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Time-restricted feeding attenuates age-related cardiac decline in Drosophila
Open accessAbstract
Circadian clocks orchestrate periods of rest or activity and feeding or fasting over the course of a 24-hour day and maintain homeostasis. To assess whether a consolidated 24-hour cycle of feeding and fasting can sustain health, we explored the effect of time-restricted feeding (TRF; food access limited to daytime 12 hours every day) on neural, peripheral, and cardiovascular physiology in Drosophila melanogaster. We detected improved sleep, prevention of body weight gain, and deceleration of cardiac aging under TRF, even when caloric intake and activity were unchanged. We used temporal gene expression profiling and validation through classical genetics to identify the TCP-1 ring complex (TRiC) chaperonin, the mitochondrial electron transport chain complexes, and the circadian clock as pathways mediating the benefits of TRF.
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“Thus, despite the marked LBM reduction following CR in some species, CR delays age-associated muscle dysfunction in D. melanogaster [44] and rhesus monkeys [45], and delays the onset of sarcopenia in the latter [46].”
From Resistance Training Prevents Muscle Loss Induced by Caloric Restriction in Obese Elderly Individuals: A Systematic Review and Meta-Analysis (2018) · cites this paper as [44]
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“Interestingly, the ability of TRF to prevent body weight gain and decelerate cardiac aging in Drosophila (86) indicates that it may represent a beneficial aspect of chrononutrition across species.”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [86]
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“Interestingly, the ability of TRF to prevent body weight gain and decelerate cardiac aging in Drosophila (86) indicates that it may represent a beneficial aspect of chrononutrition across species.”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [86]
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Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382
DAVID: Database for Annotation, Visualization, and Integrated Discovery
Dennis, G., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., & Lempicki, R. A. (2003) · Genome Biology · doi:10.1186/gb-2003-4-5-p3 · Cited by 9,327
Cappuccio, F. P., Cooper, D., D'Elia, L., Strazzullo, P., & Miller, M. A. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr007 · Cited by 2,146
Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986
Self-citationCorrelates of Sleep and Waking in Drosophila melanogaster
Shaw, P. J., Cirelli, C., Greenspan, R. J., & Tononi, G. (2000) · Science · doi:10.1126/science.287.5459.1834 · Cited by 1,300
Rest in Drosophila is a sleep-like state
Hendricks, J. C., Finn, S. M., Panckeri, K. A., Chavkin, J., Williams, J. A., Sehgal, A., & Pack, A. I. (2000) · Neuron · doi:10.1016/s0896-6273(00)80877-6 · Cited by 1,050
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression.
Vollmers, C., Gill, S., DiTacchio, L., Pulivarthy, S. R., Le, H. D., & Panda, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909591106 · Cited by 765
Self-citationPrandiology of Drosophila and the CAFE assay
Ja, W. W., Carvalho, G. B., Mak, E. M., de la Rosa, N. N., Fang, A. Y., Liong, J. C., Brummel, T., & Benzer, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702726104 · Cited by 717
High-Fat-Diet-Induced Obesity and Heart Dysfunction Are Regulated by the TOR Pathway in Drosophila
Birse, R. T., Choi, J., Reardon, K., Rodriguez, J., Graham, S. M., Diop, S. B., Ocorr, K. A., Bodmer, R., & Oldham, S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.014 · Cited by 402
Insulin regulation of heart function in aging fruit flies
Wessells, R. J., Fitzgerald, E., Cypser, J. R., Tatar, M., & Bodmer, R. (2004) · Nature Genetics · doi:10.1038/ng1476 · Cited by 325
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Impact of intermittent fasting on health and disease processes
