Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria
Open accessAbstract
To elucidate the evolutionary origin of nervous system centralization, we investigated the molecular architecture of the trunk nervous system in the annelid Platynereis dumerilii. Annelids belong to Bilateria, an evolutionary lineage of bilateral animals that also includes vertebrates and insects. Comparing nervous system development in annelids to that of other bilaterians could provide valuable information about the common ancestor of all Bilateria. We find that the Platynereis neuroectoderm is subdivided into longitudinal progenitor domains by partially overlapping expression regions of nk and pax genes. These domains match corresponding domains in the vertebrate neural tube and give rise to conserved neural cell types. As in vertebrates, neural patterning genes are sensitive to Bmp signaling. Our data indicate that this mediolateral architecture was present in the last common bilaterian ancestor and thus support a common origin of nervous system centralization in Bilateria.
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- Authors
- Denes, A. S., Jékely, G., Steinmetz, P. R. H., Raible, F., Snyman, H., Prud'homme, B., Ferrier, D. E. K., Balavoine, G., & Arendt, D.
- Affiliations
- European Molecular Biology Laboratory (DE)
- University of Oxford (GB)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Arendt, Detlev
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 129
- Issue
- 2
- Pages
- 277-288
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2134436946
- Cited by
- 480
- References
- 62
- Citations by year
- 2026: 8 · 2025: 20 · 2024: 37 · 2023: 16 · 2022: 7 · 2021: 18 · 2020: 23 · 2019: 19 · 2018: 25 · 2017: 28 · 2016: 21 · 2015: 37 · 2014: 26 · 2013: 23 · 2012: 19
- FWCI
- 16.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- HAL AMU (submittedVersion)
- HAL (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BBS/B/12067)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Keywords
- Platynereis dumerilii, Bilateria, neural patterning, neuroectoderm, Pax genes, BMP signaling, neural tube, common ancestor, nervous system evolution
- MeSH terms
- Animals, Central Nervous System, Biological Evolution, Neurons, Polychaeta, Transcription Factors, Vertebrates, Homeodomain Proteins, Gene Expression Regulation, Developmental, Bone Morphogenetic Proteins, Body Patterning, Paired Box Transcription Factors
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