The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens
Open accessAbstract
A neuropeptide kills patient's motivation: Chronic pain is not only extremely disturbing and unpleasant; it can also make people depressed and demotivated. What causes these effects? Schwartz et al. discovered that chronic pain causes changes in the way a neuropeptide called galanin affects certain neurons in a brain region called the nucleus accumbens (see the Perspective by Fields). Galanin influences a variety of behaviors, including feeding and certain aspects of pain. In this case, it depresses synaptic transmission at specific excitatory synapses. It does so, in part, by changing the ratio of subunits of an important receptor protein. Science , this issue p. 535 ; see also p. 513
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“The morphology and function of NAc and vmPFC cells changes with the chronification of pain after nerve injury [59],[60],[84] in a way that predicts and causally affects depression-like behavior [84]”
From Distinct Brain Systems Mediate the Effects of Nociceptive Input and Self-Regulation on Pain (2015) · cites this paper as [84]
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Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin
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Self-citationCorticostriatal functional connectivity predicts transition to chronic back pain
Baliki, M. N., Petre, B., Torbey, S., Herrmann, K. M., Huang, L., Schnitzer, T. J., Fields, H. L., & Apkarian, A. V. (2012) · Nature Neuroscience · doi:10.1038/nn.3153 · Cited by 1,050
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Metadata
- Authors
- Schwartz, N., Temkin, P., Jurado, S., Lim, B. K., Heifets, B. D., Polepalli, J. S., & Malenka, R. C.
- Affiliations
- Stanford Medicine (US)
- University of Maryland, Baltimore (US)
- University of California San Diego (US)
- Corresponding author
- Malenka, Robert C.
- Venue
- Science
- Published
- 2014-08
- Volume
- 345
- Issue
- 6196
- Pages
- 535-542
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4219555
- OpenAlex
- W2133656662
- Cited by
- 278
- References
- 54
- Citations by year
- 2026: 8 · 2025: 23 · 2024: 19 · 2023: 18 · 2022: 26 · 2021: 29 · 2020: 24 · 2019: 32 · 2018: 21 · 2017: 24 · 2016: 28 · 2015: 20 · 2014: 6
- FWCI
- 17.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- National Institutes of Health
- School of Medicine, Stanford University
- National Institute on Drug Abuse (P01DA008227)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- chronic pain, motivation, nucleus accumbens, long-term depression, galanin receptor 1, medium spiny neurons, indirect pathway, excitatory synaptic transmission, fatigue
- MeSH terms
- Animals, Disease Models, Animal, Male, Mice, Inbred C57BL, Motivation, Nucleus Accumbens, Long-Term Synaptic Depression, Receptor, Galanin, Type 1, Mice, Gene Knockdown Techniques, Chronic Pain
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