Mattson, M. P., Longo, V. D., & Harvie, M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.10.005 · Cited by 1,187
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Panda, S. (2016) · Science · doi:10.1126/science.aah4967 · Cited by 1,092
Self-citationFasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan
Longo, V. D., & Panda, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.001 · Cited by 1,013
Self-citationWilkinson, M. J., Manoogian, E. N. C., Zadourian, A., Lo, H., Fakhouri, S., Shoghi, A., Wang, X., Fleischer, J. G., Navlakha, S., Panda, S., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.004 · Cited by 927
Self-citationGill, S., & Panda, S. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.005 · Cited by 894
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Chaix, A., Lin, T. C., Le, H. D., Chang, M. W., & Panda, S. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.004 · Cited by 687
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Uğur, B., Chen, K., & Bellen, H. J. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.023762 · Cited by 570
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Acosta-Rodríguez, V., Rijo-Ferreira, F., Izumo, M., Xu, P., Wight-Carter, M., Green, C. B., & Takahashi, J. S. (2022) · Science · doi:10.1126/science.abk0297 · Cited by 390
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Sato, S., Solanas, G., Peixoto, F. O., Bee, L., Symeonidi, A., Schmidt, M. S., Brenner, C., Masri, S., Benitah, S. A., & Sassone‐Corsi, P. (2017) · Cell · doi:10.1016/j.cell.2017.07.042 · Cited by 366
Time-restricted eating for the prevention and management of metabolic diseases
Manoogian, E. N. C., Chow, L. S., Taub, P. R., Laferrère, B., & Panda, S. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab027 · Cited by 344
Self-citationCircadian rhythms, time-restricted feeding, and healthy aging
Manoogian, E. N. C., & Panda, S. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.006 · Cited by 330
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Vasim, I., Majeed, C. N., & DeBoer, M. D. (2022) · Nutrients · doi:10.3390/nu14030631 · Cited by 327
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Zarrinpar, A., Chaix, A., & Panda, S. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.11.007 · Cited by 263
Self-citationCircadian rhythms, metabolism, and chrononutrition in rodents and humans
Johnston, J. D., Ordovás, J. M., Scheer, F. A., & Turek, F. W. (2016) · Advances in Nutrition · doi:10.3945/an.115.010777 · Cited by 258
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Abdellatif, M., Sedej, S., Carmona-Gutierrez, D., Madeo, F., & Kroemer, G. (2018) · Circulation Research · doi:10.1161/circresaha.118.312208 · Cited by 239
Adafer, R., Messaadi, W., Meddahi, M., Patey, A., Haderbache, A., Bayen, S., & Messaadi, N. (2020) · Nutrients · doi:10.3390/nu12123770 · Cited by 243
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Tahara, Y., & Shibata, S. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.8 · Cited by 238
Flanagan, A., Bechtold, D. A., Pot, G. K., & Johnston, J. D. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15246 · Cited by 258
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Ulgherait, M., Midoun, A. M., Park, S. J., Gatto, J. A., Tener, S. J., Siewert, J., Klickstein, N., Canman, J. C., Ja, W. W., & Shirasu-Hiza, M. (2021) · Nature · doi:10.1038/s41586-021-03934-0 · Cited by 226
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Regmi, P., & Heilbronn, L. K. (2020) · iScience · doi:10.1016/j.isci.2020.101161 · Cited by 232
Che, T., Cheng, Y. Z., Tian, D., Zhang, X., Liu, X., & Wu, Z. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00613-9 · Cited by 221
The mammalian circadian clock and its entrainment by stress and exercise
Tahara, Y., Aoyama, S., & Shibata, S. (2017) · The Journal of Physiological Sciences · doi:10.1007/s12576-016-0450-7 · Cited by 198
Nohara, K., Mallampalli, V. K. P. S., Nemkov, T. G., Wirianto, M., Yang, J., Ye, Y., Sun, Y., Han, L., Esser, K. A., Mileykovskaya, E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11926-y · Cited by 185
