Cited by 104Developmental Biology and Gene RegulationMarine Invertebrate Physiology and EcologyPlanarian Biology and Electrostimulation

Development of the annelid axochord: Insights into notochord evolution

Lauri, Antonella, Brunet, Thibaut, Handberg-Thorsager, Mette, Fischer, Antje H.L., Simakov, Oleg, Steinmetz, Patrick R. H., Tomer, Raju, Keller, Philipp J. +1 more·2014·Science

Abstract

The origin of chordates has been debated for more than a century, with one key issue being the emergence of the notochord. In vertebrates, the notochord develops by convergence and extension of the chordamesoderm, a population of midline cells of unique molecular identity. We identify a population of mesodermal cells in a developing invertebrate, the marine annelid Platynereis dumerilii, that converges and extends toward the midline and expresses a notochord-specific combination of genes. These cells differentiate into a longitudinal muscle, the axochord, that is positioned between central nervous system and axial blood vessel and secretes a strong collagenous extracellular matrix. Ancestral state reconstruction suggests that contractile mesodermal midline cells existed in bilaterian ancestors. We propose that these cells, via vacuolization and stiffening, gave rise to the chordate notochord.

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Crossref · 10.1126/science.1253396

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147 of 147 references verified0 citation errors · 0 not checkable

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Authors
Lauri, A., Brunet, T., Handberg-Thorsager, M., Fischer, A. H. L., Simakov, O., Steinmetz, P. R. H., Tomer, R., Keller, P. J., & Arendt, D.
Affiliations
  • European Molecular Biology Laboratory (DE)
  • Howard Hughes Medical Institute (US)
  • Heidelberg University (DE)
Corresponding author
  • Lauri, Antonella
  • Brunet, Thibaut
  • Arendt, Detlev
Venue
Science
Published
2014-09-12
Volume
345
Issue
6202
Pages
1365-1368
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2015121260
Cited by
104
References
147
Citations by year
2026: 2 · 2025: 7 · 2024: 13 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 8 · 2019: 4 · 2018: 11 · 2017: 8 · 2016: 12 · 2015: 20 · 2014: 2 · 2012: 1
FWCI
5.74
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
Funders
Howard Hughes Medical Institute
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
Keywords
chordate origin, Platynereis dumerilii, Annelida, chordamesoderm, mesoderm, convergence and extension, collagen extracellular matrix, ancestral state reconstruction, bilaterian evolution, vacuolization
MeSH terms
Abdominal Muscles, Animals, Biological Evolution, Mesoderm, Notochord, Phylogeny, Polychaeta, Gene Expression Regulation, Developmental

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