Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens

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KCNQ Channels in the Mesolimbic Reward Circuit Regulate Nociception in Chronic Pain in Mice

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Disinhibition of Mesolimbic Dopamine Circuit by the Lateral Hypothalamus Regulates Pain Sensation

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A neural circuit for the suppression of feeding under persistent pain

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Increased iron deposition in nucleus accumbens associated with disease progression and chronicity in migraine

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Neurogenesis of medium spiny neurons in the nucleus accumbens continues into adulthood and is enhanced by pathological pain

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Gabapentin regulates dopaminergic neuron firing and theta oscillation in the ventral tegmental area to reverse depression-like behavior in chronic neuropathic pain state

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Photon-Induced Reshaping in Perovskite Material Yields of Nanocrystals with Accurate Control of Size and Morphology

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Neurobiological aspects of pain in the context of alcohol use disorder

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RGS4 Maintains Chronic Pain Symptoms in Rodent Models

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Circuit-selective properties of glutamatergic inputs to the rat prelimbic cortex and their alterations in neuropathic pain

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CCL2/CCR2 Contributes to the Altered Excitatory-inhibitory Synaptic Balance in the Nucleus Accumbens Shell Following Peripheral Nerve Injury-induced Neuropathic Pain

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Brain Connectivity Predicts Chronic Pain in Acute Mild Traumatic Brain Injury

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Temporal Dynamics of Anxiety Phenotypes in a Dental Pulp Injury Model

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The Effects of Extended Pain on Behavior

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Apparent Effects of Opioid Use on Neural Responses to Reward in Chronic Pain

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Uncovering the analgesic effects of a pH-dependent mu-opioid receptor agonist using a model of nonevoked ongoing pain

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Oxycodone withdrawal induces HDAC1/HDAC2-dependent transcriptional maladaptations in the reward pathway in a mouse model of peripheral nerve injury

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Age-related cognitive decline in baboons: modeling the prodromal phase of Alzheimer's disease and related dementias

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Characterizing Sex Differences in Depressive-Like Behavior and Glial Brain Cell Changes Following Peripheral Nerve Injury in Mice

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Excitatory Projections from the Prefrontal Cortex to Nucleus Accumbens Core D1-MSNs and κ Opioid Receptor Modulate Itch-Related Scratching Behaviors

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Dopamine receptor D2, but not D1, mediates the reward circuit from the ventral tegmental area to the central amygdala, which is involved in pain relief

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Behavioral responses to noxious stimuli shape the perception of pain

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Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats

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Attenuated dopamine receptor signaling in nucleus accumbens core in a rat model of chemically-induced neuropathy

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Elucidation of the mechanisms of exercise-induced hypoalgesia and pain prolongation due to physical stress and the restriction of movement

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Neural Habituation to Painful Stimuli Is Modulated by Dopamine: Evidence from a Pharmacological fMRI Study

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Altered mesocorticolimbic functional connectivity in chronic low back pain patients at rest and following sad mood induction

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Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice

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The analgesic effect of refeeding on acute and chronic inflammatory pain

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Chronic inflammatory pain decreases the glutamate vesicles in presynaptic terminals of the nucleus accumbens

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Mesocorticolimbic system abnormalities in chronic cluster headache patients: A neural signature?

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CCL2 Potentiates Inflammation Pain and Related Anxiety-Like Behavior Through NMDA Signaling in Anterior Cingulate Cortex

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Kappa opioid receptors mediate an initial aversive component of paclitaxel-induced neuropathy

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The partial saphenous nerve injury model of pain impairs reward-related learning but not reward sensitivity or motivation

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Altered Reward Processing and Sex Differences in Chronic Pain

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Regulatory effects of galanin system on development of several age-related chronic diseases

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Delta/mu opioid receptor interactions in operant conditioning assays of pain-depressed responding and drug-induced rate suppression: assessment of therapeutic index in male Sprague Dawley rats

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Pain chronification and chronic pain impair a defensive behavior, but not the ability of acute pain to facilitate it, through the activation of an endogenous analgesia circuit.

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Exploring the potential role of mesocorticolimbic circuitry in motivation for and adherence to chronic pain self-management interventions

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NMDA Receptors and Signaling in Chronic Neuropathic Pain

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Optical Modulation on the Nucleus Accumbens Core in the Alleviation of Neuropathic Pain in Chronic Dorsal Root Ganglion Compression Rat Model

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Spared nerve injury decreases motivation in long-access homecage-based operant tasks in mice

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Estradiol protects against pain-facilitated fentanyl use via suppression of opioid-evoked dopamine activity in males

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Pharmacological sensitivity of reflexive and nonreflexive outcomes as a correlate of the sensory and affective responses to visceral pain in mice

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More pain; less gain

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Sex-dependent effect of inflammatory pain on negative affective states is prevented by kappa opioid receptors blockade in the nucleus accumbens shell

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Glial activation in pain and emotional processing regions in the nitroglycerin mouse model of chronic migraine

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How Accurate Appraisal of Behavioral Costs and Benefits Guides Adaptive Pain Coping

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Reward Processing under Chronic Pain from the Perspective of “Liking” and “Wanting”: A Narrative Review

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Chronic pain susceptibility is associated with anhedonic behavior and alterations in the accumbal ubiquitin-proteasome system

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μ-Opioid and dopamine-D2 receptor expression in the nucleus accumbens of male Sprague-Dawley rats whose sucrose consumption, but not preference, decreases after nerve injury

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Pain, Motivation, Migraine, and the Microbiome: New Frontiers for Opioid Systems and Disease

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SIRT1 Mediates Neuropathic Pain Induced by Sciatic Nerve Chronic Constrictive Injury in the VTA-NAc Pathway

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Chronic venlafaxine treatment fails to alter the levels of galanin system transcripts in normal rats

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Peripheral nerve injury impairs the ability to maintain behavioural flexibility following acute stress in the rat

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Distinct nucleus accumbens neural pathways underlie separate behavioral features of chronic pain and comorbid depression

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Hyperexcitation of the glutamatergic neurons in lateral hypothalamus induced by chronic pain contributes to depression-like behavior and learning and memory impairment in male mice

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