Sleep Duration and Diabetes Risk: Population Trends and Potential Mechanisms
Grandner, M. A., Seixas, A. A., Shetty, S., & Shenoy, S. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0805-8 · Cited by 201
Gene expression hallmarks of cellular ageing
Frenk, S., & Houseley, J. (2018) · Biogerontology · doi:10.1007/s10522-018-9750-z · Cited by 181
Arble, D. M., Bass, J., Behn, C. D., Butler, M. P., Challet, E., Czeisler, C., Depner, C. M., Elmquist, J., Franken, P., Grandner, M. A., et al. (2015) · Sleep · doi:10.5665/sleep.5226 · Cited by 173
Self-citationDietary restriction with and without caloric restriction for healthy aging
Lee, C. D., & Longo, V. D. (2016) · F1000Research · doi:10.12688/f1000research.7136.1 · Cited by 178
Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease
Saran, A., Dave, S., & Zarrinpar, A. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.01.050 · Cited by 179
Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence
Gude, N. A., Broughton, K. M., Firouzi, F., & Sussman, M. A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0061-5 · Cited by 172
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Lee, Y., Field, J. M., & Sehgal, A. (2021) · Journal of Biological Rhythms · doi:10.1177/07487304211044301 · Cited by 185
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Abbott, S. M., Malkani, R. G., & Zee, P. C. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14298 · Cited by 161
Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms
Hwangbo, D., Lee, H., Abozaid, L. S., & Min, K. (2020) · Nutrients · doi:10.3390/nu12041194 · Cited by 173
Time‐restricted feeding for prevention and treatment of cardiometabolic disorders
Melkani, G. C., & Panda, S. (2017) · The Journal of Physiology · doi:10.1113/jp273094 · Cited by 155
Self-citationCatterson, J. H., Khericha, M., Dyson, M. C., Vincent, A. J., Callard, R., Haveron, S. M., Rajasingam, A., Ahmad, M., & Partridge, L. (2018) · Current Biology · doi:10.1016/j.cub.2018.04.015 · Cited by 152
Villanueva, J. E., Livelo, C., Trujillo, A. S., Chandran, S., Woodworth, B., Andrade, L., Le, H. D., Manor, U., Panda, S., & Melkani, G. C. (2019) · Nature Communications · doi:10.1038/s41467-019-10563-9 · Cited by 160
Self-citationChung, H., Chou, W., Sears, D. D., Patterson, R. E., Webster, N. J. G., & Ellies, L. G. (2016) · Metabolism · doi:10.1016/j.metabol.2016.09.006 · Cited by 149
Sardeli, A. V., Komatsu, T. R., Mori, M. A., Gáspari, A. F., & Chacon-Mikahil, M. P. T. (2018) · Nutrients · doi:10.3390/nu10040423 · Cited by 138
“melanogaster [44] and rhesus monkeys [45], and delays the onset of sarcopenia in the latter [46].”
BackgroundChoi, I. Y., Lee, C., & Longo, V. D. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.042 · Cited by 133
Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals
Deota, S., Lin, T. C., Chaix, A., Williams, A. E., Le, H. D., Calligaro, H., Ramasamy, R., Huang, L., & Panda, S. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.12.006 · Cited by 142
Self-citationMetabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease
Nowak, K. L., & Hopp, K. (2020) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.13291019 · Cited by 128
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Rund, S. S. C., O’Donnell, A. J., Gentile, J. E., & Reece, S. E. (2016) · Insects · doi:10.3390/insects7020014 · Cited by 120
Circadian Metabolism: From Mechanisms to Metabolomics and Medicine
Brown, S. A. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.03.015 · Cited by 122
Entrainment of the mouse circadian clock: Effects of stress, exercise, and nutrition
Tahara, Y., & Shibata, S. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.12.026 · Cited by 120
Ruiz, T., Vidal, J., de Hollanda, A., Scheer, F. A. J. L., Garaulet, M., & Izquierdo-Pulido, M. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.02.007 · Cited by 115
Mitophagy Receptors and Mediators: Therapeutic Targets in the Management of Cardiovascular Ageing
