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Time-restricted feeding attenuates age-related cardiac decline in Drosophila
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Circadian clocks orchestrate periods of rest or activity and feeding or fasting over the course of a 24-hour day and maintain homeostasis. To assess whether a consolidated 24-hour cycle of feeding and fasting can sustain health, we explored the effect of time-restricted feeding (TRF; food access limited to daytime 12 hours every day) on neural, peripheral, and cardiovascular physiology in Drosophila melanogaster. We detected improved sleep, prevention of body weight gain, and deceleration of cardiac aging under TRF, even when caloric intake and activity were unchanged. We used temporal gene expression profiling and validation through classical genetics to identify the TCP-1 ring complex (TRiC) chaperonin, the mitochondrial electron transport chain complexes, and the circadian clock as pathways mediating the benefits of TRF.
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“Thus, despite the marked LBM reduction following CR in some species, CR delays age-associated muscle dysfunction in D. melanogaster [44] and rhesus monkeys [45], and delays the onset of sarcopenia in the latter [46].”
From Resistance Training Prevents Muscle Loss Induced by Caloric Restriction in Obese Elderly Individuals: A Systematic Review and Meta-Analysis (2018) · cites this paper as [44]
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“Interestingly, the ability of TRF to prevent body weight gain and decelerate cardiac aging in Drosophila (86) indicates that it may represent a beneficial aspect of chrononutrition across species.”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [86]
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“Interestingly, the ability of TRF to prevent body weight gain and decelerate cardiac aging in Drosophila (86) indicates that it may represent a beneficial aspect of chrononutrition across species.”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [86]
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Metadata
- Authors
- Gill, S., Le, H. D., Melkani, G. C., & Panda, S.
- Affiliations
- Salk Institute for Biological Studies (US)
- San Diego State University (US)
- Corresponding author
- Melkani, Girish C.
- Panda, Satchidananda
- Venue
- Science
- Published
- 2015-03-13
- Volume
- 347
- Issue
- 6227
- Pages
- 1265-1269
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4578815
- OpenAlex
- W1975439065
- Cited by
- 272
- References
- 23
- Citations by year
- 2026: 11 · 2025: 21 · 2024: 28 · 2023: 26 · 2022: 33 · 2021: 27 · 2020: 25 · 2019: 22 · 2018: 22 · 2017: 23 · 2016: 26 · 2015: 8
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (DK091618, EY016807, NS066457, RR032100, P30 CA014195, P30 EY019005)
- American Federation for Aging Research (M14322)
- American Heart Association (13BGIA17260057)
- H. A. and Mary K. Chapman Trust
- Leona M. and Harry B. Helmsley Charitable Trust (2012-PG-MED002)
- Aginsky Research Scholar Award
- Glenn Center for Aging
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- time-restricted feeding, cardiac aging, circadian clock, Drosophila melanogaster, sleep, weight gain, TRiC chaperonin, mitochondrial electron transport chain, feeding-fasting cycle
- MeSH terms
- Animals, Energy Intake, Drosophila melanogaster, Electron Transport, Feeding Behavior, Flight, Animal, Heart, Male, Mitochondria, Myocardial Contraction, Sleep, Weight Gain, Chaperonins, Drosophila Proteins, Metabolic Networks and Pathways, Circadian Clocks, Transcriptome
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