Cited by 278Pain Mechanisms and TreatmentsNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

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Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens

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Schwartz, Neil, Temkin, Paul, Jurado, Sandra, Lim, Byung Kook, Heifets, Boris D., Polepalli, Jai S., Malenka, Robert C.·2014·Science

DOI 10.1126/science.1253994PMC PMC4219555

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Abstract

A neuropeptide kills patient's motivation: Chronic pain is not only extremely disturbing and unpleasant; it can also make people depressed and demotivated. What causes these effects? Schwartz et al. discovered that chronic pain causes changes in the way a neuropeptide called galanin affects certain neurons in a brain region called the nucleus accumbens (see the Perspective by Fields). Galanin influences a variety of behaviors, including feeding and certain aspects of pain. In this case, it depresses synaptic transmission at specific excitatory synapses. It does so, in part, by changing the ratio of subunits of an important receptor protein. Science , this issue p. 535 ; see also p. 513

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Authors: Schwartz, N., Temkin, P., Jurado, S., Lim, B. K., Heifets, B. D., Polepalli, J. S., & Malenka, R. C.
Affiliations: Stanford Medicine (US)
University of Maryland, Baltimore (US)
University of California San Diego (US)
Corresponding author: Malenka, Robert C.
ORCID: Temkin, Paul
Jurado, Sandra
Lim, Byung Kook
Heifets, Boris D.
Polepalli, Jai S.
Malenka, Robert C.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2014-08
Volume: 345
Issue: 6196
Pages: 535-542
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1253994
PMC: PMC4219555
OpenAlex: W2133656662
Cited by: 278
References: 54
Citations by year: 2026: 8 · 2025: 23 · 2024: 19 · 2023: 18 · 2022: 26 · 2021: 29 · 2020: 24 · 2019: 32 · 2018: 21 · 2017: 24 · 2016: 28 · 2015: 20 · 2014: 6
FWCI: 17.29
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders: National Institutes of Health
School of Medicine, Stanford University
National Institute on Drug Abuse (P01DA008227)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: chronic pain, motivation, nucleus accumbens, long-term depression, galanin receptor 1, medium spiny neurons, indirect pathway, excitatory synaptic transmission, fatigue
MeSH terms: Animals, Disease Models, Animal, Male, Mice, Inbred C57BL, Motivation, Nucleus Accumbens, Long-Term Synaptic Depression, Receptor, Galanin, Type 1, Mice, Gene Knockdown Techniques, Chronic Pain

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Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens

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