. L. (2007) · Experimental Brain Research · doi:10.1007/s00221-007-1067-0 · Cited by 74
Self-citationd-Amphetamine enhances skilled reaching after ischemic cortical lesions in rats
Adkins, D. L., & Jones, T. A. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.01.036 · Cited by 64
Starkey, M. L., Bleul, C., Maier, I. C., & Schwab, M. E. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.006 · Cited by 52
Self-citationDifferential Joint-Specific Corticospinal Tract Projections within the Cervical Enlargement
Asante, C. O., & Martin, J. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074454 · Cited by 44
Seeing the Objects Behind the Dots: Recognition in Videos from a Moving Camera
Ommer, B., Mader, T., & Buhmann, J. M. (2009) · International Journal of Computer Vision · doi:10.1007/s11263-009-0211-7 · Cited by 38
Self-citationFrom Meaningful Contours to Discriminative Object Shape
Yarlagadda, P., & Ommer, B. (2012) · Lecture notes in computer science · doi:10.1007/978-3-642-33718-5_55 · Cited by 21
Self-citationBeyond Bounding-Boxes: Learning Object Shape by Model-Driven Grouping
Monroy, A., & Ommer, B. (2012) · Lecture notes in computer science · doi:10.1007/978-3-642-33712-3_42 · Cited by 20
Self-citationMax-Margin Regularization for Reducing Accidentalness in Chamfer Matching
Eigenstetter, A., Yarlagadda, P., & Ommer, B. (2013) · Lecture notes in computer science · doi:10.1007/978-3-642-37331-2_12 · Cited by 1
Self-citation
Cited by
Sorted by citations
Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities
Candelario‐Jalil, E., Dijkhuizen, R. M., & Magnus, T. U. (2022) · Stroke · doi:10.1161/strokeaha.122.036946 · Cited by 1,007
Intrinsic Control of Axon Regeneration
He, Z., & Jin, Y. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.022 · Cited by 654
Shrinkage-mediated imaging of entire organs and organisms using uDISCO
Pan, C., Cai, R., Quacquarelli, F. P., Ghasemigharagoz, A., Lourbopoulos, A. I., Matryba, P., Plesnila, N., Dichgans, M., Hellal, F., & Ertürk, A. (2016) · Nature Methods · doi:10.1038/nmeth.3964 · Cited by 621
Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration
Kadoya, K., Lu, P., Nguyen, K., Lee-Kubli, C. A., Kumamaru, H., Yao, L., Knackert, J. A., Poplawski, G. H. D., Dulin, J. N., Strobl, H., et al. (2016) · Nature Medicine · doi:10.1038/nm.4066 · Cited by 399
Restoring function after spinal cord injury: towards clinical translation of experimental strategies
Ramer, L. M., Ramer, M. S., & Bradbury, E. J. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70144-9 · Cited by 330
Metadata
- Authors
- Wahl, A. S., Omlor, W., Rubio, J. C., Chen, J. L., Zheng, H., Schröter, A., Gullo, M., Weinmann, O., Kobayashi, K., Helmchen, F., Ommer, B., & Schwab, M. E.
- Affiliations
- University of Zurich (CH)
- Heidelberg University (DE)
- Institute for Biomedical Engineering, ETH Zurich, Zurich, Switzerland.
- National Institute for Physiological Sciences (JP)
- Corresponding author
- Wahl, A. S.
- Schwab, M. E.
- ORCID
- Venue
- Science
- Published
- 2014-06-13
- Volume
- 344
- Issue
- 6189
- Pages
- 1250-1255
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2001165604
- Cited by
- 322
- References
- 34
- Citations by year
- 2026: 7 · 2025: 25 · 2024: 11 · 2023: 23 · 2022: 30 · 2021: 28 · 2020: 23 · 2019: 35 · 2018: 29 · 2017: 42 · 2016: 33 · 2015: 26 · 2014: 10
- FWCI
- 35.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (25560436)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Keywords
- stroke, corticospinal tract, motor recovery, immunotherapy, neurite outgrowth inhibition, axonal sprouting, forelimb function, motor rehabilitation, intensive training, spinal cord, pharmacogenetics, functional recovery
- MeSH terms
- Nogo Proteins, Stroke Rehabilitation, Animals, Female, Immunotherapy, Motor Cortex, Myelin Proteins, Physical Conditioning, Animal, Pyramidal Tracts, Prosencephalon, Recovery of Function, Rats, Long-Evans, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