Ajoolabady, A., Aslkhodapasandhokmabad, H., Aghanejad, A., Zhang, Y., & Ren, J. T. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101129 · Cited by 103
Gupta, N. J., Kumar, V., & Panda, S. (2017) · PLOS ONE · doi:10.1371/journal.pone.0172852 · Cited by 100
Self-citationTime-Restricted Eating and Metabolic Syndrome: Current Status and Future Perspectives
Świątkiewicz, I., Woźniak, A., & Taub, P. R. (2021) · Nutrients · doi:10.3390/nu13010221 · Cited by 106
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Hillyer, J. F., & Pass, G. (2019) · Annual Review of Entomology · doi:10.1146/annurev-ento-011019-025003 · Cited by 97
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Makrecka‐Kuka, M., Liepinsh, E., Murray, A. J., Lemieux, H., Dambrova, M., Tepp, K., Puurand, M., Käämbre, T., Han, W. H., de Goede, P., et al. (2019) · Acta Physiologica · doi:10.1111/apha.13430 · Cited by 93
Wang, H. B., Loh, D. H., Whittaker, D. S., Cutler, T., Howland, D., & Colwell, C. S. (2018) · eNeuro · doi:10.1523/eneuro.0431-17.2017 · Cited by 95
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Greco, C. M., & Sassone‐Corsi, P. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0096-y · Cited by 94
Mihaylova, M. M., Chaix, A., Delibegović, M., Ramsey, J. J., Bass, J. T., Melkani, G. C., Singh, R., Chen, Z., Ja, W. W., Shirasu-Hiza, M., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.06.008 · Cited by 97
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Zhao, Y., Jia, M., Chen, W., & Liu, Z. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.02.021 · Cited by 89
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Quiles, J. M., & Gustafsson, Å. B. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00515 · Cited by 86
Erion, R., King, A. N., Wu, G., Hogenesch, J. B., & Sehgal, A. (2016) · eLife · doi:10.7554/elife.13552 · Cited by 85
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Takeda, N., & Maemura, K. (2016) · Hypertension Research · doi:10.1038/hr.2016.9 · Cited by 82
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Allen, C. N., Nitabach, M. N., & Colwell, C. S. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a027714 · Cited by 73
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Soliman, G. A. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1017254 · Cited by 75
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Galenza, A., Hutchinson, J., Hazes, B., Campbell, S. D., & Foley, E. (2016) · Biology Open · doi:10.1242/bio.015016 · Cited by 66
Tahara, Y., Takatsu, Y., Shiraishi, T., Kikuchi, Y., Yamazaki, M., Motohashi, H., Muto, A., Sasaki, H., Haraguchi, A., Kuriki, D., et al. (2017) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2016.30 · Cited by 63
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Stahl, B. A., Peco, E., Davla, S., Murakami, K., Moreno, N. A. C., van Meyel, D. J., & Keene, A. C. (2018) · Current Biology · doi:10.1016/j.cub.2018.10.039 · Cited by 59
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Dourlen, P., Sujkowski, A. L., Wessells, R. J., & Mollereau, B. (2015) · Progress in Lipid Research · doi:10.1016/j.plipres.2015.08.001 · Cited by 59
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Lal, H., Verma, S. K., Wang, Y., Xie, M., & Young, M. E. (2024) · Circulation Research · doi:10.1161/circresaha.123.323520 · Cited by 67
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Zhang, J., Chen, Y., Zhong, Y., Wang, Y., Huang, H., Xu, W. L., Pan, W., Chen, L., Zhu, Y., Bischof, E. Y., et al. (2025) · 中国科学通报：英文版 · doi:10.1016/j.scib.2025.05.017 · Cited by 61
Central and peripheral circadian clocks and their role in Alzheimer's disease
Chauhan, R., Chen, K.-F., Kent, B. A., & Crowther, D. C. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030627 · Cited by 58
“Remarkably, similar studies in ageing Drosophila have shown that daytime-only feeding consolidates the sleep/wake cycle and slows age-related degeneration, at least in cardiac function (Gill et al., 2015).”
BackgroundNew perspectives on chrononutrition
Crispim, C. A., & Mota, M. C. (2018) · Biological Rhythm Research · doi:10.1080/09291016.2018.1491202 · Cited by 60
Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington’s Disease
Whittaker, D. S., Loh, D. H., Wang, H. B., Tahara, Y., Kuljis, D. A., Cutler, T., Ghiani, C. A., Shibata, S., Block, G. D., & Colwell, C. S. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730418790401 · Cited by 54
Bhide, S., Trujillo, A. S., O'Connor, M. T., Young, G. H., Cryderman, D. E., Chandran, S., Nikravesh, M., Wallrath, L. L., & Melkani, G. C. (2018) · Aging Cell · doi:10.1111/acel.12747 · Cited by 53
Self-citationMisaligned feeding impairs memories
Loh, D. H., Jami, S. A., Flores, R. E., Truong, D. A., Ghiani, C. A., O’Dell, T. J., & Colwell, C. S. (2015) · eLife · doi:10.7554/elife.09460 · Cited by 52
Zeb, F., Wu, X., Fatima, S., Zaman, M. H., Khan, S. A., Safdar, M., Alam, I., & Feng, Q. (2021) · Nutrition · doi:10.1016/j.nut.2021.111244 · Cited by 51
Aging and the clock: Perspective from flies to humans
Nobrega, A. K. D., & Lyons, L. C. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14176 · Cited by 50
Innate immune remodeling by short‐term intensive fasting
Qian, J., Fang, Y., Yuan, N., Gao, X., Lv, Y., Zhao, C. N., Zhang, S., Li, Q., Li, L., Li, X., et al. (2021) · Aging Cell · doi:10.1111/acel.13507 · Cited by 49
Protein and Mitochondria Quality Control Mechanisms and Cardiac Aging
Ghosh, R., Vinod, V., Symons, J. D., & Boudina, S. (2020) · Cells · doi:10.3390/cells9040933 · Cited by 52
Zhao, L., Hutchison, A. T., Liu, B., Yates, C., Teong, X. T., Wittert, G., Thompson, C. H., Nguyen, L., Au, J., Manoogian, E. N. C., et al. (2022) · Nutrition · doi:10.1016/j.nut.2021.111583 · Cited by 48
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Livelo, C., Guo, Y., Daya, F. A., Rajasekaran, V., Varshney, S., Le, H. D., Barnes, S., Panda, S., & Melkani, G. C. (2023) · Nature Communications · doi:10.1038/s41467-023-36474-4 · Cited by 41
Self-citationHu, D., Xie, Z., Ye, Y., Bahijri, S., & Chen, M. (2020) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn-20-317 · Cited by 45
Circadian regulation of metabolism and healthspan in Drosophila
Giebultowicz, J. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.12.025 · Cited by 45
Liu, H., Chen, S., Ji, H., & Dai, Z. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1020887 · Cited by 37
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Metabolic signals in sleep regulation: recent insights
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Self-citation
Metadata
- Authors
- Gill, S., Le, H. D., Melkani, G. C., & Panda, S.
- Affiliations
- Salk Institute for Biological Studies (US)
- San Diego State University (US)
- Corresponding author
- Melkani, Girish C.
- Panda, Satchidananda
- Venue
- Science
- Published
- 2015-03-13
- Volume
- 347
- Issue
- 6227
- Pages
- 1265-1269
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4578815
- OpenAlex
- W1975439065
- Cited by
- 272
- References
- 23
- Citations by year
- 2026: 11 · 2025: 21 · 2024: 28 · 2023: 26 · 2022: 33 · 2021: 27 · 2020: 25 · 2019: 22 · 2018: 22 · 2017: 23 · 2016: 26 · 2015: 8
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (DK091618, EY016807, NS066457, RR032100, P30 CA014195, P30 EY019005)
- American Federation for Aging Research (M14322)
- American Heart Association (13BGIA17260057)
- H. A. and Mary K. Chapman Trust
- Leona M. and Harry B. Helmsley Charitable Trust (2012-PG-MED002)
- Aginsky Research Scholar Award
- Glenn Center for Aging
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- time-restricted feeding, cardiac aging, circadian clock, Drosophila melanogaster, sleep, weight gain, TRiC chaperonin, mitochondrial electron transport chain, feeding-fasting cycle
- MeSH terms
- Animals, Energy Intake, Drosophila melanogaster, Electron Transport, Feeding Behavior, Flight, Animal, Heart, Male, Mitochondria, Myocardial Contraction, Sleep, Weight Gain, Chaperonins, Drosophila Proteins, Metabolic Networks and Pathways, Circadian Clocks, Transcriptome
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